Characterization of the European type of maternal lineage evident in extant Jeju native pigs

Byeong‐Woo Kim,In‐Cheol Cho,Moon‐Sung Park,Tao Zhong,임현태,Sung‐Soo Lee,Hee‐Bok Park,Moon‐Suck Ko,Jun‐Heon Lee,Jin‐Tae Jeon 한국유전학회 2011 Genes & Genomics Vol.33 No.2

Using a partial D‐loop sequence of mtDNA, an intensive analysis was conducted of the maternal lineages of Jeju native pigs (JNPs) from Korea. In total, 100 mtDNA sequences were obtained from Asian wild boars (AWBs), European wild boars (EWBs), Asian domestic pigs (ADPs), European domestic pigs (EDPs), and JNPs and were used for phylogeny and network analyses. Two distinct JNP groups - one (JNPA) in the Asian cluster and the other (JNPE) in the European cluster - were identified in the estimated phylogenetic tree and network. The maternal lineage of JNPE was the closest to that of EWB and a clear haplogroup was identified that shared an identical haplotype (hap04) among 15 individuals of JNPE and 2 individuals of EWB. A Landrace and an EWB shared hap03with a JNPE. EWB, Landrace, Large White, and Duroc formed two clear haplogroups with JNPE in a parsimonious medianjoining network analysis, suggesting that an obvious maternal contribution of EDP has occurred in JNPE in recent years. A pair‐wise mismatch analysis also indicated that JNPE may have experienced a sudden population expansion, suggesting a more recent establishment compared with the gradual population expansion of JNPA. The JNPE group therefore should be further evaluated in order to decide whether this group should be culled or accepted into further programs for maintenance of the JNP population as a pure breed.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Clinical Characteristics and E cacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels

Tae-Joon Kim,Jin-Sun Jun,Keun Tae Kim,Tae Won Yang,Byeong-Su Park,Jung-Ah Lim,변정익,선우준상,신정원,정기영 대한수면학회 2018 sleep medicine research Vol.9 No.2

Restless legs syndrome (RLS) is associated with dopaminergic dysfunction, and iron de ciency, manifesting as low ferritin. However, ferritin levels do not correlate well with demographic data. Based on the hypothesis that very low ferritin can accurately re ect clinical information, we herein described characteristics and treatment e cacy of RLS patients with ferritin levels under 15 ng/mL. We retrospectively reviewed 196 patients and collected clinical data. Twenty-one patients had ferritin levels under 15 ng/mL and were compared with those having ferritin levels over 15 ng/mL. e pa- tients with very low ferritin levels were predominantly female, had earlier onset of symptoms, and showed a superior response to iron therapy. In conclusion, RLS patients with ferritin levels under 15 ng/mL showed distinct demographic features and treatment e cacy. Further studies on more patients with long-term follow-up are warranted to support this observation.

CAFS 최적공기포비 도출을 위한 일반화재 및 유류화재 적용 실험

박태희(Tae-Hee Park),김태선(Tae-Sun Kim),박정화(Jeong-Hwa Park),양지현(Ji-Hyun Yang),이병채(Byeong-Chae Lee),김태동(Tae-Dong Kim),김봉준(Bong-Jun Kim),권진석(Jin-Suk Kwon) 한국화재소방학회 2023 한국화재소방학회논문지 Vol.37 No.4

High-performance gas sensors based on single-wall carbon nanotube random networks for the detection of nitric oxide down to the ppb-level

Jeon, Jun-Young,Kang, Byeong-Cheol,Byun, Young Tae,Ha, Tae-Jun The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.4

