설인신경 절단이 성곽유두 미뢰에 미치는 영향

박병건,노용관,차경,김재곤,백병주 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

The effect of glossopharyngeal nerve transection on the taste buds of the rat vallate papilla was examined by using the method of DNA nick-end labeling (TUNEL) and standard electron microscopic technique at 1,3,5,7,9 days after denervation. In general, the number and size of taste buds decreased as more days passed after denervation. They started decreasing on day 3 post denervation. In studies using TUNEL method, TUNEL postive cells markedly increased in their numbers one day post denervation, as compared with controls. The number of apoptotic taste bud cells per taste bud profile was averaged to be 0.64 and 0.44 for day 1 and 3 post denervation, respectively, whereas it was 0.10 in controls. In electron microscopy, apoptotic cells were identified by the presence of condensed and fragmentary nuclei in a cytoplasm, which resulted in increased density. In control rats, only few apoptotic cells were found. On days 1 and 3 post denervation, nerve fibers almost disappeared from the taste buds and some apoptotic cells were apparent. On days 7 and 9 post denervation, a few taste bud cells were still present in the epithelium of the bottom of the trench wall of the vallate papilla and most of them showed apoptotic changes. The results indicate that the death of taste bud cells in normal conditions is controlled by apoptosis and the decrease and disappearance of taste buds sfter denervation is also caused by apoptosis of taste bud cells.

유한요소법에 의한 헬리컬기어의 맞물림 강도특성에 관한 연구

박성환,유용석,김병석,최명진,오택열 慶熙大學校 大學院 1993 高凰論集 Vol.12 No.-

In this study, the mesh stiffness characteristics of helical gears are evaluated by applying the finite element method. The bending and shear deflections on the contact line are obtained by the finite element method, and the contact deflections are obtained using the equation of Weber and Banaschek. Finally, using the influence method, contact ratio and load sharing ratio, the mesh stiffness characteristics of helical gears are evaluated. The results obtained could be summarized as follows: 1) By increasing the facewidth and helix angle of helical gears, a more constant mesh stiffness and transmission errors are obtained. 2) m_p+m_f〈2.0 The characteristics of this class helical gear pair are similar to that of spur gear. 3) m_p+ 1.0m_f≥2.0 This class helical gear pair gives a good performance as expected from helical gears.

면역방사계수법을 이용한 Thyroglobulin 측정시 항 Thyroglobulin 항체의 존재가 미치는 영향

안병철,배진호,정신영,박호용,김정국,하승우,이재태,김보완,이규보 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

