뇌경색을 동반한 Haemophilus parainfluenzae에 의한 감염성 심내막염 1예

오은영,배상수,정윤재,이창근,이혁,김성민,박승우,백경란,송재훈 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.3

저자들은 뇌경색을 동반한 H. parainfluenzae에 의한 심내마염을 ampicillin과 gentamicin의 병합요법으로 치료한 1예를 경험하였기에, 이를 문헌고찰과 함께 보고하는 바이다. We experienced a case of infective endocarditis due to Haemophilus parainfluenzae complicated by cerebral infarction. A 40 year-old woman was admitted because of right-sided hemiparesis and dysarthria, which was accompanied by high fever up to 40 C with chills. She had been suffering from low-grade fever and general weakness for one month prior to admission. Blood cultures grew H. parainfluenzae, and the brain CT scan demonstrated cerebral infarction of MCA territory. Transesophageal echocardiogram showed mitral valve prolapse with regurgitation, and no vagetation was found. She was successfully treated with ampicillin and gentamicin for six weeks. To our knowledge, this is the first case of infective endocarditis caused by H. parainfluenzae in Korea.

용융염합성법에 의한 Ba-페라이트 미립자의 형상 제어

오영우,이승관,김영근 경남대학교 신소재연구소 1996 論文集 Vol.7 No.-

용융염 합성법으로 Ba-페라이트 미세입자를 합성하기 위하여, 염으로 NaCl과 KCl을 선택하였으며, 이들을 단독 또는 NaCl-KCl의 공정 조성 혼합물로서 시료에 50wt% 첨가하고, 바륨 페라이트의 입자형상을 제어하기 위해 1㏖%의 SiO₂를 첨가 하였다. 보자력 제어를 위한 BaFe_(12-2x)Co_(x)Ti_(x)O_(19) 조성에서 x=0→x=1.0으로 Fe^(3+)를 Co^(3+), Ti^(4+)로 치환량이 증가할수록 H_(c)와 M_(r)값은 큰 폭으로 감소하였고, SiO₂를 1㏖% 첨가한 경우는 첨가하지 않은 경우보다 6각 판상의 c축이 짧아졌고 판상비가 커졌다. In order to synthesize Ba-ferrite fine particles by molten salt method, NaCl and KCl were added to basic composition to 50% by weight, and added 1 mole% of SiO₂to control the shape of the Ba-ferrite particles. H_{c} and M_{r} were decreased when Fe^{3+} was substituted with Co^{2+} and Ti^{4+} from x=0 to x= 1.0 in BaFe_{12-2x}CO_{x}Ti_{x}O_{19}, and 1 mole% SiO₂increased the size but shortened c-axis of hexagonal ferrite.

Helicobacter pylori 감염과 위선암의 발생 사이의 연관성에 관한 최근 연구 : a Review of the Literature

오소영,신애선,황승식,유근영 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Purpose : Stomach cancer is a major cancer in the world as well as in Korea. Helicobacter pylori infection was suggested causing atropic gastritis, but there has been a debate on the association with the gastric adenocarcinoma. We reviewed recent literatures and meta-analyses on the association between Helicobacter pylori infection and the development of gastric adenocarcinoma. Results : The animal experiments suggested that Helicobacter pylori is a causative agent of gastric adenocarcinoma. Meta-analyses on the relationship between Helicobacter pylori infection and gastric adenocarcinoma showed increased risk in infected person, but the strength of association was varied with study design, characteristic of study participants and the nature of tumors. Conclusions : Recent study results suggested that Helicobacter pylori is a necessary causative agent for development of gastric adenocarcinoma. Assessment of the association between Helicobacter pylori infection and other related with gastric cancer risks and the effects of the eradication therapy of Helicobacter pylori infection on the prevention of gastvic cancer need further evaluation.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Macrophage Inflammatory Protein-1α의 浩血幹細胞 억제 작용에 관한 실험적 연구

고승오,서기향,신효근,김오한 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.2

The proliferation of bone marrow stem cell compartment is thought to be under both positive and negative controls by cytokines and colony stimulation factors. Macrophage inflammatory protein-1α(MIP-1α) has been assessed for its potential to protect hematopoietic stem cells from cytotoxic effects of a cycle-specific antineoplastic agents. We have tested the ability of MIP-1α to suppress the proliferation of stem cell line Du.528.101 in variety of active status by using [³H]-thymidine incorporation test. The results were as follows. 1. The effect of MIP-1α on steady-state Du.528.101 cell represented the cell growth suppression at the concentration of 10, 50, 100nM of MIP-1α(P<0.001). 2. MIP-α stimulated the proliferation of Du.528.101 cells previously treated with IL-1 at the concentration of 5, 50nM of MIP-1α(P<0.01) 3. The suppression effect of MIP-1 on Du.528.101 cells at the concentration of 5, 50nM was shown when cells were treated with MIP-1α before activation with IL-1β(P<0.01). 4. The growth rate of synchronized cells were slower than that of non-synchronized ones, and MIP-1α represented the similar suppression effect on both synchronized and non-synchronized cells.