<P>We demonstrate highly sensitive and selective gas sensors based on solution-processed single-wall carbon nanotube (SWCNT) random networks for the detection of nitric oxide (NO) down to the ppb-level operating at room temperature. The proposed gas sensors exhibited a response of 50% under both inert and air atmospheres with a theoretical detection limit of 0.2 ppb and a selectivity toward different target gases of volatile organic compounds, including benzene, toluene, and ammonia. The outstanding sensing performance was realized by functionalizing SWCNT random networks with polyethylenimine (PEI), which possesses a repeating structure of amine groups. We investigate the functionalization properties of SWCNT random networks by using atomic force microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy and the sensing mechanism in the proposed NO gas sensors. We note that solution-process technologies, from the deposition of SWCNT random networks to the polymeric functionalization of amine groups, were employed at room temperature under an ambient atmosphere to fabricate highly sensitive and selective NO gas sensors, which are based on low-cost, effective, and scalable merits in the industry of sensors. We also investigate the effect of ultraviolet (UV) irradiation on the recovery time underlying the sensing mechanism. Photodesorption energy obtained by UV irradiation reduced the recovery time of the proposed NO gas sensors to within a few tens of seconds. We believe that this work is a promising and practical approach for realizing health-care monitoring systems by real-time analyzing NO gas at the ppb level in the field of biosensors.</P>

Functionalized Carbon Nanotube Sensors for the Detection of Sub-ppm Nitric Oxide Gas

Kang, Byeong-Cheol,Jeon, Jun-Young,Byun, Young Tae,Ha, Tae-Jun American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.9

유미흉수를 동반한 폐 임파관 평활근종증

박병준 ( Park Byeong Jun ),조재화 ( Jo Jae Hwa ),문태훈 ( Mun Tae Hun ),박상준 ( Park Sang Jun ),류정선 ( Lyu Jeong Seon ),이홍렬 ( Lee Hong Lyeol ),곽승민 ( Gwag Seung Min ),조철호 ( Jo Cheol Ho ) 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.1

