Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

Dong-Chun Lecture : Cell-based High Content Screening (HCS) for action modes of drug targets by using systematic deletion mutants of Schizosaccharomyces pombe

( Dong Uk Kim ),( Im Seon Woo ),( Mi Sun Won ),( Young Joo Jang ),( Kyung Sook Chung ),( Han Oh Park ),( Hyang Sook Yoo ),( Kwang Lae Hoe ),( Doo Sik Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

가공 및 측정이 가능한 복합나노가공시스템의 개발

장동영,박만진,김진현,한동철 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

In focused-ion-beam (FIB) application of micromachining and device transplantation, four kinds of FIB processes, namely FIB sputtering, FIB-induced etching, redeposition, and FIB-induced deposition, are well utilized. As with FIB systems, scanning electron microscopes(SEMs) were extensively used in the semiconductor industry. They are the tools of choice for defect review and providing the image resolution needed for process monitoring. The enhanced capabilities of a dual-column on one chamber system are quickly becoming realized by the nano industry for performing a wide range of application.

2급 응급구조사의 성인외상환자에 대한 처치의 적절성 평가

장문수,어은경,김상현,김창섭,송근정,박한규,유지영,최동섭 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

In Korea, EMT have two classified subgroup of first and second degree : EMT-P, and EMT. For the beginning, authorization of the first EMT was made in this year through the EMT educational program. There are 8 items which EMT can perform the treatment without the supervision by a physician. But there was no previous report of pertinent assesment of treatment performed by the EMT. There upon authors have conducted review of assessment done by the EMT in EC setting, and proposed the following treatment application can be used by EMT at the field of accident. The study materials include adult trauma patient older than 15 years, and sustained trauma within 48 hours before visiting Ewha University DongDaeMoon Hospital Emergency Deparment. The duration of study was from Apr. 1 1995 to Aug. 31 1995. the study was conducted by 5 certified EMT. The EMT's performance was evaluated by the attending Emergency Medicine physician. The result were as followings ; 1. Among the total 5532 ED visiting patients during the study period, 1267 were adult trauma patients who recieved treatment within 48 hours of injury. 2. Among 1222 out of 1267 patients have completed performed survey. 3. Male to female ratio was 2.6 : 1, age distribution was from 15 to 87 years old and mean age was 34.6 years old. 4. The MOI showed : MVA (33.1%), blunt trauma (29.9%), slip down (16.8%), penetrating injury(15.4%), and miscellaneous (5.7 %), burn (3.1%), falling down injury(2.9 %), bite injury(1.1%) in order. 5. There were 437 cases of survey completed by the EMT. For assessment of mental status of 3 different method : AVPU, 5 scale mental status and GCS, were correlated with EM physician with 99.1%, 98.6%, 97.7 %, respectively. 6. For 320 out of 437 cases of survey completed, 319 patients recieved treatment by the EMT within 30 minute and 1 patient between 30 to 60 minute of an ED arrival. 7. For those 437 cases of survey completed, 266 patient (60.9%) had adequate treatment and 54 patients (12.4%) had inadequate treatment. 67 patient (15.3%) did not received treatment but it was adequate inway, and 50 patients (11.9%) did not received treatment even though patient required treatment. In cases of adult trauma patients, EMT's mental status assessment was correlated with EM physician's assessment. But treatment done by EMT without the supervision of EM physician was adequate only in 76.2 %. Therefore, continuous education and assessment of treatment performed by EMT in needed to improve field treatment by EMT future.

장기간의 장거리 달리기가 골대사 마커에 미치는 영향

장성동,이은희,홍명엽,문성진,김주혁,이윤관,김영준 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

This study is purposed to analyse the effects of long-term & one-time 10km running exercise from bone metabolic marker change on bone metabolism. 7 male members(18.6±1.08) from a marathon club were subjected to the study. They were allowed to do long-term 10 km running training once a week for 6 months. And bone metabolism mark was determined according to the respective times : before/after 6 months training, before/after 10 km race, one day after the race, 3 days after the race. The examination items of bone metabolism mark were serum calcium, phosphorus, paratyroid hormone, osteocalcin, calcitonin, alkaline phosphatase in blood and calcium, phosphorus, deoxypyridinolin in urine. The results of study were as follows; 1) There was no change in deoxypyridinolin and alkaline phosphatase but there was significant change in calcitonin, paratyroid hormone and osteocalcin(p<.01). 2) There was no change of Calcium in serum and urine but there was significant change of phosphorus in blood(p<.01). To make a conclusion, it is determined that long-term 10 km running at low intensity and low frequency tends to restrict bone metabolism circulation, but exercise at a little high level activates bone metabolism into building up bones and absorbing bones and finally shows up high bone metabolism circulation, which is inferred to have an effective influence on bone health. It is considered there is a possibility that different exercise intensity, even same kind of exercise, influences on bone metabolism sdifferently.

ATM망에서 실시간 연결수락제어에 관한 연구

장혁,김영훈,김용수,김희철,나상동 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1

본 논문은 이질적 버스트 트래픽을 갖는 ATM(Asynchronous Transfer Mode) 망에서 실시간 연결 수락 제어를 위한 유체 흐름 모델(fluid flow model)에 기반을 둔 실시간 알고리즘을 제안한다. 셀 손실 확률은 QOS(Quality of Service)의 기준이 되므로 제안된 실시간 알고리즘은 일정한 메모리 크기와 연결 요청의 수락 여부 즉, 연결 수락 여부의 결정을 위한 하나의 영역을 필요로 한다. 이러한 트래픽 소스 각 타입에 대한 셀 손실 확률은 트래픽 소스 타입 전체에 하나만 존재하더라도 요구를 충족 시킬 수 없으므로, 본 논문에서 제안된 실시간 알고리즘에 의해 산출되는 각각의 셀 손실확률에 충분한 상한선을 제공하는 전형적 트래픽 매개변수를 사용하여 성능을 분석한다.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업의 효과와 학생들의 인식

