신형원자로 제어봉의 핵적 특성연구

김종채,김명현 慶熙大學校 레이저 工學硏究所 1993 레이저공학 Vol.4 No.-

Advanced reactor is supposed to be capable of load following operating by gray rods. A new computational tool of CASMO-3 and KINS-3 are benchmarked for UCH 3&4 PSAR. A sensitivity analysis is performed for both the compositional change of rod material and the dimensional change in AP600. Peak pin power of a option with all-stainless steel-gray rods are shown to be decreased a little more throughout the cycle compared to the original design. Also all-stainless steel-gray rods are shown to have a capability of load following operation.

혼합핵연료를 이용한 초장주기 무붕산 노심 핵설계

김종채,김명현 경희대학교 산학협력기술연구원 1997 산학협력기술연구논문집 Vol.3 No.-

The feasibility of nuclear design for the ultra long cycle with soluble boron free operation option was investigated for the medium-size commercial reactors. MOX fuel is used because of its lower excess reactivity at BOC and higher conversion ratio than those of HEU UO_2. IFBA and WABA are chosen as a burnable poison to control the initial reactivity. In order to compensate the large excess reactivity at BOC, isotopic abundance of B-10 in IFBA and WABA is raised up to 80%. For the shutdown reactivity, B_4C control rod with highly enriched B-10 is used. Ag-In-Cd with standard isotope composition is used for the control of excess reactivity. Designed Core satisfied design requirement for ultra long cycle SBFO. Critical control rod positions are found throughout 1,600 EFPD. Axial Offset and E_Q are found to be kept within the safety limits. Shutdown margin also is preserved at the refueling cold standby condition as well as HZP condition.

수입 외국산 모발세정용 화장품의 중금속 농도에 관한 연구

문정아,문덕환,박명희,안진홍,김종은,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : For the purpose of preparing the fundamental data and preventing the health impairment due yo heavy metals in hair cleaner. Methods and Material : The author determined the concentration of heavy metals(Fb, fn, Cr, Ni and Cu) in hair cleaner with flameless atomic absorption spectrophotometer. Results : The results were as follows : 1. The mean concentration of heavy metals in total hair cleaner were 0.046㎍/g for Pt, 0.O67㎍/g for Mn, 0.069㎍/g for Cr, 0.046㎍/g for Ni, and 0.022㎍/g for Cu, respectively. 2. There was not statistically significant difference to mean concentrations of each heavy metal in hair cleaner by producing nation. 3. The highest mean concentration of each heavy metal in hair cleaner by type of use were 0.140㎍/g for Mn in sensitive hair cleaner(p<0.05), 0.053㎍/g for Cu in others products(p<0.01). 4. The mean concentration of heavy metals in hair cleaner by type of hair cleaner were high at 0.O54㎍/g for Pb in shampoo products(p<0.O5), 0.120㎍/g for Cr and 0.06㎍/g for Cu in combination products(p<0.01). 5. The mean concentration of heavy metals in hair cleaner by acidity were high at 0.056㎍/g for Pb, 0.124㎍/g for Cr, and 0.032㎍/g for Cu in alkali products (p<0.05). 6. Correlation coefficient of heavy metal concentration in hair cleaner were 0.175 for Pb and Cr, 0.165 for Pb and Mn, 0.824 for Cr, and Mn, 0.189 for Cr, and Ni, 0.406 for Cr, and Cu, 0.197 for Mn and Ni, and 0.375 for Mn and Cu(p<0.05). 7. Exposure amount of heavy metals per when we used lOg of hair cleaner (onetime using amount) were 0.46㎍ for Pb, 0.67㎍ for Mn, 0.69㎍ for Cr, 0.46㎍ for Ni, and 0.22㎍ for Cu, respectively. Conclusion : As above results, there was very low level concentration of heavy metal in hair cleaner but we are using the hair cleaner everyday, therefore we can exposed to heavy metals as cronic exposure so the author suggest to prepare the program of preventing the health impairment due to heavy metals.

강섬유를 이용한 RCS 보-기둥 접합부의 내진 거동에 관한 실험적 연구

김신호,양성철,박종원,정명채,이정원 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

This study develops the mixed structure joint which could improve the strength, deformation, and energy dissipation capacities compared to existing mixed structure joints. The type of joint developed in this study is called "the beam penetration joint" where the web of steel beam penetrate into the column confined by the concrete. This paper describes the cyclic test on the RC column-steel beam joint for investigating the hysteretic behavior of the joint. From this test its strength. stiffness and ductility capacity are discussed.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Peroxisome proliferator-activated receptor γ 배위자의 간암 세포에 대한 항암 효과

채명종 ( Myung Jong Chae ),심재준 ( Jae Jun Shim ),김병호 ( Byung Ho Kim ),황보영 ( Bo Young Hwang ),이영주 ( Young Ju Lee ),하승형 ( Seung Hyung Ha ),장재영 ( Jae Young Jang ),동석호 ( Seok Ho Dong ),김효종 ( Hyo Jong Kim ),장영 대한내과학회 2008 대한내과학회지 Vol.75 No.3

