[다층_석정호 수상소감] 요동치는 흔들림을 되찾을 계기

석정호 고요아침 2019 열린시학 Vol.24 No.3

[다층_석정호 수상작] 메롱 말매미 외 1편

석정호 고요아침 2019 열린시학 Vol.24 No.3

[다층_석정호 신작] 꽃

석정호 고요아침 2019 열린시학 Vol.24 No.3

급성 자발성 척수 경막외 혈종 2예 -증례 보고-

석정호,전진우,임윤희,우승훈,이우용 대한마취통증의학회 2012 Anesthesia and pain medicine Vol.7 No.3

A spontaneous spinal epidural hematoma (SSEH) is a rare disease that accompanies severe axial pain in the spine with various levels of paralysis depending on the location of the hematoma. A SSEH is mainly caused by a coagulating disorder or anticoagulants medication, while certain cases relate this disease with spinal inflammatory conditions. The early diagnosis of a SSEH is important for its treatment. Most cases with neurologic symptoms can be treated with an immediate laminectomy and decompression. If the neurologic symptom improves within 12 hours, a conservative treatment is effective; however few cases have been reported. We report this case with a review of the relevant literature.

Relationship between Negative Mental Adjustment to Cancer and Distress in Thyroid Cancer Patients

석정호,최원정,이용상,박청수,오영자,김종선,장항석 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.3

Purpose: Previous studies have reported that over a third of cancer patients experience significant psychological distress with diagnosis and treatment of cancer. Mental adjustment to cancer as well as other biologic and demographic factors may be associated with their distress. We investigated the relationship between mental adjustment and distress in patients with thyroid cancer prior to thyroidectomy. Materials and Methods: One hundred and fifty-two thyroid cancer patients were included in the final analysis. After global distress levels were screened with a distress thermometer, patients were evaluated concerning mental adjustment to cancer, as well as demographic and cancer-related characteristics. A thyroid function test was also performed. Regression analysis was performed to discern significant factors associated with distress in thyroid cancer patients. Results: Our regression model was significant and explained 38.5% of the total variance in distress of this patient group. Anxious-preoccupation and helpless-hopeless factors on the mental adjustment to cancer scale were significantly associated with distress in thyroid cancer patients. Conclusion: Negative emotional response to cancer diagnosis may be associated with distress in thyroid cancer patients awaiting thyroidectomy. Screening of mental coping strategies at the beginning of cancer treatment may predict psychological distress in cancer patients. Further studies on the efficacy of psychiatric intervention during cancer treatment may be needed for patients showing maladaptive psychological responses to cancer.

