정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

철염인화법의 효과적인 톤재현을 위한 실험적 연구 : 반다익 브라운 프린트와 사이아노 프린트를 중심으로 with Cyano and Van-dyke Brown Print

梁成哲,李承珉 대구산업정보대학 1997 논문집 Vol.11 No.2

In the 1950s television appeared and threatened the original position of photography as an image delivering medium After television many new media were brought to the world with the help of the computer. The original position of photography changed and its field lessened. The development of civilization and media leads the organization of society to be more complicated and the boundary line of art does not exist any more. Photography is looking for various ways to survive as a traditional medium. This tendency is utilized as a good chance to try new materials and it becomes an opportunity to evaluate the nonsilver prints widely used in the 19th century again. This paper is on the iron salts photography. Ironsalts photography differs from silver salts photography in its process and reproduction. Among all of the iron salts photography, I ehase two : cyano print and Van Dyke print. They are commonly used and have unique characteristics in reproductions. I carried out the study to find a efficient production process. The emulsion needs to be made by hand and many elements of the prints are influenced by this emulsion. I varied many factors needed to get the final image and with the different results I found the way to present the finest prints. The major factors are : the contrast and density range of the negative, the quality of light sources, the mixed proportion of chemicals and the surface and texture of the base. Each time I repecited the experiment, I mingled these four in different portions and I arrived at the following conclusions. Above all, negatives with narrow ranges of density are good and the contrast should not be too low. These two iron salts prints, not like the silver prints, are reproduced with narrow exposure and tone range. The light quality should be decided in advance, for it can cause the difference by using different light sources. For the second, it is about the production of emulsion. In Van Dyke prints, the amount of silver nitrate is concerned with tone and sensitivity of the imagery and it becomes a much denser brown with the increase of the amount of silver nitrate. In the case of Cyano prints, the amount of Ferric Ammonium Citrate and Potassium Ferricyanide influences sensitivity of emulsion alone and almost do not affect the image tone of prints. Finally, base turns out to be an easily changeable element in its visual effect. Different base produces more distinguishable contrast and tone than expected especially with the surface texture.

學位論文 審査스케쥴링에 관한 硏究

梁光敏,申承澈 한국경영과학회 1990 韓國經營科學會誌 Vol.15 No.2

The problem analyzed in this paper is to specify a schedule for thesis committee allowing maximum committee members' preference over thesis topics and meeting time-slots while satisfying other related scheduling requirements such as prohibiting simultaneous assignment of a committee member to more than one committee at a time. Two mathematical programming approaches are presented to solve the thesis committee scheduling problem in a professional graduate school. They include LP-based branch-and-bound approach with linear subproblems with tighter added constraints and branch-and-bound approach with network subproblems. Characterization of the problem is analyzed to develop an efficient solution algorithm. Implementation and computational experiments are also performed for real size problems on an IBM PC/AT to show the relative performance of the proposed approaches along with an ordinary ILP solution approach.

수소화된 비정질 규소에서 바이어스에 의한 실리사이드 형성

梁承勳,金鐵河,李原鎭 慶北大學校 1990 論文集 Vol.49 No.-

We show that biased annealing of a-Si:H contacted with metal gives rise to silicide growth and the creation of metastable states that can be to some extent removed by unbiased annealing. This paper gives the first report of a direct correlation of Ⅰ-Ⅴ characteristics to silicide growth in a-Si: H. Variations of Ⅰ-Ⅴ characteristics with annealing biases are analysed by the two series-connected diodes model.

경도관 동맥색전술을 이용한 비정상 자궁출혈의 치료

양승부,최교창,이상진,정영진,임한혁,한효상,황인철,조환성 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Objective : Our purpose of this study is to evaluate the effectiveness of the transcatheter arterial embolization for the management of abnormal uterine bleeding. Materials and Methods : 14 patients with massive or recurrent uterine bleeding underwent percutaneous transcatheter arterial embolization between February 2003 and September 2004. We reviewed 14 cases of uterine artery or internal iliac artery embolization using gelfoam or PVA particles. Results : Good management of uterine bleeding was achieved in 13 of 14(93%) cases. The cause of abnormal uterine bleeding was myoma(5 case), post D & E bleeding(3), acquired vascular malformation(3), pseudoaneurysm(1), adenomyosis(1), and endometrial hyperplasia(1). Conclusion : Transcatheter artery embolization is an effective and life-saving procedure in massive or recurrent uterine bleeding. Early diagnosis and prompt transcatheter arterial embolization is a useful mangement of uterine bleeding.

