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      • 소아 뇌성마비의 조기 진단 및 조기 수술적 치료

        이건수,변상현,신현대,송시헌 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

        Cerebral palsy is a static encephalopathy that is caused by multifactorial disorders. Treatment should be approached by a team of physicians from various specialties. But usually the detection of abnormal behavior might be delayed. We used Bayley scales for the patients which were transfered for the evaluation of behavior disorder and tried to detect earlier as cerebral palsy. We recommended selective posterior rhizotomy to the patients who was spastic quadriplegia as early as possible. We evaluated 154 patients with Bayley scale and 85 patients were followed. Among them we applied selective posterior rhizotomy to 25 patients who were spastic quadriplegia. The result was very excellent. We conclueded that Bayley scale is a good tool for evaluation of developmental delay esp. cerebral palsy earlier than usual physical examination and selective posterior rhizotomy is satisfactory treatment method for spastic quadriplegia.

      • KCI등재
      • KCI등재

        난치성 소아 간질에서 levetiracetam의 효과

        이건수,강준원,Lee, Keon-Su,Kang, Joon-Won 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.4

        목 적: 간질 환자의 20-30%는 난치성 간질로 알려졌는데, 기존의 항경련제나 새로운 항경련제에 반응하지 않는 난치성 간질환자에게 LEV를 부가요법으로 투여 후 효과와 부작용을 알아보고자 본 연구를 시행하였다. 방 법: 1989년 3월부터 2009년 3월까지 충남대학교병원 소아청소년과를 방문하여 난치성 간질로 진단받은 환자 중 6개월 이상 추적 관찰한 86명을 대상으로, LEV 투여 전 6개월간의 평균 경련 횟수를 기준으로 LEV외에 다른 항경련제를 추가하기 전까지의 평균 경련 감소 정도를 백분율로 분석하였다. 결 과: 86명의 환자 중 남자는 47명, 여자는 39명이었고, 발작 소실은 86명 중 44명(51.1%), 50% 이상 발작 감소는 86명 중 62명(72.1%)이었고, 19.8%는 변화가 없었으며, 5.8%는 발작이 증가했다. 나이, 동반질환, 발작형 및 치료 전 6개월간 발작 횟수는 발작 소실이나 50% 이상 발작 감소율과 관계가 없었다. 통계적으로 의미 있는 발작 소실과 50% 이상 발작 감소를 보인 경우는, 질병기간, LEV 투여 전 치료기간, LEV의 용량과 치료 전 사용한 항경련제의 숫자였으며, LEV 치료 기간과 뇌파는 발작 소실에만 의의가 있었고, 원인은 50% 이상 감소율에만 의의가 있었다. 부작용은 86명 중 40명(46%)에서 나타났고, 부작용은 기면, 과잉 행동, 과민성, 공격성, 피로 등이었으며, 대부분 일시적이거나 경미하여 치료 도중 소실되었다. 결 론: 난치성 소아 간질의 치료에 LEV의 부가 요법은 부분 발작뿐만 아니라 전신발작에도 효과와 반응이 좋고, 심각한 부작용도 없었다. Purpose : To evaluate the efficacy and safety of levetiracetam adjunctive therapy for reducing the rate of seizure frequency in children with intractable pediatric epilepsy. Methods : We reviewed the medical records of 86 patients with intractable pediatric epilepsy who visited our hospital between March 1989 and February 2009. Levetiracetam was included in the previous anticonvulsant regimen for at least 6 months and the reduction in the rate of seizure frequency was determined in follow-up examinations. We analyzed demographic data, seizure types, antiepileptic drug history, levetiracetam dose, adverse effects of levetiracetam therapy, treatment outcome, electroencephalogram findings, etc. Results : More than 50% reduction in the seizure frequency was observed in 62 of the 86 (72.1%) patients; 44 patients (51.1%) became seizure free, while the seizure frequency increased in 5.8% patients. The associations between seizure reduction rate and age, associated diseases, seizure types, and seizure frequency before treatment were not significant. However, the duration of disease, dose of levetiracetam, duration and frequency of anticonvulsant administration before levetiracetam therapy were significantly correlated. Electroencephalogram findings and the cause of epilepsy showed partial correlation. Forty (46%) patients showed adverse symptoms; the symptoms in the order of their frequency were somnolence, hyperactivity, irritability, aggressiveness, tiredness, etc. Conclusion : The findings of our study provide the evidence that levetiracetam adjunctive therapy is efficacious and well tolerated in various refractory childhood epilepsy cases.

