국가 대향 레이저 연구시설 소개 - 페타와트 극초단 초강력 레이저 연구시설(PULSER) 구축 및 국내 펨토과학기술 연구 현황

이종민,Lee, Jong-Min 한국광학기기산업협회 2013 光學世界 Vol.144 No.-

펨토초는 1000조 분의 1초를 말한다. $10^{-15}$를 의미하는 단위명이 펨토(Femto)이기 때문에 붙여진 이름이다. 눈을 한 번 깜박이는 시간이 약 10분의 1초, 총알이 물체를 통과하는 데 걸리는 시간이 약 100만 분의 5초인 점을 감안하면 펨토초는 상상하기도 힘들 정도로 빠른 시간인 셈이다. 이런 펨토초 동안 벌어지는 물리, 화학, 생물학적 현상을 연구하는 학문이 펨토과학이며 주로 펨토초 레이저를 이용해 관찰한다. 현재 전 세계적으로 펨토초의 극히 짧은 시간에 1000조 와트(페타와트)의 고출력 레이저를 발생시킬 수 있는 광양자빔 연구시설 구축 사업이 활발하게 진행되고 있다. 국내에서는 광주과학기술원(GIST) 고등광기술연구소가 '극초단 광양자빔 연구시설 설치 운영사업(사업책임자: 이종민 교수)'을 통해 국가 대형 레이저 연구시설인 '페타와트 극초단 초강력 레이저 연구시설(PULSER)'을 최근 구축 완료했다. 이번호에서는 21세기를 이끌 신성장동력 중 하나로 각광 받고 있는 펨토과학기술의 국내 연구 현황과 페타와트 극초단 초강력 레이저 연구시설(PULSER)에 대해 자세히 소개하고자 한다.

高麗時代 寺址 出土 磁器의 器種과 性格 : 생산과 소비의 관점에서 Variety and the Characteristics

이종민 용인대학교 박물관 2004 丹豪文化硏究 Vol.- No.8

Since 1990s, the major achievement in Korean Archaelogical studies includes the excavations of temple sites, where a lot of ceramics has been dug up as their major specimens. The excavations from temple sites reflect the consumptive trend of the monks, the largest consumer group in the times when Buddhism was the dominant religion. Goryeo monks consisted of the social elites and cultural leaders in the hierachical society, so we can say their consumptive trend had a lot of influence on making of the celadon porcelain. It can be summarized briefly according to the data from excavations: porcelain excavations from temple sites can be categorised in celadon, white porcelain, and imported porcelain; historic temples seemed to have consumed common items from the early Goryeo to later times. Among these items, Korean celadons were found in the form of bowl and tea vessels even in the earliest stage. In the Middle Goryeo Dynasty, various everyday vessels appeared in place of bowl and tea vessels; and in later Goryeo celadon items were simplified, usually in the forms of food vessels. Celadons were circulated nationwide if they were in high quality, but if they were in low quality, they came from the kiln near the temples. Compared to this, white porcelain was found in the temples near the workshops, which signified the consumptive pattern different from the ones of the high quality celadon. The import porcelain such as Yaozhouyao-type(燿州窯系 celadon(靑磁), Dingyao-type(定窯系) white porcelain(白磁), Jingdezhenyao-type(景德鎭窯系) qingbaiporcelain(靑白磁, porcelain with bluish-white glaze), Jianyao-type(建窯系) tenmoku(天目, stoneware with black-glaze), Jizhouyao-type(吉州窯系) tenmoku(天目) were found as many as the high quality celadon in proportion and numbers, which was related to the conditions for domestic porcelain production. Especially the celadons with molded design and hard white porcelains in good quality, and black glazed tea bowls were the major imports, which could not be produced found in Goryeo dynasty (高麗) Porcelains from the temple sites consistently corresponded to the products from kilns in each age. This implies most of the kiln products were consumed in temples. As time passed by, the items changed in types, and this might be because the new forms of porcelain from China accelerated the change. Also it was partly due to the gradual change in social institutions. It is not certain how much the temples have contributed to the change, but it is for certain that since the active majority who accepted the new culture of ceramics gathered around the temples. thus playing an important role the change of the types in Goryeo celadon.

