Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

충남대학교 부속동물병원에 의뢰된 개의 뇨결석 성분 분석 결과

노경완,송근호,조종기,박성준 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

A retrospective analysis was performed with 14 cases of canine urolithiasis examined at Laboratory of Clinical Pathology, College of Veterinary Medicine, Chungnam National University in the period between January 2005 and November 2005. The female (8 cases) had most occurrence about 14 cases. The Shih-tzu (8 cases), Poodle (4 cases) had higher incidences than other breeds. Canine urolithiasis occurred from 1 year 3 months to 7 years 6 months, but the most prevalence age was 3 years. The major mineral component of calculi was calcium oxalate (64.28%) and struvite(21.44%).

생물전극 반응조를 이용한 영양물질 제거

김성완,윤철종,최성우,김성우,우성훈,신남철,박승조 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

We have investigated a performance of bio-electrode reactor for removal of nutrient like a nitrogen, phosphorus and organic substrate. Lab scale of bio-electrode reactor was operated with synthetic and tannery wastewater. Iron bar and stainless steel used for anode and cathode respectively. In experiment with synthetic wastewater, we were able to obtain the optimal current density range of 2.4-40 mA/dm² after 48 hrs operating time. And in that experiment, about 70~73% of ammonia nitrogen and 54~64% of phosphorus were removed. In experiment with tannery wastewater at 2.4-4.0 mA/dm², the removal rate of ammonia nitrogen, phosphorus and organic substract were about 62-69%, 45~59% and beyond 79% respectively.

칼라 영상의 분할을 위한 Mean Field Annealing EM 알고리즘

박종현,박순영,강성준,조완현 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

In this paper we present a statistical model-based approach to the color image segmentation. A novel deterministic annealing EM and mean field theory are used to estimate the posterior probability of each pixel and the parameters of the Gaussian mixture model which represents the multi-colored objects statistically. Image segmentation is carried out by clustering each pixel into the most probable component Gaussian. The experimental results show that the mean field annealing EM provides a global optimal solution for the ML parameter estimation and the real images are segmented efficiently using the estimates computed by the maximum entropy principle and mean field theory.

동종 조혈모세포이식 후 발생한 크립토콕쿠스 척추염 1예

고윤호,임동준,이성수,조유경,이동건,최정현,김유진,민창기,김동욱,박정미,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7∼10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome□ (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.(Korean J Infect Dis 33:298∼301, 2001)

사지의 주요 동맥손상의 처치: 23증례에 대한 분석

원형섭,김상은,배성만,박철완,이 근,조상훈,김상일,우병완 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1

Extremity vascular trauma is common in most emergency centers, and controversy remains about the optimal management of arterial injuries. Retrospectively we reviewed the records of 23 patients who had upper or lower extremity arterial trauma from July 1994 to December 1995. The purpose of this study was to evaluate our department`s management policy to major arterial injuries. The leading cause of major arterial injuries was penetrating trauma. We found that there were clinical findings such as absence of or decreased strength of pulsation(82.6%), cool ischemic extremity(69.6%), large expanding hematoma(43.5%), major bleeding(17.4%) and bruit or thill(8.7%). We gave the priority to management of life-threatening injuries and applied the pressure dressing to wounds as early as possible. There were 18 men(78.3%) and 5 women(21.7%); the mean age was 35(range 20-56 years old) years. There were 12 arterial injuries(52.2%) in the upper extremity and 11 arterial injuries(47.8%) in the lower exteremity. The most commonly injured artery was the brachial artery in the upper(34.8%) and the femoral artery in the lower(30.4%) extremity. The etiology included knife stabbing in 10 patients(43.5%), motor vehicle accidents in 6(26.1%), industrial accidents in 4(17.4%), falls in 2(8.7%) and a farm equipment accident in 1 patient(4.3%). The associated injuries were muscle injuries(78.3%), fracture(56.5%), nerve injuries(52.2%), vein injuries(43.5%), shock(17.4%) and dislocation(13.0%). All patients with arterial injuries were given a preoperative prophylactic antibiotic and TIG(tetanus immunoglobulin). We used Doppler technique as a means of detecting the blood flow. Fourteen patients(60.9%) underwent preoperative arteriography in the radiology department. We performed surgical exploration as soon as major arterial injuries were suspected. The most common methods of treating major arterial injuries were interposition vein graft(69.6%) and end to end anastomosis(21.7%). Systemic or locally infused heparin was used for all vascular repairs. In many of our patients(56.5%), fasciotomy was performed before the vascular repair, as a part of the exploration of the distal arteries. There were 2 amputations(8.7%) but no death. The reason for secondary amputation were wound infection in one and failure to achieve sufficient arterial flow to the involved extremity with resulting gangrene in the other. As the time factor is vitally important in the management of arterial injuries, we advocate prompt and early surgical treatment within 6 hours of the trauma. In conclusion, we believe that the crucial factorsin successful management of major arterial injuries of the extremities are early diagnosis, prompt treatment, complete debridement, fasciotomy when indicated, and simultaneous treatment of concomitant injuries.