      • 신생아 Apgar Score에 관한 연구

        이건수 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

        This clinical study was made on 1000 newborns delivered at the Chungnam University Hospital in 1982-1985 to figure out any relations between Apgar score and problems such as gestational period, birth weight, maternal age, delivery type, meconium staining, and mortality. The results were summerized as followings: 1. The distribution of 1-minute Apgar score was 3.7% for score 0-3, 10.8% for score 4-6, 85.5% for score 7-10, and 5-minutes Apgar score was 2.3% for score 0-3, 2.3% for score 4-6, 95.4% for score 7-10, 5-minutes Apgar score was higher than 1-minute Apgar score. 2. The Apgar score of preterm & postterm newborns were lower than term, especially less than 32 weeks gestational age. 3. There was a trend to lower score in the newborns of the less than 2500 gm or more than 3500 gm. 4. There was no significant differance between maternal age and Apgar score. 5. The Apgar score of C-section delivery was lower than spontaneous & vaccum delivery. 6. There was a trend to lower Apgar scores in the newborns of meconium staining. 7. Perinatal death rate was 3.1% of all newborns, and mortality was higher in low Apgar score. Mortality of 5-minutes Apgar score was more significant than 1-minute Apgar score.

      • 유관순 열사의 독립운동 정신에 관한 연구

        이건수 백석대학교 유관순연구소 2021 유관순 연구 Vol.26 No.-

        전국에서 이루어진 비폭력 독립운동은 수많은 사람들의 붉은 선혈로 처참하게 이루어진 결과이다. 일제는 총과 창검 등으로 만세 부르는 농민, 서민, 부녀자 등 사람들을 닥치는 대로 대검과 총으로 사람들을 살해하였다. 자신과 가족의 목숨이 위협받는 자유와 독립을 위한 비폭력저항 운동의 결과는 큰 어려움이 따른다는 것을 알고 있음에도 김복순, 국현숙, 서명학, 김희자 등과 독립운동 단체를 만들고 독립만세운동에 참여하는 행동은 쉽게 설명이 되지 않는 부분이다. 제2차 서울 독립만세운동은 남대문 역 앞에서 학생들이 주도했다. 이화학당 프라이 교장선생님의 만류를 뿌리치고 이화학당 학생들은 학교 담을 넘어 탑골공원까지 비폭력 만세운동을 하던 중 유관순은 경무총감부로 연행되었다. 그 이후 외국인 선교사들의 요구로 풀려나면서 바로 학교는 임시휴교령이 내려졌고 유관순의 고향 천안으로 내려오게 되었다. 유관순의 아버지 유중권, 어머니 이소제, 숙부 유중무, 동네 어른 조인원(조병옥 부친) 등과 서울 등지에서의 독립운동에 대한 의견을 나누고, 1919년 4월 1일(음력 3월 1일) 병천 아우내 장날에 만세운동을 계획했다. 이들은 아우내 장날에 독립선언서를 낭독하고 대한독립만세를 부르자 수많은 군중들도 만세운동에 동참을 하였다. 체포된 유관순은 1차 공주지방법원에서 5년형을 받았고 이후 항소하여 경성 복심법원 재판에서 다시 3년형을 받았다. 상고심을 놓고 조인원과 숙부 유중무가 유관순 에게 설득하였으나, 서대문 감옥에서 유관순은 삼천리강산이 어디나 지금은 감옥과 같다며 상고를 거부하고 수시로 대한독립만세를 외치면서 고문을 받았다. 더욱더 놀라운 것은 옥중 만세 시위를 주도한 것이다. 옥중만세운동 시위를 주도한 유관순에게 매를 때리고, 얼굴에 물을 붓고, 천정에 매달리게 하는 등 고문은 한층 심해졌다. 매일 이루어지는 구타, 치료받지 못한 상처, 매질, 오랜 고문 등으로 방광이 터져 몸이 썩어 들어가면서 19세에 유관순은 순국하였다. 이러한 유관순의 독립운동은 어떤 정신을 바탕으로 이루어진 행동인지 파악이 되어야 할 부분이다. 유관순 열사에 대한 민족정신 부분에 정밀한 조명을 비추어 숭고한 죽음의 의미를 기억하는데 도움이 되고자 한다. The nationwide nonviolent independence movement is a disastrous result of the red bloodshed of countless people. The Japanese killed people with their swords and guns at random, including farmers, ordinary people, and women, who were called “Long Live” by guns and swords. Even though they know that the results of the nonviolent resistance movement for freedom and independence, where their lives are threatened by themselves and their families are threatened, it is not easy to explain the behavior of forming independence movement groups such as Kim Bok-soon, Kook