[다층_석정호 신작] 꽃

석정호 고요아침 2019 열린시학 Vol.24 No.3

[다층_석정호 수상작] 메롱 말매미 외 1편

석정호 고요아침 2019 열린시학 Vol.24 No.3

[다층_석정호 수상소감] 요동치는 흔들림을 되찾을 계기

석정호 고요아침 2019 열린시학 Vol.24 No.3

Relationship between Negative Mental Adjustment to Cancer and Distress in Thyroid Cancer Patients

석정호,최원정,이용상,박청수,오영자,김종선,장항석 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.3

Purpose: Previous studies have reported that over a third of cancer patients experience significant psychological distress with diagnosis and treatment of cancer. Mental adjustment to cancer as well as other biologic and demographic factors may be associated with their distress. We investigated the relationship between mental adjustment and distress in patients with thyroid cancer prior to thyroidectomy. Materials and Methods: One hundred and fifty-two thyroid cancer patients were included in the final analysis. After global distress levels were screened with a distress thermometer, patients were evaluated concerning mental adjustment to cancer, as well as demographic and cancer-related characteristics. A thyroid function test was also performed. Regression analysis was performed to discern significant factors associated with distress in thyroid cancer patients. Results: Our regression model was significant and explained 38.5% of the total variance in distress of this patient group. Anxious-preoccupation and helpless-hopeless factors on the mental adjustment to cancer scale were significantly associated with distress in thyroid cancer patients. Conclusion: Negative emotional response to cancer diagnosis may be associated with distress in thyroid cancer patients awaiting thyroidectomy. Screening of mental coping strategies at the beginning of cancer treatment may predict psychological distress in cancer patients. Further studies on the efficacy of psychiatric intervention during cancer treatment may be needed for patients showing maladaptive psychological responses to cancer.

靜脈內 Neostigmine이 Atopine 前處理 犬의 血壓에 미치는 影響

昔廷鎬 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2

In this experiment, by-intravenously administered neostigmine the blood pressure was increased initially, decreased and increased in nonpretreated dogs, but increased response was appeared only in atropinized dogs, and the increased pressor response was inhibited by hexamethonium, regitine and reserpine. By intraventricular neostigmine the blood pressure was decreased only. These results indicate that the pressor response of neostigmine is due to stimulation on the sympathetic ganglia and not related to central effect.

급성 자발성 척수 경막외 혈종 2예 -증례 보고-

석정호,전진우,임윤희,우승훈,이우용 대한마취통증의학회 2012 Anesthesia and pain medicine Vol.7 No.3

A spontaneous spinal epidural hematoma (SSEH) is a rare disease that accompanies severe axial pain in the spine with various levels of paralysis depending on the location of the hematoma. A SSEH is mainly caused by a coagulating disorder or anticoagulants medication, while certain cases relate this disease with spinal inflammatory conditions. The early diagnosis of a SSEH is important for its treatment. Most cases with neurologic symptoms can be treated with an immediate laminectomy and decompression. If the neurologic symptom improves within 12 hours, a conservative treatment is effective; however few cases have been reported. We report this case with a review of the relevant literature.

The Prevalence and Clinical Characteristics of Borderline Personality Disorder in South Korea Using National Health Insurance Service Customized Database

석정호,신현경,이혜선,이병철,박고은,Khishigbayar Uranbileg,박윤,윤민형 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.9

Purpose: The purpose of the present study was to identify the prevalence and clinical characteristics of borderline personality disorder (BPD) in South Korea using the Korean National Health Insurance database (DB). Materials and Methods: We used the National Health Insurance Service (NHIS)’s research DB (NHIS-2021-1-790) from January 1, 2010 to December 31, 2019, to make customized DB including sociodemographic information and absence or presence of BPD and other psychiatric disorders. The prevalence and the age of onset of BPD was estimated. To compare medical service utiliza tion between the BPD group and the control group, a 1:1:1 propensity score matching was employed, and the regression analysis was conducted. Results: The prevalence of BPD per 10000 people was 0.96 in 2010 and 1.06 in 2019. The prevalence ratio of males to females was 1:1.38 in 2010 and 1:1.65 in 2019, showing that BPD was more prevalent in females. The patients’ overall average age of onset was 33.19±14.6 years, with the highest prevalence shown in 8503 people in their 20s. By administrative district, the highest prevalence of BPD per 10000 people was shown in Seoul with 8.71 and the lowest in Jeollanam-do with 2.35. The BPD patients showed a pat tern of extensive use of general and mental healthcare services. Conclusion: This study identified the prevalence of BPD on a national DB set in South Korea. Although the prevalence of BPD in South Korea was relatively low compared to other countries, there was a steady increase in the number of BPD patients over a de cade, which may be possibly due to an increased awareness of mental health and campaigns among healthcare providers and users in the country.

