Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

잡가 연구의 현황과 과제 : 국문학계의 연구를 중심으로

박애경 洌上古典硏究會 2003 열상고전연구 Vol.17 No.-

국문학계에서 잡가 연구는 가장 혼란스러운 분야라 할 수 있다. 연구 성과가 쌓일수록 잡가의 정체성과 존속 시기에 대한 합의가 이루어지기 보다는 이견이 속속 노출되고 있기 때문이다. 잡가는 19세기 중반 이후 도시 유흥의 장에 등장한 순간부터 1920년대 전성기를 맞을 때까지 상당한 수준의 대중적 파급력을 드러낸 바 있다. 뿐만아니라 잡가는 중세 해체기의 문화적 역동성을 자양분으로 하여 자기부상한 후, 근대 전화기를 거치며 전성기를 맞이 했다는 점에서 중세의 끝에 성장한 서민 예술이 근대라는 시기와 만나며 겪는 변화와 생존 방식을 선명하게 보여주고 있다. 요컨대 잡가는 19세기 문화사와 근대 전환기 예술의 운명과 존재 방식을 가늠하는 척도이며 관문이라 할 수 있다. 따라서 잡가 연구는 그 특수한 위상을 밝히는 방향으로 진행되어야 한다. 이를 구체적으로 지적하면 다음과 같다. 첫째, 문집, 가집, 고악보에 분산되어 있는 잡가 관련 기록을 수집하고, 해석할 필요가 있다. 둘째, 잡가의 존재양상과 방식을 객관적으로 살핌으로써 잡가의 개념과 범주에 대한 이견을 좁힐 필요가 있다. 셋째, 조선 후기에 형성되어 근대전환기를 거치고 일제 강점기까지 존속한 잡가를 통해 '통속예술에서 대중예술로의 상승'이라는 예술사의 발전 과정을 진단하고, 19세기 도시문화의 역동성을 밝혀낼 필요가 있다. 넷째, 전통적 장르에서 근대 대중예술로 순조롭게 발전한 잡가를 통해 시가에서 근대성이 실현되는 방식을 추적해볼 수 있다. 마지막으로 잡가를 고려가요, 사설시조 등 하위문화의 속성을 지니면서 잡종 장르의 면모를 지녔던 장르 간의 계보 속에서 파악함으로써 시가에서 장르 복합적인 현상을 해명하는 이론적 틀을 마련해볼 필요가 있다. Study on Jabka is taken as the most chaotic area in Korean literature academics. This is because different views are being raised rather than aligning on identity of Jabka and its duration as study results build up. From the moment of Jabka's introduction to urban entertainment stage in mid 19 century to height of prosperity in 1920s', Jabka demonstrated great deal of public spreading capability. Also, viewed in light of its emergence utilizing cultural dynamics during break down of middle age and having its peak passing through tansit period into modern age, Jabka demonstrates clearly as to how mass art that's developed at the end of middle age went through changes and survival measures by encounter with modern age. Jabka can be standard and gateway to discern 19 century cultural history and art's destiny and existence method during transit period into modern age. Therefore, Jabka studies need to direct towards period its unique phase. This can be illustrated in detail as follows. First, we need to collect and analyze Jabka related records scattered in various collections and music books. Second, we need toi narrow different views on Jabka's concept and criteria reviewing existence appearance and method of Jabka objectively. Third, we need to review development process of art history and to investigate dynamics of 19c urban culture through Jabka that was created at the end of Chosun dynasty and existed through modern transit period and Japanese occupation, that's summed up as rising from popular art to mass art. Forth, we can track its path in which modernity is materialized through Jabka that's developed from traditional gentr to one of modern mass art. Finally, we need to set theoretical frame that explains Jabka's hybrid genre complexity reviewing from genealogy between genres in which shows mixed gentr while maintaining character of sub culture such as Koryo Gayo and Sasulshizo.