Hyun-sook, Sign-hak, and Kim Hee-ja. The second Seoul Independence Movement was led by students in front of Namdaemun Station. Refusing to dissuade Principal Fry of Ewha School, students of Ewha School were taken to the General Administration of the Korean Military Police Agency while they were campaigning for nonviolence from the school wall to Tapgol Park. Since then, the school has been temporarily closed as soon as it was released at the request of foreign missionaries and came down to Cheonan, the hometown of Yu Gwan-sun. Yoo Gwan-soon’s father Yoo Jung-kwon, mother Lee So-je, uncle Yoo Joong-moo, and local adult Jo In-won (father of Jo Byeong-ok) shared opinions on the independence movement in Seoul and planned the independence movement on April 1, 1919 (March 1, lunar calendar). When they read the Declaration of Independence on Aunae Market Day and sang “Long Live Korean Independence,” a large number of people joined the independence movement. Yoo Gwan-soon, who was arrested, was sentenced to five years in the first Gongju District Court, and later appealed and was sentenced to three years in the Gyeongseong Reexamination Court. Jo In-won and his uncle Yoo Joong-moo persuaded Yoo Gwan-soon over the appeal, but in Seodaemun Prison, Yoo Gwan-soon refused to appeal and frequently shouted “Long Live Korean Independence,” saying that Samcheon-ri Gangsan Mountain is now like a prison. What is even more surprising is that he led the demonstration in prison. The torture was aggravated by Yoo Gwan-soon, who led the demonstration of the movement against the king, who lashed him, poured water on his face, and forced him to cling to the ceiling. Yoo Gwan-soon died at the age of 19 as his bladder burst with daily beatings, untreated wounds, smashes, and long torture. The independence movement of Yu Gwan-sun should be determined based on the spirit. It is intended to help people remember the meaning of noble death in light of the precise lighting of the national spirit of martyr Yoo Gwan-soon.

      • SCOPUSKCI등재
      • KCI등재

        Cytoprotective effects and mechanisms of quercetin, quercitrin and avicularin isolated from Lespedeza cuneata G. Don against ROS-induced cellular damage

        이건수,박수남 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.71 No.-

        The purpose of this study was to compare the anti-oxidative and cytoprotective effects of quercitrin andavicularin isolated from Lespedeza cuneata G. Don extract to those of quercetin, an aglycone of quercitrin,and avicularin. Quercetin had higher antioxidative activity and cell penetration ratio than its glycosides,resulting in greater cytoprotective effects against 1O2. The cytoprotective effects against cell damageseems to reflect 1O2 quenching rate, free radical and ROS scavenging activity, and cell permeability. Among them, cell permeability to block free radical initiation and chain reactions in cell membranes isconsidered to be the most important feature of cytoprotective activity.

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