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조현선,정은선,이윤정,임철현,정웅룡,성혜영,박재명,최명규 대한소화기내시경학회 2009 Clinical Endoscopy Vol.38 No.4
Pyogenic granulomas (PGs) are rare benign lobular capillary hemangiomas that occur on the skin or mucosa. The most common sites of PG occurrence are the skin, lip, face and finger. This entity is extremely rare in the alimentary tract, with the exception of the oral cavity. We describe here a 72-year-old man who presented with dysphagia due to the presence of a pyogenic granuloma. The tumor was located in the mid-esophagus and it was treated with endoscopic submucosal dissection. PG is considered a lesion of reactive origin that may develop in response to trauma, infection, pregnancy, angiogenic factors or hormones. Gastrointestinal PG need to be treated because it is a rare cause of gastrointestinal hemorrhage, and it is hard to differentiate from tumorous conditions such as Kaposi's sarcoma. 화농성 육아종(pyogenic granuloma, PG)은 양성의 혈관종으로 용종 형태를 띠며, 주로 피부나 점막에서 발생한다. 가장 흔한 발생 부위는 피부, 입술, 얼굴, 손가락 등으로 구강 내를 제외하고는 소화관 내에서 발생하는 경우는 매우 드물다. 소화관 중에서는 식도에서 가장 많고 소장, 대장, 위, 십이지장 순으로 발생한다. 화농성 육아종의 발생 원인에 대해서는 아직 밝혀지지 않았으나 외상, 감염, 임신, 혈관형성인자, 호르몬 등의 가능성이 제시되고 있다. 화농성 육아종은 위장관 출혈의 드문 원인이 될 수 있고, 카포시 육아종 등과 감별이 필요하기 때문에 제거할 필요가 있다. 연하곤란을 주소로 내원한 환자에서 식도의 화농성 육아종을 진단하였고, 내시경 점막하 절제술을 시행하여 성공적으로 치료한 증례이다.
유동성의 다수의 구를 포함하고 있는 성숙 난소 기형종: 증례 보고
조현선,윤성언,이영환,김혜원,박성훈,윤권하 대한초음파의학회 2006 ULTRASONOGRAPHY Vol.25 No.4
A 48-year-old woman was admitted to our hospital with a palpable mass in her lower abdomen. A left ovarian, cystic mass containing multiple mobile globules was seen on CT and MR images. The outer portion of the globules showed fat components on CT and fat-saturated T1-weighted MR images. Ultrasonography showed multiple echogenic, mobile globules with some sound attenuation and hyperechoic lines and dots within the cystic mass, which corresponded with the presence of lipid globules and hair shafts of ovarian mature cystic teratoma, respectively. 48세 여자환자가 하복부의 촉진되는 종물을 주소로 내원하였다. 컴퓨터 단층촬영과 자기 공명 단층 촬영상 내부에 다수의 유동성의 구들을 포함하고 있는 낭성 종양이 좌측 난소에서 관찰되었다. 종양의 바깥부위는 컴퓨터 단층촬영과 자기 공명 단층 촬영상 지방성분을 함유한 것으로 나타났다. 초음파상 음파 감쇠를 동반한 초음파 반향적 구 및 고 반향의 점 혹은 선들이 낭성 종괴 내에서 관찰되어 난소 성숙 기형종의 지방구와 머리카락에 합당 하였다.
조현선,장승희,정윤선,신지영,박성진,이은순,황순경,권정택,Arash Minai Tehrani,우민아,노미숙,Huda Hanifah,Hua Jin,Cheng-Xiong Xu,조명행 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.1
Tetrandrine (TET), a bis-benzylisoquinoline alkaloid from the root of Stephania tetrandra, is known to have anti-tumor activity in various malignant neoplasms. However, the precise mechanism by which TET inhibits tumor cell growth remains to be elucidated. The present studies were performed to characterize the potential effects of TET on phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase (ERK) pathways since these signaling pathways are known to be responsible for cell growth and survival. TET suppressed cell proliferation and induced apoptosis in A549 human lung carcinoma cells. TET treatment resulted in a down-regulation of Akt and ERK phosphorylation in both time-/concentrationdependent manners. The inhibition of ERK using PD98059 synergistically enhanced the TET-induced apoptosis of A549 cells whereas the inhibition of Akt using LY294002 had a less significant effect. Taken together, our results suggest that TET: i) selectively inhibits the proliferation of lung cancer cells by blocking Akt activation and ii) increases apoptosis by inhibiting ERK. The treatment of lung cancers with TET may enhance the efficacy of chemotherapy and radiotherapy and increase the apoptotic potential of lung cancer cells.
조현선,손태서,이소영,김경희,박유경,이정민,손현식 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.6
An empty sella may develop as a consequence of a primary congenital weakness of the diaphragm for which no secondary cause is evident. A secondary empty sella may develop after infarction of a pituitary adenoma or because of surgical or radiation-induced damage to the sellar diaphragm. Acromegaly is caused by growth hormone (GH) hypersecretion and the resultant elevated levels of circulating insulin like growth factor-1. The underlying abnormality in more than 98% of cases is hypersecretion of GH by a pituitary GH-producing tumor. Necrosis and hemorrhage, which frequently occur in pituitary adenomas, may lead to complete or partial disappearance of the adenoma, and subsequently, to an empty sella. We report two cases of acromegaly with empty sella, and the patients had no symptoms of pituitary apoplexy. (J Kor Endocrinol Soc 21:572~576, 2006) 저자들은 100 g 경구당부하검사로 확진한 말단비대증 환자의 뇌하수체 자기공명영상에서 공터키안을 관찰한 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.