The Korean Association of lnternal Medicine : Poster Session ; PS 1357 : Nephrology ; Age is the Strongest Effector for the Relationship between Estimated Glomerular filtration Rate and Coronary Artery Calcifi cation in Apparently Healthy Korean Adults

( Hyun Beom Chae ),( Eun Jung Rhee ),( Hae Jung Park ),( Min Kyung Lee ),( Won Seon Jeon ),( Se Eun Park ),( Cheol Young Park ),( Won Young Lee ),( Ki Won Oh ),( Sung Woo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Cardiovascular disease (CVD) is a major clinical problem and the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). Coronary artery calcifi cation (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects. Methods: In 23,617 participants in the health screening program in Kangbuk Samsung Hospital health screening program from January 2010 to December 2011, estimated glomerular fi ltration rate (eGFR) was assessed by Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured by multi-detector computed tomography (MDCT). Subjects were divided into 3 groups according to the CKD Staging system with eGFR grade; stage 1: eGFR = 90 mL/min/1.73 m2, stage 2: eGFR 60-89 mL/ min/1.73 m2, stage 3: eGFR 30-59 mL/min/1.73 m2. Results: Mean age of the participants was 41.4 years, and mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed weakly negative but signifi cant association with CACS in bivariate correlation analysis (r=-0.076, p<0.01). Mean CACS signifi cantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC signifi cantly increased from CKD stage 1 to 3. Although odds ratio for CAC signifi cantly increased from stage 1 to 3 after adjustment for confounding factors, this signifi cance was inversed when age was included in the model. Age was the strongest factor that affects CAC. Conclusions: This study performed in young Korean subjects with relatively normal renal function, age was the mostly strongest effector on the association between eGFR and the degree of CAC.

주요우울증에 대한 벤라팍신의 효과 및 안전성

이민수,남종원,강성민,연병길,오병훈,이철,정인과,채정민,백인호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 주요우울증 환자에서 벤라팍신의 치료 효과와 안정성을 조사하기 위해 다기관 개방연구를 시행하였다. 방 법 : DSM-IV 진단 기준에 의거하여 주요우울증으로 진단된 환자중 벤라팍신 투여에 동의한 환자를 대상으로 하였다. 선택된 환자에서 다른 항우울제를 복용하고 있는 경우 14일 이상의 약물 배설기간을 가진후 벤라팍신을 6주간 투여하였으며, 기준점, 1주, 2주, 4주, 6주 후에 HAM-D, MADRS, 그리고 CGI등을 사용하여 평가하였다. 본 연구기간중 발생된 모든 부작용은 부작용의 발생 및 소설 시기, 심한 정도, 발생 빈도, 벤라팍신과의 관련성, 관련 조치 및 결과에 대하여 증례기록서에 기록하도록 하였다. 결 과 : 총 141명을 대상으로 하였으며, 이중 94명(66.7%)이 6주간의 연구를 완결하였고, 47명(33.3%)이 중도탈락하였다. HAM-D총점수는 벤라팍신 투여 1주후부터 유의한 감소를 나타내었으며, 2주,4주, 6주후에도 지속적인 감소를 보였다. MADRS의 총점수도벤라팍신 투여 1주 후부터 유의한 호전을 나타내었으며, 2주, 4주, 6주 후에도 지속적인 감소를 보였다. CGI에서도 기준점, 1주, 2주, 4주, 6주 후 각각의 시점 사이에 유의한 호전이 보였다. 활력징후, 일반 혈액학, 생화학, 심전도 검사 등에서 유의한 변화는 없었다. 벤라팍신과 관련된 부작용으로 흔히 보고한 증상은 오심(10.6%), 소화불량(9.5%), 변비(8.5%), 현기증(8.5%)등 이었다. 결 론 : 다기관 개방연구를 통해 주요우울증 환자에 대한 벤라팍신의 투여는 우울증상의 호전에 효과적이었으며 안전하였다. Objective : A Multicenter open-label study was conducted to evaluate the clinical efficacy and safety of venlafaxine for the tretment in patients with major depression. Method : The study was done in patients with major depression diagnosed by DSM-IV who accepted venlafaxine medication. In cases of the patients taking other antidepressants, 6 weeks of venlafaxine medication was carried out after 14 days of drug excretion period and evaluation using HAM-D, MADRS, and CGI was done at baseline, and after 1, 2, 4, and 6 weeks. Regarding all side effects that had occurred during the period of our study such as their developed/disappeared time, severities, incidences, relationship with venlafaxine, managements and results have been putted into the records. Results : A total of 141 patients were enrolled. Among 94 of them finished the 6 weeks of research and 41 of them did not make it through the research. Total HAM-D scores showed significant decrease after 1 week of venlafzxine medication and continous decrease through the study period. Total scores of MADRS also showed significant improvement after 1 week and continuous decrease through the study period. Similarly, CGI showed significant improvement between baseline, 1, 2, 4, and 6 weeks. There were no significant changes in vital sign, CBC, chemistry, and EKG. The commonly reported side effects of venlafaxine were nausea(10.6%), indigestion(9.5%), constipation(8.5%), and dizziness(8.5%). Conclusion : According to the results, venlafaxine was effective and safe in the treatment of patients with major depression.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

