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        • Rat에 있어서 Norfloxacin의 체내동태에 미치는 제산제의 영향

          전영빈,이광표 중앙대학교 약학연구소 1991 약학 논총 Vol.5 No.-

          The effect of antacids on the pharmacokinetic parameters(mean±S.E.) was inverstigated in rats. The pharmacokinetic data were evaluated by the residual method assuming one compartment open model. K_ei, t_1/2β, K_a, t_1/2α and Cp^max in the oral administration of norfloxacin were 0.138hr^-1, 5.05hr, 1.356hr^-1, 0.61hr, 10.074㎍/㎖, respectively and these parameter values were significantly increased or decreased according to the type of antacids, when norfloxacin and antacids were concurrently administered. AUC in case of the administration of norfloxacin alone was 62.49㎍ · hr · ㎖^-1, and AUC was significantly decreased in case of the concurrent administration of norfloxacin and antacids(except magnesium oxide 1×0.5g/kg and aluminum hydroxide gel 2×0.3g/kg). The bioavailability of norfloxacin was generally decreased by the coadministration of antacids on the basis of Cp^max, T_max and AUC data.

        • SCIESCOPUSKCI등재
        • 특이한 형태를 취한 거대 위선종의 내시경적 절제 1예

          전영빈,배원기,이승진,양대열,문정섭,유권 인제대학교 1998 仁濟醫學 Vol.19 No.2

          위선종은 세포 이형성을 가진 선상피의 양성 종양으로, 대부분 2cm 미만의 편평한 융기 형태를 취하며 6∼75%에서 악성 변화가 보고되고 있다. 다양한 내시경적 절제술이 시도되고 있는데 고장식염수-에피네프린 국주를 병용한 점막절제술(ERHSE)은 병변의 가장자리를 미리 절개함으로써 정확하게 완전 절제가 가능하다는 장점이 있다. 저자들은 주름 형태의 거대 위 선종에서 이러한 방법으로 완전 절제가 가능하였던 1예를 경험하여 보고하는 바이다. The gastric adenoma is a benign tumor of glandular epithelium with varying degrees of cellular atypia and with papillary and/or tubular structures. Macroscopically, the gastric adenoma usually looks like a plaque or a polypoid protrusion. The gastric adenoma is considered as a precancerous condition and should be removed. Many techniques have been developed to remove the adenoma. The technique of endoscopic resection utilizing the local injection of hypertonic saline-epinephrine(ERHSE), has the advantage of accurate resection by marking and precutting the resection margin with a needle knife. We report a case of 4.5×1.5cm sized, thickened fold-like adenoma, in a 65 year-old woman, which was successfully reseated with endoscopy using ERHSE technique. Pathological examination of the resected adenoma showed tubular adenoma wish severe dysplasia and focal adenocarcinomatous transformation.

        • Cushing 증후군 2예 : 부신피질 선종으로 인한 due to Adrenocortical Adenoma

          전영빈,이의용,김면호,박호진,유건,왕희정,이혁상,고일향 인제대학교 1984 仁濟醫學 Vol.5 No.3

          Cushing's syndrome is the clinical and metabolic disorder resulting from a chronic excess of glucocorticoids. Approximately 20-25% of patients with Cushing's syndrome have primary overproduction of cortisol and other adrenal steroids due to an adrenal neoplasm. We recently experienced two cases of Cushing's syndrome due to adrenocortical adenoma. The diagnosis was confirmed by clinical features, biochemical, hormonal and radiological studies and finally pathologic examination. A brief review of literature was presented and our cases were reported.

        • 콜레스테롤 담석형성의 병인론

          전영빈,유권 인제대학교 1993 仁濟醫學 Vol.14 No.1

          콜레스테롤담석 형성과정에 대한 이해를 돕고자 병인론에 관한 최신지견들을 요약 기술하였다. Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation. namely supersaturated bile, cholesterol nucleation leading to crystal fomation and finally retention of the crystals in the gallbladder resulting in stone formation. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation. For cholesterol gallstones formation all the above conditions must be achieved. In this review article, we summarized the recent concepts regarding the pathogenesis of cholesterol gallstone.

