고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

소아 기관지 천식에서 혈청 총 IgE 치와 알레르기 피부반응 검사에 관한 고찰

정용헌 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Author attempts to clarify the association with serum total IgE value and skin reactivity to common allergens. 92 cases of children with bronchial asthma seen in pediatric department of Chungnm National University Hospital, being followed up for more than 12 months of period, were selected and studied retrospectively. The results were as follows: 1. First visiting age to hospital for asthma was the most between 2-5.9 years and then above 6.0 years and below 1-9 years old in order. 2. Onset of asthma was the most 2-5.9 years, below 1.9 years and above 6.0 years of age. 3. Male and female ratio was 3:1 at first hospital visit, 3.5:1 below 6 years, 2.6:1 above 6 years of age. 4. Serum total IgE level over 201 IU was noted in 72% of cases, 50% under 1.9 years and 73% over 2 years of age. 5. Skin reactivity to common allergens over 3 positive was noted in 77.6% of cases, 50% below 1.9 years, 76.5% above 2 years and 86.8% above 6 years of age. 6. Serum IgE level and skin-test reactivity to common allergens in bronchial asthma was highly interrelated, showing the higher serum IgE, the stronger skin reactivity and vice versa.

소아 천식의 혈청 총 IgE치의 변화에 관한 연구

정용헌 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

A study was performed to evaluate a change of the different serum total IgE values in childhood bronchial asthma with long-term immunotherapy. Study subjects were 36 cases in total and divided into 4 groups according to the differences of IgE values as below 200, 201-500, 501-1000, over 1001 IU/ml. Serum total IgE were measured on 3 occasions every 6 to 12 month interval. The results were summarized as follows. 1. No significant change was noted in IgE values of below 200 IU/ml groups during the study period. 2. A significant change was noted in IgE values of 201-1000 IU/ml groups between 1st & 3rd study. 3. A significant change was noted in IgE values of 501-1000 IU/ml groups between 1st & 2nd, 1st & 3rd study. 4. A significant change was noted in IgE values of over 1001 IU/ml groups between 2nd & 3rd, 1st & 3rd study 5. A significant change was noted in IgE values of all groups between 1st & 3rd study.

소아기 외과계질환의 통계적 관찰

정용헌,이재호,이건수,서종진 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Child is not little man but rather a father of man. Children are faced to surgical and medical problems reqiring various specialists. Authors analized 1126 pediatric surgical in-patients of Chung-nam National Univ. Hospital from Jan. to Dec. 1988 by departments, age, sex, duration of admission and types of diseases in order to get the information for management of children’s hospital. The results are as follows: 1. Absolute numbers of in-patients by departments are above 200 in general surgery and opthalmology, between 100-199 in plastic surgery, ENT, chest surgery and below 99 in urology and neurosurgery. 2. Male to female ratio as a whole is 1.8:1, male dominant. 3. Duration of admission within 1 week was of 55% as a whole, 87% in ENT, 85% in ophthalmology, 13% in orthopedic surgery. 4. Average duration of admission was 10.8 days as a whole, 4.6 days in ENT, 5.1 in ophthalmology, 29.7 days in orthopedic surgery, and variable by types of diseases. 5. The most frequent disease by departments was hernia in general surgery, fracture in orthopedic surgery, cerebral contusion in neurosurgery, ventricular septal defect in chest surgery, strabismus in ophthalmology, tonsillitis & adenoiditis in ENT.

소아갑상선 질환에서 갑상선 항체의 의의

정용헌,이양원 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Goiter is the most common endocrine disorder in childhood. To determine the significance of thyroid antibodies, authors studied 58 cases of children with goiter during the period of Jan. 1983 and Dec, 1984 on age, sex and functional distributions by presence of antibodies. The results were as follows : 1. Most goiters in childhood were observed in adolesence and female. 2. Distribution of goiter by function were encountered euthroidism in 72.8%, hypothyroidism in 17.2%, and hyperthyroidism in 10.4%. 3. No age prevalence was seen in presence of thyoid antibodies. 4. Microsomal antibody was more higher than that of thyroid antibody. 5. No correlation between presence of thyroid antibodies and function was noted. 6. Antithyroglobulin antibody was appeared later than microsomal antibody. 7. Antithyroid therapy was adversely affected by presence of thyroid antibodies, especially in goiter with euthyroidism.