급성기 뇌졸중에서 섬망이 기능 회복에 미치는 영향

이종민,김보람,임정훈,고성은,이인식,김종문,김한영,이종민 대한재활의학회 2010 Annals of Rehabilitation Medicine Vol.34 No.4

Objective: To investigate the risk factors for poststroke delirium and evaluate its influence on functional recovery after ischemic stroke. Method: Risk factors for delirium were investigated retrospectively in three hundred twenty nine acute ischemic stroke patients over 60 years of age. Among the 329 patients, sixty seven developed delirium. Data were analyzed between delirium group (n=22) and control group (n=22) according to age, sex, lesion location and clinical features. Korean modified Barthel index (K-MBI), Korean National Institutes of Health stroke scale (K-NIHSS) and Korean mini-mental state examination (KMMSE) were measured at second and sixth weeks after onset and compared for both groups. Results: Parameters showing statistically significant difference between two groups were age over 80, hyponatremia, sleep deprivation, cognitive impairment and cardiogenic embolism. There was no significant difference in K-MBI, K-NIHSS and K-MMSE scores at second week between the two groups. The delirium group showed significantly less improvement in K-MBI and K-NIHSS scores compared to control group (9.5±10.2 vs 18.5±11.6, p=0.011; −0.7±1.2 vs −1.8±1.3, p=0.014). There was no significant improvement in K-MMSE score. Conclusion: The possible risk factors for delirium in acute ischemic stroke are age over 80, hyponatremia, sleep deprivation, cognitive impairment and cardiogenic embolism. Stroke patients with comorbid delirium showed poorer functional outcome. Delirium seems to have detrimental effect in functional recovery after stroke. (J Korean Acad Rehab Med 2010; 34: 403-408)

韓國初期靑磁의 形成과 傳播 -塼築窯와 土築窯를 중심으로-

이종민 한국미술사학회 2003 美術史學硏究 Vol.- No.240

곧 보내겠습니다(번역중..). B4 2장 분량입니다.문의전화 이종민 016-345-2583.. 월화수는 강의중이므로 문자메시지나밤에 연락바람. 사진과 도면은 빠른 등기로 보내겠습니다.원고는 한글 97로 작업함.

고려시대 중기 청자에 대한 새로운 인식 : 장남원 저, 『고려중기 청자 연구』(혜안, 2006)

이종민 이화여자대학교 한국문화연구원 2006 한국문화연구 Vol.11 No.-

F-109 Effect of nintedanib on airway inflammation in a mouse model of acute asthma

이종민,이진국,이종혁,윤현지,김인경,허정,강지영,윤형규,권순석,이숙영,김영균 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Purpose: New treatments are needed for asthma that is resistant to traditional therapies. Here, we examine the effect of oral nintedanib, an intracellular inhibitor of tyrosine kinases, on airway hyper-responsiveness (AHR) and airway smooth muscle cells. Methods: Asthma was experimentally induced in mice via subcutaneous injection of ovalbumin (OVA). A group of mice were injected with saline and served as a control group. The OVA mice were then divided into the following 3 treatment groups: none (OVA), 50 mg nintedanib/kg body weight (OVA+BIBF50), and 100 mg nintedanib/kg body weight (OVA+BIBF100). The AHR was examined using exposure to vaporized methacholine. Airway inflammation was examined using bronchoalveolar lavage fluid (BALF) cell counts (measured with a cytometer) and Th2 cytokine concentrations (measured with teal time polymerase change reaction). Results: Baseline levels of AHR and airway inflammation where higher in OVA mice than in the control group. Treatment with nintedanib lowered AHR, BALF cellular counts, and BALF cytokine levels in a dose-dependent fashion. More specifically, treatment with nintedanib lowered levels of TGF-β1 and inhibited expression and phosphorylation of PDGF receptor (PDGFR) β, VEGFR1, VEGFR2, FGFR2, and FGFR3. Conclusion: Nintedanib lowered AHR and factors associated with airway inflammation and remodeling in a mouse model of acute asthma. Therefore, this compound should be further examined for treating asthma that is refractory to traditional therapies.

