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당뇨병을 동반한 한국인 고지혈증 환자에서의 atorvastatin의 유효성 평가
최동섭,김덕규,김성연,남문석,박용수,손호상,안철우,이관우,이기업,이문규,정춘희,차봉연,김두만 대한당뇨병학회 2006 Diabetes and Metabolism Journal Vol.30 No.4
연구배경: NCEP ATP III 가이드라인에 의하면 당뇨병을 관상동맥질환 위험인자로 분류하여, 당뇨병을 동반한 고지혈증 환자의 적극적 치료를 권장하고 있다. 이에 시판 후 조사를 통해 당뇨병을 동반한 고지혈증 환자에서의 atorvastatin의 유효성과 안전성을 평가하기 위해 본 연구를 시행하였다.방법: 2004년 3월부터 2004년 9월까지 내분비내과를 방문한 고지혈증 환자 중 atorvastatin을 처음 투여 받은 환자를 대상으로 개방표지, 다기관, 비비교, 가변용량 연구를 실시하였다. 전국 66개 병원에서 96명의 내분비 전문의가 본 연구에 참여하였다. 총 2,182명의 환자가 등록되었으며, 이 중 당뇨병을 동반한 환자는 1,514명이었다. 유효성 평가는 atorvastatin을 4주 이상 복용하고, 기초 및 4주 이후에 총콜레스테롤 수치가 측정된 환자를 대상으로 이루어졌고, 안전성 평가는 atorvastatin을 1회 이상 투여한 모든 환자를 대상으로 이루어졌다. 연구자들은 환자 등록 시점에 당뇨병 동반 여부를 확인하였다. Atorvastatin을 최소 4주 이상 투여한 후, 총콜레스테롤, 중성지방, 고밀도지단백 및 저밀도지단백 콜레스테롤을 측정하도록 하였으며, 투여 전후의 각 수치의 변화율로부터 유효성을 평가하였다. 저밀도지단백 콜레스테롤의 치료목표인 100 mg/dL 미만을 달성한 환자의 비율도 분석하였다. 또한 이상반응 발현 여부 및 임상검사치의 이상 여부로부터 안전성을 평가하였다.결과: Atorvastatin 투여 후 당뇨병성 고지혈증 환자에서 총콜레스테롤, 중성지방, 저밀도지단백 콜레스테롤의 수치가 각각 26.6%, 12.0%, 34.8%의 높은 감소율을 나타냈으며, 100 mg/dL 미만의 저밀도지단백콜레스테롤을 가진 환자도 2.8%에서 52.6%로 크게 증가하였다. 총 2,182명의 환자 중에서 32명의 환자가 이상약물반응을 보고하여 1.5%의 발현율을 보였으며 매우 안전한 것으로 생각되었다. -Background: NCEP ATP III Guideline recommends aggressive treatments of diabetic dyslipidemia, recognizing diabetes mellitus as CHD risk equivalents. This study was conducted to evaluate the effectiveness and safety of atorvastatin in hyperlipidemic patients with Type 2 diabetes mellitus through post-marketing drug use investigation of atorvastatin.Methods: An open, multi-center, non-comparison, titrated dosage study was conducted in hyperlipidemic patients, who were treated with atorvastatin at first visiting hospitals from Mar. 2004 to Sep. 2004. 96 endocrinologists participated from 66 centers in this study. Total 2,182 hyperlipidemic patients were enrolled and 1,514 patients among them were accompanied by diabetes mellitus. Efficacy was evaluated at later than 4-week treatment by % change of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol from baseline. Percent of patients reaching LDL-cholesterol level less than 100 mg/dL was also analyzed.접수일자: 2006년 4월 24일, 통과일자: 2006년 7월 5일, 책임저자: 최동섭, 고려대학교 의과대학 내분비내과* 이 연구는 한국화이자제약㈜의 연구비 지원으로 이루어졌음.The adverse events incidence and abnormalities of clinical laboratory values were evaluated for safety monitoring.Results: Total cholesterol, triglycerides, and LDL-cholesterol level were reduced by 26.6%, 12.0%, and 34.8%, respectively, in diabetic hyperlipidemic patients after atorvastatin treatment. The patients with LDL-cholesterol level of less than 100 mg/dL were increased from 2.8% to 52.6%. Atorvastatin was considered to be safe because adverse drug reactions were reported in 32 patients (1.5%) of total 2,182 patients.Conclusion: Atorvastatin was effective and safe in hyperlipidemic patients with type 2 diabetes mellitus. (J Kor Diabetes Assoc 30:292~302, 2006)
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최동섭,우태하 대한피부과학회 1972 大韓皮膚科學會誌 Vol.10 No.2
One of the most interesting subjects in the field of dermatology has become the clarifying of the action mechanism of various drugs in promoting skin permeability in regard to their usefulness or harmfulness to various skin diseases. Although dimethyl sulfoxide (DMSO) detergents and propylene glycol were well known as having a promoting effect on the skin permeability, but the exact action mechanism of them was still unknown because of difficulty in methodology. So an attempt to clarify the action mechanism and find out the differences in the mode of action between them have been made by using frog skin, which has been used in research for the 'membrane transport', during past but having complex structures i.e. soley as 'skin' in this study was done. Abdominal skin was removed from frogs, Rana nigromaculata, captured on the area of Kyung Ki Do. In a series of experimental procedures about effect of experimental agents, short circuit current (SCC) as