연구배경: 혈청 thyroglobulin (Tg)은 옥소전신스캔과 함께 분화갑상선암환자에서 갑상선암 재발에 대한 추적관찰에 매우 예민하고, 중요한 표지자로 임상에서 널리 이용된다. 그러나 많은 수의 분화갑상선암환자는 Tg 항체인 항 Tg 항체를 가지고 있고, 이는 방사면역검사법 (radioimmunoassay) 및 면역방사계수 검사법(immunoradiometric assay)으로 Tg 측정시 영향을 미칠 수 있다. 이에 연자들은 면역방사계수법으로 Tg를 측정할 경우, 항 Tg항체에 의하여 어떤 영향이 생길수 있는지를 알아보고자 하였다. 방법: 이중위치 고상법 (solid phase two-site)법을 이용하는 ELSA-hTg in vivo test (CIS international, Schering, France) 시약을 이용하여 Tg를 측정하였다. Tg과 항 Tg 항체는 검사시약에 포함된 표준용액을 사용하였으며, Tg는 두 가지 농도 (23.5 ng/mL, 62.5 ng/mL)로, 항 thyroglobulin 항체는 세 가지 농도(25U/mL, 50U/mL, 100U/mL)로 이용하였다. Tg가 높게 나타나는 환자의 혈청에 항 Tg 항체가 높게 나타나는 환자의 혈청을 혼합하여 동일한 방법으로 Tg 검사를 시행하였다. 통계학적 분석은 ANOVA와 Scheffe test 및 Quadratic regression modeling을 시행하였다. 결과: 면역방사계수법을 이용한 Tg 측정시 항 thyroglobulin 항체가 존재하는 경우 그 값이 낮게 측정되었다. Tg 농도가 23.5 ng/mL인 표준용액이 항 Tg 항체의 농도가 0, 25, 50 및 100U/mL 경우, 각각 24.5±1.1, 11.8±0.4, 7.7±0.1 및 4.5±0.4ng/mL로 측정되었으며, Tg 농도가 62.5 ng/mL인 표준용액은 각각 65.9±5.7, 36.3±2.2, 23.7±0.7, 및 14.0±1.0 ng/mL로 측정되었다(ANOVA test, p=0.000). 항 Tg 항체에 의한 Tg 측정값의 저하 정도는 항 Tg 항체의 농도에 비례하는 것으로 나타났다 (Quadratic model regression, SigT=0.000). 결론: 분화갑상선암환자에서 항 Tg 항체의 존재는 면역방사계수법을 이용한 혈청 Tg 측정으로 갑상선암 재발을 파악하는데 방해하는 인자로 작용될 수 있으며, Tg 측정시 항 Tg 항체의 측정이 꼭 필요하며, 항 Tg 항체를 가진 분화갑상선암환자에서 Tg 수치를 해석할 경우 세심한 주의가 요구된다. Background: Serum thyroglobulin (Tg) is a valuable and sensitive tool needed in the follow-up of patients with differentiated thyroid cancer (DTC), but antithyroglobulin antibody (Anti-Tg), common in patients with DTC, can interfere with the assay for Tg. In this study, we evaluated the influence of Anti-Tg on the measurement of Tg using the immunoradiometric assay (IRMA). Methods: In using ELSA-hTg in vivo test (CIS international, Schering, France), a solid phase two-site IRMA was used to measure Tg (23.5 ng/mL, 62.5 ng/mL) under the absence or presence of three concentrations of Anti-Tg (25U/mL, 50U/mL, 100U/mL). We also performed Tg measurement using patients serum that was mixed with patients serum containing high Anti-Tg. ANOVA and Scheffe tests were performed to evaluate the effect of Anti-Tg on Tg IRMA, and an inverse regression was made to calculate the level of Tg from measured Tg and used Anti-Tg levels and also to assess the degree of effect of anti-Tg on Tg IRMA. Results: In measuring Tg using the standard solution, the presence of Anti-Tg resulted in a falsely suppressed Tg value. The IRMAs for 23.5ng/mL of the standard Tg solution resulted in 24.5±1.1 ng/mL under no Anti-Tg, 11.8±0.4 ng/mL under 25U/mL of Anti-Tg, 7.7±0.1 ng/mL under 50U/mL of Anti-Tg, and 4.5±0.4 ng/mL under 100U/mL of Anti-Tg. IRMAs 62.5 ng/mL of the standard Tg solution resulted in 65.9±5.7 ng/mL under no Anti-Tg, 36.3±2.2 ng/mL under 25U/mL of Anti-Tg, 23.7±0.7 ng/mL under 50U/mL of Anti-Tg, and 14.0±1.0 ng/mL under 100U/mL of Anti-Tg. (ANOVA test, p=0.000). The degree of suppression of the measured Tg value was positively correlated with the Anti-Tg level (Quadratic model regression, Sig T=0.000). The presence of Anti-Tg also resulted in a falsely suppressed Tg value for the Tg measurement using patient's serum. 2004). Conclusion: The presence of Anti-Tg could consist of the use of Tg as a tumor, therefore Anti-Tg should be measured in all patients diagnosed with DTC. The interpretation of the Tg level must be performed with extreme caution in patients with Anti-Tg (J Kor Soc Endocrinol 19:42∼47, 2004)

Cryptococcal 뇌막염이 병발된 수막 암종증 1예

안병철,고지영,이현옥,최진영,권오상,박용욱 중앙대부설한국의과학연구소 1990 한국의과학 Vol.22 No.1

고주파수 PWM 제어를 이용한 ABS의 특성 평가에 관한 연구

김병우,이용주,박호 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.2

In general the surge pressure generated in hydraulic systems causes noise, vibration and odd effect to the system. To reduce the surge pressure, high frequency PWM control of 20KHz was attempted. To estimate the braking noise caused by surge, a vehicle equipped with on-board ABS hydraulic modulator has been experimented with respect to the various breaking condition. Though this experiments, it was found that breaking noise has been reduced using high frequency PWM control method compare with low frequency method. To evaluate high frequency control in practice, including verification of general functionality, EM tests was experimented. Its was found that it is necessary to have the solution to electromagnetic interference(EMI) generated by switching elements.