칼라 영상의 분할을 위한 Mean Field Annealing EM 알고리즘

박종현,박순영,강성준,조완현 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

In this paper we present a statistical model-based approach to the color image segmentation. A novel deterministic annealing EM and mean field theory are used to estimate the posterior probability of each pixel and the parameters of the Gaussian mixture model which represents the multi-colored objects statistically. Image segmentation is carried out by clustering each pixel into the most probable component Gaussian. The experimental results show that the mean field annealing EM provides a global optimal solution for the ML parameter estimation and the real images are segmented efficiently using the estimates computed by the maximum entropy principle and mean field theory.

한국산 어류 미토콘드리아 DNA의 분자계통학적 이용 및 보존

김영자,김일찬,이세영,이완옥,조용철,이재성 한국육수학회 2003 생태와 환경 Vol.36 No.3

종다양성 규명을 위한 계통분류학적 연구는 원시형질의 상동성에 근거한 기존의 형태형질과 효율적인 새로운 분자계통분류학적 연구방법이 병행된다면 좀 더 정확한 분류 및 계통을 추적하는데 객관적인 결론을 제시할 수 있을 것이다. 현재 활발히 연구되고 있는 미토콘드리아 DNA를 이용한 분자계통분류학적 연구는 기존의 형태적 특징을 근간으로 한 계통분류를 재검토할 뿐 아니라 계통진화학상 조상과 자손과의 관계를 유추하는데 새로운 가설을 세울 수 있는 토대를 제공하는 기초자료로서 이용될 수 있다. Phylogenetic studies would clarify the diversity of fishes if the morphological analysis based on plesimorphy characters combined with new genetic analysis on molecular level, inferring more accurate and objective phylogeny and the taxonomy. Current molecular phylogenetic approach using mitochondrial genome provides the framework for a new hypothesis not only inferring the relationships between ancestor descendants but raveling the intra-, interspecies variation.

A report of 29 unrecorded bacterial species belonging to the phylum Bacteroidetes in Korea

Cho, Sang Hyun,Yoon, Jung-Hoon,Kim, Seung-Bum,Jahng, Kwang-Yeop,Cho, Jang-Cheon,Joh, Ki-seong,Cha, Chang-Jun,Seong, Chi-Nam,Bae, Jin-Woo,Im, Wan-Taek,Jeon, Che Ok The National Institute of Biological Resources 2017 Journal of species research Vol.6 No.2

Within a comprehensive, widescale investigation of indigenous prokaryotic species in Korea, 29 bacterial strains in the phylum Bacteroidetes were isolated from diverse environmental habitats that included soil, plant roots, natural caves, tidal flats, freshwater from lakes, and seawater. Based on their high 16S rRNA gene sequence similarities (>99.1%) and the formation of robust phylogenetic clades with the closest type species, each strain likely belonged to an independent and predefined bacterial species. There are no publications or official reports of the isolation of these 29 species in Korea. Our study provides strong evidence that seven species in three genera in the order Cytophagales, 15 species in 13 genera in the order Flavobacteriales and seven species in five genera in the order Sphingobacteriales, all within the phylum Bacteriodetes, are new reports of bacterial species in Korea. Gram reaction, colony and cell morphology, basic biochemical characteristics, isolation source, and strain IDs are described in the species description section.