과량의 방사선에 노출된 흰쥐 소뇌외측핵의 미세구조

정재삼,양남길,안의태,고정식,박경호,김진국 대한해부학회 1992 Anatomy & Cell Biology Vol.25 No.3

세선화 작성에 있어서의 과도무늬에 관한 연구

박삼진,정경민 선문대학교 첨단과학기술연구소 1997 첨단과학기술연구소 논문집 Vol.2 No.-

지폐와 우표 등에서 볼 수 있는 세선화를 CAD 기술을 이용하여 자동으로 작성함에 있어서 여러가지의 무늬가 동시에 사용되고 있다. 명암의 크기 범위에 따라 사용 무늬를 변경하는 방법이 사용되어 왔으나, 질감이 같은 곳에서의 무늬의 변화는 뚜렷한 질감의 변화를 가져온다. 따라서 질감의 변화 없이 넓은 명암의 범위에서 아용할 수 있는 무늬의 활용에 대한 연구가 수행되었다. 이를 위하여 무늬의 모양을 서서히 변화시키는 과도무늬를 사용하는 방법과 한 가지 무늬를 사용하되 무늬를 구성하는 선의 가중치를 서서히 변화시키는 방법이 개발되었다. 전자의 경우는 무늬의 특성이 뚜렷하게 나타나서 질감의 변화를 가져온 반면, 후자의 경우는 질감의 변화 없이 넓은 영역의 명암 범위에서 활용될 수 있음을 알았다. For an automatic fine line drawing of the bank notes and stamps, several patterns are utilized according to a range of the darkness and a character of the region. Use of the different patterns in a same character region, simply because of the darkness limits in which a specified pattern can properly represent the darkness, shows distinctive boundaries in the region. In order to avoid this kind of undesirable boundaries, a transient pattern in which each lines have different weighting factors according to the range of the darkness is developed. By introducing the transient pattern, a region which has a wide range of darkness can be expressed without change of its character.

전치부 반대교합아동의 발음장애에 관한 음향적 연구

박정삼,손동수,이상훈,김진태,한세현,장기택,김종철 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

It has widely known for speech problem in patients with malocclusion,but there have been insufficient studies on degrees of serverity.Patients with openbite and CIⅢ malocclusion usually have speech problem.It has widly known that fricative /s/ is pronunciated most abnomally in CIⅢ malocclusion than any other consonant.Therefore 20 childen with anterior crossbite selected for control group.7 sounds such as /사(sa),서(sδ),소(so),수(su),스(sω),시(si),세(se)/ were recorded,and the formants and formants ratio were measured by using Sensimetric Speech Station,which is speech analyzing program in IBM pc. The results were as follows: 1.In anterior crossbite group,F1 of all 7 sounds were significantly higher than normal anterior relationship group(P<0.05). 2.There were no significant difference in F2 between two groups except/소(so),수(su)/(P>0.05). 3.In anterior crossbite group,F2/F1 ratio of all 7 sounds were significantly smaller than normal anterior relationship group(P<0.05). 4.There were no significant difference in accordance with tongue position(P>0.05).

우리 대학 기계공학 계열 학과의 교육성과 및 만족도에 관한 설문분석 사례 연구(1)

김진남,승삼선,이정우 三陟大學校 2001 論文集 Vol.34 No.1

Mechanical engineering educational survey for graduating seniors has been conducted in school of mechanical engineering, precision mechanical engineering and vehicle engineering to improve educational program objectives, accomplishment and curriculum. The questionnaire is prepared for according to KCUE(Korean Council For University Education) estimated criteria and 12 outcomes of the ABEEK(Accreditation Board of Engineering Education in Korea) accredited criteria. And the contents of questionnaire consist of engineering education ability, design ability, experiment and exercise, and etc.. The collected data have been analyzed statistically based on 12 outcomes of the ABEEK accredited criteria to estimate how much students are satisfied with the current engineering education. Its results help professors to setup the directions of education and to teach the proper subjects. The analysis results show that the current engineering educational objectives need to be modified to satisfy the ABEEK accredited criteria and engineering curriculum restructuring is inevitable to include more design and experiment/exercise courses.

HPLC에 의한 복어 및 생체시료 중 Tetrodotoxin의 분리정량에 관한 연구

민승식,정진일,손행자,노미정,박유신,김춘삼 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

All-Trans Retinoic Acid에 의한 HL-60 세포 분화유도중 H2B Histone, c-Myc 및 DNA Topoisomerase I 발현에 관한 연구

임규,박정동,최병한,이용진,김계영,이명선,장은미,김삼용,권기량,곽상태,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Effects of all-trans retinoic acid(retinoic acid) on DNA replication, H2B histone and DNA topoisopmerase I(Topo I) gene expression have been investigated in human promyelocytic leukemia cell line HL-60. DNA synthesis decreased at 24 hours after exposure of retinoic acid in the HL-60 cells. H2B histone mRNA rapidly reduced at 48 hours and Topo I and c-myc mRNA at 24 hours in retinoic acid-exposured HL-60 cells, respectively. The levels of c-myc, H2B histone and Topo I gene expression were reduced in proportion to the concentration of retinoic acid. The H2B histone mRNA in retinoic acid-exposured cells was elevated by cycloheximide treatment, while the level of Topo I mRNA was constant. These results suggest that regulations of H2B histone, c-myc and Topo I gene expression are different from one another, and repression of Topo I gene is closely correlated with c-myc gene during retinoic acid-induced differentiation of HL-60 cells.

