정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

1995년도 대구지역 법의 부검 통계

채종민,이숙희,정민희,곽정식 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

This is a statistical observation by authors based on data of deaths brought to department of forensic medicine, Kyungpook National University School of Medicine for medicolegal autopsy by all of law enforcement agencies in Taegu area during the year of 1995. The report aims to reveal facts on various causes of death in Taegu area in attempt to analyse 205 cases statistically. The following are the summary of results ; 1. The total numbers of autopsy were 205 cases, of these 121 cases (58%) were males and 83 cases (40%) were females. 2. The violent deaths were 135 cases (66%) and the natural deaths were 63 cases (31%) and unknown cases were 7 (3%). 3. The percentage of autopsied cases with 30's age group was 28.2% (the most), 20's was 17.2%, 40's was 13.8%, 10's was 13.8%... in violent deaths. The percentage of autopsied cases with 30's age group was 31%, 40's was 20%, 20's was 20%, 50's was 15.5%...in natural deaths. 4. For the violent deaths, the percentage deaths due to injury was 52.9%, asphyxia was 29.8%, intoxication was 10.4% and abnormal temperature(hypothermia or fire) or electrocution was 6.7%. 5. For deaths due to injuries, the percentage of deaths due to blunt injury was 45.7%, sharp force injury was 29.5%, fall was 17.1%. and traffic accident was 7.1%. 6. For the natural deaths, 60 cases were recorded and the death due to the disese of the cardiocascular system was taking the most of the total percentage with 53%. 7. For deaths due to injuries, the percentage of accidental death was 57.3%, homicide was 22% and suicide was 14.7%. 8. 31 subjects (51.7%) of 128 violent deaths have positive blood alcohol concentrations (0.05% and above) , and 8.1% of natural deaths were associated with alcohol intake. 9. For deaths by medical dispute, 7 cases were recorded and deaths combined with operation were taking the most of the total percentage with 43%.

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

이트리아 첨가 붕규산염 유리로 제조한 알루미나-유리 복합체의 강도 평가

채민수,배태성,이주형,원대희,진영철 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1

This study was performed to investigate the strength of dental alumina-glass composites. Four different brosilicacte glasses containing 1, 3, 6, 9 mol% Y₂O³ were prepared. Alumina compacts were prepared by pressing 150㎏/㎠ and sintering at 1100℃ for 2 hours. Dense composites were made by infiltrating partially sintered alumina with at 1200℃ for 6 hours. The obtained results were summarized as follows: 1. With increasing the amount of Y₂O₃ the peak of exothermic heat and softening point were shifted to the higher temperature. 2. Borosilicate glasses showed the coefficient of thermal expansion in the range of 6.36 to 6.56×10-6/℃. 3. The maximum biaxial strength of 385.7±34.4MPa was obtained with an addition of 6mol% Y₂O₃. 4. The observation of fracture surfaces showed the crack deflection and crack bridging and that appeared to be the principal strengthening mechanism in the alumina-glass composites.

효소를 이용한 식물성 식품가공부산물의 식품 소재화 탐색 연구

채희정,한민수,인만진 한국응용생명화학회 2004 Applied Biological Chemistry (Appl Biol Chem) Vol.47 No.1

電壓形 PWM Inverter에 依한 誘導電動機의 精密 速度制御

金玟會,鄭瓊採,金東熙,李達海,黃敦夏 嶺南大學校 工業技術硏究所 1992 연구보고 Vol.20 No.1

For precision control of Induction Motor with Voltage Source PWM Inverter, the current component should be converted into the voltage one. We are in difficulties for precision control with simple current feedback control because of the oscillation in system and torque ripple on high speed rotation and transient switching resulted from the disturbance which is generated by the mutual interference between d-axis and q-axis during conversion. This paper propose linearized Decoupling Control Theory in Field-Oriented Control and presents controllable system with Microcomputer software in the whole control system. In addition, by experiment it is proved that the system is controlled well in both steady and transient states. The proposed system is expected to be applied in industrial AC Servo System.

만성 부비동염에서 섬모운동과 전산화 단층촬영에서의 상악동 점막비후의 상관관계

민양기,전상준,이재서,이철회,이강수,윤자복,이원진,박광석 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

중학생을 위한 학교 성교육 프로그램 개발 및 효과

이채희,정민자 울산대학교 2000 생활과학논문집 Vol.1 No.2

본 연구는 �소년기 성교육의 중요성을 인식하여 중학생을 위한 학교 성교육프로그램을 개발하여 그 효과를 검증하는 것을 목적으로 한다. 본 연구의 대상은 울산시에 소재 한 2개의 중학교를 임의 표집하여 4학급을 선정한 후 성교육 실시가 가능한 2학급을 실험집단으로 나머지 2학급을 통제집단으로 편의 표출하였다. 연구대상에 대한 자료는 질문지와 과제지, 사후 검사지를 통하여 수집하였다. 자료분석을 부호화한 후 SPSS 프로그램을 이용하여 빈도, 백분율, 평균, 표준편차, χ²-test, t-test를 사용하였으며, 신뢰도 검증을 위해 Cronbach's Alpha를 사용하였다. 그리고 과제지와 사후검사지는 프로그램에 대한 질적 분석을 하였다. 본 프로그램을 진행한 연구 결과는 다음과 같다. 첫째, 전반적인 성에 대한 지식수준이 교육실시 후, 사전검사에서 측정된 수준보다 통계적으로 유의하게 높아졌으며, 영역별로 인간 발달에 관련된 성 지식 수준이 유의하게 증가 되었다. 또 성 건강과 사회와 성문화에 대한 성 지식 수준도 성교육을 통해 우의하게 향상 되었다. 둘째, 전반적인 성에 대한 태도가 사전검사에서 측정된 수준보다 통계적으로 유의하게 높아졌으며, 영역별로 성건강에 관련된 성태도 수준이 유의하게 증가되었다. The purpose of this study is to verify the effects of the sex education program developed. The subjects this study were to middle schools located in Ulsan metrupolitan city were drawn and used as four classes on the basis of conveniences. Tow classes which could have the sex education became experimental groups and two classes became control groups. After the treatment both groups were asked to answer the questionnaires, solve tasks, and posttest. data were analyzed as frequency, percentage, mean, standard deviation, chi-square test and t-test by SPSS statistical program. Reliability is tested by Cronbach's alpha. And the resuls of the tasks and posttest were analysedr qualitatively. The results of this program are as follows: first, the level of general knowledge about sex is significantly higher than that of the pretest. Especially sex knowledge related to human development is significantly increased. And the knowledge about sex related health and society and sex are improved significantly by the sex education. Secondly, the student's attitude to sex is significantly increased than that of pretest. Attitude concerned sex relatd health increased significantly.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.