Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

실천적 추론 가정과 수업이 중학생의 도덕성에 미치는 효과

채정현,유태명,박미정,이지연 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.12

The purpose of thii study was to develop lesson plans and teaching materials applying practical reasoning instruction for the 7th home economics cuniculum content, and to test the effects of practical reasoning instruction on morality of middle school students. This study is a quasiaperimental research with a pretest-postkt &qn. Practical reasoning instruction for experimental group and traditionally lecture oriented insbuction for comparison group were input, and tested the statistical differences between two groups before and after the treatment. The subjects for this study were 8th grade students of a mi& school located in Kwangiu city. Two classes of 76 students homogeneous in characteristics and academic record for each experimental and comparison group were assigned. lnstnunent used for this study was a revised moral indicator, that was developed by KEDI(2001). Spss/wi for 10.0 statistics program was used for analysis of data. ANCOVA was done for testing statistical difference been pretest and posttest of experiment group and comparison group. Result of study which showed statistically significant difference between groups were: 1. V i e of responsibility for words and deeds (from 3.22 to 3.61 for experimental group and from 3.27 to 3.26 for comparison group) in domain of responsibility and cooperation, and virtue of punduality (from 3.59 to 3.76 for experimental group and from 3.41 to 3.28 for comparison group) in domain of trustworthiness, 2. V i e of conversation etiquette (from 3.47 to 3.67 for experimental group and from 3.28 to 3.31 for comparison group) in domain of caring for others, 3. Virtue of forgiveness other s mistakes (from 3.32 to 3.65 for experimental group and from 3.33 to 3.25 for comparison group) in domain of kindness, concession, forgiveness, and virtue of volunteering activity from 2.89 to 3.71 for experimental group and from 3.36 to 3.45 for comparison group) in domain of compassion and service, 4. Virtue of equip the convenient facility for handicapped (from 4.19 to 4.29 for experimental group and from 4.17 to 3.91 for comparison group) in domain of equality and human rights, virtue of recovering selfness for own community (from 2.34 to 2.79 for experimental group and from 2.14 to 2.29 for comparison group), virtue of opposing way of accomplishing purpose by all means (from 3.27 to 3.31 for experimental group and from 3.47 to 3.05 for comparison group), virtue of opposing election of considering aquaintance (from 3.35 to 3.56 for experimental group and from 3.12 to 3.14 for comparison group) in domain of fairness, and virtue of eradication of military force or violence among countries (from 3.49 to 3.57 for experimental group and from 3.38 to 3.05 for comparison group) in domain of love for humanity. The morality of experimental group was improved more than that of comparison group in all of above items. From the results of thii study, following conclusion was drawn. Practical reasoning insbudion in home economics is effective in raising students virtue and value of responsibility in words and deeds, trustworthiness in punctuality, courtesy of not intempting conversation, forgiveness of other s mistakes, volunteering activity, equity for handicapped, fairness opposing selfness for own community, fairness opposing way of accomplishing purpose by all means, fairness opposing election of considering acquaintance, and love for humanity opposing war.

자궁경부의 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53 및 E-cadherin 발현양상

서재홍,양정원,성정희,오수섭,이미자 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives: Correlation of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression was analyzed in cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and microinvasive and invasive squamous cell carcinoma (SCC) according to human papilloma virus (HPV) inffection. Materials and Methods : (23 CIN 1, 28 CIN 2, 23 CIN 3), 18 CIS, and 24 SCC. Results: Expression of cyclin E was significantly higher in CIN 2, CIN 3, CIS and SCC than CIN 1 with or without HPV infection. Expression of bcl-2 was significantly higher in CIN 3 than SCC. There was no association between expression of p27 and VEGF and progression of CIN 1 to SCC. Expression of p53 was significantly high in CIN 3, CIS and SCC with or without HPV infection. Expression of the E-cadherin was significantly high in CIN 2, CIN 3, CIS and SCC with or without HPV infection. Conclusion: There was correlation between expression of cyclin E, b치-2, ㅔ53, E-cadherin and progression of CIN to SCC. It is suggested that cyclin E may play an important role in the neoplastic transformation of cervical squamous cell.

생애주기비용과 계층적분석과정 기반의 최적 교량대안 선정

장미숙,정근채 충북대학교 건설기술연구소 2004 建設技術論文集 Vol.23 No.1

The value of a structural system is dependent on the performance and the cost. To increase the value of a structural system, we should increase the performance and decrease the cost at the same time. When selecting an adequate alternative among various candidates, we should consider criteria both in performance and cost. In this paper, we propose an Analytic Hierarchy Process based methodology for selecting the optimal bridge alternative among various candidate bridges, which consider multiple evaluation criteria simultaneously. The proposed selection methodology can give the optimal alternative by using not only general qualitative criteria such as sociality, shape and constructibility, but also quantitative criteria such as life cycle cost, structural stability, usability, and environment. However, the proposed methodology is difficult to use manually since it requires much information and complex analysis models. To overcome the lack of practical usability, we also propose a framework for a decision support system which can help the decision maker by using information technology. We expect that the proposed selection method and the decision support system framework can be used as a useful tool for initial planning of structural systems, especially bridges.