FEM을 이용한 선삭가공 절삭조건의 영향 분석

임세환,송춘삼,홍석관,강정진,김주현 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

A plane strain finite element model is developed to simulate turning with continuous chip formation using adaptive remeshing during the thermal-mechanical coupled analysis. Comparisons between the experimental and simulation results for cutting forces are performed to validate FE analysis results. Influences of machining parameters such as depth of cut, cutting speed and feed rate on cuting force and shear angle are analyzed by Taguchi method. The more depth of cut and feed rate result in the increase of cutting forces, but the rates of increase are decrease due to the larger shear angle. As the cutting speed increases, von Mises stress of workpiece near the tool tip decreases because the strength of specimen decreases at high temperature above 500℃. This thermal effect on cutting force is negligible because the affected area is very localized and the average values of von Mises stress in the shear plane are the same among the diverse cutting parameters.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

신경교세포 및 RAW 264.7 세포에서 Protein kinase의 활성에 의한 유도성 Nitric oxide synthase의 발현

박상철,노삼길,배소현,박지선,이충재,허강민,석정호,이재흔 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

NO(nitric oxide) plays an important role as neurotransmitter or cytokine, and pathologic factor for some diseases by the large amount production with iNOS(inducible NO synthase) expression in macrophages or glial cells. The expression of iNOS is regulated by various cytokines, protein kinases and transcription factors. In this experiment, to investigate the roles of progein kinase and NF-kB for iNOS expression, the effects of PMA(phorbol 12-myristate 13-acetate), cAMP, and various protein kinase inhibitors on LPS(lipopolysaccharide)-induced iNOS mRNAN expression and nuclear NF-kB binding complex were examined in C6 glial cells and RAW 264.7 cells. In C6 glial cells, iNOS mRNA expression by LPS was induced from 1 hour and peak at 3 hour after treatment. In RAW 264.7 cells, the mRNA was observed from 3 hour and peak at 6 hour. PMA enhanced markedly LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but did not much influence on LPS-induced iNOS mRNA expression in RAW 264.7 cells, in spite of increased LPS-induced NF-kB binding complex at 30 min. cAMP(dibutyryl cAMP) did not much influence on LPS-induced iNOS mRNA expression, by increased LPS-induced NF-kB binding complex in C6 glial cells. However, in RAW 264.7 cells, cAMP increased slightly LPS-induced iNOS mRNA expression without change of NF-kB binding complex. Staurosporine did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression and NF-kB binding complex. Ro-31-8220 did not much influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased significantly LPS-induced iNOS mRNA expression in spite of increased LPS-induced NF-kB binding complex for 3hours. G 6976 did not much influence on LPS-induced iNOS mRNA expression with decreased NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased iNOS mRNA expression without influence on LPS-induced NF-kB binding complex. Genistein did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression inspite of increased NF-kB binding complex. These results suggest that LPS-induced regulation of iNOS expression or NF-kB activity in C6 glial cells, might be different from RAW 264.7 cells through various protein kinases or other factors.

초피 추출물의 수율 및 항균활성

임상빈,송대진,좌미경,고정삼 濟州大學校工科大學産業技術硏究所 1995 尖端技術硏究所論文集 Vol.6 No.-

초피를 유기용매 및 초임계이산화탄소와 보조용매로서 에탄올로 추출하여 각각의 추출수율을 측정하고, 이들 추출물들의 항균활성을 검색하였다. 유기용매별로 추출하여 각각의 추출수율을 측정한 결과, 증류수인 경우 20%로서 가장 높았고, 나머지 헥산, 에테르, 에탄올인 경우 3%이하로 매우 적었다. 또한 추출 용매로 초임계이산화탄소-에탄올을 병용했을 때 초피의 추출수율과 용해도는 초임계이산화탄소만을 사용했을 때보다 1.4배 이상 높았다. 용매별 추출물들의 항균성을 검색한 결과 모든 추출물들이 B.cereus에 대해 항균성을 나타내었는데, 특히 에탄올, 에테르 추출물들의 항균성이 더 큰 것으로 나타났다. 초임계이산화탄소-에탄올 추출물은 초임계이산화탄소만을 사용한 추출물과 거의 동일한 항균성을 나타내었다. Extraction yields of Zanthoxylum piperitum by organic solvents and supercritical carbon dioxide(SC-CO₂) with and without ethanol as a cosolvent, and antimicrobial activities of the extracts against Bacillus cereus were determined. Extraction yield by distilled water was the highest, 20%, while those by ethanol, ethyl ether and hexane were less than 3%. Extraction yield by SC-CO₂ with ethanol was 1.42 times greater than that by only SC-CO₂ Ethyl ether- and ethanol-extracts had potent antimicrobial activities against B.cereus. Extraction yield by SC-CO₂ with ethanol showed almost the same degree of microbial growth inhibition as that by only SC-CO₂.