췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

솔-젤법에 의한 Nb_2O_5-Fe_2O_3 혼합산화물의 제조 및 산 특성조사

정석조,양희정,권재범,이내우,우희철 釜慶大學校 2000 釜慶大學校 論文集 Vol.5 No.-

In this study, some of results from a study conducted on the preparation of niobium coated hematite particles to be used as a catalyst are presented.α-Fe_2O_3 (hematite) particles obtained by aging an acidic solution of ferric(Ⅲ) ions at high temperature were first prepared as core particles and synthesised by hydrolysis at high temperature with layers of amorphous niobium pentaoxide (Nb_2O_5) deposited by the hydrolysis of niobium pentachloride. The effects of varying molecular ratio of Nb/Fe (10/1, 5/1, 1/2, 1/5, 1/10) were studied. The synthesised particles were characterized for their physical and chemical properties using XRD, SEM, TPD, BET etc. The process of the surface coating showed heterocoagulation rather than surface nucleation and growth. A preliminary investigation of the acidic characterization and specific surface area of the synthesised particles showed that these particles can achieve an acidic characteristic changed and enhanced specific surface area of that of pure niobia and α-Fe_2O_3 prepared here.

위삼차신경핵에서 일차구심성 신경섬유 종말부의 미세구조 및 연접양상

배용철,박국필,정경원,박매자,조희중 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.5

침엽수 구조용 정각재의 천연건조곡선과 함수율분포

정희석,이철현,강욱,엄창득 한국목재공학회 2003 목재공학 Vol.31 No.1

이 논문은 소나무와 일본잎갈나무의 변장 14.0cm와 16.5cm인 큰 정각재의 천연건조과정과 함수율분포에 관한 내용으로서 건조속도는 건조개시 첫 8주 동안 비교적 컸었으나 그 이후부터 점차 감소하였다. 생재에서 규격함수율 18% 수준까지 건조시간은 소나무 14.0cm와 16.5cm가 각각 26주와 32주이고, 일본잎갈나무의 경우는 각각 32주와 48주이었다. 이들 정각재의 재장방향과 두께방향의 수분경사는 비교적 완만하였다. 일본잎갈나무의 수분경사는 소나무의 것보다 컸었고, 일본잎갈나무의 변장의 크기가 수분경사에 미치는 영향은 소나무의 것보다 컸었다. This paper presents the results of air-drying processes and mositure content (MC) distribution of red pine (P. densiflora) and Japanese larch (I. leptolepis) square timber with 14 cm and 16.5 cm of face size, respectively. The air-drying rates of square timber were comparatively high during the first 8 weeks, after that gradually decreased. The time to air dry square timber from initial MC to specified MC of 18 percent required about 26 weeks for 14.0 cm and 32 weeks for 16.5 cm square of red pine, and 32 weeks for 14.0 cm and 48 weeks for 16.5 cm square of Japanese larch. The longitudinal-and transverse MC distribution of these air-dried squares showed slight moisture gradient. The effect of face size on moisture gradient of Japanese larch square was more pronounced comparing with red pine one.

큰 정각재의 가열판과 고주파 진공건조간 건조특성의 비교

정희석,강욱,이철현 한국목재공학회 2002 목재공학 Vol.30 No.2

변장 14.0 ㎝와 16.5 ㎝인 소나무 정각재의 가열판진공건조와 고주파진공건조간의 건조속도, 함수율분포와 比에너지를 비교하였다. 고주파진공건조는 가열판진공건조보다 건조속도 및 변장이 건조속도에 미치는 영향이 컸었다. 가열판진공건조 목재의 재장방향, 두께방향과 폭방향의 함수율분포는 볼록 형태를 나타내었고, 고주파진공건조 목재는 오목 형태를 나타내었다. 가열판진공건조 목재의 폭방향과 두께방향간의 수분경사는 유사하였으나 고주파진공건조 목재의 경우는 폭방향의 수분경사가 두께방향보다 완만하였다. 가열판진공건조와 고주파진공건조의 比에너지곡선은 함수율이 감소할수록 증가하는 경향을 나타내었고, 가열판진공건조의 比에너지는고주파진공건조보다 컸었다. Red pine(Pinus densiflora) square timbers with 14.0 ㎝ and 16.5 ㎝ of face size and 2.4 m long were dried in a vacuum-press kiln and in a radio-frequency/vacuum(RF/V) kiln to compare drying rate, moisture content(MC) distribution and specific energy. RF/V drying rate was higher than vacuum-press drying rate. The effect of size of cross section on the RF/V drying rates were more pronounced than those of vacuum-press drying. The longitudinal- and the transverse MC distribution of dried square timber showed convex profile for the vacuum-press drying and concave profile for the RF/V drying. Moisture gradient of width direction was similar to the thickness direction in vacuum-press dried square timber and was more slight than that of the thickness direction in the RF/V dried large square timber. The specific energy consumption curve increased as MC decreased. Specific energy(kWh/㎏ of water evaporated) of the vacuum-press process required more than that of the RF/V process.

진행파를 이용한 디지탈 거리 계전기법의 고장발생각에 따른 고장거리 산출 보정에 관한 연구

정주환,서희석,김철환,신명철 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

For many years digital protective methods have employed for the calculation of transient phenomena on power system networks caused by faults. This paper presents a travelling wave digital protection scheme to be used as an ultra high speed EHV/UHV transmission line relay. A detection of fault is made by a highly reliable relaying algorithm which makes use of the modal components of the voltage and currents which are caused to be superimposed on the steady state prefault power frequency components following the fault inception. Some of the potential problems and limitations associated with fault angles are achieved using correction factor. Varification of the algoithm is presented through digital computer numerical simulation using electromagnetic transients program(EMTP).