Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

운동성 산화 스트레스와 항산화비타민의 보충이 말초단핵세포의 NF-kB 활성에 미치는 영향

진영수,박건구,박준영,김미정,이왕록,김혜영,이한준,박은경 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Reactive oxygen species(ROS) are implicated in the pathogenesis of a wide variety of human diseases. Numerous studies indicate that ROS may serve as common intracellular molecules that contribute to the process of nuclear factor(NF)κB activation in response to a diverse stimuli. In our laboratory, we have demonstrated tat antioxidants could reverse the decline of immune function caused by exercise-induced ROS. Furthermore, it in necessary to understand a mechanism underlying ROS-dependent disorder in biological system. Recent studies have been shown that several gene expression were regulated by oxidants, antioxidants and other determinants of the intracellular reduction-oxidation(redox) state. In this process, NF-κB have been shown to play a important role. The purpose of the present investigation was to evaluate the effect of exercise-induced oxidative stress and antioxidnt supplementation on NF-κB activation in peripheral mononuclear cells. Forty male SD rats(4 weeks old) were randomly divided into noraml diet group and antioxidants(ATO) supplement group, and then ATO groups were treated with antioxidants(VE: 2001U/kg, VC: 50mg/rat, β-carotene: 300mg/kg, vitamin B6: 250㎍/100g, selenomethionine: 0.1mg/kg) for 16 weeks. After 16 weeks breeding at each condition, each group divided into two groups: Control group(CR) fed generally, Exercise group(CE) fed generally and followed by acute exercise 16 weeks later. Antioxidant Antioxidants and Exercise group(AE) fed with antioxidants and followed by acute exercise. The activation of NF-κB binding activity was increased after exhaustive exercise bout in both group. In addition, pretreatment of ATO group with the antioxidants mixture lead to the inhibition of NF-κB binding activity. This results suggest that NF-κB activation should be further studies in response to a variety of exercise.

주편 연속주조시 Thermal Soft Reduction 적용에 의한 중심 편석 개선

정영진,김지준,김선구,강충길 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.11

Centerline macrosegregation is one of the most significant problems in continuous casting on stainless steel slabs. Numerical model have been developed in order to decrease centerline macrosegregation during continuous casting of STS 420J2 stainless steel slab. Extra cooling zone and extra cooling water quantity are determined by iterative coupled analysis of heat transfer and segregation. Segregation ratio is decreased by the intensive cooling at the extra cooling zone above the solid fraction of the slab center 0.7, so called thermal soft reduction (TSR). The experimental results show good agreements with numerical results.

우리 나라 租稅制度의 所得再分配 效果

李常英,李俊求 서울大學校經濟硏究所 1996 經濟論集 Vol.35 No.2

우리 나라 조세제도의 부담분배에 관한 최근의 연구는 조세부담의 누진성이 점차 강화되는 방향으로 변화되고 있다는 분석결과를 제시하여 우리의 관심을 끌고 있다. 본 논문은 이와 같은 연구결과가 과연 현실을 정확하게 반영하고 있는지 다시 한번 그 결론의 타당성을 검증할 필요가 있다는 데서 그 출발점을 찾고 있다. 기존 연구가 갖는 방법론상의 문제점을 보완하고 새로운 시각에서 우리 나라의 조세제도가 부담분배의 측면에서 갖고 있는 성격을 분석하려는 것이 이 논문의 주안점이다. 본 연구는 대우경제 연구소에서 수집한 『1993년도 한국가구 패널조사』의 통계자료를 분석의 기초로 삼는다는 점에서 기존의 연구와 차이를 갖고 있다. 이 자료는 전국가구를 모집단으로 하여 표본조사한 미시자료라는 점에서 기존의 연구가 기초하고 있는 자료들에 비해 상대적인 장점을 갖고 있다. 또한 본연구는 탈세가 이루어지고 있는 사실을 명백히 고려에 넣었다는 점에서도 기존의 연구와 큰 차이를 보인다. 우리 사회에서 탈세가 광범하게 이루어지고 있는 것이 사실인데도 기존의 연구들은 이를 전혀 고려에 넣지 않았고, 그 결과 우리 나라 조세제도가 갖는 부담분배의 누진성을 과장해서 평가하게 되었다. 본 연구는 실제의 부담분배가 기존의 연구에서 밝혀진 것보다 훨씬 더 역진적이라는 분석결과를 제시하고 있다.

몸 개념을 통해서 본 현대도시에서의 공공성에 관한 연구

최호준,구영민 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

This study departs from the recognition of the absence of public sphere in the present time, when the human beings have become alienated by the rapid growth of technology and the progression of the society. The study intends to reexamine the public through the discourse of 'body' with its extension through media. The argument is focused on investigating the territories extended by the changes in the recognition of body, reviewing the public sphere through the body and its extension and the relationship with the others, and exploring any applicabilities of the new concept of the public sphere into today's city and architecture.

