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Risk Factors for Rituximab-Induced Interstitial Lung Diseases in Patients with Malignant Lymphoma
차승익,이소연,이용훈,유승수,이재희,이신엽,김창호,박재용 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Rituximab, a key drug used in therapeutic strategies for treatment of CD20+ non-Hodgkin`s lymphoma, can cause drug-induced interstitial lung disease (ILD). Despite recent accumulation of data regarding the clinical features of rituximab-induced ILD, its risk factors have yet to be clarified. Objectives: The purpose of the present study was to investigate the clinical features of and risk factors for rituximab-induced ILD in patients with non-Hodgkin`s lymphoma who undergo treatment with rituximab-containing regimens. Methods: A retrospective study of patients with non-Hodgkin`s lymphoma treated with rituximab was conducted in a tertiary referral center in Korea. We compared various clinical parameters of patients with and without rituximab-induced ILD and determined its risk factors. Results: Of 264 patients with non-Hodgkin`s lymphoma who were treated with rituximab-containing chemotherapy regimens, nine (3.5%) were diagnosed as having rituximab-induced ILD, including clinically suspected cases (n=5). Based on clinical and radiologic findings, the most common pattern was organizing pneumonia (n=7 [78%]). Three patients (33%) for whom treatment failed died from respiratory failure caused by rituximab-induced ILD. Poor ECOG performance status and age were significant risk factor for rituximab-induced ILD (odds ratio [OR] 10.8, 95% confidence interval [CI] 1.6-74.8, p=0.016; and OR 1.1, 95% CI 0.0-1.2, p=0.048, respectively).
미만성 범세기관지염(Diffuse panbronchiolitis) 2예
차승익,한춘덕,김창호,김연재,이영석,박재용,정태훈 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.3
미만성 범세기관지염은 주로 일본, 한국, 중국 등지에서 발생하는 만성 염증성 호흡기질환으로 임상적으로는 기관지천식, 만성기관지염, 폐기종, 기관지확장증, 간질성폐질환 등과 감별진단이 필요하다. 임상소견, 방사선 사진 소견 및 폐기능검사 성적 등으로 임상적인 진단이 가능하지만 확진을 위해서는 폐조직검사가 필요하다. 저자들은 임상적으로 의심되었고 개흉술을 통한 폐조직생검으로 확진된 미만성 범세기관지염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Diffuse panbronchiolitis(DPB) is a chronic inflammatory lung disease, characterized by chronic cough, copious sputum and exertional dyspnea. Bilateral small nodular shadows often associated with f hyperinflation of the lungs, are seen on chest x-ray films. Morphologically the disease is composed of respiratory bronchiolitis and peribronchiolitis which are diffusely disseminated throughout the bilateral lungs, especially in the lower lobes. In 1966, the disease was first described in Japan. Although it is prevalent in Japan, but it is known to be rare out of Japan. Only a few cases have been reported in our country. We report 2 cases of DPB confirmed by open lung biopsy.
P-98 Risk factors for mortality in patients with septic pulmonary embolism
차승익,김현정,유승수,이재희,이신엽,김창호,박재용 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Background: Data regarding prognostic factors for patients with septic pulmonary embolism (SPE) are lacking. The purpose of the present study was to investigate the clinical features of SPE and to ascertain the risk factors for mortality in patients with this condition. Methods: Patients with SPE, whose data were retrospectively collected from a tertiary referral center in Korea, were categorized by the presence or absence of in-hospital death into two groups: death and survival groups. The two groups were compared for clinical and radiologic parameters. Results: SPE was community-acquired in most patients (78%). The most common focus of primary infection was that of bone, joint, or soft tissue (33%), followed by liver abscess (17%). The in-hospital mortality was 12%. Multivariate analysis showed that tachypnea (odds ratio [OR] 4.73, 95% confidence interval [CI] 1.09-20.53, p = 0.038) and segmental or lobar consolidation on computed tomography (CT) scan (OR 10.79, 95% CI 2.51-46.43, p = 0.001) were independent predictors of in-hospital death in SPE patients. Conclusion: Taken together, the primary infectious foci of SPE in Korea are different from those reported in Western countries. Tachypnea and segmental or lobar consolidation on CT scan may be independent risk factors for in-hospital death in these patients.