Protective Effect of Baicalin Against Carbon Tetrachloride–Induced Acute Hepatic Injury in Mice

Park, Sang-Won,Lee, Chan-Ho,Kim, Yeong Shik,Kang, Sam Sik,Jeon, Su Jin,Son, Kun Ho,Lee, Sun-Mee The Japanese Pharmacological Society 2008 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.106 No.1

<P>This study examined the effects of baicalin, a bioactive flavonoid isolated from <I>Scutellariae Radix</I>, on carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl<SUB>4</SUB> and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl<SUB>4</SUB> treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl<SUB>4</SUB>-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-α were markedly increased by the CCl<SUB>4</SUB> treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl<SUB>4</SUB> treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl<SUB>4</SUB>, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.</P>

자연산 점몰개, Squalidus multimaculatus Hosoya et Jeon의 새인두흡충, Clinostomum complanatum (Rudolphi, 1814) 감염

박명애 ( Myoung Ae Park ),서정수 ( Jung Soo Seo ),정승희 ( Sung Hee Jung ),최희정 ( Hee Jung Choi ),전은지 ( Eun Ji Jeon ),지보영 ( Bo Young Jee ),이완옥 ( Wan-ok Lee ),우승호 ( Sung Ho Woo ),이은혜 ( Eun Hye Lee ) 한국어병학회 2011 한국어병학회지 Vol.24 No.2

The metacercariae of Clinostomum complanatum (Rudolphi, 1814) were isolated in the whole body muscle of wild freshwater fish, spotted barbel gudgeon (Squalidus multimaculatus Hosoya et Jeon) from the local river in Yeongdeok, Gyeongsangbuk-do, Korea. The infected fish with bumpy body surface by yellow grub showed erratic swimming behavior and some fish were died. The isolated excysted metacercariae were tongue shaped and 2.85~5.89 mm × 0.8~1.99 mm in size. 1~98 metacercariae were isolated in individual fish and mean infection intensity was 25. All examined adult spotted barbel gudgeon sizing 7 cm in body length were infected. This is the first report of disease outbreak and mortality caused by C. complanatum infection in wild freshwater fish in Korea.

EMR 남중생의 심폐기능에 관한 연구

전동호,노영태,이상봉,이영덕,박병주,박철준 釜山大學校 附設 體育科學硏究所 1997 體育科學硏究所 論文集 Vol.13 No.-

The purpose of this study is to offer proper physical programs to the middle school EMR boys and to improve their cardiorespiratory function through measuring cardiorespiratory function when they are rest situation, all out situation ten EMR boys, divided into two groups as five exercise boys and five non- exercise ones, played soccer game more than one hour a week for 10 weeks. The results of the measurement by treadmill were as fallows 1. In analyzing the two group t-test score it was found that HR and RQ of both group didn't show statistically significant difference of all(p<0.05). 2. VE, VO₂, Vt, O₂,pluse, CO₂,were revealed the significant difference of rest situation with the exception of all-out situation and recovery(p<0.05) 3. VE, VE/VO₂, O₂/ml/kg. O₂/kg/HR, were revealed the significant difference of all-rest situation with the exception of rest situation and recovery(p<0.05) 4. VO₂, Vt, O₂pluse were revealed the significant difference of recovery situation with the exception of all-out situation and rest(p<0.05) 5. The non-exercise group higher figure in HR, Vt, O₂/ml/kg than exercise group except in VE in the rate of recovery situation in 3 minute

골반통증을 동반한 폐쇄신경 기원의 퇴행성 신경초종

이상욱,김두상,조현득,이창호,전윤수,이남규 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

악성 섬유성 조직구종의 기원에 관한 면역조직화학적 및 초미세형태학적 연구

전호종,임성철,강종식,김일,황호원 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1

Malignant fibrous histiocytoma(MFH) was first terminologically introduced in 1963 to refer to a group malignant soft tissue tumors characterized by a stonform growth pattern and these tumors are a oup of sarcomas composed of cells morphologically resembling fibroblast and histiocvte. The histogeisis of MFH is still controversial, but a more complete appreciation of it's morphogenesis has been ovided by tissue culture and ultrastructural studies. In the present study, ultrastructural and immunohistochemical studies of seven cases of MFH disclosee maturation and development of principal types of cells constituting MFH and immunohistochemical actions to investigate the histogenesis of malignant fibrous histiocytoma. The results obtained were as follows. Malignant fibrous histiocytoma composed of different portions of fibroblast-like cells, histiocyte-like cells, cells intermediate between histiocyte-and fibroblast-like cells, multinucleated giant cells, undif ferentiated cells, xanthomatous cells and myofibroblast. The principal cell types of malignant fibrous histiocytoma were fibroblast-like, histiocyte-like, intermediate (fibrohistiocytoid) and undifferentiated cell. There were cells bearing variable stages of differentiation along the fibroblastic and histiocytic lines from undifferentiated cells. 2. There was no difference in cellular composition ultrastructurally between storiform-pleomorphic, myxoid and inflammatory subtypes. 3. Junctional complexes were shown in fibroblast-like, histiocyte-like cells, intermediate cell and myofibroblasts. Long desmosomes were observed in histiocyte-like cells, intermediated cells and myofibroblasts, Paired subplasmalemmal densities were also shown in fibroblast-like cells and. intermediate forms. 4. Immunohistochemical reactions revealed strong staining reactions for α1-antitrymotrypsin in histiocyte=like cells and multmucleated giant cells. Vimentin was reactive for fibroblast-like cells, histsiocyte-like cells and multinucleated giant cells. However, no evidence of staining reactions for α1-antitrypsin, a1-antichymotrypsin, vimentin, lysozyme in the cells of early stage of differentiation along the fibroblast and histiocyte-like cells from the undifferentiated cells. 5. In conclusion it is suggested that malignant fibrous histiocytoma may be considered a primitive mesenchymal tumors originating from undifferentiated cells.