TMS320C6711을 이용한 Digital X-ray 신호처리 시스템 개발

정민수,이재균,강문호,이채욱 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.1

기존의 의료용 X선 영상장치에 있어서 TV 방식은 형광증배관에 나타나는 잡음과 TV자체의 잡음으로 인하여 비교적 잡음이 많이 발생한다. 그리고 interlace 주사로 인한 화면 떨림 현상이 발생하여 카메라 해상도가 저하되어 모니터에 나타나는 전체적인 화면의 화질이 그다지 선명하지 않다. 본 논문에서는 NTSC 방식의 잡음 문제를 해결하기 위해, X-ray에 의해 투시된 X-ray 형광증배의 아날로그 화면은 A/D converter를 이용하여 디지털 신호를 만든다. 또한 interlace 방식의 화면이 깜박거리는 현상을 제거하기 위해 double scanning 하고 interlace 주사를 noninterlace로 주사하는 방식을 도입한다. 그리고 실시간 처리를 위하여 TMS320C6711을 이용한 Digital X-ray 신호처리 시스템을 개발하고자 한다. The TV injection method of general X-ray image system has a problem because of the fluorescent increased dividend tube and the TV itself. As the screen trembling by interlace injection decreases the camera resolution, the total quality of monitor is not so clear. In this paper, we make the analog signal of X-ray fluorescent increased dividend tube into digital signal by using A/D converter. Also, to remove the twinkles from interlace method, we adapt the double scanning and the noninterlace method. For realtime processing we develop the digital X-ray signal processing system which uses a TMS320C6711.

용혈성 요독 증후군 부검 1예

채종민,곽정식,임재원 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

We experienced an autopsy case of hemolytic uremic syndrome. Over 75% of cases occur in children with intestinal infection with verocytotoxin-producing E.coli. The disease is one of the main causes of ARF in children. It is characterized by the sudden onset, usually after a gastrointestinal or flu-like prodromal episode of bleeding manifestations(especially hematemesis and melana), severe oliguria, hematuria, a micro-angiophathic hemolytic anemia, and prominent neurologic changes?

中共의 現代化 政策

蔡政旻 대구효성가톨릭대학교 1987 연구논문집 Vol.34 No.1

Commuist China has driven forward the modernization policy of agricultre, industry, national defense, science and technology to construct the powerful socialist state by Deng Xiaoping system after Mao's death in the year of 1976. By the Cultural Revolution, confusion of political and social situation adn economic breakdown brought about economic poverty of national life, so she should reform the economic and social situation. Communist China chose the modernization in prefernce to class struggle bringing the capitalist factors, and inspired the productivity of agricultrue and industry by stimulating individual profit and by the free marketing system. At the same time, she took the open door policy in spite of 'Self-revival principle' in the foreign policy during Mao's system, and propelled to import the capital and technology from the West and the others. In this porpose, Communist China made the 'Law on Joint Chinese and Foreign Investment Enterprises' 1976. She increased the investment in the modernization of science and technology with sending many students to studying abroad to the United States or others. But, there are distinct ideological limits as long as emphasizing the Marx-Le-ninism, Maoism, Proletarian dictatorship, Party's leadership and socalistic line. The opposite functions of Reform those are various corruptions, injustice and spoiling are so diffusing that its become serious social problems. So, Deng Xiaoping stress 'Preventation of Mental polution'. After being forced of it for the past seven years, it is true that she attained a measure of success. This so called 'Long March' will advise and stimulate to North Korea's opendoor policy and will contribute the detente of Penisula of Korea. On the other hand, it will grow larger in trading and other aspects with Korea but Communist China would become poweful competitior to Korea in the export foreign markets.

