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Helicobacter pylori가 만성위염과 위종양에 미치는 영향에 관한 면역조직화학적 밑 초미세구조적 연구
문경래,정순봉,이미숙,이미자,서재홍,김만우,박찬국 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : Helicobacter pylori (H. pylori) is accepted as a principal cause of chronic gastritis and an important factor in the pathogenesis of peptic ulcer and gastric malignancy. The aim of our studies is to investigate relationships between H. pylori and gastric epithelial cells. Materials ðods : One hundred and eighty one H. pylori positive cases of gastric biopsy specimens were studied immunohistochemically and ultrastructurally. Results : p53 positive staining exhibited foveolar epithelial hyperplasia in 1 out of 32 cases, regeneration in 2 out of 12 cases, incomplete intestinal metaplasia in 5 out of 41 cases, complete intestinal metaplasia in 3 out of 18 cases, chronic ulcer in 1 out of 9 cases, tubular adenoma in 2 out of 14 cases and intestinal type of adenocarcinoma in 16 out of 21 cases. Ultrastructurally, H. pylori was observed to be in direct contact with the microvilli of the target cells and was demolishing the surface microvilli. The organisms were in close contact with the uncoated cell membrance. Penetration into the gastric cells by a few organisms was associated with marked cell damage and ultimately to cell disintegration. Conclusion : Our results suggest that H. pylori plays a role in the pathogenesis of gastric cancer, leading a relatively slow, long lasting process that induces chronic active gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma of intestinal type.
이미숙,최상준,장하종,임성철,정유경,정순봉 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.7
Lipoleiomyoma of the uterus is extremely rare and consists of mixed smooth muscle and adipose cells. The histogenesis of this tumor is not clear. It usually occur in the corpus uteri as intramural growth. We report a unique case of a uterine lipoleiomyoma occuring in the isthmus as a subserosal polypoid mass, measuring 3.5x3.0x3.0cm. Histologically, it was mostly composed of mature fatty tissue intermingled with small amount of fibrous and smooth muscle components in an irregularly reticular pattern. Immunohistochemical study revealed a positive reaction of α-smooth muscle actin in smooth muscle fibers. Its histogenesis and a brief review of the literatures also have been discussed.