청심연자탕(淸心蓮子湯)으로 호전된 뇌내출혈에 고혈압이 동반된 태음인 환자 치험 1례

오정민,엄태민,최고은,허종원,유호룡,설인찬,김윤식,Oh, Jeong-Min,Eom, Tae-Min,Choi, Ko-Eun,Heo, Jong-Won,Yoo, Ho-Ryong,Seol, In-Chan,Kim, Yoon-Sik 대한중풍순환신경학회 2014 대한중풍.순환신경학회지 Vol.15 No.1

■ Objectives The purpose of this case study is to report that a hypertension with intracerebral hemorrhage of tae-eumin was treated with 'Cheongsim Yeunja-tang' and then the symptoms were improved and blood pressure was decreased. ■ Methods Although the patient who had hypertension with intracerebral hemorrhage took antihypertension drugs, intermittent increase of blood pressure was shown. We diagnosed him as Tae-eumin and treated with Cheongsim Yeunja-tang. We daily checked blood pressure and evaluated the symptoms. ■ Results After the treatment with Cheongsim Yeunja-tang, blood pressure was decreased and symptoms were improved. ■ Conclusion The result shows Cheongsim Yeunja-tang has antihypertensive effect and improve hypertension symptoms of Tae-eumin patient with intracerebral hemorrhage.

중학교 가정과 '인간발달과 가족관계' 영역의 교육자료 (CD-Rom) 개발 및 현장 적용 연구 : 실천적 추론 수업을 중심으로

유태명,장혜경,유지연,김주연,김항아,김효순 한국 가정과 교육 학회 2000 한국가정과교육학회지 Vol.12 No.3

The purpose of this study is to develop lesson plans. teaching guide, and teaching materials applying practical reasoning teaching model in the area of 'human development and family relationship' in middle school home economics. The practical reasoning teaching model consists of five factors: Desired results, Awareness of context. Alternative approaches, Consequences of action, and Action. This study based on practical reasoning has following process: Curriculum development, Developing lesson plan. teaching material, and teaching guide. Experimental teaching and evaluation, Feedback, Production of CD-Rom. Teaching guide includes lesson Plan. workbook, multimedia materials and teaching resources, Especially teaching guide in CD-Rom can be used effectively in the actual teaching. In the classroom, this teaching model accomplished active and interesting Participation of teachers and students. It is proposed that practical reasoning teaching model should be applied to other areas of home economics. In addition, various teaching materials based on Practical reasoning need to be developed.

간세포암환자에서 간동맥 화학 색전술 후 발생한 리피오돌에 의한 폐렴 1예

김소이,김유리,허현미,배서은,이명원,최윤정,김고흔,김태헌,유 권,문일환 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.2

Hepatocellular carcinoma(HCC)is one of common causes of cancer-related death in Korea where the majority of HCC patients were Hepaitc B virus(HBV)carriers and have cirrhosis. Transarterial chemoembolization(TACE)is commonly applied to the treatment of multinodular HCC in Korea and careful selection of candidate is important for the risk of various side effects. Besides common side effects as fever, nausea, abdominal pain and elevation of liver enzyme, TACE may predispose to hepatic failure, ischemic cholecystitis, pulmonary embolism, cerebral embolism and pneumonitis. In previous studies, some cases of pulmonary and cerebral embolism cases were reported but lipiodol pneumonitis after TACE was rarely reported. A 65-year-old woman with a multinodular HCC associated with HBV infection, was treated with TACE. Seven days after the procedure, nonspecific respiratory symptoms such as dyspnea and dry cough developed. Chest X-ray and chest computed tomography showed diffuse ground glass opacities in whole lung fields, suggestive of lipiodol pneumonitis. After several days of supportive care with steroid administration, radiologic abnormalities and subjective symptoms were much improved, considered that the disease was compatible with lipiodol pneumonitis.

응급실을 내원한 65세 이상 노인 환자의 분석

김진년,김태훈,강양욱,오명,김상철,김성훈,권계형,남홍우,이홍순,유형준 대한노인병학회 2001 대한노인병학회지 Vol.5 No.3

비혈연간 동종조혈모세포이식의 단일기관성적 : Single Center Experience

김유진,김동욱,이석,이동건,박윤희,김희제,김태규,민우성,김춘추 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2