an estimate of net flux of sodium transport and potential difference (PD) was measured by the method of Ussing and Zerahn(1951). And changes of SCC and PD was observed during treatment with bathing mediums which contained agents and maintained iso-osmorality by varying amount of sodium chloride. These were compared including the effect of concentration of each experimental agent. The experimental agents used were DMSO and various detergent, i.e., sodium lauryl sulphate(SLS): anionic detergent, benzalkonium chloride (BAC): cationic detergents, and 'Tween-80: nonionic detergents. Results obtained are summarized on the followings. 1. The promoting effect of the sodium lauryl sulphate on the active sodium transport was reached to maximum within 10 to 20 min and was present until 40 min. after bathing with it, and thereafter, sodium transport was inhibited irreversibly at the both sides of the frog skin. And the maximal promoting effect of the SLS induced by increasing concentration had relationship in such a way on the saturation curve. 2. The active sodium transport was always increased on the inside of the frog skin after bathing with benzalkonium chloride (BAC) and in spite of changing of bathing medium with Ringer's solution, the active sodium transport was steadiIy increased even beyond the effect of BAC except temporally decreasing just after the bathing with Riger's solution. But the frog skin died within 20 min. at the outside after bathing with BAC. 3. Tween-80 brought about reversible reaction increasing the active sodium transport across the frog skin at the inside after bathing. And it seemed to be parallel to the degree of tle coneentration of it. 4. The effect of dimethyl sulfoxide (DMSO) on the active sodium transport across the frog skin was altered seasonaly, i.e., promoting sodium transport during the summer months hut inhibiting it during the winter months. So it was suggested that the action of DMSO on the sodium transport depends on the metabolic rates of the frog skin and the action differed from that of ADH hormone which promotes the sodium transports only in winter months. Also the effect of the DMSO differed from various detergents in view of seasonal variation and reversibility of the action of it. From the above resu]ts, this experimental method should be used more preferably using isolated frog skin in the research for clarifying the action mechanisms of the various other drugs in skin permeability.
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최동섭,Jiyull Kim,김나연,주지봉 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
Designing Ni-based catalyst with high performance is one of the most important challenges for operationof practical steam-methane reforming (SMR) processes. We report control of the textural properties ofcommercial alumina ball for Ni-supported catalysts in SMR. The textural properties of the commercialAl2O3 sphere are successfully controlled by aqueous HCl treatment for elongated periods. The pore diametersand pore volumes of the controlled alumina supports are finely tuned by varying the HCl treatmentperiod. The catalytic activity of the corresponding Ni-supported alumina is significantly enhanced withincreasing HCl treatment period on alumina ball. The alumina supports with longer HCl treatment periodhave larger pore size and bigger pore volume, and the corresponding Ni-Alumina catalysts exhibitedhigher catalytic activity at even higher space velocity, due to the increased intraparticle diffusion of reactantmolecules inside the catalyst. Ni-supported alumina catalyst prepared by using alumina supporttreated with HCl for 18 h showed the largest pore size and pore volume, revealing enhanced catalyticactivity in terms of CH4 conversion and H2 yield. It showed the well-maintained activity without any furtherdeactivation in both continuous operation for 24 h and cyclic operation at different WHSVconditions.
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