소아의 하악골 골절에 관한 임상적 연구

민승기,최문기,오승환,이동근 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The jaws of children differ from those of adults in the aspects of architectural and mechanical properties, sites, form and treatment modality. This study reviews the result of treatment of pediatric mandibular fractures between 1994 and 1998 at dept. of Oral & Maxillofacial Surgery, School of dentistry, Wonkwang University by means of the age and sex distribution, mechanism of injury, location of fractures and associated patterns, fracture management, postoperative complications, any associated injuries to other organ systems. Total number of these study was 61 facial bone fractures in 32 patients. The results were as follows. 1.The pediatric mandibular fractures predominated in the age of 6∼12, and had no sexual predilection. 2.The main cause of pediatric mandibular fractures was the traffic related accidents(56.2%) 3.The condylar fracture only was 23 cases (37.7%) in total 61 sites of mandibular fractures and the symphysis fracture was 20 (32.7%) ; the highest incidence of mandibualr fracture was the symphysis with unilateral condyle combined fracture in 61 total mandibular fracture sites. 4.The major postoperative complication was deviation during mouth opening (41.2%) and the facial asymmetry(17.7%) in second. 5.Soft tissue laceration(53%) was the most associated injury with mandibular fracture and the abdominal injury(12.5%), the head injury(12.5%), and the extrimity injury (6.2%) in order.

중안면부 골절이 하악 과두 골절에 미치는 영향에 관한 임상적 연구

민승기,이동근,오승환,이은택,조이수,김종구 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

This is clinico-statistical & retrospective study of 30 patients with only unilateral mandibular condyle fracture and combined with 24 midface fracture patients who were treated with open reduction in Wonkwang University Dental Hospital during the period 1993 to 2000. The results were as follows : 1. In mandibular condyle fracture combined with midface fracture, the most incident type is associated with zygomaticomaxillary complex fracture and level Ⅳ of mandibular condyle fracture combined with ZMC fracture is the most related(33.32%). 2. In the period of intermaxillary fixation, unilateral mandibular condyle fracture group (9.8 days) is shorter than combined with midface fracture group (15.3 days), but no statistical difference between two groups(p.>0.05). 3. In the mouth opening recovery, unilateral mandibular condyle fracture group is faster than combined with midface fracture group in post-operative 1 month, but no significant difference between two-groups after 3 months postoperatively (p>0.05). 4. In two-groups, treatment method is almost open reduction with internal fixation(ORIF) and overall 25% temporary complications were shown, but little lower incidence in unilateral condylar fracture group.

악교정 수술 후 발생하는 신경회복에 대한 연구Ⅰ

이동근,조이수,민승기,오승환,정창주,이은택 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

Dysfunction of the inferior alveolar nerve indicated by various degree of numbness of the lower lip and chin is one of the few drawbacks of mandibular osteotomy, especially Bilateral Sagittal Split Ramus Osteotomy(BSSRO) and genioplasty. Although it has been recorded throughout the history of this techniques, it is true etiology poorly understood. In this study, 22 consecutive patients under class III malocclusiion impression and undergoing orthognathic surgery(BSSRO only 11 case, BSSRO with genioplasty 11 case) were studied using 4 neurosensory test(static light touch, directional discrimination, two-point discrimination, pin pressure nociception) with post OP 1 week, 2 weeks,4 weeks, 8 weeks, 12 weeks, 24 weeks, On control group, 10 members without trauma and nerve damage history, nerve test was accomplished. We concluded majority of patients return of sensation during post operative 24 weeks. Althought immediate nerve deficit are 92.2%, 97.2% 88.9% these are recovered to 25%, 35.72%, 10.71% at 24 weeks. Nerve recovery rate increased prominently between post 4 weeks and 8 weeks. There is no statistically difference about neurosensory deficit among the chin area. Neurosensory deficit more severe when the BSSRO with genioplasty group than the only BSSRO group. Immediate neurosensory deficit is larger left side than right side but after 6 months, there is no significantly difference between left side and right side. Static light touch and pin pressure nociception are more sensitive method of neurosensory deficit than two point discrimination.

유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.