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Differential Effects of Typical and Atypical Antipsychotics on MK801-induced EEG Changes in Rats
권지숙,장수민,김충영,정태호,최병주,이만기,김기민 대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.1
We examined whether the abnormal EEG state by NMDA receptor blocker MK-801 can be reversed by typical and atypical antipsychotics differentially by comparing their spectral profiles after drug treatment in rats. The spectral profiles produced by typical antipsychotics chlorpromazine (5 mg/kg, i.p.) and haloperidol (0.5 mg/kg, i.p.) were differ from that by atypical antipsychotic clozapine (5 mg/kg, i.p.) in the rats treated with or without MK-801 treatment (0.2 mg/kg, i.p.) which produce behavioral abnormalities like hyperlocomotion and stereotypy. The dissimilarity between the states produced by antipsychotics and the control state was examined with the distance of the location of the canonical variables calculated by stepwise discriminant analysis with the relative band powers as input variables. Although clozapine produced more different state from normal state than typical antipsychotics, clozapine could reverse the abnormal schizophrenic state induced by MK-801 to the state closer to the normal state than the typical antipsychotics. The results suggest that atypical anesthetic can reverse the abnormal schizophrenic state with negative symptom to the normal state better than typical antipsychotic. The results indicate that the multivariate discriminant analysis using the spectral parameters can help differentiate the antipsychotics with different actions
제왕 절개술을 위한 전신마취 시 Entropy와 BIS값의 비교
권지숙,김동연,정락경,김치효,이희승 대한마취통증의학회 2009 Anesthesia and pain medicine Vol.4 No.2
Background: This study was designed to compare the measured values between the measured EEG-entropy and BIS monitor values during general anesthesia for cesarean section. Methods: Fourteen patients who were to undergo cesarean section were randomly selected for this study. After induction of anesthesia, desflurane was administered to achieve a steady-state end-tidal concentration of 3 vol%. The state entropy (SE), the response entropy (RE), the BIS and hemodynamic variables were collected at various time points. Results: During the induction period, the SE, RE and BIS values were slightly different. However, these indices were not significantly different during the maintenance period. The SE and RE values correlated with the BIS value during general anesthesia for cesarean section. Conclusions: The changes in the SE and RE values followed a pattern that was similar to the BIS values during general anesthesia for cesarean section.
Factors Influencing Residual Pleural Opacity in Tuberculous Pleural Effusion
권지숙,차승익,전경녀,김영주,김은진,김창호,박재용,정태훈 대한의학회 2008 Journal of Korean medical science Vol.23 No.4
Tuberculous pleural effusion (TPE) leads to residual pleural opacity (RPO) in a significant proportion of cases. The aim of this study was to investigate which TPE patients would have RPO following the treatment. This study was performed prospectively for a total of 60 TPE patients, who underwent pleural fluid analysis on the initial visit and chest radiographs and computed tomography (CT) scans before and after the administration of antituberculous medication. At the end of antituberculous medication, the incidence of RPO was 68.3% (41/60) on CT with a range of 2-50 mm. Compared with the non-RPO group, the RPO group had a longer symptom duration and lower pleural fluid glucose level. On initial CT, loculation, extrapleural fat proliferation, increased attenuation of extrapleural fat, and pleura-adjacent atelectasis were more frequent, and parietal pleura was thicker in the RPO group compared with the non-RPO group. By multivariate analysis, extrapleural fat proliferation, loculated effusion, and symptom duration were found to be predictors of RPO in TPE. In conclusion, RPO in TPE may be predicted by the clinico-radiologic parameters related to the chronicity of the effusion, such as symptom duration and extrapleural fat proliferation and loculated effusion on CT.
권지숙(Kwon Ji Suk),심재헌(Shim Jae Heon),이성호(Lee Sung Ho) 한국지역개발학회 2011 韓國地域開發學會誌 Vol.23 No.1
This paper explores the determinants of industrial land values classified by location types by means of Hedonic Price Model. Major findings from the empirical analysis can be summarized as follows: In all the models, the results commonly show that workforce in the surrounding area have a strongly positive influence on industrial land values, and that, contrary to expectations, the amount of added value of local manufacturing companies has a negative relationship with them. It is also found that there exists a distinct difference between the planned and footloose location models in terms of the effects of the parcel size and the width of the road on industrial land values. Lastly, this paper is considered significant in that it might be the first step toward a series of domestic research to break down industrial land values into its different attributes.
