정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

PMDA-ODA 폴리이미드의 합성 및 특성에 관한 연구

정용재,한태성,최성부,남석태,김병식 동국대학교 산업기술연구원 1996 산업기술논문집 Vol.8 No.-

Pyromellitic dianhydride(PMDA) 와 Oxydianiline(ODA)를 N, N-dimethylacetamide (DMAc)에 녹여 Polyamic acid(PAA)를 2단계 열이미드화법으로 제조하였다. 제조된 폴리이미드 막의 이미드화도는 FT-IR에 의하여 분석되었다. 또한 PAA의 농도를 10~30wt%로 변화시키며 합성하여 열이미드화 시킨 후 농도에 따른 단면의 상태를 SEM사진을 통하여 관찰하였다. 농도 변화에 따른 밀도와 T_g의 변화는 혼합액체부상법과 DSC로 분석되었다. 열처리 온도를 증가시킬수록 이미드화도는 증가되었고 PAA의 농도가 증가할수록 필름의 단면이 치밀해짐을 알 수 있었다. 또한 제조된 PMDA-ODA 폴리이미드의 T_g는 215℃ 이었다. Polyamic acid(PAA) was synthesised with Pyromellitic dianhydride(PMDA) and Oxydianiline (ODA) in N, N-dimethylacetamide(DMAc). PMDA-ODA polyimide membranes were obtained by two step thermal imidization, and the degree of imidization of polyimide membranes was observed by the FT-IR. After the thermal imidization through the concentration of varied synthesis of PAA, 10~30wt%, SEM photographies of section state were observed. The density and glass transition temperature on the varied concentration were replace with investigated test of density and Differential Scanning Calorimetry (DSC). With increasing thermal treatment temperature, the degree of imidization was increased. While the concentration of PAA increases, the section of membrane was densed. The glass transition temperature was maintained to be constant(215℃) within the PAA concentration range.

안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성

안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.

장애인 및 노약자를 위한 생활관련 시설의 연계방향

강병근,성기창,박광재,윤영삼,김상운,정현정,류상오 한국의료복지시설학회 2009 의료·복지 건축 Vol.15 No.1

This study aims to plan connecting living facilities considering on the Barrier Free Walking of the disabled and the elderly in the residential area. We had found several physical problems on the peestrian's way that becomes the major factor of disturbing the barrier free movement for using living facilities in the local area by investigations and enquetes. We had suggested the arrangement method for these physical problems on the pedestrian's way and building the ideal area for living facilities by the disposition stages with the result of investigations and enquetes. After these process, we had planned connecting living facilities considering on the Barrier Free WaIking of the disabled and the elderly in the residential area.

보툴리눔독소 A를 이용한 반복적인 nasal flare의 치료

이상주,김현정,김병대,정원순,이승헌 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.12

Repeated nasal flare is a condition that one repeatedly dilates one's nostrils unconsciously. It is not pathogenic, however, may be a cosmetic problem. This is caused by excessive activities of the alar part of nasalis. We, herein, report a successfully treated case with the botulinum toxin A. (Korean J Dermatol 2003;41(12):1689~1690)

동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종

이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.

소아와 청장년기 아토피 피부염 환자에서 MAST 화학발광법에 관한 비교연구

김성한,최규철,정병수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Background and Objective: The MAST-CLA (multiple allergosorbent test-chemiluminescent assay) is a new assay for serum allergen specific IgE and allows many allergens to be tested simultaneously. Futhermore, it has shown good sensitivity, specificity and a correlation with the RAST and skin prick test. The purpose of this study was comparatively to evaluate results of the MAST-CLA between child and adolescence atopic dermatitis. Materials and Methods: Our study was designed by analyzing outpatients with atopic dermatitis through the MAST-CLA with a total IgE and allergen specific IgE in fifty children and twenty adolescence patients. Results: The results were as followings; 1) Among the subjects, 77% (child group; 76%, adolescence group; 80%) of patients showed elevated serum total IgE levels and 57.1% (child group; 50%, adolescence group; 75%) revealed at least more than one allergen specific IgE by the MAST-CLA. But, this did not show statistical significance. 2) Patients positive rates of commonly detected allergens were D. farinae 47% (child group; 42%, adolescence group; 60%), D. pteronyssinus 34% (child group; 28%, adolescence group; 50%), house-dust 23% (child group; 20%, adolescence group; 30%). But, all food allergens were positive lower than 5%. 3) The positive allergen specific IgE in food allergens was detected in only child atopic dermatitis patients. This difference between child and adolescence group showed statistical significance(P=0.027). 4) Good correlation was obtained between total IgE levels and number of positive allergen speficif IgE in the MAST-CLA, with 0.465 correlation coefficient. Conclusion: Our results suggest that MAST-CLA may be used as an effective method to evaluate inhalant allergens in adolescence more than child atopic dermatitis patients. Additionally, it is recommended that more speficif allergens should be added to Korean panel of MAST-CLA.

진성다혈구증에서의 심근 및 뇌경색증 1예

조영호,유벙전,서영환,조경상,김상도,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Polycythemia vera is one of the myeloproliferative diseases, and as such, is an example of clonal hematopoiesis. The progeny of a single, abnormal, hematopoietic stem cell gain a grwoth advantage over their normal counterparts resulting in overproduction of red cells generally accompanied by overproduction of granulocytes and platelets as well. There are a variety of nonspecific symptoms at onset related to the increased red cell mass and hematocrit accompanied by the more specific manifestations of pruhtis, erythromelalgia, and hepatic, portal, and mesenteric vein thrombosis. Splenomegaly and hypertension are common. Thrombosis and leukemia are frequent complication in polycythemia vera and are associated with severa organ damage and a high mortality. We report here the case of occurrence of myocardial and cerebral infarction in a patient with polycythemia vera.

[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

Real-time PCR 기술의 생물학적 폐수처리에서의 응용

엄호섭,이선미,상병인,정윤철 한국물환경학회 2006 한국물환경학회지 Vol.22 No.2