임신중 산전 초음파로 진단된 자궁근종의 임상적 고찰

서정호,김윤숙,김대원,이동운,최규연,이정재,이임순 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Objectives: To study the clinical manifestations; time, mode of delivery, size of myomas and outcome of pregnancy in cases of myomas that were detected prior to pregnancy or during the antenatal care and after delivery. Methods: We statistically analyzed 76 patients with uterine myomas in pregnancy admitted to Soonchunhyang Seoul Hospital during the period of Jan. 1999 and Dec. 2001. Results: The results are as follows. 1. The mean age of patients in the detected group and undetected group were 32.9 years and 32.3 years, respectively. There was no difference in the proportion of primarity between the detected group(98.2%) and the undetected group(79.6%) 2. The most common type of uterine myoma in both groups was intramural myoma (detected group 94.1% vs undetected group 81.3%). The uterine myomas were most commonly located in the anterior portion and fundus(detected group 52.9% and 23.5% respectively vs undetected group 47.4% and 23.7% respectively) and the proportion was not significantly different between the two groups. Uterine myomas with a diameter of 3cm or more in the detected group were detected by clinical examination and ultrasonogram. Rate of uterine myomas with a diameter of 3cm or more in the detected group is 76.5% and less than 3cm is 54.2% which detected incidentally at delivery. 3. The proportion of term infants were detected group 88.2% vs undetected group 91.5%. 4. The most common indications for cesarean section in both groups were cephalopelvic disproportion and repeated cesarean section (detected group 41.2% and 45.8% respectively vs undetected group 11.8% and 18.6% respectively) and there was no significant difference between the two groups. 5. Secondary pathologic changes in the all myomectomy specimens were degeneration in both groups but there was no necrosis or sarcomatous change. 6. Antenatal complications were preterm labor, premature repture of membranes, spontaneous abortion, malpresentation, and placenta previa. Intrauterine growth retardation and placental abruption were not seen in both groups. Conclusion: Myoma detected by ultrasonogram before or during pregnancy is not a significant implication of pregnancy outcome.

에니어그램 유형카드의 개발 및 타당화 연구

윤서연,이소희 숙명여자대학교 아동연구센터 2008 兒童硏究 Vol.21 No.1

본 연구는 에나어그램 성격유형 파악을 위한 탐색적 연구로서 에니어그램 성격유형카드 도구를 개발하고 본 도구가 에니어그램 성격유형을 얼마나 잘 나타낼 수있는지에 대한 타당도를 검증하는데 그 목적이 있다. 본 연구에서는 에니어그램 유형카드 도구의 문항추출 및 문항선정과정은 1차,2차 및 3차에 걸처 이루어졌다. 차 문항선정과정은 문헌조사와 성인 대상 워크숍을 통해 문항을 추출한 후 전문가 내용타당도를 토대로 총 114개의 에니어그램 성격유형별 문항을 추출하였다. 2차 문항선정과정은 1차 문항선정에서 추출한 114개 의 문항을 에니어그램 전문가 5인 에게 내용타당도를 검증받아 총 77문항을 선정하였다. 3차 문항선정과정은 2차 문항 과정에서 선정된 총 77개 의 문항분석으로 경인지역에 살고 있는 성인남녀 168 명의 자료로 분석을 실시하여 각 성격 유형별로 문항 전체 상관계수가 .30이상인 것을 선정하여 본 연구도구 최종문항 총 69문항으로 문항을 구성하여 에니어그램 유형카드 도구를 개발하였다. 공인타당도검증을 위해 서울 경인지역 성인40명을 대상으로 한국형 에니어그랩 성격유형척도검사 결과와 본 연구도구 검사결과의 성격유형의 일치도를 살펴보면 7유형이 66.6%로 가장 높은 일치도를 보였으며, 1유형과 9유형이 60.0%의 일치율을 보였으며, 2유형, 4유형, 6유형이 50.0%,5유형이 40.0%, 3유형이 33.3%의 일치율을 보이고 전체적인 일치율은 52.5%로 나타났다. 본 연구 결과의 의의는 문항구성 시 유형별 특성의 구인을 강점, 약점, 스트레스포인터, 안정포인터로 4개의 구인으로 문항을 구성했으며, 에니어그램 성격유형을 파악함에 있어 좀 더 쉽고, 융통성 있고, 자신을 보다 심도있게 관찰할 수 있는 정성적 방법으로 접근한 유형카드의 장점을 활용함과 더불어 자신의 성격유형을 검사하는데 기존척도와 상호보완할 수 있도록 기초자료로 제공할 수 있다. This study is an exploratory study to identify Enneagram personality types. It aims to develop barometers for Ennegram personality type cards and to verify how those barometers reflect the Enneagram personality types. In this study, question items that serve as barometers for Enneagram personality type cards were sampled and selected through the first, second and third processes. During the first question selection process, question items was sampled through literature search and workshops for adults, and then a total of 114 questions per Enneagram personality type were sampled based on experts' validation. In the second process, the 114 questions sampled in the first process were validated by 5 Enneagram experts to select 77 questions. In the third process, the selected 77 questions were used to analyze the data from 168 females and male adults living in the Gyeongin area, and then questions whose correlation coefficient is 0.30 or higher were selected per personality type. A total of 69 questions were finally taken as the confirmed set of barometers. The meanings of the result of this study are as follows; First, this study selected questions based on four elements of personal types such as strength, weakness, stress pointer and stability pointer. Second, in order to understand the Enneagram personality types, this study broke away from the existing quantitative approach while using the advantage of personality type cards that take a qualitative approach, which enables one to observe oneself more easily, flexibly, and minutely. Third, this study can provide the basic data which are mutually complementary with the existing barometers in examining the personality type of one own. Furthermore, if the barometers are supplemented through the more elaborate study designs and its execution, they could become the highly reliable and validate barometers which is very useful as personality test too.