정신분열병 입원 환자에서 단축형 증상관리 훈련의 효과:예비적 연구

최충식,채정호,우동원,최영희,함웅,이규항,장미화 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

연구목적: 정신분열병 환자에서의 재활치료는 개인의 극복 기술과 능력을 향상시키고 재발을 유발시킬 수 있는 스트레스의 부정적인 영향을 중화시킴으로써 질병의 만성화를 막고 사회기능을 호전시킬 수 있기에 점차 그 중요성이 대두되고 있다. 본 연구는 만성 정신분열병 입원 환자에서 재활치료의 하나인 단축형 증상관리 훈련이 정신장애에 대한 자기 인식에 미치는 효능을 알아보기 위하여 시행되었다. 방법: 정신분열병으로 진단받고 입원 중인 환자들에게 재발경고징후를 규명하는 것, 재발경고징후를 관리하는 것, 지속증상을 극복하는 것, 술과 불법 약물을 피하는 것 등으로 구성된 승인-UCLA 사회기술 및 독립적인 생활기술훈련 단위 중 증상관리단위를 기초로 한국실정에 맞게 축약한 증산관리 훈련을 주 1회, 60분씩, 4∼5주간 실시하였고 실시 전후에 전신장애 비인식 평가 척도(Scale to Assess Unawareness ofMental Disorder; 이하 SUMD)로 자신의 정신장애에 대한 인식을 평가하였으며 임상적 전반적 인상(Clinical Global Impression;이하 CGI)로 임상 상태를 조사하였고 각 인구학적 변인들을 조사하였다. 결과: 환자 30명이 훈련을 완수하였으며 이들의 평균 연령은 36.6±7.6세였고 남자가 14명(46.7%), 여자가16명(53.3%)이었다. SUMD 점수는 훈련 전 16.9±4.0점에서 훈련 후 12.9±4.2점으로 유의하게 줄어 정신장애에 대한 자기 인식 정도가 향상되었으며(p<0.01), CGI도 훈련전의 3.7±0.9점에서 훈련 후 2.8±0.8점으로 유의하게 호전되었다(p<0.01). 환자의 연령, 발병시 연령, 유병 기간, 입원 기간, 항정신병약물 사용 용량, 교육 정도, CGI로 평가한 임상 상태등은 정신장애의 자기 인식 정도와는 관련성이 없었다. 결론: 정신분열병 입원 환자에서 단축형 증상관리 훈련은 정신장애에 대한 자기 인식을 증가시킬 수 있는 방법이 될 가능성을 확인하였으며 이 방법이 정신분열병 재활치료의 중요한 요소가 될 수 있음을 알 수 있었다. Objectives : The purpose of this study was to examine whether Symptom Management Module-Korean Brief Version(SMM-B) is effective as a psychosocial treatment of the inpat-ients with chronic schizophrenia. We also questioned which of demographic and clinical characteristics could be predictors of differential treatment response. Methods : The subjects were composed of 30 inpatients with chronic schizophrenia, who were trained with weekly session of SMM-B for 5 weeks. Before and after the training, the level of psychopathology, knowledge about schizophrenia were assessed as dependent variables by using Clinical Global Impression(CGI) and Scale to Assess Unawareness of Mental Disorder(SUMD). Results : Overall, patients showed improvement over the treatment period on psychopath-ology as well as knowledge about psychosis. Total scores of SUMD were changed from 16.9±4.0 before training to 12.9±4.2 after training(p<0.01) and scores of CGI were improved from 3.7±0.9 to 2.8±0.8<p<0.01). Howver age, gender, years of education, age of onset, duration of illness, duration of admission, numbers of psychiatric admission, and clinical status evaluated by CGI were not correlated with unawareness of psychosis. Conclusion : These results suggest that SMM-B could be a reliable method to improve self-aw-areness of psychosis in patients whth chronic schizophrenia and one of important elements in rehabilitation.

