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Tcp10 Promoter-directed Expression of the Nek2 Gene in Mouse Meiotic Spermatocytes
이건수,Debra J. Wolgemuth 한국분자세포생물학회 2002 Molecules and cells Vol.13 No.1
Nek2 is a cell cycle regulator that is involved in diverse cell cycle events. The expression pattern and biochemical properties of Nek2 in mammalian male germ cells suggested its involvement on regulation of the meiotic cell cycle. To further investigate specific roles of Nek2 in meiosis, we generated transgenic mice in which the Nek2 transgenes were expressed specifically in spermatocytes using the Tcp10 promoter. The Nek2 transgenic mice did not reveal any significant defect in gross testicular anatomy as well as in fertility. However, we observed significant increases in defective spermatogenic cells, such as apoptotic cells and giant degenerating cells, in the Tcp10/Nek2 transgenic mice. These results revealed that even only slightly elevated production of the Nek2 protein disturbed the normal development of male germ cells, possibly in meiosis.
법집행 실종조사에서 안면인식 적용사례에 대한 책임제한을 위한 정책 프레임워크
이건수 사단법인 한국법이론실무학회 2022 법률실무연구 Vol.10 No.1
Recently, face authentication technology has been introduced for all life scenes. Face authentication is a type of biometric authentication that verifies the identity of the person based on the location and size of the eyes, nose, and mouth. The image of the person stored in the database and the face image of the subject photographed by the camera are collated and authenticated. It is characterized by being able to quickly perform non-contact identity verification. For example, in China, digitalization is progressing rapidly, and face authentication technology is being used to respond to the new coronavirus. In places where many people gather, CCTV or temperature sensors detect people with high body temperatures, and face recognition systems identify people. The results are notified to the local authorities, and measures are being taken to test specific people for the new coronavirus. In addition, in Japan, taking advantage of the characteristic of "smoothly identifying individuals", face authentication is widely used in boarding and admission procedures at airports, commercial facilities, amusement parks, and large-scale events, in payment at retail stores, and in the entry/exit management system at offices. On the other hand, because it is natural, there are cases where our faces are being used for crime prevention and marketing purposes, such as street surveillance cameras, without even being aware of it. In this study, after introducing the benefits and system of face authentication, we would like to mention the potential risks of the face authentication system and countermeasures that policy makers, business operators, investigative agencies, and judges should take note of. The biggest advantage of face authentication is that it can be authenticated even if it is not a short distance away, so it can be authenticated even with a large number of people and under a wide range of conditions. Face authentication can obtain two types of information. The first is information unique to an individual that proves that it is the person in the form of eyes, nose, or mouth on the face. The second is information on thinking and thinking based on facial expressions and gestures. Emotions are read from facial expressions and used for marketing and customer satisfaction improvement purposes. Even the seemingly universal face recognition technology has its risks. The first is that there are cases where the level of the facial recognition technology itself is low. It is good if all face authentication is high-performance like the NEC system, but the more you try to increase the level, the higher the introduction cost. Therefore, depending on the introducing company, the accuracy or security is lowered and face authentication technology is introduced, so there is a high probability of misunderstanding in identity verification. Second, if the authentication conditions are not met, the accuracy is lowered. Third, facial data has a greater impact when leaked compared to other data. General driver's license number, ID number, personal number, and various passwords used for financial and electronic transactions can be changed after being leaked, but the face cannot be easily changed. Various risks must be considered when reviewing the practical application of face authentication technology.
이건수 사단법인 한국법이론실무학회 2024 법률실무연구 Vol.12 No.1
CU편의점은 전국 최대 1만 6000여 점포 네트워크를 통해 실종예방, 안전지킴이집 운영, 아동학대예방 및 보호조치 등 지역사회 안전 플랫폼 역할을 하고 있다. CU편의점에 설치되어 있는 결제단말기(POS) 긴급신고 시스템 및 아이CU 프로그램을 통해 위험에 처해 있는 아동학대 및 실종아동 등 140명을 가족의 품으로 안전하게 귀가시켰다. 우리나라는 해마다 실종아동 발생과 아동학대 발생사건은 심각한 수준이다. CU편의점은 그동안 아동안전과 실종아동 예방과 찾기 등을 위해 업계에서 가장 적극적인 움직임을 보여 왔다. CU편의점이 지속적인 아동안전과 실종아동 예방을 위해서는 지역사회 주민들과의 소통을 통해 실종예방 정책과 업무상황을 공유하고 지속할 수 있는 협력 프로그램 사업을 위해 역할 논의가 필요하다. 경제적인 가치와 인간적인 가치를 중요시하고 사회적 책임을 통해 다양한 사회적 문제 해결을 위해 노력하는 사회적 기업이 많이 생겨나고 있다. 본고의 내용은 사회적 기업을 장려하고 발굴하여 우리 사회 올바른 인식개선을 위해 아동안전 및 실종아동 예방사업을 하고 있는 CU편의점 현장직원 대상으로 실종아동 예방 활동에 대한 효과성을 분석하였다. 내부직원들의 평가를 통해 현황을 조사하고 보완할 부분을 고찰하였다. CU convenience stores serve as community safety platforms such as prevention of disappearances, operation of safety guard homes, and prevention and protection measures for child abuse through a network of up to 16,000 stores nationwide. Through the payment terminal (POS) emergency reporting system and iCU program installed at CU convenience stores, 140 people, including at-risk child abuse and missing children, were safely returned home to their families. In Korea, the number of missing children and child abuse cases is serious every year. CU convenience stores have been the most active in the industry to prevent and find child safety and missing children. CU convenience stores need to discuss roles for cooperative program projects that can share and sustain missing prevention policies and work conditions through communication with local residents to ensure continuous child safety and prevention of missing children. There are many social enterprises that value economic and human values and strive to solve various social problems through social responsibility. The contents of this paper analyzed the effectiveness of the prevention activities of missing children for CU convenience store field workers who are promoting and discovering social enterprises and conducting child safety and missing child prevention projects to improve the correct awareness of our society. Through the evaluation of internal employees, the current status was investigated and the areas to be supplemented were considered.