목적: PPARγ는 핵 수용체의 일종으로 혈당 조절과 지방세포의 분화에 작용하는 것뿐만 아니라 각종 암세포에 대한 항암 작용과도 연관되어 있다고 알려져 있다. 대표적인 합성 PPARγ 배위자인 thiazolidinediones계 혈당 강하제와 내인성 배위자인 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2)가 간세포암(이하 간암)에도 항암 효과가 있는지 조사하였다. 방법: 간암 세포주로는 HepG2, Hep3B, PLC/PRF5를 사용하였는데, 이들 세포주에서 PPARγ 유전자 발현은 역전사-중합효소연쇄반응으로 확인하였다. Thiazolidinediones계 약물인 troglitazone (TGZ), pioglitazone (PGZ) 그리고 rosiglitazone (RGZ)을 각각 25~100 μM의 농도로 각 세포주에 투여하였고, 15d-PGJ2는 20~80 μM의 농도로 투여하였다. MTT assay를 이용하여 세포 생존률을 72시간까지 대조군과 비교하였다. 세포 주기 분석은 flow cytometry를 이용하였고, 세포자멸사는 ELISA kit를 이용하였다. Caspase-3와 caspase-8 그리고 caspase-9의 활성도를 caspase colorimetric assay를 이용하여 분석하였다. Caspase 억제제를 투여하여 PPARγ 배위자에 의한 세포자멸사가 억제되는지 조사하였다. 결과: 사용된 PPARγ 배위자 중 TGZ과 15d-PGJ2가 HepG2, Hep3B 그리고 PLC/PRF/5에 뚜렷한 성장 억제를 나타냈다. 반면에 PGZ과 RGZ은 TGZ에 비해 거의 효과가 없었다. 세포 주기분석에서도 TGZ과 15d-PGJ2가 G0/G1 arrest와 세포자멸사를 일으킨 반면 PGZ과 RGZ은 효과가 없었다. 세포 주기 및 세포자멸사 분석에서 TGZ과 15d-PGJ2의 항암효과는 세포주에 따라 서로 다르게 나타났다. TGZ은 HepG2에서 G0/G1 arrest를 일으켰고 PLC/PRF5의 세포자멸사를 유도한 반면 15d-PGJ2는 HepG2에서 세포자멸사를 일으키고 PLC/PRF5에서는 뚜렷한 세포자멸사를 일으키지 못하였다. TGZ과 15d-PGJ2은 caspase-3 활성도를 크게 증가시켰으며 (p<0.01) caspase-9의 활성도도 증가시켰다. TGZ과 15d-PGJ2에 의해 유도된 세포자멸사는 pancaspase 억제제와 caspase-3 특이 억제제에 용량 의존적으로 억제되었다. 결론: Troglitazone과 15d-PGJ2는 간암 세포에서 세포자멸사를 유도하여 항암 작용을 나타내는데, PPARγ 이외의 다른 기전이 작용하는 것으로 보이며 항암 기전도 서로 다른 것으로 생각한다. Background/Aims: Thiazolidinediones, which are synthetic insulin sensitizers, are known activators of peroxisome proliferator-activated receptor gamma (PPARγ). PPARγ ligands, including endogenous 15-deoxy-Δ12,14-prostaglandin J2(15d-PGJ2), are thought to elicit antineoplastic effects in various cancer cells. In this study, the antineoplastic effects of PPARγ ligands against hepatocellular carcinoma (HCC) cells were investigated. Methods: HepG2, Hep3B, and PLC/PRF5 cells were cultured with troglitazone (TGZ), pioglitazone (PGZ), rosiglitazone (RGZ), or 15d-PGJ2 at concentrations of 20-100 μM.. Cell viability, cell cycle arrest, apoptosis, and caspase activity were measured using the MTT assay, flow cytometry, enzyme-linked immunosorbent assay (ELISA), and colorimetric assays, respectively. The effects of various caspase inhibitors were also measured using a cell death detection ELISA. Results: All three cell lines expressed the PPARγ gene. TGZ and 15d-PGJ2 strongly inhibited growth in HepG2, Hep3B, and PLC/PRF5 cells. In contrast, PGZ and RGZ showed a much weaker effect in all cell lines. In terms of cell cycle arrest and apoptosis, TGZ induced G0/G1 arrest in HepG2 cells and increased the apoptotic fraction in Hep3B and PLC/PRF5 cells. In contrast, 15d-PGJ2 induced apoptosis only in HepG2 and Hep3B cells. TGZ and 15d-PGJ2 increased caspase-3 activity significantly and increased caspase-9 activity slightly. TGZ- and 15d-PGJ2-induced apoptoses were inhibited by a pancaspase inhibitor (Z-VAD-FMK) and a caspase-3 specific inhibitor (Z-DEVD-FMK) in a dose-dependent manner. Conclusions: TGZ and 15d-PGJ2 elicit antineoplastic effects in various HCC cells via caspase-dependent apoptotic induction. Their differential effects on similar cell types suggest that another antineoplastic mechanism, most likely a PPARγ-independent pathway, is involved. (Korean J Med 75:288-299, 2008)

22 만성 B형 간염 환자에서 급성 악화의 원인 및 임상 경과

채명종 ( Myung Jong Chae ),김병호 ( Byung Ho Kim ),정경환 ( Kyung Hwan Jeong ),한요셉 ( Yo Seb Han ),정용희 ( Yong Hee Jeong ),이병욱 ( Byung Wook Lee ),동석호 ( Soek Ho Dong ),김효종 ( Hyo Jong Kim ),장영운 ( Young Woon Chang 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

High affinity peptide-tethered electrochemical biosensor for the detection of neutrophil gelatinaseassociated lipocalin

Chae Hwan CHO,Ji Hong KIM,Myung Yi RYU,Jae Hwan SHIN,Jong Pil PARK 한국생물공학회 2019 한국생물공학회 학술대회 Vol.2019 No.10

Re-Engineering of Affinity Peptides for the Improvement of Detection Performance

Jong Min LIM,Ji Hong KIM,Chae Hwan CHO,Myung Yi RYU,Jong Pil PARK 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.10