출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

간 허혈성괴상의 CT소견에 대한 실험적 연구 : 간실질 및 피막의 경시적 변화와 병리조직의 비교 Changes of CT Findings of Liver Parenchyama and Capsule with Time Lapse Correlated with Histopathology

김창근,김강득,최시성,정선관,노병석,원종진 圓光大學校 醫科學硏究所 1994 圓光醫科學 Vol.10 No.1-2

In order to evaluate CT findings with time and to confirm the capsular structure correlating with its histopathologic findings, we experimentally induced ischemic necrosis of liver in 20 rabbits. Incision of the abdomen was performed under anesthesia. Ligation of hepatic artery, portal vein and hepatic duct of right inferior posterior lobe of the liver after injection of macroaggregated albumin into right inferior posterior portal vein in order to prevent from developing collateral circulation as possible. Precontrast and postcontrast enhanced CT images were obtained at 1. 2. 4 days and 1, 2. 4. 6 weeks after induction of ischemic necrosis. Necrotic area in the liver showed homogeneous low density compared to normal liver, and no contrast enhancement after contrast material administration, and marked volume loss with time. CT attenuation value of necrotic area at 1 day(36.7±6.4 M±SD, Hounsfield unit) approached to two third of that of normal liver(56.3±7.3) and showed no significant change until two weeks but increased significantly after four weeks. On contrast enhanced CT images, capsular structure was obsereved as a high density rim along the liver surface of the necortic area in 8 of 15 cases. From the first day on, homogenous ischemic or coagulation necrosis was observed but rarely findings of edema, hemorrhage and cystic change were observed on histopathologic specimen. In all of the histologic samples taken from 10 cases during th 2nd to 6th week, fibrous thickening with rich vascularity was observed along the surface of the necrotic area. In conclusion, ischemic necrosis of the liver showed homogeneous low density and no contrast enhancement. CT attenuation value of necrotic area increased significantly with time associated with markedly decrease in volume. Capsular structure attributed to the hypertrophy of the liver capsule and rich vascularity within it.

일측 폐이식 성견에서 혈역학과 체액조절 호르몬의 상관관계

서강석,박창권,송대규,배재훈,박원균 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1

폐이식에 의한 체액이나 혈압의 변동 및 신경의 절단은 혈압 및 체액의 조절에 관여하는 호르몬의 분비에 영향을 미치리라 생각되어 좌일측 폐이식 시 이식폐에 분포하는 신경이 절단된 상태에서 폐이식 후 수용견의 혈역학적 변동이 ANP 및 ADH의 분비와 어떠한 상관관계가 있는지를 관찰하였다. 한국산 성견 12마리를 대상으로 좌일측 폐이식을 시행하였다. 공여폐의 보존은 low potassium dextrane glucose용액을 이용하여 10℃에서 20시간동안 보존한 다음 수용견에 이식하였다. 수용견의 좌측 폐를 적출하기 전과 후, 그리고 이식 후 재관류 30분, 2시간 후에 각각 혈역학 및 동맥혈 가스분압을 측정하였고, 동맥혈에서 ANP 및 ADH의 농도를 측정하였다. 동맥혈의 P_(O_2) 및 P_(CO_2)는 유의한 변동은 없었다. 대퇴동맥압을 재관류 후 30분에는 유의하게 감소하였고, 재관류 2시간 후에는 다소 회복세를 보이는 경향이었으며, 맥압은 비교적 유지되었다. 폐동맥압은 좌측폐 절제 시 이완기 폐동맥압은 변동이 없는 반면에 수축기 폐동맥압은 증가하였고, 재관류 시 폐동맥압은 어느 정도 회복되는 양상이었다. 심박출량은 좌측 폐절제 후에는 감소하였으며 재관류후에도 낮게 유지되는 양상이었다. 반면에 심박수는 유의한 변화없이 유지되었다. 전신혈관저항 및 폐혈관저항은 좌측 폐절제 후나 재관류 30분에 증가하였으며, 재관류 2시간 후 폐혈관저항은 회복되는 양상이나 전신혈관저항은 회복되지 못하였다. 혈중 ANP는 일측 폐절제 후 증가하였고, 재관류 후에는 점차 회복되는 양상을 보였고, ADH는 일측 폐절제 후, 30분에 증가한 후 회복되는 양상을 보였다. 동맥혈 ANP의 변동은 동맥혈 P_(O_2)및 P_(CO_2)와 상관관계를 보였고, ADH는 전신 동맥압의 변동과 상관관계가 있었다. 이상의 결과로 좌일측 폐이식 시에도 ANP 및 ADH는 혈역학적 변화와 연관하여 동맥압 및 체액의 조절에 생리적으로 관여하는 것으로 사료되며, ANP의 분비는 동맥혈의 저산소증 그리고 ADH의 분비는 동맥의 압수용기를 통한 신경성 조절의 영향을 받을 수 있는 것으로 생각된다. The purpose of this investigation was to study changes of plasma atrial natriuretic peptide (ANP) and antidiuretic hormone (ADH) in Korean mongrel dogs after a left single lung transplantation and to evaluate the correlation between hemodynamic factors and secretory responses of ANP and ADH. Arterial P_(O_2 and P_(CO_2) did not change significantly. Femoral arterial pressure decreased after 30 min of reperfusion and recovered slightly at 120 min, whereas pulse pressure did not change. After pneumonectomy, systolic pulmonary arterial pressure increased, whereas diastolic pulmonary pressure remained unchanged. Althought cardiac output fell following pneumonectomy and reperfusion, heart rate was unchanged. The secretion of plasma ANP initially increased follwoing pneumonectomy, but subsequently recoverd. In each subject, ANP values showed stronger correlation with arterial P_(O_2) than other hemodynamic parameters. The secretion of plasma ADH also initially increased (p<0.05) after 30 min of reperfusion and thereafter recoverd, showing the strongest correlation with mean femoral arterial pressure. The present results suggest that the secretion of ANP and ADH seem to be well regulated in accordance with hemodynamic changes after a single lung transplantation. Hypoxia and systemic arterial pressure are the prominent factors in the secretion of ANP and ADH, respectively.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