소아기관지 천식에서 연령별 알레르기 지표에 관한 고찰

정용헌 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

To evaluate allergic paramenters according to age, 90 cases of asthmatic children seen in pediatric department of Chungnam National University Hospital, followed up for more than 5 months of period, were studied. Study groups were divided into 4 by age as below 2, 3-5, 6-8 and over 9 years. In allergic parameters, concordance with allergic rhinitis, blood total eosinophil count, serum IgE level and skin sensitivity to common allergens were encountered. The results were summarized as follows : 1. The most frequent attendance age to hospital for asthma was between 3-5 years, then 0-2, 6-8, over 9 years in order. 2. Onset of asthma under 6 years of age encountered in 74.4% of asthma, noted mostly in age between 3-5 years and rarely over 9 years of age. 3. The concordance rate of asthma with allergic rhinitis was 56.7%, noted mostly in age between 6-8 years and leastly below 2 years. 4. Blood total eosinophil counts were mildly elevated in 33.3%, highly in 44.4% of asthma, low in age between 0-2 years and high between 6-8 years. 5. Serum total IgE levels were mildly elevated in 27.9%, highly in 43.0%, low more than half in age below 2 years and high more than half of cases over 3 years. 6. The degree of skin sensitivity to common allergens was weaker in age below 2 Fears than over 3 years. Above results may be suggested the differences of allergic parameters by age and required to be estabilished the different standards of allergic parameters by age, especially for infant below 2 years of age.

소아 급성 간염의 비교 고찰

정용헌,황정순 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

The authors studied retrospectivly on 46 children with viral hepatitis who admitted to the pediatric department of Chungnam National University Hospital during the period of 2 years from Sept. 1981 to Aug. 1982 to clarify any clinical differences between B-hepatitis and Non B-hepatitis. Subjects divided into two groups as B-hepatitis & Non B-hepatitis determined by Radiommunoassay which compared to various clinical parameters such as demographic (age, sex, living place, season etc.) clinical (chief complaints, physical findings, duration of hospitalization) & laboratory (hematologic & biochemical) findings. The results are concluded as follow: 1. There is a difference of affecting age between B-and Non-B-hepatitis groups 2. Marked increase in ESR & slight increase in Thymol turbidity was noted more in Non B-hepatitis than in B-hepatitis. 3. No differences between two groups were observed in other parameters at all.

간염 환아에서의 B형 항원 및 항체의 빈도에 관한 연구

정용헌,황정순 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1

The authors studied on 77 children with acute hepatitis who admitted to the pediatric department of Chungnam National University Hospital during the period of 2 years from April 1982 to March 1984 to observe frequency of Hepatitis B antigen & antibody and to analysis any differences between B and Non-B marker groups by age, sex, living place, duration of hospitalization and various lab. parameters. The results are summarized as follows: 1. Positive rates of HBs Ag., HBs Ab., HBc Ab. and HBe Ag. tested seperately were encountered in 20.8, 15.6, 29.9 and 14.3% respectively. 2. In cases tested both HBs Ag. & HBs Ab., positive rates of HBs Ag. or HBs Ab. and both were 16.9, 11.7 and 3.9%. 3. In cases tested HBs Ag., HBs Ab. and HBc Ab., positive rates of HBs Ag. or HBcAb. were 5.2 & 6.5%, those of HBs Ag. & HBc Ab. or HBs Ab. & HBc Ab. being each 11.7%, those of HBs Ag., HBs Ab. & HBc Ab. being 3.9%. 4. In cases tested HBs Ag., HBs Ab., HBc Ab. and HBe Ag., negative rates of HBs Ag or HBc Ab were 2.6% and 6.5% and positive rates of HBs Ag & HBc Ab being 3.9%, those of HBs Ab. & HBc Ab. being 3.9%, of HBs Ab. & HBc Ab. being 11. 7%, of HBs Ag, HBc Ab. & HBe Ag. being 7.8%, of HBs Ag. and HBeAg. 2.6% and of all antigen & antibody being 3.9%. 5. Hepatitis B marker demonstrated higher in older than younger age groups. 6. Childhood Hepatitis were more frequently occurred in boys than in girls and in urban than in rural area. 7. Duration of hospitalization is more prolonged in B-marker positive than in negative groups.

Mycoplasma Pneumoniae 폐렴 환아에서의 Polymerase Chain Reaction 법과 혈청학적 검사법의 상관성에 관한 연구

정용헌,임혜경 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

A study was done on 58 cases of children with pneumonia, admitted to the pediatric department of Chungnam National University Hospital during the period of 9 months from Feb. to Sept. 1997, in age between 2 years and 12 years, to confirm the correlation between mycoplasma antibody, cold agglutinin and PCR test. The results were as followings. 1. The total numbers of PCR positive to mycoplasma pneumoniae were 30 cases and those of PCR negative 28 cases. 2. In PCR positive group, distribution of cold agglutinin values over 1:64 and below 1:32 showed 56.7% and 43.4% in early stage, those values 94.5% and 5.6% respectively in later stage. Distribution of mycoplasma antibody over 1:160 shoved 60% and below 1:80 40% in early stage, 1005 and 0% in later stage. 3. In PCR negative group, cold agglutinin values showed wide ranges of 1:2 to over 1:64, mycoplasma antibody showed mostly below 1:40. 4. In PCR positive group, mycopasma antibody values were correlated with cold agglutinin value in later stage It's concluded that PCR test in highly correlated with mycoplasma antibody test.