본태성 고혈압환자의 순응도에 관한 연구 IV : 의사개입과 제도개선의 합동효과 Effect of Combined Strategies Provided by Physician and Insurance

유원상,김용균,김준희,최석구,전영빈 인제대학교 1991 仁濟醫學 Vol.12 No.1

본태성 고혈압환자의 순응도 제고를 위하여 채택한 방책중 의사의 단독개입만으로는 13%의 통원탈락율의 개선, 보험급여 제도의 일부개선만으로는 3%의 악화에 비하여 양자 합동으로는 17%의 개선효과를 보았다. 따라서 진료의사의 좀 더 적극적인 개입과 보험급여의 진료일수제한 철폐가 요망된다. One hundred patients with essential hypertension, consecutively and newly diagnosed, were followed up at hypertension clinic of Paik Hospital to evaluate their compliance for 12 months with combination strategies provided by physician's intervention and extended insurance coverage. Rate of drop-out from reserved visit to clinic were 23% at the end of 3 months, 52% at the end of 12 month, which showed decrease, compared with 26%, and 63% respectively of ordinary management. In conclusion, in order to improve patient's compliance, a positive intervention by physician as well as lifting of insurance limitation should be intensified drastically.

병원단위의 임상진료지침 개발과정

신영수,김창엽,오병희,한규섭,윤병우,한준구,강영호 한국의료QA학회 1997 한국의료질향상학회지 Vol.4 No.1

Background : With increased concerns about variation among physician a practice pattern and their impact on the quality of care, clinical practice guidelines have been developed by many different organizations, with differing aims and incentives. From the same point of view, there is growing interest in the development of clinical practice guidelines in Korea, but with only a few examples. As a result, there is not much exploration on the incentive and barrier to development guidelines as well as description on the development process. The purposes of this study are to describe the process of the four different clinical practice guidelines in a hospital setting, and to identify incentives and barriers in the development of guidelines. Methods : For this research, a clinical practice guideline development committee and four clinical practice guideline development teams were organized in a university hospital which has more than 1,200 beds. Twenty eight doctors, three nurses, and one technician participated as members of development teams for eight months. Four to six meetings were held, and three to seven departments in the hospital were involved. Results : The topics which developed into clinical practice guidelines were cardiopulmonary resuscitation(CPR), blood transfusion, anticoagulation, and angiography. The main goals set by teams were education(CPR, angiography), risk management(blood transfusion), and to enhance quality of care(anticoagulation). Among four teams, only in the team for anticoagulation guideline medical record review and pilot-testing were performed. Also literature review was not carried out systematically. However, all the guidelines were developed by multidisciplinary participation by personnels of related departments. All the team expected guidelines to be used as standard protocols in the practice. Conclusion : Experience and skill in developing process has to be improved to have a more valid and useful practice guideline. In particular, literature review and problem identification by examining medical record should be emphasized. Also further studies of the clinical outcomes of the guidelines application and changes in physicians behaviors would be required.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

The Interval Between Initiation of Anti-tuberculosis Treatment in Patients with Culture-positive Pulmonary Tuberculosis and Receipt of Drug-susceptibility Test Results

Joon Sung Joh,Chang Hoon Lee,Ji Eun Lee,Young Kil Park,Gill Han Bai,Eui Chong Kim,Sung Koo Han,Young Soo Shim,Jae Joon Yim 대한의학회 2007 Journal of Korean medical science Vol.22 No.1

Sound Analysis in an In Vitro Endotracheal Tube Model

( Young Sik Park ),( Young Wook Kee ),( Kwang Suk Park ),( Jin Woo Lee ),( Sang Min Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Seok Chul Yang1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: Complete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to the lack of proper detection methods. We tested whether the sound of an endotracheal tube could be used to detect an endotracheal tube obstruction using an in vitro model. Methods: An endotracheal tube was connected to a ventilator on one end and a test lung on the other. Sounds were recorded with a microphone located inside the endotracheal tube via a connector. During mechanical ventilation, we changed the endotracheal tube internal diameter from 5.0 to 8.0 mm and different grades of obstruction at different sites were used along the tube. Sound energy was compared among the different conditions. Results: The energy of endotracheal tube sounds was positively correlated with the internal diameter and negatively correlated with the degree of obstruction. The rate of decline in energy differed with obstruction location. When the obstruction was more distal, the rate of decline in endotracheal sound energy was more rapid. Conclusions: Changes in the sound of an endotracheal tube can be used to detect an obstruction. Further studies are needed for clinical application.