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뇌졸중 환자에서 Cutaneous Silent Period와 경직의 상관관계
정광익,최형종,고원진,전아영,유우경,이정기 대한근전도전기진단의학회 2008 대한근전도 전기진단의학회지 Vol.10 No.1
Objectives: The cutaneous silent period (CSP) is a spinal inhibitory reflex related to the stimulation of slow-conducting A-δ fibers. The aim of this study is to evaluate the relationship between spasticity and CSP in patients with stroke. Methods: Twelve stroke patients with hemiplegia were enrolled in the study. The CSP was recorded from the thenar muscles during voluntary contraction. A stimulation train consisting of five noxious electrical shocks was applied to ipsilateral digit II cutaneous nerve to record the CSP. Modified Ashworth scale (MAS) was assessed by an experienced physician. Results: The means of CSP durations were 83.08±18.26 ms and 56.50±9.74 ms on the affected side and the sound side respectively. The CSP duration on the affected side was significantly longer than that of the sound side (p<0.05). The difference of CSP duration between sound side and affected side did not correlate well with the MAS. Conclusion: Our findings showed that the CSP duration on the affected side was longer than that of the sound side and did not correlate well with the MAS. The CSP may be one of the useful tools to evaluate central nervous system. Further study will be needed to find out correlation between the CSP and the spasticity.
척수손상 쥐에서 인간 배아 줄기세포의 이식이 기능적 회복에 미치는 효과
정광익,박창일,박은숙,신지철 대한재활의학회 2008 Annals of Rehabilitation Medicine Vol.32 No.5
Objective: To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord. Method: Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5μl, 2×104/5μl). The hES cells were transplanted 1 week after a SCI. Results: The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter. Conclusion: These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.