연구배경: 비혈연간 조혈모세포이식은 HLA체계에 대한 이해의 증진과 새로운 검사법의 개발, 그리고 기증자 수의 증가에 힘입어 최근 빠르게 증가하고 있다. 방법: 가톨릭조혈모세포이식센터에서 1995년 10월부터 2001년 12월까지 비혈연간 이식을 받은 138명의 성인 환자를 대상으로 후향적 분석을 하였다. 결과: 질환별로 만성골수성백혈병 66예, 급성림프구성백혈병 23예, 급성골수성백혈병 16예, 재생불량성빈혈 21예, 골수이형성증후군 9예, 비호지킨림프종 2예, 그리고 발작성야간혈색소뇨증이 1예였다. 일차 생차부전은 분석가능한 136예 중 4예(2.9%)에서 발생하였다. Ⅱ도 이상의 급성이식편대숙주병의 발생률은 48.1%였고, 만성이식편대숙주병은 49.5%였다. 재발 이외의 사망원인 중 가장 높은 빈도를 보인 것은 폐렴으로, 독성사망 64예 중 36예(52.3%)에서 관찰 되었다. 만성골수성백혈병의 경우(n=66), 무병생존율, 재발률, 비재발성 사망률이 각각 45.7%, 11.4%, 49.2%였다. 무병생존율은 표준위험군이 고위험군에 비해 통계적으로 유의하게 높았다(50.3% vs 32.0%, p=0.03). 급성림프구성백혈병의 경우(n=23), 무병생존율, 재발률, 비재발성 사망률이 각각 30.0%와 49.4%, 44.8%였던 반면, 급성골수성백혈병에서는(n=16) 28.6%, 39.4%, 52.9%였다. 이들 급성백혈병에서는 표준위험군에 비해 고위험군에서 재발률과 비재발성 사망이 모두 높게 관찰되었다. 중증재생불량성빈혈의 경우(n=21), 무병생존율과 비재발성 사망이 37.3%와 62.7%였다. 결론: 본 연구의 결과 비혈연간 이식은 HLA적합 형제가 없는 혈액질환 환자들에게 유용한 치료법의 하나임을 알 수 있었다. 낮은 병기에서의 조기 이식과 분자생물학적 방법을 사용한 HLA 적합도의 개선이 이식관련 사망을 최소화시켜 비혈연간 이식의 효과를 더욱 확대시킬 수 있을 것으로 생각된다. Background: Unrelated allogeneic stem cell transplantation (U-SCT) is recently on a increasing trend supported by better understanding of HLA system, development of new HLA typing, and increase of donor pool. Methods: We retrospectively analyzed 138 adult patients who underwent U-SCT between October 1995 and December 2001 at Catholic Hematopoietic Stem Cell Transplantation Center. Results: Diagnoses were chronic myeloid leukemia (CML, n=66), acute lymphoblastic leukemia (ALL, n=23), acute myeloid leukemia (AML, n=16), severe aplastic anemia (SAA, n=21), myelodysplastic syndrome (MDS, n=9), non-Hodgkin lymphoma (NHL, n=2), and paroxysmal nocturnal hemoglobinuria (PNH, n=1). Primary engraftment failure was observed in 4 (2.9%) of 136 evaluable patients. Acute GVHD (≥grade II) occurred in 48.1% and chronic GVHD occurred in 49.5%. The most common cause of death other than relapse was pneumonia, which occurred 36 (52.3%) of 64 toxic deaths. In CML, disease-free survival (DFS), relapse rate, and non-relapse mortality (NRM) was 45.7%, 11.4%, and 49.2%. DFS of the standard-risk group (SR) was significantly better than that of high- risk group (HR) (50.3% vs 32.0%, P=0.03). In ALL, DFS, relapse rate, and NRM was 30.0%, 49.4%, and 44.8%, whereas corresponding figures for AML were 28.6%, 39.4%, and 52.9%. NRM and relapse rate were higher in HR compared to SR in acute leukemia. In SAA, DFS and NRM was 37.3% and 62.7%. Conclusion: We concluded that U-SCT is a feasible therapeutic option for patients lacking a HLA-matched sibling donor. Transplantation at earlier phase of disease with more accurate HLA matching by molecular typing can minimize treatment-related toxicity and could extend the benefit of U-SCT.

척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

월경주기 증상에 영향을 주는 변인들에 관한 연구

유태혁,이수일,김미영 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.1

300 nurses and nurse-aids rated their experiencies of 45 symptoms (Moos' Menstrual Distress Questionnaire) of the premenstrual, menstrual and intermenstrual phase on a 4 point scale separately. 11 predictive variables were selected through review of literatures. The names of predictive variables were as follows : chronological age, length of menstrual cycle, menstrual regularity, duration of menstruation, age of menarche, feminine hobbies or occupation, attitudes toward body parts, reaction to menarche, information of menarche, subjective evaluation of premenstrual distress and subjective evaluation of menstrual distress. 11 criterion variables were constructed on the basis of previous study "Factor Analysis of Items on the Menstrual Cycle Symptoms". The names of 11 criterion variables were as follows: concentration, pleasurable affect, motor tension, water retention, pain, autonomic reactions, unpleasurable affect, instability, withdrawal reaction, headache and depression. The scores of each criterion variables were total scores of items composing the each variables. Through multiple regression analysis, the relationships between 11 predictive and 11 criterion variables were obtained. The results were as follows: 1) Concentration was significantly correlated with duration of menstruation and length of menstrual cycle in intermenstrual phase and attitudes toward body parts, feminity and subjective evaluation of menstrual distress in menstrual phase. 2) Pleasurable affect was significantly correlated with age of menarche in premenstrual phase and feminity in menstrual phase. 3) Motor tension was significantly correlated with age of menarche in premenstrual phase and feminity in menstrual phase. 4) Water retention was significantly correlated with length of menstrual cycle and subjective evaluation of menstrual distress in premenstrual phase, menstrual regularity and length of menstrual cycle in menstrual phase and length of menstrual cycle in intermenstrual phase. 5) Pain was significantly correlated with length of menstrual cycle in intermenstrual phase. 6) Autonomic reaction was significantly correlated with feminity in premenstrual phase and feminity, reaction to menarche and subjective evaluation of menstrual distress in intermenstrual phase. 7) Unpleasurable affect was significantly correlated with age of menarche in premenstrual phase and length of menstrual cycle in intermenstrual phase. 8) Instability was significantly correlated with subjective evaluation of menstrual distress in menstrual phase and length of menstrual cycle in intermenstrual phase. 9) Headache was significantly correlated with menstrual regularity and feminity in premenstrual phase and menstrual regularity in menstrual phase. 10) Depression was significantly correlated with age of menarche in premenstrual phase, attitudes toward body parts and feminity in menstrual phase and age of menarche and length of menstrual cycle in intermenstrual phase.

