植物凝集素 Celosia argentea 와 赤血球에 의한 사람 唾液의 型分類에 關한 硏究

趙容寬,黃迪駿 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1

Phytagglutinins were utilized for the purpose of blood grouping and also are studying for the grouping of other human contents, eg. : semen. saliva, and urine. In order to classify the human saliva, hemagglutination inhibition tests were performed using a phytagglutinin, Celosia argentea, and 300 human saliva specimens. The Celosia argentea extracts, which was absorbed by the human saliva, could be grouped as inhibitor or non-inhibitor according to agglutination reaction upon the human red blood cells and were compared with the established saliva groupings, blood groups, and serum types statistically. The results obtained were summarized as follows : 1. Human saliva could be classified into two groups. One group inhibited the agglutination activity of Celosia argentea extracts to human red blood cells and the other did not. Among the investigated 300 human saliva specimens, the frequency of the former was 27% and the latter was 73%. 2. The classification and distribution of this saliva types by Celosia argentea showed no statistically significant relation with those of the other known saliva types, such as secretor and non-secretor. 3. The classification and distribution of this sailva types by Celosia argentea showed no statistically significant relation with those of the other known blood groups, such as ABO, MN, H and CI, respectively. 4. The classification and distribution of thls saliva types bY Celosia argentea showed no statistically signiflcant relation with those of the other known serum types, such as CAI,CAI-C,CAI-D,IPO,ICO, respectively. 5. The classification of this saliva types by Celosia argentea showed no statistically significant relation with those of the other known saliva types by Agastache rugosa and Sophola japonica.

아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성

조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.

北韓 家族政策의 變化와 傳統的 家庭文化

조용관 안양대학교 복지행정연구소 1998 福祉行政硏究 Vol.14 No.-

√s 침하예측기법을 이용한 현장침하량 예측

조기영,최관희,유갑용 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2

Prediction of consolidation settlement and time must be always erroneous because of soil media, errors associated with the measurement of soil parameters, drawback of consolidation theories and so on. When Oiling on compressible soils, the observational method is a useful means in pratice to evaluate the final consolidation settlement and time. However, the ousted observational procedures include some disadvantages which are difficulty of finding the linearity in the settlement curves, which a personal error seems to be unavoidable and so on. A new observational procedure(√s method) is suggested here to perform the consolidation analysis in field. As the results of applying the √s method with another methods to two field data, the final settlement predicted by the √s method as well as by the Asaoka's method agreed well with the measured value. However, one by the hyperbolic method(Tan, 1991) was overestimated, and there happened many cases not to predicted by the Hoshino's method. In the settlement curve from the √s method, the linearity between 60 and 90% of the average degree of consolidation is showed, and then the possibility of happening a personal error seems to be unusual. The final consolidation time(at 0.95s_(f)) predicted by the √s method agreed well with the measured one, but one by Asaoka and Tan(1996) methods was very much underestimated or overestimated. The big errors by the two methods seem to be the cause unconsidered the effect of step loading.

에폭시 수지 복합재료의 트래킹열화에 미치는 충전제와 자외선의 영향

박용관,조한구,김희곤 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

This paper studies on the effect of ultraviolet light and filler on the tracking characteristics of epoxy resin which is widely used to enhance the insulation capability of materials. The specimens employed in the study were bisphenol and cycloaliphatic epoxy resins filled with Si0_2. A low-pressure mercury lamp was used as the source of UV light. In order to see the phenomena of tracking of the specimen, the expoerimentation is performed to the tracking apparatus(IEC, Publication 587) which mainly used under severe ambient conditions.

유도경기상황의 심판의식 및 판단장애에 관한 연구

김관현,조용철,조문근,김태훈 龍仁大學校 武道硏究所 2002 武道硏究所誌 Vol.13 No.1

The purpose of this study is to produce fair judo judges by examining and analyzing the judicial consciousness during the authentic judo games as well as to attribute to consistent and clear judgment. In accordance with the result of the study I suggest: First, we must try to make judo judges participate continuously in the training program for judo judges and offer them some helpful programs to judge modern judo which is changing right now and to adapt to the new skills or the changed judicial rules so that they may enhance their accurate positions. Second, the judo judges are required to perceive their concrete judicial criteria by repeated practice considering when to give the positive scores and when to give the negative scores after being given the information. Third, more organized training project is needed especially before judo competition, in addition, simulated judicial practice by analyzing some real games on video is helpful to relieve the judo judges' anxiety. Fourth, the judo judge who commited misjudgment or made mistakes on account of his/her circumstances such as his/her academical, regional connections and the teal leaders must be got cold and definite punishment. Lastly, more qualified judo judges, who are distributed fairly in order to be offered more experience are the resources toward he equally high-leveld-judo judges-state. Therefore, we need to study more on the specific elements which influence on the judo judges' judgment and the giving scores.

Escherichia coli(M15)을 이용한 serotonin N-acetyltransferase 유전자의 발현

김용만,정미영,윤경식,진병관,백행운,조용호,백형환 慶熙大學校 1997 論文集 Vol.26 No.-

AA-NAT cDNA was obtained by RT-PCR technique from total RNA of rat sacrified at night(02:00am). pCRNAT was cloned using the pCRII vector with insertion of AA-NAT cDNA(about 1.4 kb) at EcoRI site. For the expression of the gene, pQECNAT was subcloned, in which the coding region of AA-NAT was inserted into expression vector pQE30 at BamHI and HindIII sites. According to the experimental results, Escherichia coli strain M15, transformed by the expession vector pQECNAT, was selected as a host to express AA-NAT gene with the induction of isopropyl β-D-thiogalactoside(IPTG). Optimal condition for the expression of AA-NAT gene was achieve from the experimental results, showing that the expression of the protein was inducible much 19.800 ± 2,200 dpm per ml of culture volume in 4 hours at the concentration of 2 mM IPTG. Partial purification through the affinity column(Ni-NTA agarose) binding to the continuous 6 histidine residues of protein resulted in 5 times more increase in the specific activity of AA-NAT than that of the homogenate of bacterial pellet. These experimental results will provide basic data in further study for the enzymatic kinetics and antibody production of AA-NAT.

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.