매복된 견치의 Tunnel을 통한 교정적 견인

전정훈,오유향,이난영,이창섭,이상호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

매복된 상악 견치를 위한 외과적 수술을 동반하는 교정치료는 주위조직에 손상을 주지 않고 치열궁내에 적절히 위치시켜야 한다. 이를 위해 매복된 치아의 위치에 따라 다양한 외과적, 교정적 방법이 소개되었으며, 그 방법으로 window procedure, apically positioned flap, closed eruption technique, tunnel traction 등이 있다. 깊은 골연하 매복에서 사용할 수 있는 방법으로 closed eruption technique 그리고 tunnel traction이 있는데, closed eruption technique은 점막 및 치은 하방으로 지나는 견인 와이어의 자극으로 염증 발생 가능성이 높으며 치은퇴축 및 부착 치은의 소실이 발생할 수 있다. 하지만, tunnel traction은 치아의 맹출이 터널을 통해서 유도되어 각화치은에 둘러싸인 채 치조골의 중앙으로 나오게 되므로 치은퇴축이나 치주부착의 소실 없이 적절한 각화치은을 얻을 수 있으며 매복치가 치조골의 중심부로 맹출함에 따라 생리적 맹출과 같은 효과 얻을 수 있다. 본 증례는 깊은 매복을 보이는 상악 견치를 tunnel traction을 이용한 치료를 보고한 것으로, 적절한 방향을 가지고 맹출하였으며 치은퇴축이나 부착치은의 소실이 발생하지 않았다. The impacted maxillary canine is a common problem of which all dental practitioners should be aware. The surgical orthodontic treatment of impacted canines is replaced correction position in dental arch without periodontal damage. Many treatment possibilities have been considered for this goal; window procedure, apically positioned flap, closed eruption technique and tunnel traction. Prognosis for these treatment may be very uncertain in many case(infraosseous impacted tooth). Other steps are required to achieve a satisfactory periodontal outcome. Satisfactory results could be expected if the physiologic eruption pattern is restored by tunnel traction, because permanent tooth erupts through the gingiva near the crest of the ridge so that periodontal damage is reduced. This article report that the surgical orthodontic treatment using tunnel traction is obtained proper position and reduced periodontal damage in facially impacted maxillary canines.

시멘트 킬른 더스트를 사용한 콘크리트의 역학적 특성에 관한 연구

전충근,차천수,차완호,손성운,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

This paper is intended to investigate the properties of fresh and hardened concrete, in which cement and fine aggregate are replaced with cement kiln dust(CKD), for effective using method of CKD, a by-product produced in the process of making cement. According to the results, as the replacing ratio of CKD increases, slump and air content of concrete decreases remarkably due to an increase of viscosity and filling of the pores respectively. As the properties of setting, setting time are shortened with an increase of the replacing ratio of CKD. Compressive strength increases due to the filling effect of the pores in comparison with plain concrete, and compressive strength ratio is high at early age.

C₄유분을 이용한 옥텐류의 합성에 있어서 1,3-Butadiene의 함량에 따른 이량화 촉매의 수명에 관한 연구

전종기,한원희,조정호,고승태,노상균 동양대학교 2001 동양대학교 논문집 Vol.7 No.1

Selective hydrogenation of 1,3-butadiene in C4 raffinate was carried out in fixed bed reactor using Pd/a1unina catalysts, Concentration of 1,3-butadiene in C4 raffinate could be reduced under 100 ppm.The life of dimerization catalyst using C4 raffinate after selective hydrogenation was longer than that of dimerization catalyst without selective hydrogenation.It was found that dilution of olefin concentration in feed was effective to increase dimerization catalyst life.

황색포도구균의 coagulase형과 항생제감수성 양상의 상관관계

전창호,서헌석,김상경 대한임상병리학회 1996 대한임상병리학회지 Vol.16 No.6