정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

술中毒의 槪觀 : 現在와 未來 Present and Future

鄭東哲 서울대학교 의과대학 정신과학교실 1983 精神醫學報 Vol.7 No.10

유도전동기 드라이브의 고성능 제어를 위한 새로운 퍼지제어기

정동화,이정철,이홍균 한국산업안전학회 2002 한국안전학회지 Vol.17 No.4

This paper is presented new fuzzy controller for high performance of induction motor drive. New fuzzy controller took out appropriate amounts of accumulated control input according to fuzzily described situations in addition to the incremental control input calculated by conventional direct fuzzy controller. The structures of the proposed controller was motivated by the problems of direct fuzzy controller. The direct controller was given generally inevitable overshoot when one tries to reduce rise time of response. The undesirable characteristics of the direct fuzzy controller are caused by integrating operation of the controller, even though the integrator itself is introduced to overcome steady state error in response. The proposed controller clear out fuzzily integrated quantities according to the situation. This paper attempts to provide a thorough comparative insight into the behavior of induction motor drive with direct and new fuzzy speed controller. The validity of the comparative results is confirmed by the simulation results for induction motor drive system.

유도전동기의 고성능 제어를 위한 퍼지-뉴로 제어기

정동화,이정철,이홍균 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This paper proposes a fuzzy neural network controller based on the vector controlled induction motor drive system. The hybrid combination of fuzzy control and neural network will produce a powerful representation flexibility and numerical processing capability. Also, this paper is proposed estimation and control of speed of induction motor using ANN Controller. The back propagation neural network technique is used to provide a real time adaptive estimation of the motor speed. The error between the desired state variable and the actual one is back-propagated to adjust the rotor speed, so that the actual state variable will coincide with the desired one. The back propagation mechanism is easy to derive and the estimated speed tracks precisely the actual motor speed. This paper is proposed the theoretical analysis as well as the simulation results to verify the effectiveness of the new method.

Dicyma sp. YCH-37이 생산하는 효모세포벽 용해효소 : 1. 생산균주의 분리 및 효소의 정제 l. Isolation of the Strain and Purification of the Enzyme

정희철,함병권,배동훈,하세가와토루,유주현 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.4

효모세포벽 용해효소를 생산하는 균주를 토양으로부터 분리하였다. 본 균주에 대한 현미경 관찰 및 형태학적, 배양상의 특징을 검토한 결과 Dicyma sp.로 동정되어, 본 균주를 Dicyma sp YCH-37로 명명하였다. 세포에 아무런 처리도 가하지 않은 생균상태의 세균, 효모, 곰팡이에 대한 용균 spectrum을 측정한 결과, 세균 중에서는 Salmonella typhimurium을, 효모 중에서는 Torulopsis, Hansenula, Zygosaccharomyces rouxii 등을 잘 용해시켰으며, 가압증기살균 처리된 효모는 모두 용해시킬 수 있었다. 배양상등액을 yeast glucan을 이용한 affinity adsorption 및 DEAE-cellulose column chromatography로 정제한 결과, 13%의 수율과 204배의 정제도로 정제되었다. SDS-PAGE, gel filtration을 통해 분자량은 약 25,000 daltons임을 확인하였으며, 용균활성의 최적 pH와 온도는 각각 8.0과 50℃이고, pH 4.0~pH 10.0, 40℃까지 안정하였다. The strain YCH-37, which produces yeast cell wall lytic enzyme, was isolated from soil. From the microscopic observation, morphological and cultural characteristics, this strain was identified to fungus, Dicyma sp. So, we named this strain as Dicyma sp. YCH-37. The lytic enzyme effectvely lysed Salmonella typhimurium among intact living bacteria and Torulopsis, Hansenula, Zygosaccharomyces among intact living yeast, as well as autoclaved yeast strains. The yeast cell wall lytic enzyme was succesively purified to 204 folds with 13% yields through yeast glucan affinity adsorption and DEAE-cellulose column chromatography. The enzyme was identified to monomeric protein with molecular weight of 25,000 daltons from the results of SDS-PAGE and gel filtration. The optimum pH and temperature for the yeast lytic activity were 8.0 and 50℃, respectively. The enzyme was stale up to 40℃, and between pH 4.0~pH 10.0.

