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      • KCI등재

        Antithrombotic and Antiallergic Activities of Rhaponticin from Rhei Rhizoma Are Activated by Human Intestinal Bacteria

        박은경,추민경,Hae-KyungYoon,김동현 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.4

        To evaluate the antithrombotic and antiallergic properties of rhaponticin extracted from RheiRhizoma, the in vitro and ex vivo inhibitory activities of rhaponticin and its metabolite, rhapontigenin,were measured. These compounds inhibited in vitro ADP- and collagen-induced plateletaggregation. Rhapontigenin was more potent, with IC50 values of 4 and 70 mg/ml,respectively. In ex vivo ADP- and collagen-induced rat platelet aggregation, these compoundsalso exhibited a potent inhibitory effect. The antiplatelet aggregation effects of rhaponticin andrhapontigenin were more potent than those of aspirin. Rhapontigenin showed significant protectionfrom death due to pulmonary thrombosis in mice. Rhapontigenin also showed thestrongest inhibitory activity against b-hexosaminidase release induced by DNP-BSA. Thesecompounds inhibited PCA reaction in mice. Rhapontigenin intraperitoneally administeredshowed the strongest inhibitory activity and significantly inhibited PCA at doses of 25 and 50mg/kg, with inhibitory activities of 48 and 85%, respectively. The inhibitory activity of orallyadministered rhaponticin was stronger than that of intraperitoneally administered rhaponticin. These results suggest that rhaponticin, in the rhizome of Rhei Rhizoma, is a prodrug that hasextensive antiallergic and antithrombotic properties.

      • KCI등재후보

        중국보험법의 주요 개정내용과 그 시사점

        박은경 한중법학회 2010 中國法硏究 Vol.13 No.-

        The insurance contract law has experienced important changes in many countries worldwide. The issue concerning the duty to disclose in the insurance law holds an important position in these changes. Recently, Chinese Insurance Law has greatly been revised, and in particular, it has achieved the modernization of the duty to disclose. The changed system about the duty of disclosure is as follows: China has changed to the duty of voluntary disclosure, so that the prospective policyholder has a duty to answer the insurer"fs questions. This means Chinese Insurance Law makes a noticeable progressive in protection of policyholder. The Korean insurance industry has developed to a remarkable degree but Korean insurance contract law did not be updated since Dec. 31, 1991. So in order to cope with fundamental changes in the insurance environment, Korean insurance contract law should be revised in view of recent modernization of insurance law such as China, Germany, and Japan. The writer thinks that this work of revision has to be based on the comparative legal research. This paper aims at studying on the reform of the Chinese insurance law 2009, and the writer offers the proposals to Korean insurance contract law reform on the duty of disclosure system.

      • KCI등재후보
      • KCI등재

        The problems and suggestions of possible improvement of the current car insurance in Korea : Focusing on the compensation of personal injury

        박은경 제주대학교 법과정책연구원 2015 法과 政策 Vol.21 No.3

        Korean general insurance industry has grown fast. However, Korean auto insurance industry has experienced serious difficulties due to market saturation, high loss rate m.asiae.co.kr/view.htm?sec=n1&no=2008042408312091125 (the last access 2015.10.05.) and price regulations by authority lately. There have been various efforts to overcome the current difficult situation through the improvement and reform of automobile insurance system in Korea. There is a research proving that the current compensation system that embraces the principle of liability with fault and the liability insurance in relation to the motor vehicle accident which leads to physical injuries has a limitation on fairness, promptness, and efficiency. Firstly, looking from the fairness aspect, under the tort law compensation system, quite a few victims suffered physical injuries from motor vehicle accidents were not compensated at all, and many others who received the compensation were not appropriately compensated. Even sometimes, victims who received a serious bodily injury from motor vehicle accidents were given not enough compensation to cover their medical treatment. Secondly, looking from the promptness aspect, compensation process under the tort law compensation system is complicated and slow. As a result, victims are disadvantaged from it, this often leads to lawsuits. Thirdly, looking from the efficiency aspect, costs for operating the current compensation system is way too expensive. Younger the victim is and more serious the injury is, more court proceedings will be brought forward and the time for compensation will become even slower. This will later create transaction costs and therefore the compensation becomes inefficient. Kwon, Teckyeon, “Study on the Performance of the Personal Injury Reparation System from Automobile Accidents and the Recommendations for Future Development : The Implication of No-Fault Reparation Systems in Korea”, Sogang University, Thesis of Doctorate Degree, 2000, pp.163~172. In this context I have a very keen interest in Accident Compensation Act(AC Act) of New Zealand. In my research on the improvement of Korean automobile insurance compensation system I am trying to use AC Act of New Zealand as a model for legislation. So the purpose of this study is to examine the New Zealand accident compensation scheme, so called ‘No-fault insurance system’ But I think ACC is not a kind of insurance but belongs to a social contract. , focusing the compensation for car accident victims, A recent report shows us that public trust and confidence on the services of ACC is 60%, clients’ satisfaction is 76%, and levy payers’ satisfaction is 69% in June 2015.(“Improve our customers’ outcomes and experience”, ACC Annual Report, 2015, pp.14~15) and compare it with Korean auto liability insurance system and related laws. Thereby, I want to have useful implications for the reform of Korean automobile insurance system. This article will focus on compensating personal injury caused by car accident. Currently in Korea, the motor vehicle insurance (liability for bodily injury Ⅰ) is a compulsory insurance under the law, and also it is operated as a semi no-fault system. That is, if a driver cannot prove that a passenger had committed a suicide or had an intention to harm him or herself, a driver is liable for the compensation. Therefore, analysis of the New Zealand’s Accident Compensation Act and its outcome will become great resources in the future for us to be able to efficiently reform the motor vehicle insurance and the tort law based compensation system. Once Korea implements a one entity system (ACC) like New Zealand, issues like the conflict of compensation between social insurance and private insurance, and the problems arising from different insurance premiums will be resolved. Looking from the victim’s perspective, one entity system will provide a prompt compensation. Further, if the relevant costs can be re... Korean auto insurance industry has experienced serious difficulties due to market saturation, high loss rate and price regulations by authority. There have been various efforts to overcome the current difficult situation through the improvement and reform of automobile insurance system in Korea. In this context I have a very keen interest in Accident Compensation Act of New Zealand. New Zealand has an unique compensation scheme, so called ‘No-fault scheme’, for the injured people by accident including motor accident. 40 years ago, the New Zealand legislated ‘Accident Compensation Act’ by operated ACC for accomplishment the responsibility of society for the injured. In this paper, I will analysis the current situation and problems of Korean car insurance and examine NZ’s ACC. Thereby, I want to have useful implications for the reform of Korean automobile insurance system. This article will focus on compensating personal injury caused by car accident. Korean car insurance has several problems related in personal injury compensation. There are: Insufficient compensation for the victims, Inadequate compensation for the insureds, Increasing in lawsuits against insurers and Expensive medical fees. There are two ways in approaching the reform of the current Korean compensation scheme for physical injuries. Firstly, maintaining the framework of the tort law compensation system and the liability insurance in order to strengthen the social security through social welfare and social insurance. On the other hand, the compensation for a physical injury issues to be handled only by the social insurance process. The compensation system that acclimatized to the principle of liability with fault may be difficult to change it to the no-fault system straight away in the first place. However, it is important to take a step by step. Looking from the long term perspective, those steps will later shift from the fault based compensation system to the no-fault based compensation system; make worker’s compensation scheme and the accident compensation scheme unified; and finally it will become one entity system like New Zealand where all accident injuries covered under the ACC which are governed by the Accident Compensation Act. New Zealand's universal injury compensation scheme might resolve the problems of overlapped compensations by social insurance and private insurance and of different charges for medical treatments. And also it provides prompt compensations for injured persons and operates efficiently because all the processes take place in the one entity. In these respects this study on the New Zealand's accident compensation scheme will contribute to social cost reduction of the operation of auto insurance system in Korea.

