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유승수,강효경,최진은,최선하,이소연,유승수,이신엽,이재희,차승익,김창호,석양기,이응배,조석기,전상훈,박재용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.0
Recently, it has been reported that variants of mitosis-related genes can be affect chromosome stability. We evaluated the association between these variants and survival outcome in patients with non-small cell lung cancer (NSCLC). In total, 766 patients with NSCLC who underwent curative surgery were enrolled. Seventy-three variants form 25 mitosis-related genes were genotyped and their associations with survival outcome were analyzed. BUB3 rs7897156 C>T and AURKB rs1059476 G>A were significant associated overall survival under a recessive model (adjusted hazard ratio [aHR], 1.58, 95% confidence interval [CI] 1.07-2.33, P = 0.02 and aHR 0.64, 95% CI 0.41-0.99, P = 0.05, respectively). PTTG1 rs1895320 T>C and RAD21 rs1374297 C>G were associated with worse disease-free survival under a recessive model (aHR 2.46, 95% CI 1.43-4.23, P = 0.001 and aHR 1.32, 95% CI 1.00-1.75, P = 0.05, respectively). We conducted functional analysis of the BUB3 rs7897156 C>T using luciferase reporter assay. Relative luciferase activity of BUB3 rs7897156 T allele was higher than C allele in H1299 and A549 cell line (P = 0.02 and 0.003, respectively). The BUB3 mRNA expression level in normal tissue also higher in rs7897156 CT or TT genotypes than in rs7897156 CC genotype (P = 0.04). These results suggest that four variants of mitosis-related genes (BUB3 rs7897156 C>T, AURKB rs1059476 G>A, PTTG1 rs1895320 T>C and RAD21 rs1374297 C>G) may affect prognosis of surgically resected NSCLC.
유승수,( Hyo Gyoung Kang ),( Jin Eun Choi ),( Hyo Sung Jeon ),( Jae Hee Lee ),( Shin Yup Lee ),( Seung Ick Cha ),( Chang Ho Kim1 ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Purpose: A genome-wide association study has identified the 15q25 region as being associated with the risk of chronic obstructive pulmonary disease (COPD) in Caucasians. This study intended as a confirmatory assessment of this association in a Korean population. Methods: The rs6495309C>T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (CHRNA3) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control subjects. Results: The rs6495309 CT or TT genotype was associated with a significantly decreased risk of COPD when compared to the rs6495309 CC genotype (adjusted odds ratio=0.69, 95% confidence interval=0.50-0.95, P=0.02). The effect of the rs6495309 C>T on the risk of COPD was more evident in moderate to very severe COPD than in mild COPD under a dominant model for the variant T allele (P-value of test for homogeneity=0.02). Conclusions: We confirmed the association between the 15q25 region and the risk of COPD in a Korean population.
유승수,김선용 제어·로봇·시스템학회 2022 제어·로봇·시스템학회 논문지 Vol.28 No.3
Frequency hopping binary offset carrier (FH-BOC) signals use a wider band than other BOC signals, resulting in high signaltracking accuracy and low ambiguity for their correlation functions. Even with these improved metrics, ambiguities remain in correlationfunctions and could lead to false locking during code tracking. The FH-BOC signal is obtained from a time division multiple combiningmultiple BOC signals with different frequencies through a process called frequency hopping. This report outlines the common pulsecomponent between several sub-carriers of the FH-BOC signal. This pulse is correlated with the received signal and combined to design anunambiguous correlation function for the FH-BOC signal. Compared to the FH-BOC signal’s correlation function, the designedunambiguous correlation function is less affected by multipaths because more power is concentrated at the main peak. .
유승수,( Su Man Lee ),( Hyo-sung Jeon ),( Shin Yup Lee ),( Jae-hee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Dong Sun Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression in an epigenetic manner. Tumor suppressor P53 plays an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. A Wrap53α (WD40-encoding RNA anti-sense to p53) that transcription initiated from exon 1α is required for p53 induction upon DNA damage. However, involvement of Wrap53α in lung cancer has not been reported to date. We determined the methylation status of Wrap53α genes in primary lung tissues using a methylation-specific PCR (MSP) and evaluated their relationship with clinicopatholgial features and sur-vival in patients with non-small cell lung cancer (NSCLC). Wrap53α promoter was unmethylated in most malignant and corre-sponding nonmalignant tissues. Wrap53α methylation was detected in 19 (13.3%) of 146 tumor tissues and 12 (8.2%) of 146 normal tissues. In addition, Wrap53α methylation in normal and non-malignant tissues was frequently detected in p53 muta-tion-negative patients and in patients with stages II-IV. Patients with Wrap53α methylation in normal tissues exhibited sig-nificantly worse overall survival, while methylation in tumor tissues did not affect the survival outcome of patients. These findings suggest that Wrap53α methylation play a role in lung carcinogenesis. However, further studies with a large number of cases are needed to confirm this.
차세대 GNSS를 위한 GIG 부호 기반 시간다중 이진부호심볼 변조기법
유승수,김선용 제어·로봇·시스템학회 2022 제어·로봇·시스템학회 논문지 Vol.28 No.10
In this paper, we propose a time multiplexed binary coded symbol (TMBCS) modulation scheme based on Gray and inverse Gray (GIG) codes for the next generation global navigation satellite system (GNSS). A representative binary coded symbol (BCS) is a binary offset carrier (BOC). Compared to the existing binary phase shift keying (BPSK) modulation, which is a representative GNSS modulation scheme, BOC modulation has a high degree of freedom in terms of frequency band shape design and is less affected by multipaths because the correlation function is sharper at the correct code phase. However, since several sub-peaks occur in the correlation function of the BOC-modulated pseudo-noise signal, false locks can easily occur during code tracking. This disadvantage is called the ambiguity of the BOC modulated signal. Time multiplexed binary Walsh spreading (TMBWS) modulation, which is a TMBCS scheme that uses a Walsh code, is one method for reducing ambiguity and is a perfectly orthogonal code with a very good correlation among BCSs. However, Walsh codes can only be generated with a power of two length. In this paper, we propose a novel TMBCS modulation scheme using quasi-orthogonal GIG codes that can be generated with lengths that are multiples of 2. The proposed scheme maintains the same bandwidth and spectral separation coefficient compared to TMBWS when a symbol of length 8 is used. In addition, the proposed scheme has a higher degree of freedom in terms of band shape design compared to TMBWS modulation, because the length can be designed in multiples of 2 (such as 6, 10, or 12) and has high multipath immunity with unambiguity. .