Binding Energy of Oxigen and Methane Adsorbed on Bundles of Open-Ended Single-Wall Carbon Nanotubes

서주연,유대황,곽진성,황윤회,김형국 부산대학교 유전체물성연구소 2004 유전체 논문집 Vol.3 No.

The adsorption of oxygen and methane on the bundles of open-ended single wall carbon nanotube(SWNT) was studied using the volumetric adsorption qst was obtained from the adsorption isotherm measurements performed at different temperatures. The trend in the values of the methane isosteric heat of adsorption showed three regions, representative of the adsorption on the different types of adsorption sites. In case of oxygen, on the other hand, such distinguishable regions were not appeared in the N-qst graph. From the results of qst the binding energies of oxygen and methane adsorbed on open-ended SWITs were estimated.

부천세종병원에서 시행된 부검의 분석

오미혜,서정욱,명나혜,서연림,송계용,윤동헌 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.1

뇌낭미충증으로 인한 난치성 간질에서 병변 주변의 간질 생성 소견

윤수진,서대원,홍승봉,홍승철,서연림,이광호,이원용,김병준 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

Depth Jump 시 하지 관절 상해에 관한 운동역학적 분석

소재무,김윤지,이종희,서진희,정연옥,김광기 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

J. M. SO, Y. J. KIM, J. H. LEE, H. J. SEO, Y. O. CHUNG ? K. K. KIM. The analysis of lower extremities injury on depth jump. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 127-142, 2005. The purpose of this study was to analysis biomechanics of the lower extremities injury the heights(40cm, 60cm, 80cm) of jump box as performed depth jump motion by 6 females aerobic athletes and 6 non-experience females students. The event of depth jump were set to be drop, landing and jump. The depth jump motions on the force plate were filmed using a digital video cameras, and data were collected through the cinematography and force plate. On the basis of the results analyzed, the conclusions were drawn as follows: 1. The landing time of skill group was shorter than unskill group at 40cm, 60cm drop height during drop-landing-jump phase especially. The landing time of 60cm drop height was significant between two group(p<.05). 2. The peak GRF of sagittal and frontal direction following drop height improve was variety pattern and the peak vertical force of 40cm drop height was significantly(p<.05). 3. The magnitude of peak passive force was not increase to change the drop height. 4. The peak passive forces was significant at 40cm drop height between two groups(p<.05)

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

Intrathecal RGS4 Inhibitor, CCG50014, Reduces Nociceptive Responses and Enhances Opioid-Mediated Analgesic Effects in the Mouse Formalin Test :

Yoon, Seo-Yeon,Woo, Jiwan,Park, Joon-Oh,Choi, Eui-Ju,Shin, Hee-Sup,Roh, Dae-Hyun,Kim, Key-Sun International Anesthesia Research Society 2015 Anesthesia and analgesia Vol.120 No.3

<P>The regulator of G-protein signaling protein type 4 (RGS4) accelerates the guanosine triphosphatase activity of G(αi) and G(αo), resulting in the inactivation of G-protein-coupled receptor signaling. An opioid receptor (OR), a G(αi)-coupled receptor, plays an important role in pain modulation in the central nervous system. In this study, we examined whether (1) spinal RGS4 affected nociceptive responses in the formalin pain test, (2) this RGS4-mediated effect was involved in OR activation, and (3) the ?-OR agonist-induced antinociceptive effect was modified by RGS4 modulation.</P>