댄스스포츠 트레이닝이 여대생의 심폐기능과 신체구성 및 혈중 콜레스테롤에 미치는 영향

정진욱,전태원,김연수,김은경,김광준,이경영,박성태,전병환 한국운동과학회 2003 운동과학 Vol.12 No.1

정성태, 전태원, 정영수, 이동기, 박익렬, 엄우섭, 우재홍, 김경래. 대도시 직장인의 체력과 건강인식에 대한 연구. 운동과학, 제12권 제1호, 133-152, 2003. 본 연구의 목적은 대도시 직장인의 체력과 건강인식의 관계를 규명하는 데 있다. 연구대상자는 서울 지역에서 3개구를 임의 선정하여 각 구별로 3개의 단체를 무선 표집하여 연령별로 30-50대의 남·여 130명을 선정한 후, 이들을 대상으로 건강인식에 대한 설문조사와 건강관련 기초체력검사를 실시하였다. 자료처리 방법은 Crosstab을 통하여 사회인구학적 변인과 각 문항간의 χ^2검정을 실시하였으며, 사회인구학적 변인별로 체력과 건강인식관련 하위 변인간의 유의도 검증은 독립 t-test를 사용하여 분석하였다. 체력과 건강인식에 대한 설문조사와 기초체력검사를 실시한 결과 다음과 같은 결과를 얻었다. 첫째, 남자가 여자에 비해 직장 취업률이 높은 것으로 나타났다. 둘째, 남자보다 여자가 체중감소 노력을 더 많이 하는 것으로 나타났다. 셋째, 체중감소 희망부위에 대해 남자는 허리인 반면에 여자는 복부인 것으로 나타났다. 넷째, 비반의 원인에 대해 남자의 경우 운동부족을, 여자의 경우 음식 불균형에 의해 비만이 주로 초래된다고 인식하는 것으로 나타났다. 다섯째, 체중조절 방법에 대해 30대의 경우 주로 운동요법에 의해, 50대의 경우 식이요법에 의해 체중을 조절하고 있는 것으로 나타났다. 여섯째, 남자는 대다수가 흡연을 하는 것으로, 여자는 대다수가 흡연을 하지 않는 것으로 나타났다. 일곱번째, 흡연기간에 대해 남자는 흡연기간이 주로 10년 이상으로 나타났으며, 반면에 여자 흡연자의경우 흡연기간은 1년 미만인 것으로 나타났다. 여덟째, 음주횟수는 남자의 경우 평균 주 3회, 여자의 경우 평균 주 1회 술을 마시는 것으로 나타났다. 아홉째, 음주량은 남자의 경우 평균 7-9병을, 여자의 경우 4병 정도를 마시는 것으로 나타났다. 열번째, 스트레스 원인에 대해 남자는 주로 직장문제로, 여자는 주로 경제적 문제 때문에 스트레스를 받는 것으로 나타났다. 열한번째, 스트레스 해소방법에 대해 고학력자인 경우 이완요법을, 고졸이하의 경우 주로 운동에 의해 스트레스를 해소하는 것으로 나타났다. 열두번째, 운동횟수에 대해 연령이 증가함에 따라 운동횟수가 감소하는 것으로 나타났다. 열세번째, 운동시간에 대해 남자는 주당 평균 2-4시간 정도를, 여자는 1시간에서 1시간 30분 정도를 운동하는 것으로 나타났다. 열네번째, 운동종목 선호도에 대해 남자는 주로 조깅 및 헬스를, 여자는 주로 헬스 및 수영을 주로 선호하는 것으로 나타났다. 열다섯번째, 여가시간 운동여부에 대해 남자는 여가시간에 주로 운동을 하는 것으로 나타났으며, 여자는 주로 운동을 하지 않은 것으로 나타났다. 열여섯번째, 남자가 여자에 비해 근력, 근지구력, 심폐지구력 등이 높은 것으로 나타났다. 반면에, 여자가 남자에 비해 유연성, 체지방율 등이 높은 것으로 나타났다. Chung, S.T., Jun, T.W., Chung, Y.S., Lee, D.K, Park, I.R., Eom, W.S., Woo, J.H., Kim, K.L The Study of Fitness and Health Consciousness for Big City Company Employee's. Exercise Science, 12(1): 133-152, 2003. The purpose of this study is to examine closely big city company employee's relationship between fitness and health consciousness. Research targets were 130 men and women in ages of 30-50 of 3 organizations that were chosen randomly in 3 districts (gu)'s of Seoul area and they took the survey about health consciousness, basic physical test. Ran χ^2 test between society-population factor and each questions by doing cross-tab method to get the statical analysis and used independent-test between society-population factor and other subordinate factor(about fitness and health consciousness) to see the significant level. Got the following results after taking the surveys and physical tests. First, man appeared that man has higher employment rate than woman does. Second, woman was more exposed to weight loss effort than man did. Third, man's weight loss hope region was waist while woman was abdomen area. Fourth, in man's case about cause of corpulence was exposed due to lack of exercise and imbalance of food in the case of woman. Fifth, weight control system was exercising in ages of 30 and food control by people in ages of 50. Sixth, most of the men were smokers but only a few women were smokers. Seventh, smoking period of man was more than 10 years mainly and while smoking period was less than 1 year in woman's case. Eighth, in average man usually drinks 3 times a week and 1 time a week in woman's case. Ninth, man drinks 7 - 9 bottles and woman drinks about 4 bottles in averages. Tenth, about stress cause, man appeared to be as company problems, that woman receives stress from economical problem mainly. Eleventh, people with high education levels did relaxation(이완??) method to treat stress but people's with less than high school levels got rid of stress by exercise. Twelfth, exercise number decreased as people gets older. Thirteenth, man's average exercise time was about 2 - 4 hours per week, and 60 - 90 minutes in a week for woman. Fourteenth, man prefers jogging and health-club exercise, and woman prefers also health-club exercises and swimming. Fifteenth, man exercises mainly at leisure times but woman usually does not exercise during spare time. Sixteenth, man has higher muscle strength, muscle endurance, cardio-respiratory function than woman has. However, woman has higher value on flexibility and % body fat than man has.