      • KCI등재
      • KCI등재

        Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

        박은경,곽임수,이상엽,이창훈,이선희,김기형,정주섭,조희림,이승근 대한의학회 2014 Journal of Korean medical science Vol.29 No.1

        The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution of HPV infection among HIV-infected women in Korea. HPV DNA genotype and cervical cytology were examined in 60 HIV-positive women and 1,938 HIV-negative women. HPV genotypes were analyzed by using a HPV DNA chip. HIV-infected women had higher prevalence of high-risk HPV (hr-HPV) infection (30% vs 4.9%, adjusted odds ratio [AOR], 6.96; 95% confidence interval [CI], 3.63-13.34, P<0.001) and abnormal cervical cytology (18.3% vs 1.8%, AOR, 10.94; 95% CI, 5.18-23.1, P<0.001) compared with controls. The most common hr-HPV genotype detected in HIV-infected women was HPV 16 (10%), followed by 18 (6.7%) and 52 (5%). Prevalence of quadrivalent vaccine-preventable types (HPV 6, 11, 16, and 18) was 21.7% and 2.3% in HIV-positive women and HIV-negative women, respectively. Age was a significant risk factor for hr-HPV infection in HIV-infected women (P=0.039). The presence of hr-HPV was significantly associated with abnormal cervical cytology (P<0.001). These findings suggest that HPV testing for cervical cancer screening in HIV-infected women would be necessary, particularly among young age group.

      • KCI등재

        Follow-Up of Cryoablated Renal Cell Carcinoma with Residual Contrast Enhancement on CT and MRI

        박은경,성득제,박범진,김민주,한나연,조성범,강석호 대한영상의학회 2012 대한영상의학회지 Vol.67 No.5

        Purpose: To describe the characteristics of residual contrast enhancement (CE) in cryoablated renal cell carcinoma (RCC) with regard to eventual resolution and the presence of residual tumor on follow-up CT and MRI. Materials and Methods: 22 patients with 24 RCCs underwent laparoscopic renal cryoablation and follow-up CT (n = 19) and MRI (n = 3) for a mean of 28 months. Two radiologists retrospectively assessed the CT and MRI images for the tumor size and characteristics of residual CE in the cryolesions: peripheral rim (< 10% of the maximum cryolesion diameter), focal eccentric (10-25%), and thick internal enhancement (> 25%). Results: Residual CE was seen in 13 cryolesions (54%) at 3-month follow-up. Peripheral rim and focal eccentric enhancement was seen in six (25%) and four (16.7%) cryolesions, persisted for a mean follow-up of 4.5 and 6 months, and disappeared completely at a mean follow-up of 10.5 and 12 months, respectively. Three (12.5%) cryolesions showed persistent thick internal enhancement at 6-month follow-up, and were treated with radiofrequency ablation or chemotherapy. The cryolesions had decreased in size by an average of 20.2% and 39.7% at 6 and 12 months after cryoablation, respectively. Conclusion: Follow-up for ≥ 12 months is needed to assess treatment outcomes in patients with peripheral rim or focal eccentric enhancement of cryoablated RCCs, which may persist until 12 months postoperatively without remnant viable tumor.

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