Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Simplified Effective Compressive Strengths of Columns with Intervening Floor Slabs

Seung?Ho Choi,Jin?Ha Hwang,Sun?Jin Han,Hae?Chang Cho,Jae Hyun Kim,Kang Su Kim 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.5

The current design codes discuss the effective compressive strengths of columns, which reflect a decrease in load transfer performance that can occur when columns and slabs have different concrete compressive strengths. The effective compressive strength of a column increases as it is confined by the slab, and the design codes mandate three different effective compressive strengths for interior columns (confinement on four sides), exterior columns (confinement on three sides), and corner columns (confinement on two sides). For both corner and exterior columns, the confinement effect of the slab is significantly smaller than that for the interior column, and there is a more marked decrease in load transfer performance. However, there is still a lack of theoretical studies investigating the effective compressive strengths of the corner and exterior columns. Therefore, based on the analysis model established in previous research, this study has proposed an equation for calculating the effective compressive strengths of the corner, exterior and isolated columns without any confinement effects of the slab. In addition, axial loading tests of isolated columns were conducted and the proposed equation was verified.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

울산연안 定置網에 어획된 漁類의 종조성 및 양적변동

한경호,김종헌,백승록 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.1

울산 정자연안 외측에 위치한 정치망에서 1998년 2월, 4월 ,6월 ,8월 10월 및 12월, 총 6회에 걸쳐 어획물을 채집하여, 魚類의 種組成, 量的變動 및 群集構造에 대하여 연구하였다. 채집된 어류는 총 12目 45科 89種, 62,978개체였고, 총 생체량은 6,494㎏이였다. 농어目 어류와 쏨뱅이目 어류가 총 56種으로 전체 出現種數의 62.9%를 차지하여 가장 우점하는 目들로 나타났으며, 科別로는 전갱이科와 참복科 어류가 각각 7種 出現하여 가장 많은 種이 出現하였다. 총 89種의 어류중 個體數는 고등어, 전갱이, 멸치 및 말쥐치의 4種이 全個體數의 89.7%를 차지하여 우점하였다. 生體量은 고등어, 전갱이, 꽁치, 말쥐치, 전어, 꼬치고기, 멸치, 정어리, 임연수어 및 덕대의 順으로 이들 10種이 全生體量의 95.5%를 차지하여 우점하였다. 出現 個體數와 生體量은 고수온기인 여름에 높게 나타났으며, 저수온기인 봄과 겨울에 낮게 나타나 수온과 밀접한 관계가 있었다. 월별 出現種數는 2월과 10월에 비교적 적은 種이 출현하였으며, 4월에 49種, 6월에 50種이 나타나 가장 많은 種이 출현하였고, 8월에 46種, 12월에 44種이 出現하였다. 종다양도지수(H')와 0.693~2.146으로 4월에 가장 높은 값을 보였고, 8월에 가장 낮은 값을 보였으며, 우점도지수는 다양도지수와 반대로 4월에 가장 낮은 값을 8월에 가장 높았다. 주요 魚種의 出現頻度를 보면 고등어, 전갱아. 멸치, 말쥐치, 꽁치, 전어, 망상어 및 정어리가 거의 年中 出現하여 본 해역에서의 주거종이었다. Fishes were collected by set net to determine seasonal species composition and fluctuation in abundance in coastal waters of Ulan. Korea, in February, April, June, August and December, 1998. A total of 62,978 fishes (6,494㎏) were sampled and classified into 12 orders, 45 families and 89 species. The most dominant orders were Perciformes and Scorpaeniformes, which accounted for 62.9% of the total. The most dominant families were Carangidae and Tetraodontidae, each represented seven species. The most dominant species were Scomber japonicus, Trachurus japonicus, Engraulis japonicus and Maurolicus muelleri, which accounted for 89.7% of the total fishes collected. The most dominant in biomass were Scomber japonicus, Trachurus japonicus, Cololabis saira, Thamnaconus modestus, Konosirus punctatus, Sphyraena pingues, Engraulis japonicus, Sardinops melanostictus, Pleurogrammus azonus and Pampus echinogaster. Those species together accounted for 95.5% of the total biomass. The number of individuals and the biomass were much higher in summer than in spring and winter, and closely correlated with water temperature. The number of species showed a peak in August, with 46 species, and the lowest number in February, with 30 species. The diversity index was the highest in April(H'=2.146) and the lowest in August(H'=0.693).