괴상형 간세포암 동시 간동맥 항암-방사선요법으로 부분관해 획득 후 근치적 간절제술을 시행한 간세포암
권지숙 ( Jee Suk Kwon ),박우영 ( Woo Young Park ),이경인 ( Kyung In Lee ),이정은 ( Jeong Eun Lee ),김은수 ( Eun Soo Kim ),장병국 ( Byoung Kuk Jang ),정우진 ( Woo Jin Chung ),박경식 ( Kyung Sik Park ),조광범 ( Kwang Bum Cho ),황재 대한간암학회 2009 대한간암학회지 Vol.9 No.-
Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis is not suitable candidates for surgical treatment at the most of diagnosis because of poor liver function, extensive tumor involvement of the liver, vascular involvement, and/or intra/extrahepatic metastasis. We attempted localized concurrent chemo-radiation therapy (CCRT) in patients having locally advanced HCC with left and main portal vein thrombosis. We report a case of locally advanced HCC patient who became surgically resectable by downstaging after localized CCRT. Localized CCRT was performed with a total radiation dose of 5,040 cGy (180 cGy×28 times) and hepatic arterial infusion of 5-fluorouracil (5-FU, 250 mg/day) and cisplatin (10 mg/day) for 5 days via implantable port system during the second and the fifth weeks of the radiotherapy. Marked contraction of HCC was noted on follow up computerized tomography (CT) after localized CCRT, and subsequently surgical resection with curative aim was performed. He was gave a additional transcatheter arterial chemoembolization (TACE) because follow up CT revealed intrahepatic metastasis at subcapsular portion of right hepatic lobe after 3 months of operation. The patient is in complete remission status without recurrence to date.
권지숙 ( Jee Suk Kwon ),유승수 ( Seung Soo Yoo ),강예림 ( Yeh Rim Kang ),이정우 ( Jeong Woo Lee ),김은진 ( Eun Jin Kim ),차승익 ( Seung Ick Cha ),박재용 ( Jae Yong Park ),정태훈 ( Tae Hoon Jung ),김창호 ( Chang Ho Kim ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.6
연구배경: 객혈에 대해 안정, 진해제, 및 항생제 등의 보존적 치료를 요하는 환자에서 단기간의 겉질스테로이드 사용이 미치는 영향을 알아보고자 하였다. 방법: 2005년 2월부터 2006년 8월까지 객혈을 주소로 응급실을 내원한 환자 중 폐암, 활동성 폐결핵 및 폐렴이 의심되는 환자는 제외하고, 그 중 보존적인 치료를 필요로 하는 환자만을 대상으로 하였다. 이들을 무작위로 겉질스테로이드 투여군(37명)과 대조군(41명)으로 나누어 객혈의 평균 중지 시점, 평균 재원기간 및 합병증에 대하여 전향적으로 조사하였다. 결과: 비활동성 폐결핵 단독 혹은 그에 합병된 질환을 가진 환자가 가장 많았고(51%), 다음으로 기관지확장증 및 기관지염이 각각 15%였으며, 겉질스테로이드 투여군과 대조군 사이에 환자의 특성과 원인질환의 분포에 따른 차이는 없었다. 겉질스테로이드 투여군이 대조군에 비해 평균 객혈의 평균 중지 시점(4.0±2.7일 vs. 6.1±4.8일)과 재원기간(5.8±3.4일 vs. 7.9±4.8일)이 유의하게 짧았다 (각각 p=0.022, p=0.036). 그리고 겉질스테로이드 사용과 관련된 병원성 폐렴이나 위장관 출혈 등 심각한 합병증의 발생은 없었다. 결론: 기관지염, 기관지확장증, 비활동성 폐결핵 및 그에 합병된 질환에 의한 객혈의 보존적 치료에서 단기간의 겉질스테로이드 사용은 안전하게 객혈 증상과 재원기간을 단축시킬 수 있는 것으로 사료된다. Background: This study examined the effect of corticosteroids as a short-term treatment for patients with hemoptysis that requires conservative treatment including bed rest, antitussives and antibiotics. Methods: From February 2005 to August 2006, 78 consecutive patients who visited the emergency room because of hemoptysis were enrolled in the study. Patients with hemoptysis due to lung cancer, active pulmonary tuberculosis, and pneumonia were excluded. The 78 patients were divided randomly into a corticosteroid medication group (n=37) and a control group (n=41). The mean control time of hemoptysis, mean in-hospital days, and complications of treatment were investigated prospectively. Results: For the etiology of hemoptysis, inactive pulmonary tuberculosis alone or its associated complications (bronchiectasis and/or aspergilloma) were the most common causes (51%); bronchiectasis alone and bronchitis were the next most common causative diseases (15%, respectively). The patients` characteristics and symptoms in the corticosteroid medication and control groups were similar. The steroid medication group showed a significantly lower mean control time of hemoptysis than the control group (4.0±2.7 days, 6.1±4.8 days, respectively) (p=0.022) and had a lower mean number of in-hospital days (5.8±3.4 days, 7.9±4.8 days, respectively) (p=0.036). There were no significant complications, such as hospital-acquired pneumonia or gastrointestinal bleeding, related to the use of corticosteroids. Conclusion: The use of corticosteroids as a conservative treatment for hemoptysis due to bronchitis, bronchiectasis, inactive pulmonary tuberculosis and its related complications safely reduces the control time of hemoptysis as well as the number of in-hospital days. (Tuberc Respir Dis 2007;63:486-490)