중학생을 위한 학교 성교육 프로그램 개발 및 효과

이채희,정민자 울산대학교 2000 생활과학논문집 Vol.1 No.2

본 연구는 �소년기 성교육의 중요성을 인식하여 중학생을 위한 학교 성교육프로그램을 개발하여 그 효과를 검증하는 것을 목적으로 한다. 본 연구의 대상은 울산시에 소재 한 2개의 중학교를 임의 표집하여 4학급을 선정한 후 성교육 실시가 가능한 2학급을 실험집단으로 나머지 2학급을 통제집단으로 편의 표출하였다. 연구대상에 대한 자료는 질문지와 과제지, 사후 검사지를 통하여 수집하였다. 자료분석을 부호화한 후 SPSS 프로그램을 이용하여 빈도, 백분율, 평균, 표준편차, χ²-test, t-test를 사용하였으며, 신뢰도 검증을 위해 Cronbach's Alpha를 사용하였다. 그리고 과제지와 사후검사지는 프로그램에 대한 질적 분석을 하였다. 본 프로그램을 진행한 연구 결과는 다음과 같다. 첫째, 전반적인 성에 대한 지식수준이 교육실시 후, 사전검사에서 측정된 수준보다 통계적으로 유의하게 높아졌으며, 영역별로 인간 발달에 관련된 성 지식 수준이 유의하게 증가 되었다. 또 성 건강과 사회와 성문화에 대한 성 지식 수준도 성교육을 통해 우의하게 향상 되었다. 둘째, 전반적인 성에 대한 태도가 사전검사에서 측정된 수준보다 통계적으로 유의하게 높아졌으며, 영역별로 성건강에 관련된 성태도 수준이 유의하게 증가되었다. The purpose of this study is to verify the effects of the sex education program developed. The subjects this study were to middle schools located in Ulsan metrupolitan city were drawn and used as four classes on the basis of conveniences. Tow classes which could have the sex education became experimental groups and two classes became control groups. After the treatment both groups were asked to answer the questionnaires, solve tasks, and posttest. data were analyzed as frequency, percentage, mean, standard deviation, chi-square test and t-test by SPSS statistical program. Reliability is tested by Cronbach's alpha. And the resuls of the tasks and posttest were analysedr qualitatively. The results of this program are as follows: first, the level of general knowledge about sex is significantly higher than that of the pretest. Especially sex knowledge related to human development is significantly increased. And the knowledge about sex related health and society and sex are improved significantly by the sex education. Secondly, the student's attitude to sex is significantly increased than that of pretest. Attitude concerned sex relatd health increased significantly.

韓國 傳統的 政治思想에서의 民主主義的 要素

蔡政旻 대구효성가톨릭대학교 1987 연구논문집 Vol.35 No.1

This thesis intend to research the domocratic elements in the traditional political thoughts of Korea to assist the optimism of democratic development of Korean politics. In the spirit of Hong-ik-in-kan, ruling principle of of Dan Gun Korea in antiquity, we can find the ideas of equality, peace, general similarity and government for the people. These democratic elements had been institutionalized simply in the Hwa-beck System in Sila, the jae-ka council in Ko-ku-ryu, and the Electoral system of Prime Minister of Back-jae Dynasty. After that, although long period of political system of absolutism had passed, Shil-hak(practical Scinece) was apperaed in the late Li Dynasty. Most of Shil-hak scholars asserted equality of all men, taking a serious view of individuality and independence of man philosophically. So, they denied traditional social class sytem and assert that anyone who was capable of taking charge of public affairs could be appointed to the positions of governmental institutions. Also, they maintained to abolish slavery, discriminative treatment to illegitimate son and discriminative reguirement to enter school by social class. Especially, Jung, Yjark Yong stressed that rulers had to be elected by the people, suggesting the people were not the object but the subject. These fundamental rules of democracy are not different from those of todays. After all, democratic ideas in the Sil-kak political thoughts influenced on the Korean Enlightenment in the late Li Dynasty. On the other side, we must emphasize significantly the thought of Dong-hak, established by Choi, Jae Woo, stressing the subjectivity and equality of man. There are certain pessimism about the democratic development of current political reality of Korea because of political culture of Korean people-authoritarianism or other factors, but today, we must objectify and socialize the democratic ideas in the traditional political thoughts of our Korean history by research and revelation of those ideas for the democratic development of Korea politics.

1995년도 대구지역 법의 부검 통계

채종민,이숙희,정민희,곽정식 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

This is a statistical observation by authors based on data of deaths brought to department of forensic medicine, Kyungpook National University School of Medicine for medicolegal autopsy by all of law enforcement agencies in Taegu area during the year of 1995. The report aims to reveal facts on various causes of death in Taegu area in attempt to analyse 205 cases statistically. The following are the summary of results ; 1. The total numbers of autopsy were 205 cases, of these 121 cases (58%) were males and 83 cases (40%) were females. 2. The violent deaths were 135 cases (66%) and the natural deaths were 63 cases (31%) and unknown cases were 7 (3%). 3. The percentage of autopsied cases with 30's age group was 28.2% (the most), 20's was 17.2%, 40's was 13.8%, 10's was 13.8%... in violent deaths. The percentage of autopsied cases with 30's age group was 31%, 40's was 20%, 20's was 20%, 50's was 15.5%...in natural deaths. 4. For the violent deaths, the percentage deaths due to injury was 52.9%, asphyxia was 29.8%, intoxication was 10.4% and abnormal temperature(hypothermia or fire) or electrocution was 6.7%. 5. For deaths due to injuries, the percentage of deaths due to blunt injury was 45.7%, sharp force injury was 29.5%, fall was 17.1%. and traffic accident was 7.1%. 6. For the natural deaths, 60 cases were recorded and the death due to the disese of the cardiocascular system was taking the most of the total percentage with 53%. 7. For deaths due to injuries, the percentage of accidental death was 57.3%, homicide was 22% and suicide was 14.7%. 8. 31 subjects (51.7%) of 128 violent deaths have positive blood alcohol concentrations (0.05% and above) , and 8.1% of natural deaths were associated with alcohol intake. 9. For deaths by medical dispute, 7 cases were recorded and deaths combined with operation were taking the most of the total percentage with 43%.