발치 직후 시행된 즉시 임플란트 식립술에 관한 임상적 평가

양은영,천상득,노재환,이승은,송재철,진병로 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.1

Background: Immediate implant placement has become an acceptable treatment for the edentulous area. The advantages of the immediate implant placement include considerable decrease in time from tooth extraction to placement of the finial prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plans. But the success is dependent on the quantity and quality of the extraction socket. The purpose of this study is to evaluate the success of the immediate implant placement. Materials and Methods: Twenty-one sites in 16 patients were selected for the evaluation of the immediate implant placement. All of the cases were followed using clinical and radiographic examinations. Criteria of success were the absence of peri-implant radiolucency, mobility, and persistent pain or sign of infection. Results: Of the 21 implants, 13 implants have been succeeded. Of the 13 implants, 10 implants were replaced for the periodontal disease and 3 implants were replaced for the trauma. Conclusion: The criteria of the success in immediate implant placement are as follows. 1) Implants placed into fresh extraction sockets have a high rate of survival. 2) Implant should be placed as close as possible to the alveolar crest. 3) Implant placed into available bone beyond the apex have a high success rate.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Creutzfeldt-Jacob병 1례

홍승철,한진희,정종현,김소양,허균,이성필 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

저자들은 Creutzfeldt-Jacob병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 약 4개월에 걸친 비교적 짧은 기간 동안 중증의 인지 기능 장애와 시각 장애, 보행장애와 하지의 약화, 불수의적 운동 등과 함께 섬망상태에까지 이르게 되어 본원 정신과에 입원하게 되었다. 정신상태 검사상, 반응시간의 지체, 언어장애와 보속증, 시간에 대한 지남력 장애, 주의 집중력 장애, 단기 및 장기 기억 장애, 추상적 사고능력 장애 등의 소견을 보였고, 이러한 증상들은 입원후 치료에도 불구하고 빠르게 악화되었다. 뇌파검사상 지속적인 다발초점성 서파가 모든 전극에서, 특히 우측 전두부에서 현저하게 나타나는 소견을 보였고, 병리조직학적 검사상 대뇌 피질에 신경손실을 동반한 해면화와 신경교 증식증을 나타냈다. 이상의 소견들은 모두 CJD의 진단에 합당하였다. We report a case of Creutzfeldt-Jacob disease and review the relevant literatures. This 56-year-old male patient was admitted to our hospital with a history of rapidly progressing cognitive dysfunction, visual disturbance, gait disturbance, weakness, involuntary movement of lower extremities, and the symptoms of delirium. On mental status examination, he showed psychomotor retardation, speech disturbance, perseveration, disorientation, impairment of short-term and long-term memory, and inability of abstract thinking. He had a rapid downhill course, along with shakiness of trunk, rigidity of the limbs, myoclonus, confusion, and finally, inability to speak or move on the bedside. On electroencephalogram(EEG), continuous multifocal show delta activities were found in all leads, especially in the right frontal areas. Brain biopsy showed, spongiosis with neuronal loss and gliosis noted at the cerebral cortex. These findings were compatible with Creutzfeldt-Jacob disease.

TCD를 이용한 뇌사의 판정기준

권양,김창진,임승철,권병덕,황충진 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.4

It is generally known that demonstration of absence of cerebral blood flow is necessry to confirm brain death. Transcranial Doppler(TCD) is an accurate method of monitoring the blood flow velocities of the cerebral vessels. We performed transcranial doppler(TCD) examinations on 15 patients in brain death. Anterior criculation was examined through the temporal window or transorbiral window and basilar arteries were examined through the suboccipital window. All of the patients fulfilled the criteria for determination of brain death by clinical criteria, EEG and/or Brainstem Auditory Evoked Response(BAER) or clinical criteria alone, were mechanically ventilated. A TCD waveform abnormality consisting of reversed diastolic components was found in all brain death patients. The net flow veloicties of <10 ㎝/sec were present in all brain death patients. TCD may be a rapid and convenient alternative to cerebral angiography for confirming brain death when institutional protocols require such comfirmation.

Sol-gel法에 의한 超微細 Co_(0.9)Zn_(0.1)Fe₂O₄粉末의 合成과 磁氣的 特性에 關한 硏究

李承和,梁桂儁,金賢哲 충주대 산업과학기술연구소 2001 産業科學論文集 Vol.9 No.-

Ultrafine Co0.9Zn0.1Fe2O4 particles are fabricated by a sol-gel method. The magnetic and structural properties of powders were investigated by x-ray diffraction, vibrating sample magnetometery and Mo¨ssbauer spectroscopy. Co-Zn ferrite powders that were annealed at and above 673 K have only a single phase spinel structure and behave ferrimagnetically. Powders annealed at 523 K and 573 K have a typical spinel structure and are simultaneously paramagnetic and ferrimagnetic in nature. The magnetic behavior of Co-Zn ferrite powders annealed at and above 573 K shows that an increase of the annealing temperature yields a decrease of the coercivity and an increase of the saturation magnetization. The maximum of the coercivity and the saturation magnetization of Co-Zn ferrite powders are 1328 Oe and 81.1 emu/g, respectively. Mo¨ssbauer spectra of Co-Zn ferrite have been obtained at various temperatures from 20 to 800 K. The isomer shifts indicate that the iron ions were ferric at the tetrahedral [A] and the otahdral [B]. The Ne´el temperature was determined to be TN=790 K. It is found that Debye temperature for A and B sites of the sample annealed at 1,123 K is found to be ΘA=756± 5K and ΘB=199±5K.