P-9 Safety of percutaneous dilatational tracheostomy in patients with hematologic malignancy

이종민,김석찬,이종욱,이진국 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Purpose: In patients with hematologic malignancies, acute respiratory failure requiring mechanical ventilation is a severe and frequent complication. Recent have shown that the outcome of mechanically ventilated patients with hematologic malignancies over the last decade. This study conducted to clarify if percutaneous dilatational tracheostomy (PDT) is safe in this group of patients and to report the outcome of patients with hematologic malignancies requiring long-term mechanical ventilation. Methods: To evaluate the safety of PDT in patients with hematologic malignancies, we retrospectively analyzed the clinical characteristics of patients who underwent PDT in medical ICU from January 2012 to January 2017. Results: PDT was safely performed in all 55 patients. Although 5 (9.1 %) patients developed major bleeding that required electric coagulation, fatal complications were not observed. Of the 55 patients in this study, 21 (38.2 %) could be weaned from ventilator, and 19 (34.6%) survived the intensive care unit stay. There were no differences in the demographics, laboratory findings between patients with bleeding complication and those with none. Bleeding complications were significantly fewer in patients with history of hematopoietic stem cell transplantation (p = 0.032). Conclusion: PDT can be safely performed on patients with hematologic malignancies. The procedure did not result fatal complications in this study.

Neural Stem Cell Death Mechanisms Induced by Amyloid Beta

이종민,박현희,고성호,최호진 대한치매학회 2017 Dementia and Neurocognitive Disorders Vol.16 No.4

Background and Purpose Amyloid beta (Aβ) is the main component of amyloid plaques, which are deposited in the brains of patients with Alzheimer’s disease (AD). Biochemical and animal studies support the central role of Aβ in AD pathogenesis. Despite several investigations focused on the pathogenic mechanisms of Aβ, it is still unclear how Aβ accumulates in the central nervous system and subsequently initiates the disease at the cellular level. In this study, we investigated the pathogenic mechanisms of Aβ using proteomics and antibody microarrays. Methods To evaluate the effect of Aβ on neural stem cells (NSCs), we treated primary cultured cortical NSCs with several doses of Aβ for 48 h. A 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, trypan blue staining, and bromodeoxyuridine cell proliferation assay were performed. We detected several intracellular proteins that may be associated with Aβ by proteomics and Western blotting analysis. Results Various viability tests showed that Aβ decreased NSCs viability and cell proliferation in a concentration-dependent manner. Aβ treatment significantly decreased lactate dehydrogenase B, high-mobility group box 1, aldolase C, Ezrin, and survival signals including phosphorylated phosphoinositide 3-kinase, Akt, and glycogen synthase kinase-3β. Conclusions These results suggest that several factors determined by proteomics and Western blot hold the clue to Aβ pathogenesis. Further studies are required to investigate the role of these factors.

Trichoplusia ni 세포의 apoptosis 메커니즘 규명을 위한 기초연구

이종민,정인식,양재명,이윤형 한국농화학회 2001 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.1

To elucidate the apoptosis mechanism of Trichoplusia ni cell, fundamental studies for apoptosis induction and suppression were performed. Hygromycin B, a known inducer of apoptosis, started the inhibition of T. ni cell growth at 200 ㎍/㎖ concentration. Furthermore, at 400 ㎍/㎖ concentration, DNA fragmentation was detected on day 2 of incubation. Although both dexamethasone and sodium butyrate inhibited T. ni cell growth, DNA fragmentation was not detected by both treatments. Also, when apoptosis induced T. ni cells with 200 ㎍/㎖ hygromycin B were treated with caspase inhibitor (Ac-DEVD-CHO), the apoptotsis was suppressed by 36%. In addition, N-acetylcysteine, another apoptosis repressor, also inhibited the apoptosis of T. ni cells. In order to express the anti-apoptosis gene (bcl-2), T. ni cells were transiently transformed with bcl-2 and its expression was confirmed by western blot analysis. These results showed the potential of developing new insect cell lines with suppressed apoptosis.

Christian Camping as a Temporary Learning Organization

이종민 한국기독교교육정보학회 2016 Journal of Christian education information tech Vol.0 No.29

This study is research on Christian camping as a temporary learning community. The first part of this paper defines camping as a temporary learning community, dealing with traditional definitions of camping and contemporary theory of learning organizations. First of all, this section reviews Christian Camping International’s definition and Slater’s definition of the temporary community. Then, it also covers Senge’s description of the learning organization and concludes that Christian camping is considered to be a temporary learning organization. The second part of this paper covers the three different kinds of theories in educational psychology—Lewin’s field theory, Bandura’s modeling process, and Vygotsky’s zone of proximal development—in order to understand individuals’ learning in a temporary learning organization. In order to elucidate the value of each educational psychology, this section theorizes about educational psychology related to camping practices, using an analytical grid. Its components include: the main educational idea, means, and methods, the nature of students, and the roles of teachers. The last section of this paper portrays a Christian camping environment which is characterized by the roles of teachers and counselors with small group dynamics, experiential learning and life change experiences.