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이세영,지연태,김익영 한국유전학회 1984 Genes & Genomics Vol.6 No.3
Klebsiella pneumoniae lacks tryptophanase and, therefore, is better host of the amplified trp operon for the production of tryptophan. For the purpose of host development, tryptophan repressor deficient mutation, tryptophan aminotransferase-deficient mutation and L-serine deaminase-deficient mutation were introduced into the K. pneumoniae host cell and their effects on the expression of amplified recombinant E. coli trp operon (R_6K: :Mu-trpL (Δatt) trpE^(FBR)) were examined. The trpR^- mutation derepressed the expression of the recombinant E. coli trp operon and both tat^- and ssd^- mutation also increased the activities of anthranilate synthetase and tryptophan synthetase as well as the production of tryptophan in K. pneumoniae.

이세영,김승회,이윤영,구양모,Se Young Lee,Seung Hoi Kim,Youn Young Lee,Yang Mo Goo 대한화학회 1992 대한화학회지 Vol.36 No.2
3-알킬리덴-2,4-펜탄디온(1)과 아릴히드라진을 메탄올에서 반응시키면 4-아세틸(2), 4-(1-메톡시알킬)-(3) 또는 4-비닐피라졸 유도체(4)가 얻어진다. 3-(2,2,2-트리클로로에틸리덴)-2,4-펜탄디온(9)과 아릴히드라진과의 반응에서는 4-아세틸-1-아릴-3-메틸피라졸(11)이 생성된다. 이 반응들의 가능한 메카니즘을 제시하였다.

대장 선종 이형성 및 대장암과 임신, 출산, 월경 요인의 관련성에 관한 환자-대조군 연구
이세영,최규용,김미경,이진희,맹광호,이원철,Lee, Se-Young,Choi, Kyu-Yong,Kim, Mi-Kyung,Lee, Jin-Hee,Meng, Kwang-Ho,Lee, Won-Chul 대한예방의학회 2003 예방의학회지 Vol.36 No.3
Objectives : Evidence for an effect of rerroductive factors on colorectal carcinogenesis is not yet consistent. Little research has been conducted to investigate whether reproductive factors were associated with colorectal adenomas that are the precursors of colorecta1 cancer, We evaluated the relationships between reproductive factors and the degree of dysplasia of the colorectal adenoma and cancer as colorectal adenoma-carcinoma sequence. Methods : For this study, 241 adenoma cases with histopathologically confirmed incident colorectal adenoma, 76 cancer cases with colorectal cancer and 1677 controls were collected from Our Lady of Mercy Hospital, The Catholic University of Korea, during 1994-1999. Before colonoscopy, information on demographic characteristics, reproductive factors, life style habits and dietary intake were obtained by interviewed questionnaire. Adjusted OR and 95% CI were estimated by using polytomous logistic regression model, Potential confounders that were selected based on the goodness of fit Statistics and interaction between risk factors were considered in this adjustment. The Wald statistic was calculated to test the heterogeneity of the odds ratios for each case. Results .: Postmenopausal women with natural menopause were found to be positively associated with the risk of mild dysplasia adenoma (multivariate-adjusted OR : 2.59, 95% CI=1.1-0.2). Parity was found to be negatively associated with the risk of colorectal lancer (age-adjusted OR : 0.40, 95% CI=0.2-0.9), but did not significantly decrease the risk of colorectal cancer (multivariate-adjusted OR : 0.95, 95% CI=0.3-2.9). Me associations were seen between a9e at menarche, breast feeding, induced abortion, oral contraceptive use, menopausal types, menopausal age or hormone replacement therapy (HRT and the degree of dysplasia of the colorectal adenoma and cancer. However, none of these associations differed' significantly between the degree of dysplasia of the colorectal adenoma and cancer. Conclusions : These findings suggest that postmenopausal women with natural menopause may experience increased risk of mild dysplasia adenorna among colorectal adenoma-carcinoma sequence.