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Background and Objectives:Cervical lymph node metastasis in head and neck cancer patients is one of the most important prognostic factors. The previous studies have shown that the detection of ocult micrometastases using imunohistochemical missed occult micrometastases on routine hematoxylin-eosin stain. Materials and Method:Sixty-nine tumors from the pa-tients with squamous cel carcinoma of the head and neck were included. Imunohisto-chemical staining was performed using Pan-cytokeratin AE1/AE3 antibody. The number of lymph nodes examined was 1710 (mean per patient:24.8;ra-nge:one to 66). Results:Of 69 tumors studied, 14 lymph nodes had occult metastases detected by the imunohistochemical hematoxylin-eosin stain. Hematoxylin-eosin stain was not sufficient to detect occult micrometastases in 10. Conclusion:Because im uno-histochemical method enhanced the detection rate of occult micrometastases in cervical lymph nodes of head and neck squamous cell carcinoma patients, it is recomended for routine diagnostic use in every patient, in whom the lymph nodes show negative for metastasis on routine hematoxylin-eosin stain. (Korean J Otolaryngol 2002;45:495-50 )
Background and Objective:Adhesion and stenosis are important in causing poor results of sinus surgery. Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. This study was designed rate after an endoscopic sinus surgery. Materials and Methods:A total 20 patients diagnosed with chronic sinusitis with nasal polyp were used. After midle meatal antrostomy, a piece of merocel soaked with 0.04 mg/mL MMC 1.5 mL was ap-lied on right antrostomy site for 5 minutes. Left antrostomy site was used as control without applying MMC. The antrost-omy size was measured by using gauze instrument under endoscopy at operation, 1, 3 and 6 months after surgery. Mucocilliary clearance rate was assessed by saccharine time test after 2 weks, 1, 3 and 6 month. Results:The MC group has showed lower incidence of stenosis, granulation and adhesion than the control group. At 1 month, the percentage of remaining an-trostomy size was 61.6± 31.6% in MMC group, whereas that of the control group was 46.9± 23.3% . There was a significant difference in the antrostomy size betwen the two groups at 1 month, but there was no significant difference at 3 and 6 month. The saccharine time test between the two groups showed no significant diference after operation. Conclusion:The use of MMC will improve the success rate of sinus surgery if it is used as adjuvant therapy after antrostomy. Further study will be needed on the duration of application time, concentration of MMC and method. (Korean J Otolaryngol 2002;45:585-8)