靑少年의 身體關心度에 관한 一硏究

金泰蓮,金有進 이화여자대학교 한국문화연구원 1979 韓國文化硏究院 論叢 Vol.34 No.-

This study is intended to inquire into the degree of feeling of satisfaction or dissatisfaction with the various parts or processes of the body. Body-Cathexis Items used here consisted of a listing of 46 body parts and functions (for example: hair, appetite, and legs etc.). The responses to each item were appraised through sorting their responses according to a 5-point scale. The subjects were 409 middle school students (second grade boy 224, second grade girl 185), 457 high school students (second grade male 213, second grade female 224) and 76 Society service middle school students (second grade boy 31, second grade girl 45) The result was that on the whole, satisfying and dissatisfying parts of the body were differently distributed according to the age level, socio-economic level and sex of the subject. The specific results were as following. 1.More dissatisfaction was expressed by middle school boys than middle school girls regarding weight (10%) 2. More satisfied function of body by middle school boys than middle school girls was sex(10%) 3. More dissatisfied parts of body by middle school girls than middle school boys' were skin (25%), legs (25%), fingers (15%) etc. 4. More dissatisfied parts of body by middle school girls than middle school boys were wrist (30%), appetite (20%), hair (20%) etc. 5. More dissatisfied parts of body by society service middle school boys than s.s. middle school girls were breast (30%), trunk (29%) etc. 6. More satisfied parts of body by s.s. middle school boys than s.s. middle girls were appetite (20%), digestion (20%) etc. 7. More dissatisfied parts of body s.s. middle school boys than general middle school boys were respiration (20%), breast (30%), legs (30%), sex (60%), stature (24%)etc. 8. More satisfied parts of body by s.s. middle school boys than general middle school boys were ankle (20%), teeth (20%), nose (15%) etc. 9. More dissatisfied parts of body by s.s. middle school girls than s.s. middle school boys were hands (40%), nose (20%), eyes (20%), digestion (20%) etc. 10. More satisfied parts of body by s.s. middle school girls than s.s. middle school boys were distribution of hair (15%), breast (30%) etc. 11. More dissatisfied parts of body by general middle school boys than s.s. middle school boys were sex activities (15%), defecation (20%) etc. 12. More satisfied parts of body by general middle school boys than s.s. middle school boys were sex (60%), back of head (35%) etc. 13. More satisfied parts of body by general middle school than s.s. middle school girls were age (15%), sleeping (20%), health (20%), sex (60%) etc. 14. More dissatisfied parts of body by high school girls than high school boys were nose (20%), fingers (20%), legs (20%)m face (20%) etc. 15. More satisfied parts of body by high school girls than high school boys were teeth (20%), stature (16%), respiration (14%)etc.

Berberine glycyrrhizinate가 흰쥐 대뇌 Na^+, K^+ -ATPase활성도에 미치는 영향

金泰眞,柳柄泰 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-

Effect of several forms of berberine glycyrrhizinate on the Na^+, K^+-ATPase activity were compared with those of the mixture of berberine and glycyrrhizine. Berberine and glycyrrhizine solution (5×10 exp(2)M) was mixed at the same molar ratio and the pH of mixed solution was adjusted to 3.0, 3.5, 4.0, 4,7, and 5.0, respectively. After centrifugation, the berberine glycyrrhizinate was identified by TLC, UV, IR and M.P., and then the molar ratio was determined by UV spectrophotometer at 251nm and 350nm was examined. When incubated in Tris-buffer (pH7.4) at 37℃, the ATPase activity was improved by the berberine glycyrrhizinate (1.95:1), in case of the incubation time was less than 30 minutes. But incubated more than 30min, the enzyme activity was inhibited. Whereas, the enzyme activity was inhibited by berberine, glycyrrhizine and their mixture (1.95:1) throughout the incubation time up to 40 minutes.