갑각류 골격근의 Sarcoplasmic Reticulum에서 칼슘유리

석정호,정정구,허강민,이재흔 大韓藥理學會 1994 대한약리학잡지 Vol.30 No.1

갑각류 골격근의 SR에서 칼슘유리 channel protein complex의 성격을 규명하기 위해 민물가재 및/또는 바다가재의 SR vesicles을 분리하여 <TEX>$^{45}Ca$</TEX> 유리, <TEX>$[^3H]ryanodine$</TEX>결합, 및 immunoblot 실험을 실시하여 다음과 같은 결과를 얻었다. 1.민물가재 SR의 <TEX>$[^3H]ryanodine$</TEX>결합 실험에서 민물가재 SR의 maximal binding site및 affinity모두 바다가재에서 보다 낮았으나, high affinity binding site이었다. Extravesicles 칼슘농도를 증가시켰을 때 <TEX>$[^3H]ryanodine$</TEX>결합은 약간 증가되었으나, AMP나 AMP와 caffeine을 동시에 첨가하였을 때는 현저히 증가되었다(p<0.05). 이런 증가 현상은 <TEX>$MgCl_2$</TEX>나 tetracaine으로 유의성 있게 억제되었으나(p<0.001), ruthenium red에 의해서는 약간 억제되었다. 2.민물가재 SR을 전기영동하였을 때 바다가재의 ryanodine receptor band (HMWBr)와 비슷하나 포유류의 것(HMWBS) 보다는 약간 빠른 mobility를 나타낸다. 3.바다가재 HMWBr에 대한 polyclonal Ab를 이용한 민물가재, 바다가재 및 토끼 골격근의 칼슘유리 channel간의 면역학적 교차반응에서 민물가재와 바다가재의 칼슘유리 channel 간에는 교차반응이 있었으나, 포유류의 것과는 아무런 반응이 없었다. 4.민물가재 SR에서 <TEX>$^{45}Ca$</TEX>유리는 extravesicles의 칼슘농도 증가에 따라서 증가되었고, 낮은 외부 칼슘 농도에서 바다가재 보다 빠르게 일어났으나, AMP와 caffeine에 의해 영향을 받지 않았고, <TEX>$MgCl_2$</TEX>와 tetracaine으로 약간(<TEX>$3{\sim}8%$</TEX>) 그리고 고농도의 ruthenium red로 중등도(23%) 억제되었다. 이상의 실험성적으로 갑각류 칼슘유리 channel protein은 포유류의 것과는 기능적으로나 면역학적으로 매우 다른 특징을 가지고 있고, 민물가재와 바다가재 칼슘유리 channel은 서로 유사한 특징을 갖지만, 민물가재의 칼슘유리 channel이 바다가재의 것보다 외부칼슘에 예민한 기능을 갖는 것으로 사료된다. To characterize the SR Ca-release channel protein complex of crustacean, <TEX>$^{45}Ca-release,\;[^3H]ryanodine$</TEX> binding, and immunoblot studies were carried out in the crayfish and/or lobster skeletal sarcoplasmic reticulum. Bmax and affinity of crayfish SR to ryanodine were lower than those of lobster SR. AMP (5mM) increased <TEX>$[^3H]ryanodine$</TEX> binding significantly in both vesicles (P<0.05). <TEX>$Mg^{2+}$</TEX>(5mM) or tetracaine(1mM) inhibited <TEX>$[^3H]ryanodine$</TEX> binding significantly in both vesicles (P<0.001), but ruthenium red <TEX>$(10\;{\mu}M)$</TEX> inhibited it moderately. In SDS polyacrylamide gel electrophoretic analysis of crayfish SR vesicles, there was a high molecular weight band that showed similar mobility with Ca-release channel protein of lobster skeletal SR, but more rapid mobility (HMWBr) than that of rabbit skeletal SR (HMWBS). Immunoblot analysis showed that polyclonal Ab to lobster skeletal SR Ca-release channel protein was react with HMWBr of crayfish skeletal SR, but not with that of HMWBs of rabbit skeletal SR. <TEX>^{45}Ca-release</TEX> from crayfish skeletal SR vesicles was increased by the increase of extravesicular calcium from <TEX>$1{\mu}M$</TEX> to 1mM. This Ca-release phenomenon was similar, but more sensitive in the low concentration of <TEX>$Ca^{2+}$</TEX>, compared to that from lobster SR vesicles. AMP (5mM) or caffeine (10mM) did not affect to <TEX>$^{45}Ca-release.\;^{45}Ca-release$</TEX> was inhibited slightly (<TEX>$3{\sim}8%\;by\;Mg^{2+}$</TEX>) (5mM) or tetracaine (1mM), and moderately (23%) by high concentration of ruthenium red <TEX>$(300\;{\mu}M)$</TEX>. From the above results, it is suggested that SR Ca-release channel protein of crustacean has different properties from that of the rabbit, and similar properties between crayfish and lobster in functional and immunological aspects, but Ca-release via crayfish channel may be more sensitive to calcium.

봄밤

석정호 고요아침 2018 열린시학 Vol.23 No.2

側腦室內 r-Aminobutyric Acid가 家兎賢臟機能에 미치는 影響

昔廷鎬 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

As a result of investigation to various changes of renal function after GABA administered into lateral ventricle of the rabbit, following results were obtained. 1. Urine flow, glomerular filtration rate, renal blood flow and urinary excretion of sodium and potassium were decreased in 20 minutes after intraventricular GABA(30 or 100㎍). And correlation coefficients between two parameter changes among them were statistically significant, respectively. 2. Intravenous GABA (100 ㎍) was not effect to renal function. 3. 30㎍ intraventricular GABA was not influenced to blood pressure, while 100㎍ GABA was transient decrease in blood pressure(15mmHg) but recovered within 10 minutes. 4. The effect of intraventricular GABA on the renal function was inhibited after regitine pretreatment (2mg/kg) intravenously. From the above results, it is suggested that the effect of intraventricular GABA on the renal function of rabbit is due to renal hemodynamic changes by central sympathetic stimulation.

ong-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death

석정호,박경아,변희선,원민호,신상희,최병렬,이현지,김영래,홍장희,박종선,허강민 대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.4

Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to the tumor necrosis factor (TNF) or the genotoxic stress including DNA damaging agents. Although it is known that JNK is activated in response to genotoxic stress, neither the pathways to transduce signals to activate JNK nor the primary sensors of the cells that trigger the stress response have been identified. Here, we report that the receptor interacting protein (RIP), a key adaptor protein of TNF signaling, was required to activate JNK in the cells treated with certain DNA damaging agents such as adriamycin (Adr) and 1-β-D-arabinofuranosylcytosine (Ara-C) that cause slow and sustained activation, but it was not required when treated with N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and short wavelength UV, which causes quick and transient activation. Our findings revealed that this sustained JNK activation was not mediated by the TNF (tumor necrosis factor) receptor signaling, but it required a functional ATM (ataxia telangiectasia) activity. In addition, JNK inhibitor SP-600125 significantly blocked the Adr-induced cell death, but it did not affect the cell death induced by MNNG. These findings suggest that the sustained activation of JNK mediated by RIP plays an important role in the DNA damage-induced cell death, and that the duration of JNK activation relays a different stress response to determine the cell fate.

Transverse myelitis following combined spinal-epidural anesthesia

석정호,임윤희,우승훈,연준흠 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.5