韓國人의 性意識과 迷信

鄭東哲 大韓法醫學會 1993 대한법의학회지 Vol.17 No.2

This paper is an essay toward sexual Mind and-it's Myths in Korea. Sexual myths are one of the world wide phenomena. The contents are different between each others in little aspects. It is not a historic and anthropological overview of sexual belief, but biological, psychosocial, behavioral, clinical and cultural aspects of myths especially in recent korean life-style. The sexual information has been mixed up with Conficeus morality and shamanistic beliefs which are charaterized by all of the things, living or not, have spirit or soul itself. These concepts about sexuality have been followed by supplication for male descendant and sexual potency as possible ways. Otherwise, there is developed another myth of the reotic pleasure takes precedence of any other interest eventhough legal problems arised. It has been derived from the marketing oriented western culture. They said it is being in the natural order of events, because of sexual equality. Then I, here, recommend the sexual education is definitely for resolution of myths and corrects sexual mind in Korea.

반복하중을 받는 철근의 부착 응력도에 관한 실험적 연구

정란,박현수,조동철 단국대학교 신소재기술연구소 1991 신소재 Vol.1 No.-

지진하중에 대한 철근콘크리트 구조물의 거동을 예측하기 위해 지금까지 진행하였던 많은 실험들이 단순증가 반복하중을 작용시키고 있다. 그러나 실제 지진에 의해 발생되는 하중은 불규칙 반복하중으로써 이전까지 관례적으로 행해졌던 규칙적인 단순증가 반복하중에 의한 실험결과가 얼마만큼 신빙성이 있는가를 검토할 필요가 있다. 본 연구에서는 지진하중에 대한 실험에서는 어떠한 하중을 가져야 실제 거동과 근사한 결과를 얻을 수 있는가를 예측하기 위하여 철근콤크리트 구조물의 구조적 취약부분인 보-기둥 접합부에 규칙적인 단순증가 반복하중과 불규칙 반복하중을 작용시켜 접합부의 부착응력도의 분포를 비교 분석하였다. The prediction and estimation of R/C structure behavlor subjected to earthquake type loading is partly based on the experimental results of the monotonically increased cyclic loading, rather than that of the irregularly increased cyclic loading. However, actual earthquake is typical random vibration. In this respect, comparing and analysing experimental test results of R/C specimens subjected to monotonically increased cyclic loading and irrcgularly increased cyclic loading, this study proposes the research direction of irregularly increased cyclic loading during earthquake.

HAI를 이용한 IPMSM의 속도 추정 및 제어

정동화,이정철,이홍균 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This paper presents hybrid artificial intelligent(HAI) controller based on the vector controlled IPMSM drive system. And it is based on artificial technologies that adaptive neural network fuzzy(A-NNF) is to speed control and artificial neural network(ANN) is to speed estimation. The salient feature of this technique is the HAI controller. The hybrid action tolerates any inaccuracies in the fuzzy logic assignment rules or in the neural network stationary weights. Speed estimators using feedforward multilayer and artificial neural network(ANN) are compared. The back-propagation algorithm is easy to derived the estimated speed tracks precisely the actual motor speed. This paper presents the theoretical analysis as well as the simulation results to verify the effectiveness of the new hybrid intelligent control

勃起不全症의 診斷과 治療

鄭東哲 서울대학교 의과대학 정신과학교실 1982 精神醫學報 Vol.6 No.10

性治療의 實際, 女子

鄭東哲 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.5

The author reviewed specific problems and controversial issues in practicing sex therapy for female sexual dysfunction, in relation to korean sociocultural background. A case of sex therapy of female sexual dysfunction which implicated various issues mentioned above, was presented and the author suggested basic principles in practicing sex therapy in our culture and elucidate the effective coping with problems encountered frequently during treatment process. It cannot be overemphasized that choosing only one treatment modality, for example, directive sex therapy or intensive psychotherapy, wouldn't be desirable and that direct application of a set-model such as the Masters and Johnson model to our Korean patient without any possible modification may not be effective in our sociocultural milieu. Basically, the author emphasized again that the knowledge and experiences of intensive psychotherapy and of behaviour therapy, understanding essential techniques of dual sex therapy and of diagnostic evaluation of sexual dysfunction as well are needed as a basic qualification for sex therapist.