이건수,강준원,Lee, Keon-Su,Kang, Joon-Won 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.4
목 적: 간질 환자의 20-30%는 난치성 간질로 알려졌는데, 기존의 항경련제나 새로운 항경련제에 반응하지 않는 난치성 간질환자에게 LEV를 부가요법으로 투여 후 효과와 부작용을 알아보고자 본 연구를 시행하였다. 방 법: 1989년 3월부터 2009년 3월까지 충남대학교병원 소아청소년과를 방문하여 난치성 간질로 진단받은 환자 중 6개월 이상 추적 관찰한 86명을 대상으로, LEV 투여 전 6개월간의 평균 경련 횟수를 기준으로 LEV외에 다른 항경련제를 추가하기 전까지의 평균 경련 감소 정도를 백분율로 분석하였다. 결 과: 86명의 환자 중 남자는 47명, 여자는 39명이었고, 발작 소실은 86명 중 44명(51.1%), 50% 이상 발작 감소는 86명 중 62명(72.1%)이었고, 19.8%는 변화가 없었으며, 5.8%는 발작이 증가했다. 나이, 동반질환, 발작형 및 치료 전 6개월간 발작 횟수는 발작 소실이나 50% 이상 발작 감소율과 관계가 없었다. 통계적으로 의미 있는 발작 소실과 50% 이상 발작 감소를 보인 경우는, 질병기간, LEV 투여 전 치료기간, LEV의 용량과 치료 전 사용한 항경련제의 숫자였으며, LEV 치료 기간과 뇌파는 발작 소실에만 의의가 있었고, 원인은 50% 이상 감소율에만 의의가 있었다. 부작용은 86명 중 40명(46%)에서 나타났고, 부작용은 기면, 과잉 행동, 과민성, 공격성, 피로 등이었으며, 대부분 일시적이거나 경미하여 치료 도중 소실되었다. 결 론: 난치성 소아 간질의 치료에 LEV의 부가 요법은 부분 발작뿐만 아니라 전신발작에도 효과와 반응이 좋고, 심각한 부작용도 없었다. Purpose : To evaluate the efficacy and safety of levetiracetam adjunctive therapy for reducing the rate of seizure frequency in children with intractable pediatric epilepsy. Methods : We reviewed the medical records of 86 patients with intractable pediatric epilepsy who visited our hospital between March 1989 and February 2009. Levetiracetam was included in the previous anticonvulsant regimen for at least 6 months and the reduction in the rate of seizure frequency was determined in follow-up examinations. We analyzed demographic data, seizure types, antiepileptic drug history, levetiracetam dose, adverse effects of levetiracetam therapy, treatment outcome, electroencephalogram findings, etc. Results : More than 50% reduction in the seizure frequency was observed in 62 of the 86 (72.1%) patients; 44 patients (51.1%) became seizure free, while the seizure frequency increased in 5.8% patients. The associations between seizure reduction rate and age, associated diseases, seizure types, and seizure frequency before treatment were not significant. However, the duration of disease, dose of levetiracetam, duration and frequency of anticonvulsant administration before levetiracetam therapy were significantly correlated. Electroencephalogram findings and the cause of epilepsy showed partial correlation. Forty (46%) patients showed adverse symptoms; the symptoms in the order of their frequency were somnolence, hyperactivity, irritability, aggressiveness, tiredness, etc. Conclusion : The findings of our study provide the evidence that levetiracetam adjunctive therapy is efficacious and well tolerated in various refractory childhood epilepsy cases.