아민기 개질 탄소를 이용한 이산화탄소 분리 특성

차왕석(Wang Seog Cha),임병준(Byeong Jun Lim),김준수(Jun Su Kim),이성연(Sung Youn Lee),박태준(Tae Jun Park),장현태(Hyun Tae Jang) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.4

새로운 이산화탄소 분리용 흡착제 개발은 흡착속도, 소수성, 상용 흡착제보다 낮은 재생온도 등을 고려하여야 한다. 본 연구에서는 CO2를 분리하기 위하여 아미노실란이 그라프팅된 활성탄을 합성하였다. 아민 작용기 전구체로 methyltrimethoxysilane(MTMS) and 3-Aminopropyl-triethoxysilane(APTES)을 사용하여 그라프팅하였다. APTES를 그라프팅 활성탄이 MTMS을 사용한 것보다 우수한 흡착 특성을 나타내었다. 온도 및 이산화탄소 분압에 따른 흡착 특성으로 이산화탄소 분리 메커니즘을 규명하였다. 이산화탄소의 흡수/흡착능은 25 ℃에서 아민 그라프팅 활성탄과 활성탄과 비슷하지만 아민 그라프팅 활성탄이 75 ℃에서 더 높게 나타났다. 아민 작용기 그라프팅 활성탄은 이산화탄소 분압이 1 % 인 조건에서 활성탄보다 더 우수한 흡수능을 나타내었다. 아미노실란 그라프팅 활성탄은 물리적 흡착 특성을 지닌 화학적 흡수 메카니즘을 나타내었다. 아민 작용기가 부여되어 개질된 고체상 흡수/흡착제는 이산화탄소 흡착/흡수 공정만 아닌 재료 관련 산업에 큰 영향을 미칠 수 있는 고성능 복합 재료이며, 개발된 흡착제는 흡수/흡착 및 분리 관련 산업 공정에 적용될 수 있다. The development of a new sorbent for carbon dioxide depends on several factors, such as fast adsorption/absorption velocity, hydrophobicity, and lower regeneration temperature than commercial sorbent. In this study, aminosilane grafted activated carbon was synthesized to capture CO2. Methyltrimethoxysilane (MTMS) and 3-aminopropyl-triethoxysilane (APTES) were used as the grafting precursor of the amine functional group. The APTES grafting activated carbon showed higher sorption property than MTMS used one. The characteristics of the separation mechanism of carbon dioxide were examined by measuring the adsorption capacity according to temperature and carbon dioxide partial pressure. The absorption capacity of carbon dioxide was similar to amine grafting activated carbon and activated carbon at 25℃, but amine-grafted activated carbon was higher at 75℃. The amine functional group-grafted activated carbon showed higher absorption capacity than activated carbon with a 1% carbon dioxide partial pressure. Aminosilane grafting of activated carbon was chemically absorbed but also showed the characteristics of physical adsorption. The reforming activated carbon with an amine functional group grafted solid absorption/adsorption sorbent would significantly impact the material engineering industry and carbon dioxide adsorption process. The functionalized sorbent is a high-performance composite material. The developed sorbent may have applications in other industrial processes of absorption/adsorption and separation.

점진적 최대운동시 글루타타이온 퍼록시데이스의 활성에 관한 연구

진태원,전병환 서울대학교 체육연구소 2002 서울大學校 體育硏究所論集 Vol.23 No.1

The purpose of this study was to investigate the change of plasma glutathione peroxidase(GPx) concentration during the progressive maximal exercise test and to know the relationship between GPx and energy expenditure. The subjects were 9 healthy university students(28.2±2.6yr) without metabolic disease. In the 3 times pretest(treadmill running, Bruce protocol), the 50%, 60%, 70%, 80%, 90% and 100% of O2 max were determined. In addition, the lactate thershold(LT) was analyzed during the pretest. In the head test, the energy expenditure and concentration of plasma GPx were determined by ELISA(Enzyme -linked immunosorbent assay). After analysis, The mean and SD were determined by Spss 8.0ver. and One-way ANOVA was applied as a statistic. The significance was .05. The results were shown that there was no significance in the change of plasma GPx concentration and there was no significant relationship between the GPx concentration and energy expenditure.