장진아,이경희,박소영,김동진,최병순,박국태 韓國敎員大學校 敎育硏究院 2009 敎員敎育 Vol.25 No.3

이 연구는 7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업이 중학교 1학년 학생들의 개념 이해와 학업 성취도에 미치는 효과와 학생들의 인식을 알아보기 위한 것이다. 연구를 위하여 S시 소재 Y중학교 1학년 3개 학급 107명을 실험집단l파 실험집단2 및 통제집단으로 나누어, 실험집단l에는 학생간의 사회적 상호작용을 강조한 탐구실험 수엽을 실시하고, 실험집단2에는 교사와 학생간의 사회적 상호작용을 강조한 탐구실험 수업을 실시하였으며, 통제집단에는 전통적인 실험 수엽을 실시하였다. 수업 전과 후에 개념 이해도 검사를 하였으며, 성취도 검사와 인식 조사는 수업 후에 실시하였다. 연구 결과에 의하면, 실험집단1과 섣험집단2의 사회적 상호작용을 강조한 탐구싣험 수업이 통제집단의 전통적인 설험 수엽에 비하여 분자의 운동에 대한 개념 이해에 효과적이었다. 학업 성취도에 있어서는 사회적 상호작용을 강조한 실험집단1과 실험집단2의 학업 성취도 평균이 통제집단의 학업 성취도 평균에 비해 통계적으로 유의마하게 높았다. 실험집단1과 실험집단2의 학생들은 전반적으로 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업을 긍정적으로 인식하였다. 실험집단1에서 인지수준이 높은 학생들은 명확하게 답을 제시해 주는 것보다 동료와의 상호작용을 통해 시행착오를 거치면서 스스로의 힘으로 문제를 해결함으로써 자신감과 만족감을 느꼈다. 실험집단2에서 인지수준이 중하위인 학생들은 애매하고 시행착오적인 동료와의 상호작용보다는 교사와의 상호작용을 통해 직접적으로 답에 이르고 명확하게 개념 정리를 해주는 것을 선호하였다. The purpose of this study was to investigate effects of the inquiry experiment instruction emphasizing social interaction in the 7th grade motion of molecules unit on middle school students' scientific concept, achievement, and the perception of the instructions. For this study, 107 7th grade students were divided into three groups: the experimental group I, the experimental group 2, and the control group. The experimental group 1 were given inquiry experiment instruction emphasizing student-student interaction and the experimental group 2 were given inquiry experiment instruction emphasizing teacher-student interaction, while the control group were given traditional experiment instruction. They were all tested on their level of scientific concept understanding before and after the instruction and after the instruction they were given achievement test and surveyed on their perception. According to the result of this study, the inquiry experiment instruction emphasizing social interaction of experimental group 1 and 2 was more effective than the traditional experiment instruction of the control group in understanding the scientific concept of molecular motion, and the achievement level of experimental group 1 and 2 was significantly higher than the control group. Generally both students of group 1 and 2 were found to affirmatively perceive the inquiry experiment instruction emphasizing social interaction in the motion of molecules unit. Students of group 1 with high cognitive level were satisfied when they were able to independently solve problems by trial and error through student-student interaction than being given the exact answers. Meanwhile students of group 2 with middle to low cognitive level preferred the inquiry experiment instruction emphasizing teacher-student interaction that easily and cleary gives them the correct answer than student-student interaction which can be obscure and requires trial and error.

배추김치의 부재료와 관능적 품질

장경숙,김미정,오영애,김미향,이명숙,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-

배추김치의 부재료로서 고추, 마늘, 생강, 파, 부추, 멸치젓, 설탕 등이 젖산균 starter로써 숙성시킨 김치의 신맛, 단맛, 짠맛, 쓴맛, 매운맛, 감칠맛, 덜익은맛, 사각사각한맛, 불쾌한맛, 종합적인맛, 새콤한내, 풋내, 비린내, 마늘내, 군덕내, 색상 등 관능적 품질에 미치는 영향을 조사하였다. 그 결과 부재료 개별적으로는 균형된 조화미가 나타나지 않았으나 상호 혼합처리함으로서 맛의상호보완과 조화를 이루었다. 고추, 마늘, 생강 등의 단독처리로는 오히려 불쾌한 맛과 냄새를 가져다 주었으나 다른 부재료와 함께 존재할 경우 불쾌한맛과 군덕내, 풋내등 바람직하지 못한 맛과 냄새를 감소시켰다. 파와 부추는 강한 마늘내를 조화시켰으며 멸치젓은 감칠맛을 부여하였으며, 설탕은 종합적인 맛을 향상시켰다. 또 설탕을 제외한 대부분의 부재료는 산미를 감소시키는 효과를 나타내었다. Effects of various ingredients(hot pepper, garlic, ginger, leek, green onion, fermented anchovy juice and sugar) on the sensory quality of fermented Korean cabbage kimchi were investigated. Sixteen sensory attributes were selected and the intensity of the attributes were evaluated by 20 panels. The sensory quality of Korean cabbage kimchi fermented with only one ingredient had unharmonized taste and unplesant flavor. The inhibitory effect of undesirable flavor and the effect of mutal assistance of taste were shown in the kimchi fermented with mixed ingredients. Hot pepper, ginger and garlic contributed to reduction of undesirable flavor like unpleasant and moldy taste. Strong garlic flavor was slightly reduced and harmonized by adding green onion and leek. Fermented anchovy juice produced palatable taste in the kimchi containing all of the ingredients, and overall eating quality was improved by adding sugar. All of the ingredients expect sugar showed reducing effect of sour taste.