Propylthiouracil 투여에 의한 갑상선 기능저하 흰쥐 조직에서 알코올 탈수소효소 활성의 변화

백상현,김동선,이창범,박용수,안유헌,김태화,기춘석,강주섭 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Background: Thyroid hormone has been known to affect hepatic alcohol dehydrogenase (ADH) activity. Although the liver is the principal site of ethanol metabolism, stomach is also responsible in part for ethanol oxidation. The effects of thyroid hormone on ADH activity in gastric mucosa and other tissues of rats had not been previously examined. Method: The effects of thyroid hormone on liver, stomach, lung, and kidney ADH activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with propylthiouracil (50 mg/kg) for 14 days. Results: Whereas hepatic ADH activities were not changed by treatment with PTU(42.9(8.6 vs 45.2 (10.1), gastric ADH activities in PTU-treated rats increased by 258.8% of control rat (6.3 ( 0.6 vs 2.2 ( 1.2, p〈0.001). In the activities of other tissues, PTU treatment decreased lung ADH activity by 59.7% of control, and increased kidney ADH activities by 247.1% of control rats. Conclusion: These data suggest that hypothyroidism causes an increase of gastric alcohol metabolism, and that the increase of gastric ADH activity can partly restore the first pass metabolism of ethanol in hypothyroid rats.

산화코발트계 산소센서의 제작 및 그 특성

이재현,전춘배,이덕동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

Co_(1-x)Mg_(x)O ceramic oxygen sensors were prepared by pressing at 0.3 ~ 1.5 ton/cm^(2) with or without binder, intending to change porosity and average grain size on the surface purposely. Microstructures of prepared Co_(1-x)Mg_(x)O ceramics were observed, the electrical properties and the sensitivity characteristics for oxygen gas were investigated in the specimen temperature range of 700~1000 °C and for oxygen partial pressure range of 1~10^(-4) atm. Temperature dependence of the resistivity of the specimen showed NTC behavior, average grain size increased and porosity decreased with increasing compaction pressure. The slopes of the resistivity of the specimens on the oxygen partial pressure decreased with increasing average grain size and with decresing porosity. Particularly, specimen pressed by 0.3 and 0.5 ton/cm^(2) showed the highest sensistivity to oxygen gas. In general optimum operating temperature was 800 °C.

Iridoid 화합물이 치수절단 후 잔존치수 조직에 미치는 영향

권혁춘,박동성,손호현 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

Aucubin, an iridoid glucoside, which is isolated form Aucuba japonica, has some biological effects. This study was to investigate the effect of aucubin on the remainig pulp tissues after pulpotomy. Mongrel dog's coronal pulps were mechanically exposed with a sterile round bur and excised with sterile sharp excarvator. After bleeding was controlled, in control group, Ca(OH)_2 powder was applied on the remaining pulps and the cavities were sealed with Z.O.E cement. In experimental group 1, mixed powder with Ca(OH)_2 and aucubin(1:1 by weight) was applied on the pulotomized pulp surfaces. After th cavities were covered with sterile aluminum foil, they were sealed with Z.O.E. cement. In experimental group 2, only aucubin powder was applied on the remaining pulps and then they were treated the same as experimental group 1. In the all groups, the pulps were histopathologically observed by light microscope at the time intervals of 1, 2 and 4 weeks after experiment. The results were as follows: 1. In control and experimental groups, mild vascular congestion and bleeding were found in most of the specimens. Less inflammatory infiltration was observed in experimental groups than in control group. 2. Dentin bridge formation was found after 1 week at both control and experimental group 1. Dentin birdge had discontinuous osteodentin like appearance of contained some dentin chips. In experimental group 2, dentin bridge was not seen. 3. The coagulation necrosis layer on the remaining pulp tissues was seen in all groups. In experimental group 2, the thickest layer was observed. And in control group, coagulation necrosis layer was similar as in experimental group 1.

컴퓨터 바둑에서 상태재현 회피에 의한 탐색공간 간소화 기법

夫起東,李도漢,權六春,朴鉉秀 慶一大學校 1997 論文集 Vol.14 No.2

In this paper, we implement a methodology that searches a complete game tree to solve the problem caused by inaccuracy of a heuristic function used in the MIN/MAX algorithm. The methodology is based on the idea searching all possible paths from one root to all terminal nodes. The devised pruning method is constructed by noticing the fact that the frequent reappearances of the same status are occured in various sequences during the processing of the Life and Death problem of Go. When this algorithm detects reappearance of the same status, it links the child of current node with the already examined one. Consequently searching cost can be reduced by the linking process. Finally, generated solution tree is expanded to acyclic directed graph by the sharing method. Experimental result shows that the proposed methodology reduces the temporal and spatial traversing cost of the AND/OR game tree. And we apply the methodology to the status evaluating problem, a major problem of Go, because the problem must reflects the clear estimation of strings status on a board.

일측 자골신경의 절단 및 재연결 후 흰쥐 척수에서 신경세포 접착분자(NCAM)의 면역조직반응의 변화에 관한 형태학적 연구

황세진,전복관,안동춘,조원길,김승현 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

무기계 항균제(Ag-ZA)의 항균력에 관한 조사

조덕제,정숙현,박동근,신춘환 東西大學校 1996 동서논문집 Vol.2 No.1

Zeolite-Na에 Ag이온을 치환시켜 제조한 무기계 항균제를 이용하여 식품의 부패나 식중독을 초래할 수 있는 5종의 세균에 대한 항균력을 조사하였다. 이 들 5종에 대한 최소 저해 농도는 Escherichia coli는 0.1%이상, Pseudomonas aeruginosa는 0.01%, Klebsiella pneumoniae는 0.05%, Staphylococcus aureus와 Bacillus subtlis는 0.03%로 나타났다. 이 들 세균에 대한 0.1%의 Ag-ZA 첨가에서의 살균효과는 90%의 균 사멸시간으로 나타낼 때 Escherichia coli는 70분, Bacillus subtlis는 92분, Staphylococcus aureus는 111분, Klebsiella pneumoniae는 158분, Pseudomonas aeruginosa는 231분으로 나타났고, Ag-ZA 첨가량의 증가에 따른 사멸 속도의 변화는 Gram 음성균에서는 속도의 증가가 나타나지만 Gram 양성균에서는 속도의 변화를 관찰할 수 없었다. The investigation of antimicrobial activity on the Ag-ZA which is prepared by ion exchanging between Zeolite-Na and Ag ion. Minimum inhibitory concentrations are 0.01% for Escherichia coli and Pseudomonas aeruginosa, 0.05% for Klebsiella pneumoniae and 0.03% for Staphylococcus aureus and Bacillus subtlis. 90% sterilization time with 0.1% Ag-ZA are 70min., 92min., 111min., 158min., 231min. for Escherichia coli, Bacillus subtlis, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa respectively. The sterilization effect is more important in gram neative bacteria than gram positive bacteria.

가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

Substrate thickness: An effective control parameter for polymer thin film buckling on PDMS substrates

Hyun, Dong Choon,Jeong, Unyong Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.112 No.5

<P>Buckling patterns of polymer thin films on plasma-treated poly(dimethylsiloxane) (PDMS) substrates were sensitively affected by the thickness of the substrate in addition to the substrate modulus. On highly crosslinked PDMS substrates, the buckling wavelength of polymer thin films sharply increased as the thickness of the substrates were raised and approached a plateau value when the substrate was 2.5 mm-thick. On weakly crosslinked PDMS substrates, the wavelength still increased even when the substrate was thicker than 20 mm. The high dependence of the buckling on the substrate thickness has not been reported before and is unexpected from the current predictions. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>