        • 고립성 위정맥류 출혈의 내시경적 치료

          전영빈,문정섭,유권 인제대학교 1999 仁濟醫學 Vol.20 No.1S

          고립성 위정맥류는 혈류량이 많고 혈행동태가 복잡하여 일단 출혈하면 사망률이 높은 질환이다. 과거 이러한 질환의 내시경적 치료는 실패하는 경우가 많았으나 최근 Histoacryl 등의 조직접착제 주입요법이나 detachable snare를 이용한 결찰요법 등의 우수한 지혈효과가 보고되면서 적극적인 내시경적 치료가 시도되고 있다. 저자들은 9명의 고립성 위정맥류 출혈환자에서 경화요법, O형 고무밴드 결찰요법, Histoacryl 주입요법, detachable snare 결찰요법 등을 단독 또는 병합요법으로 시행하고 이들 방법의 치료효과, 부작용 등을 연구하였다. Background/Purpose : Gastric variceal bleeding, especially from the isolated gastric varices, is one of the most serious complications of portal hypertension and is difficult to control. Recently, various endoscopic techniques have been tried for the management of gastric variceal bleeding. We tried several techniques of endoscopic treatments in patients wish hemorrhage from the isolated gastric varices and assessed the efficacy of each method in achieving initial hemostasis and preventing early recurrent bleeding. Patients and methods: Between September 1996 and December 1998, 9 patients wish hemorrhage from the isolated gastric varices were treaded with endoscopic techniques. Emergency endoscopy showed active bleeding(n=6) or clot on the isolated gastric varlces(n=3). All patients had underlying cirrhosis and 3 patients had associated hepatocellular carcinoma. According to Child-Pugh's classification, 2 patients were class A, 3 patients class B, and 4 patients class C. The location of the gastric varices was cardia in 3 patients, fundus in 2 patients, cardia and fungus in 3 patients, and greater curvature side of the upper body in a patient. The methods of treatments are as follow; 1) sclerotherapy with 5% ethanolamine oleate(n=1), 2) variceal ligation with rubber band(n=1), 3) Histoacryl(n=4), 4) detachable snare and Histoacryl(n=2), 5) detachable snare and sclerotherapy with 5% ethanolamine oleate(n= 1). Results: Endoscopic sclerotherapy with 5% ethanolamine oleate failed to control bleeding in a patient. Initial hemostasis was achieved with endoscopic ligation with rubber band in a patient. but the bleeding recurred after a few days and was treated with Histoacryl. Endoscopic treatment with HistoaLryl(n = 4) achieved excellent Initial hemostasis, and rebleeding did not occur. Combination therapy of detachable snake with other methods(n = 3) also successfully controlled bleeding. There was no significant complication related with endoscopic treatments. Conclusion: These results suggest that endoscopic therapy wish Histoacryl or detachable snare is a safe and effective method of treatment in bleeding isolated gastric varices.

        • SCOPUSKCI등재

          메페남산 캅셀의 용출에 미치는 계면활성제의 영향

          전영빈,김승인,김영일,Jun, Young-Bin,Kim, Seung-In,Kim, Young-Il 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.3

          Mefenamic acid has been widely used clinically as an anti-inflammatory analgesic. It has poor solubility in water $(41\;{\mu}g/ml)$ and there is the difficulty of dissolution in the mefenamic acid capsules. A study was made to investigate the effect of various surfactants on the dissolution of mefenamic acid capsules. The surfactants used were sodium lauryl sulfate (SLS), Pluronic F-68, F-77, and F-127. Mefenamic acid capsule containing surfactant showed significantly improved dissolution characteristics. The dissolution rate was fast in the order of SLS > F-77 > F-68 > F-127 in mefenamic acid capsules containing 0.2 w/w % surfactant. SLS was selected for further study on the bioavailability in rabbits. The area under the plasma concentration-time curve $(AUC_{0-24})$ of mefenamic acid capsule containing SLS was higher than one of mefenamic acid capsule not containing surfactant.

        • SCOPUSKCI등재

          아세트아미노펜 정제의 제조 및 평가

          전영빈,민병희,김승인,김영일,Jun, Young-Bin,Min, Byung-Hee,Kim, Seung-In,Kim, Young-Il 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.3

          A study was made to investigate the effects of various binders on the physical properties of acetaminophen granules and tablets prepared by wet and fluidized bed granulation methods. The binders used were povidone (K-90), hydroxypropylcellulose (HPC-L) and gelatin. The fluidized bed granules were more porous than the wet massed, and the tablets prepared by fluidized system showed improved disintegration and dissolution characteristics. The dissolution rate was fast in the order of gelatin>povidone>hydroxypropylcellulose in tablets prepared by fluidized system, and povidone>hydroxypropylcellulose>gelatin in tablets prepared by wet granulation.

        • 백서 간장에서 인슐린이 지방산 합성 효소의 전사 활성 조절에 미치는 영향

          전영빈 인제대학교 1993 仁濟醫學 Vol.14 No.3

          본 연구는 인슐린이 지방산 합성 효소의 전사 활성 및 전사 후의 함량조절에 미치는 영향을 관찰하기 위하여 백서에서 당뇨병을 유발시킨 후 인슐린을 처리하고 시간별로 백서 간장세포 내 지방산 합성 효소 함량, 전사 활성 측정 및 세포질 내 이 효소를 합성하는 mRNA를 정량 분석하여 인슐린에 의한 이 효소 함량 조절 기전을 밝히려하였다. An experiment was designed to make clear the regulatory mechanism of fatty acid synthetase(FAS) gene by insulin in the diabetic rats. Diabetes was induced in rat by the injection of streptozotocin(6mg/100g B. W ) and the amounts of FAS in the liver cytosol of rats were measured at 0,1,3,6,16 and 72 hours after subcutaneous administration of insulin (2.0 unit/100g B. W, ) by immunochemical method. The amount of FAS mRNA in the liver cytosol and the transcriptional activity of FAS gene in the liver nuclei were measured by Northern blot and slot blot hybridization using "P-labeled CDNA for FAS. The amount of FAS in the liver cytosol increased from 16 hours and reached maximum value at 72 hours after the insulin treatment. The amount of FAS mRNA in the liver cytosol did not change during the first 6 hours, and then Increased rapidly at 16 hours followed by a rapid decrease at 72 hours after the insulin treatment. The transcriptional activity of FAS gene did not change during the first 3 hours, but it increased at 6 hours and reached maximum value at 16 hours after Insulin treatment. From these results, it is concluded that the increase in the amount of FAS in the cytosol of rat liver by insulin treatment may be due to the increase of transcriptional activity of FAS gene, and that the Increased amount of FAS at 72 hours after the insulin treatment might be a reflection of the accumulation of the previously synthesized enzyme.

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