만성 췌장염에 의한 십이지장 협착 1예

서백종,장기육,박용근,채현석,한석원,이창돈,정인식,차상복,박두호 대한내과학회 1997 대한내과학회지 Vol.53 No.3S

저자들은 만성췌장염환자에서 지속적인 오심과 구토를 주소로 내원하여 십이지장협착으로 진단된 1예를 경험하였기에 보고하는 바이다. Duodenal stenosis resulting from fibroinflammatory process is a rare complication of chronic pancreatitis. The mechanism of duodenal stenosis seems to be related to ischemia and edema caused by persistent inflammation, which results in irreversible change of duodenal wall structure. We experienced a chronic alcoholic male patient with duodenal stenosis who had a history of choledochojejunostomy to relieve distal bile duct stenosis several years ago. He had suffered persistent postprandial nausea and vomiting for several months. Barium study of upper gastrointestinal tract and repeated endoscopy show narrowing lumen of duodenum with coarse nodular surface due to reactive inflammatory change.

Preference Analysis for Flower Jewelry Using Conjoint Analysis

김연희(Yeon Hee Kim),김미진(Mi Jin Kim),윤숙영(Suk Young Yun),장태원(Taeg Won Chang),최병진(Byung Jin Choi) 인간식물환경학회 2022 인간식물환경학회지 Vol.25 No.3

Background and objective: This study was conducted to determine the preferences in flower jewelry by conducting a surveyusing conjoint analysis on the perception of flower jewelry and provide basic data for development of flower jewelryproducts. Methods: For the conjoint analysis, four attributes of flower jewelry were selected. Attribute 1 was related to the mainmaterial of flower jewelry, presented in three levels: cut flowers, potted flowers, and processed flowers. Attribute 2 wasrelated to wearing area presented in five levels of wearing area: hair, neck, ear, arm (wrist) and chest (shoulder). Attribute3 was related to price provided for selling products in flower shops, presented in three levels: less than 30,000 won,50,000-70,000 won, and more than 100,000 won. Attribute 4 was related to flower jewelry wearing time, presented inthree levels: less than 6 hours, 12-24 hours, and more than 24 hours. After extracting 25 profiles through orthogonaldesign, a questionnaire survey was conducted on 402 general participants, from which the responses of 343 participantswere analyzed. Results: By attribute of flower jewelry, the respondents attached most importance to price (34.14%), followed by wearingarea (29.18%), wearing time (18.51%), and material (18.17%), proving that the general public attached most importanceto price (Pearson's R = .987, p = .000). The preference in levels by attribute was highest for processed flowers in material,less than 30,000 won in price, hair in wearing area, and 12-24 hours in wearing time. Conclusion: By making flower jewelry based on the results of the analysis, it would be possible to help increase items soldin flower shops as well as their income.