우리나라 農村 保健支所에서 高血壓患者의 追求管理 方案 및 그 效果에 關한 硏究

韓聖鉉,金琅昊,李成秀 순천향대학교 1987 논문집 Vol.10 No.2

As a follow-up of the case-control study of some risk factors and status of hypertension control in rural community undertaken in May 1985, a brief assessment survey was carried out in May 1987 in order to evaluate the effectiveness of a special hypertension clinic set up at a health sub-center in Eumseong community for one year period, beginning from April 1986. The objectives of this paper were : (1) To describe a hypertension control model designed for primary care at health sub-center level (2) To present the results of follow-게 care of 39% of hypertension for one year in terms of the change in health indicator(BP level) and the factors related to compliance & non-compliance with prescribed regimen. For this study, data was obtained from 24 hypertension patients diagnosed in the previous study, dividing them into two groups : 42% as the compliance group(C-group) and 58% as the noncomplance group(NC-group). In comparing the two groups, the following results were obtained : 1. There were some difference between the two groups. In their characteristics : For example, (a) in sex composition, C-group was consisted of more female than NC-group(60% vs 50%) (b) C-group had shorter history of hypertension than NC group : the proportion of patients under 4 years group(60% vs 36%) 2. During one year period, 24 sessions of special hypertension clinics were operated at HSC. But the mean number of visits of C-group was 21.9, while NC group had 5.3 visits. 3. Knowledge & attitude toward the needs of hypertension treatment were not different between both groups. Also there were less appreciation on the prescribed duration of care to comply in both groups. 4. C-group had expressed their reliance on the treatment at the special clinic services at HSC, but NC-group *) This investiation was surpported by 1986 research grant of Soonchunhyang University. O.K. also partially sup ported by the GTZ grant. had less relied on the special clinic services at HSC and more prefered to the clinic services of the hospital. But there patients attended hospital were not referred back to HSC. 5. Main reason for compliance of C-group was their concern to prevent from stroke attack and other CV diseases. The reasons for NC-group were mainly due to (1) Geographical in accessibility, (2) Economic problems to pay, (3) Less satisfaction on progress in treatment. 6. As a results of this program in average level of BP, it was found that an average BP of C-group were decreased from 187.6㎜Hg in systolic BP and from 112.2㎜Hg to 103.4㎜Hg in diastolic BP. But, the same of NC-group increased from 169.1㎜Hg to 176.0㎜Hg in systolic & form 100.0㎜Hg to 102.3㎜Hg in diastolic BP. While it is too early to claim the success of special clinic program for hypertension control at primary care(HSC) level, this assessment survey led us a tentative conclusion that public doctor assigned at health sub-center can reasonably manage the hypetension control program if there are some support to overcome clients problems in economic & geographic accessibility and if patients adequately comply with the each special clinic sessions at HSC. In order to further strengthen the hypertension control program at primary care level, the following recommendation can be made ; (1) A set of portable EKG instrument should be equipped at health sub-center when public physicians wish to initate the community-based hypetension control program. (2) Taking into account the size of population & geographical area of each health sub-center(or township), and their work load, the HSC can inititate the H.C. program, starting from the accesible villages near HSC where & when their villages wish to participate in the program. (3) To formulate an effective community-based hypertension control program, there is a need of systematic referral system between HSC(primary) & Hospital(secondary), linking the available health resources in the community(e.g. VHW-CHP-HSC-GP-Hospital) as now being developed by the Eumseong CH project.

분자 아형에 따른 유방암의 임상병리학적 분석

한승완, 이호창 충북대학교 의과대학 충북대학교 의학연구소 2013 忠北醫大學術誌 Vol.23 No.2

연구목적: 유방암의 치료 및 예후는 병기 외에도 유전자 발현 프로파일링에 의해 결정되는 분자아형에 의해서 결정된다. 면역화학염색을 이용한 분류는 분자아형과 유사한 결과를 보인다. 이 연구의 목적은 면역화학염색을 이용하여 분자아형을 분류하고 분자아형간 임상병리학적 차이를 분석하는 것이다. 대상 및 방법: 223명의 침윤관암에서 에스트로겐 수용체, 프로게스테론 수용체, 사람상피성장인자2형 (HER2) 및 ki-67 지수에 대한 면역화학염색을 시행하여 분자아형을 다음과 같이 결정하였다: 관A 형, 관B형, HER2-양성형, 삼중음성형. 이러한 분자아형과 임상병리학적 특징을 분석하였다. 결과: 핵등급과 조직학적 등급, p53 과발현은 HER2-양성형과 삼중음성형이 가장 높았으며, 그 다음 으로 관B형, 관A형 순으로 높았다. 삼중음성형은 다른 아형에 비해 상피내암을 동반하지 않는 예가 많 았으며, 관A형, 관B형에 비해 병리학적 T병기가 높았다. ki-67 증식지수는 삼중음성형이 다른 아형에 비해 높았다. 병리학적 N병기 및 환자의 나이는 아형별로 유의한 차이를 보이지 않았다. 결론: 이 연구 결과 아형별로 임상 및 병리학적 소견에서 특징적인 양상을 보였다. 이 결과는 유방암 환자의 예후를 예측하고 치료를 결정할 때 가장 효과적인 방법을 선택할 때 도움을 줄 수 있을 것이다.

Thiamine결핍 유도후 쥐 전뇌의 성상교세포 Glial Fibrillary Acidic Protein(GFAP) 면역화학 활성도에 대한 변화

김승현,김희태,김주한,김명호,황세진,김명권,백태경 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

외이경혈 미세전류신경근 자극과 체성경혈 미세전류신경근 자극이 압통역치에 미치는 효과

한승수,고현철,조원호 한국전문물리치료학회 1997 한국전문물리치료학회지 Vol.4 No.2

기어의 자동설계와 검증에 관한 연구

한민식,김승현,송호봉,전언찬 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Gear is main machine element which is used for the power transmit device when it si short in the gear. We use a standard goods in the case of the gear. But in case of special purpose, we need to manufacture the gear that have different angles. In this paper, we manufactured standard gears using W-EDM and Hobbing machine. We got a 3D shape doing reverse engineering manufactured gears. And then compared CAD data and measured data. Finally we verified ADS through comparing ADS data and KISSsoft data.