Helicobacter pylori가 만성위염과 위종양에 미치는 영향에 관한 면역조직화학적 밑 초미세구조적 연구

문경래,정순봉,이미숙,이미자,서재홍,김만우,박찬국 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Helicobacter pylori (H. pylori) is accepted as a principal cause of chronic gastritis and an important factor in the pathogenesis of peptic ulcer and gastric malignancy. The aim of our studies is to investigate relationships between H. pylori and gastric epithelial cells. Materials ðods : One hundred and eighty one H. pylori positive cases of gastric biopsy specimens were studied immunohistochemically and ultrastructurally. Results : p53 positive staining exhibited foveolar epithelial hyperplasia in 1 out of 32 cases, regeneration in 2 out of 12 cases, incomplete intestinal metaplasia in 5 out of 41 cases, complete intestinal metaplasia in 3 out of 18 cases, chronic ulcer in 1 out of 9 cases, tubular adenoma in 2 out of 14 cases and intestinal type of adenocarcinoma in 16 out of 21 cases. Ultrastructurally, H. pylori was observed to be in direct contact with the microvilli of the target cells and was demolishing the surface microvilli. The organisms were in close contact with the uncoated cell membrance. Penetration into the gastric cells by a few organisms was associated with marked cell damage and ultimately to cell disintegration. Conclusion : Our results suggest that H. pylori plays a role in the pathogenesis of gastric cancer, leading a relatively slow, long lasting process that induces chronic active gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma of intestinal type.

유방암종에서 p53, cyclin D1 및 cathersin D 단백발현의 의의

문경래,김환정,이미자,기근홍,서재홍,양정원,조현진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives: Breast carcinoma is a heterogenous disease. The prognosis of this carcinoma correlates with various prognostic factors. The aim of this study was to assess the prognostic significance of expression of p53, cyclin Dl and cathepsin D protiens in association with various prognostic factors in invasive breast carcinoma. Materials and Methods: The relationship is presented between expression of p53, cyclin D1 and cathepsin D by immunohistochemistry and various established prognostic factors such as tumor size, histologic grade, lymph node status and extensive intraductal component in 55 cases of invasive breast carcinoma. Results: No significant correlations were observed between expression of p53, cyclin Dl and cathepsin D and tumor size. The expression of p53 correlated with high histologic grade. The expression of p53 and cyclin Dl correlated with lymph node metastasis. Conclusion: These results indicate that expression of p53 and cyclin Dl in invasive ductal carcinoma may be an important prognostic factor, closely related to the high histologic grade and lymph node metastasis.

박물관 브랜드 마케팅 및 공간 프로모션 전략 -숙명여자대학교 내 정영양자수박물관 C·E·M 공간디자인을 중심으로-

김은애,김예은,정채림,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 정영양자수박물관의 콘텐츠를 활용한 통합 브랜드를 개발함에 있어 브랜드·디자인 ·마케팅을 융합한 시점에서 바라보고 그래픽아이덴티티, 제품아이덴티티, 공간아이덴티티 통합브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구는 기존의 박물관 방문자들과 20-30대 여성을 대상으로, 디자인과 마케팅의 융합된 측면에서 도출된 ‘C·E·M’을 物, 事, 人, 場가 융합된 문화로 한정한다. 그 결과, ‘C·E·M’은 디자인과 마케팅 전략을 융합하여 로고 및 사인물의 그래픽디자인부터 제품디자인, 공간디자인에 이르기까지 일관성과 객관성, 스토리성을 도출한다. 끝으로 본 연구는 브랜드가 디자인과 마케팅을 융합하여 더 체계화된 G·I, P·I, S·I의 통합 브랜드 매뉴얼을 만든 것에 의의가 있다. 아울러 향후 이와 관련된 통합브랜드 디자인 개발에 있어서 기초 자료로 활용될 것으로 기대된다

오감각적 자극과 감성 브랜드 프로모션 공간 연출 디자인에 관한 연구 -마임 건강식품 알로주스 프로모션 연출을 중심으로-

김은애,김예은,정채림,진산,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 최근 감성중심의 디자인 환경에서 화두되고 있는 ‘오감’을 활용하여 브랜드 프로모션 공간을 연출하는 일련의 프로세스를 제안하는데 목적이 있다. 본 연구 범위는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출디자인> 수업에서 진행된 수업의 결과물로서 4개 팀 중 1개 팀의 작업물이다. 연구방법은 오감에 대한 문헌 연구와 융합연출 디자인 조사 정리한 사례 연구로 한다. 그 결과 본 연구는 산업체 <마임>과 연계하여 오감을 융합하는 쇼케이스 프로젝트부터 실제 브랜드 프로모션 공간 연출에 이르기까지 건강식품에 대한 브랜드의 일관성과 감성, 스토리성을 제시하였다. 끝으로 본 연구는 오감 을 활용한 공간 연출 디자인으로, 브랜드와 실질적으로 융합하여 브랜드를 프로모션함에 있어서 감성적인 접근방안을 제시 한 것에 의의가 있다. 또한 향후 본 연구는 이와 관련된 공감각, 오감을 담은 브랜드커뮤니케이션 디자인과 브랜드이미지, 브랜드 공간 연출개발에 있어서 기초 자료로 활용될 것으로 기대된다.