일부 시판세치제의 비교치아마모도 및 경과시간에 따른 유효불소농도변화에 관한 연구

장덕수,이병진,배광학,방금석,이원재,노정,백대일,김종배 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3

The purpose of this study was to assess relative tooth abrasivity and to measure effective fluoride concentration of dentifrices selling in Korea for help consumer's selection of suitable dentifrice. Assessment of the abrasion on tooth produced by different dentifrices were carried out on bovine teeth in the laboratory and tested by radioactive dentin abrasion method. And total soluble fluoride concentrations within the dentifrices was determined using fluoride ion selective electrode with standard curve obtained from standard solutions of known fluoride concentration. 10 dentifrice samples were stored at 49t for 15 weeks and the measurements were made for each dentifrice in 1 week, 2 weeks, 3 weeks, 13 weeks and 15 weeks and 11 dentifrice samples were stored at 40.6C for 3 weeks and the measurements were made for each dentifrice in 1 week and 3 weeks. Tooth abrasivity of selling dentifrices is suitable for toothbrushing but dentifrice which recommended for patient who have tooth abrasion or erosion was somewhat high abrasivity level. Effective fluoride concentrations of selling dentifrices were maintained generally optimal level. But some dentifrices contaning CaCO_(3), as abrasive were decreased as time elapsed. It was suggested that relative tooth abrasivity must be marked on package and fluoride level should be maintained acceptable level in dentifrices for consumer's selection of suitable dentifrice.

舊蘇聯의 經濟發展過程에 대한 評價와 統一에의 合意

張原碩 단국대학교 1993 論文集 Vol.27 No.-

The former U.S.S.R. inevitably adopted heavy industry prioity polioity not only on Marx-Leninist doctrines of socialist economy but also on the condition that she had been surrounded by the capitalist states and her economy had also been underdeveloped. On the purpose of supplying investment fund, it was based on the sacrifice of light industry and agriculture and constraint of consumption. With all the considerable cussess in construction of socialist economy, beaurocratism has been widely spead on the course industrialization and agricultural collectivization. Economic Reform carried out after the second world war was intented to solve the problems of socalled 'Stalinism'. It can be abbreviated to the democratization of planning system and enlarged the introduction of economic incentives, and the way of industrialisation came to be on the course of changing from the extensive into the intensive. The scope of economic reform include not only economic field such as price, profit, incentive system, finance, banking, production and sale and international economic relation, but also poilitical field such as plannig mechanism, economic managerial system and administrative system. But the experiance of both wartime communism and new economic policy(NEP) made the principle, way and content of economic reform drift about because of variety of etimation of construction of socialist economy in Stalin era. In short, economic reform wobbled because the result generated in course of industrialisation and agricunltural collectivization in that era had both been remarkable and created many problems unnegligible. Unstabilty of economic reform has resulted in structure generating inactivity of efficiency and productivity, as it has not overcome beaurocratic problems and the socialist passion has cooled down because it has not attracted direct producer's interest into production process. We can eaily expect that North Korea connot be any exception of this experiance of socialism. Rather North Korea took anintensified form of planned economy, adhering to centralized planned economy, politically preferred economic process and doctrine of self-efforted economy known as one of autarky. Considered in the lately circumstance, North Korea is expected to have taken difficulties, internally shortage of daily necessaries because of ill-balanced structure, underdevelopment of fundamental industry such as energy and steel, and externally accumulated debt that has been paid in hard currency nowadays. With all these situation, it is of worth noticing in relation to the furture of North Korea's economy that since 70's tchnocrat has spread in the administrative organisation on the behalf of revolutionist from anti-Japan partisan and in recent years North Korea has made efforts to improve international economic relation. A third alternative economic system is to be summarized as a properly propotionate combination of private and public economy, which could be one of harmonious forms between capitalist and socialist system, agreeable to both South and North Korea. What I would lay emphasis on is that beauroertic dictatorship cannot enter into cooperative union for it is organised to pursue economic benefit in the form of mutual aid guaranteeing autonomous management and voluntary partivipation. The system for unification should be based on private ownership and market mechanism of pricing and demand-supply balancing that can also patially take one of the forms decentered planning mechanism within the limit of not obstucting autonomy. By doing so, antagonostic relation between socialism and capitalism can be perished away in that urgent problems can be overcome. And What the experiance of socialist economy implies is that it is important to establish democracy. In short, elements of desirable economic system are activation of competitive market, establishament of system of social commom consent for fair order, democratic intervention of state, guarantee of fullfillment of necessaries and need for human life and so on. Interchange of inter of outer sectoral copital, technology, resource, products and so on will be expanded in the course of cooperation between South and North Korea. By the approach to take the merits and to discard demerits of both economic systems, social instability can be removed and economic cooperation can be maintained to be enlarged.

농어촌특별세사업의 성과와 추진방향

장원석,김호,허승욱,김성철 한국농업정책학회, 한국축산경영학회 2000 농업경영정책연구 Vol.27 No.3

Most of rural area in Korea has been faced with many problems like a increasing restrictions of the World Trade Organization and unstability of international agricultural product market. On the other hand, we should give a serious consideration about agricultural policy interior of a country. It is for reason that we have to magnify special tax project for rural area as much as possible. In addition, it will be contribute to the maintenance of development and stability on the rural area.

자궁근종에서 Phospholipase C 동종효소들의 발현에 관한 연구

윤혜원,류임주,김창미,심재철,서영석 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.4