사인에 의한 즉시형 과민반응의 억제 효과

신태용,염정열,김원,김현미,박해정,장진이,조성룡,채병숙 우석대학교 생명과학연구소 1998 생명과학연구소 논문집 Vol.2 No.-

We investigated the effect of aqueous extract of Ammomum xanthioides(AXAE) on immediate hypersensitivity. AXAE inhibited systemic anaphylaxis induced by compound 48/80 in mice. AXAE inhibited serum histamine levels induced by compound 48/80 in mice. Moreover, AXAE dose-dependently inhibited histamine release in peritoneal mast cells activated by compound 48/80. These results indicate that the AXAE may be benificial in the regulation of immediate type allergic reaction.

고주파수 PWM제어를 이용한 ABS의 맥동 저감에 관한 연구

이용주,김병우,박호 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.3

The solenoid valve in ABS hydraulic modulator is a two directional on-off valve and is controlled by around 100㎐ high speed pulse width modulation. When the valve is switched from open state to closed state, noise and vibration due to pressure surge phenomena in the hydraulic line and wheel cylinder are made. In this study, we identify pressure surge phenomenon in the braking process of a ABS, and investigate the way to reduce the phenomenon. For the purpose of theoretical analysis on the pressure surge in the closed state hydraulic line, characteristic curve method based on wave equation was utilized. To reduce the surge, high frequency control of 20KHz was attempted. The result showed that the surge pressure of 50% was reduced compared to one observed in the low frequency control. Duty variation of high frequency can control current of solenoid valve and prevent sudden changed of displacement.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

專門大學海洋土木科模型敎育課程 修正開發硏究

李東周,林秉龍,張仁奎,申文燮,金榮燮,朴昌圭,金康洙 군산대학교 1988 群山水産專門大學 硏究報告 Vol.22 No.1

This is a study to modify the curriculum of the ocean civil engineering department in junior college. We collected and analyzed data which are concerned on the curriculum development or improvement, the marine techniques and the ocean policy. And then we also gathered the opinions of the professors serving at the ocean civil engineering department by holding several conferences and investigated the opinions of the ocean civil engineers serving at the industrial organization by way of the inquring papers. In addition we collected the advices of educational specialists and ocean civil specialists by visiting personally. On the basis of above opinions we developed the jobs of graduates and made a model curriculum shown in Table 6. We tried to intensify the subjects of special basic field related to the ocean & civil engineering and the subjects of basic experiment & practise. The ocean observation practise was newly formed and the E. D. P.S was reinforced.

기-액병류상향 충전탑에서 액체체류량과 축방향혼합특성

조지훈,손민일,박용성,함병호,김태옥 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For upward cocurrent gas-liquid flow in a packed column, holdup and axial mixing characteristics of liquid were investigated. In an air-water-glass bead system. liquid holdup and residence time distribution(RTD) were measured and Peclet number based on axial dispersion model was evaluated from experimental RTD. We found that liquid holdup was increased with increasing liquid velocity and size of packing material, and it was decreased with increasing gas velocity. Also, liquid holdup for the cocurrent up flow system was larger than that for the downflow system at the same experimental conditions. As increasing gas velocity, the in fluence of packing size and operation method on liquid holdup was reduced. The calculated Peclet number was not affected by gas velocity, and it was increased with increasing liquid velocity and with decreasing packing size. Furthermore, the effect of liquid velocity on Petlet number for higher liquid Reynolds number(Re1>70) was larger than that for lower Re1. In these conditions, correlations of the dynamic liquid holdup and the Bodenstein number were obtained.