Aldosterone處理 高血壓 白鼠 心筋形質膜에서의 Ouabain-Binding Site에 關한 硏究

昔廷鎬 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

Na, K-ATPase activity and ouabain binding site of cardiac microsomal membrane, prepared from aldosterone treated hypertensive rats were compared with those prepared from normotensive rats. In the hypertensive rats, systolc blood pressure was significantly increased(178.1±5.4 mmHg), but left ventricular weight was slightly decreased (11%). Cardiac microsomal protein yield per ventricular weight was increased significantly in the hypertensive rats, but not much increased as expressed with it per ventricle. Na, K-ATPase activity in the hypertensive rat heart was not significantly changed, but ouabain binding site (high affinity site)was significantly decreased. From these results, it is suggested that, in the aldosterone treated rats, the molecular activity of Na, K-ATPase is increased if its low affinity site is changed as like high affinity site, but it should be confirmed whether low affinity site of Na-pump is decreased or not.

주요우울장애에서 시상하부-뇌하수체-부신피질 축 변화의 진단적 함의

석정호 대한우울조울병학회 2014 우울조울병 Vol.12 No.1

Functional changes of hypothalamic-pituitary-adrenal (HPA) axis have been gathering attention from many investigators since HPA axis is a main neuroendocrine system in acute and chronic stress responses. HPA axis dysfunction may be one of the important pathophysiologic mechanisms in the development of major depressive disorder (MDD). Various laboratory tests including dexamethasone suppression test (DST) and cortisol awakening response assessing HPA axis functional reactivity have been conducted to investigate diagnostic validities in MDD. Major depressive disorder is a heterogeneous clinical syndrome in which various subtypes of major depressive disorder exist. Although researchers have not reached an unequivocal conclusion about HPA axis function changes in MDD, they have found differences in HPA axis hyperactivity among melancholic and atypical depression and Cushing’s disease. Functional changes in HPA axis may have diagnostic implications in differentiating subtypes of MDD. In addition, pituitary response to corticotropin releasing hormone may be associated with phenotypic difference of hypercortisolism between melancholic depression and Cushing’s disease. Further integration about this issue should be pursued in the future.

水素 이온 濃度變化가 平滑筋 細胞膜에서의 KCI 誘導 Ca-Uptake에 미치는 影響

昔廷鎬,林鍾鎬,李載欣 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

For the purpose of studying the properties of calcium channel, the effect of pH on the KCl induced Ca-uptake in the isolated porcine intestinal sarcolemmal vesicles, which were loaded with high KCl was investigated. The obtained results were as follows; 1. Ca-uptake in the membrane of depolarized state by high KCl, compared with that of polarized state by low KCl in the medium was increased significantly(increased about 95.7% for 30 seconds, pH 7.4). 2. Ca-uptake in the membrane of predepolarized state by high KCl, compared with that of polarized state by low KCl was also increased significantly but less than that of depolarized state by high KCl (increased about 66.7% for 30 seconds, pH 7.4). 3. Influence of pH on the Ca-uptake of various membrane state was increased or decreased according to pH changes. Ca-uptake in the membranes of incubated at pH 6.0 was decreased about 48.5%, but increased about 10% and 36% at pH 8.0 and 9.0 respectively, compared with that incubated at pH 7.4. 4. KCl-induced Ca-uptake at the various pH conditions, was not inhibited by the pretreatment of diltiazem(10^-6M). From the above results, it was concluded that KCl-induced Ca-uptake at the various pH conditions in the isolated sarcolemmal membranes, prepared from porcine intestinal smooth muscle, was not mediated through channels which are inhibited by organic Ca-antagonists.