NIHSS 활용을 통한 뇌졸중 환자 간호의 질향상 전략

박경현,송경애,공혜성,나화주,유수경,박소영,김상희,최혜림,배희준,한문구,양미화 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 뇌졸중 환자를 돌보는 간호현장에서는 급성기 뇌졸중 환자의 증상악화에 대한 조기사정과 적절한 대처가 매우 중요한 문제이다. 그러나 임상현장에서는 이를 객관화하고 수치화하여 모든 의료진이 의사소통할 수 있는 유용한 도구를 사용하고 있지는 못하는 실정이다. 이러한 문제를 해결하기위해 NIHSS(National Institute of Health Stroke Scale)를 신경과 진료의사를 중심으로활용하고 있지만 아직 간호현장에서는보편적으로사용하지 않고있다. 이에 뇌졸중환자간호에 NIHSS를 활용하여 뇌졸중 증상악화의 조기사정과 빠른 대처로 궁극적으로는 뇌졸중환자 간호의 질을보다 향상시키기 위하여 본활동이 시도되었다. 목적: 첫째, 간호사의 NIHSS 측정 신뢰도의 현수준을 점검하고 이를향상시키기 위한 프로그램을 개발·적용한다. 둘째, 간호사가급성기 뇌졸중환자에게 NIHSS 측정을 통하여 뇌졸중악화를 얼마나 예측할 수 있는지 분석하고 이를 향상시킬수있는 방법을 모색한다. 셋째, 궁극적으로 급성기 뇌졸중 환자의 증상악화의 조기 발견과치료를위한의료진의 올바른 대처지침을 마련하여 이를 적용한다. 의료기관: 경기도에 소재한 대학병원의 뇌졸중 집중치료실 질 향상 활동: 첫째, 간호사의 NIHSS 측정 신뢰도 향상을 위해 「NIHSS 간호사 교육 프로그램」을 마련하였다.

화학적으로 유도한 랫드 간세포 암화과정에서 단백질 식이가 생체막 안정도와 glutathione 의존성 효소계에 미치는 영향

박경애 가야대학교 2001 가야대학교 논문집 Vol.10 No.-

The purpose of this study is to determine the effect of dietary proteins on the membrane stability and drug-metabolizing enzyme activities during chemically induced rat hepatocarcinogenesis. Weanling Sprague-Dawley rats were fed the diet containing 20% casein or soy protein isolate and 15% beef tallow for 10 weeks. Hepatocarcinogensis was initiated with diethylnitrosamine(DEN), and the rats were fed diets containing 0.02% 2-acetylaminofluorene (AAF) followed by 0.05% phenobarbital (PB). Relative liver weights were significantly increased by AAF and PB treatment in rats. Glucose 6-phosphatase (G6Pase) activities, an index of membrane stability, were not influenced by AAF and PB treatment, but were higher in soy protein diet compared to casein diet groups treated with carcinogen. Lipid peroxide values also were increased by AAF and PB treatment and were higher in soy protein diet compared to casein diet groups. NADPH-cytochrome P450 reductase activity were significantly increased by AAF and PB treatment in casein diet group and aniline hydroxylase activities were increased by AAF and PB treatment. Glutathione S-transferase enzyme activities were increased by AAF and PB and higher in soy protein diet compared to casein diet groups treated with carcinogen. Glutathione peroxidase and g1utathione reductase were influenced by AAF and PB. Our results suggest that soy protein maintain the membrane stability and influence the glutathione S-transferase during chemically induced rat hepatocarcinogenesis. Soy protein may be protective against the stage of promotion of hepatocarcinogenesis induced by chemical carcinogen. KEY WORD ; glutathione S-transferase, hepatocarcinogenesis, membrane stability, soy protein.

動物組織中의 脂質定量에 對하여

朴愛卿 이화화학회 1968 梨花化學會誌 Vol.- No.7

쥐의 뇌, 심장, 허파 등을 試料로 取하여 Thin layer chromatography에 依하여 脂質을 定量한 結果 cholesterol는 특히 뇌신경 조직과 부신에 많이 存在하며 Total cholesterol 含量은 뇌에 17.6㎎/g로 가장 많았고 심장에 3.2㎎/g로 가장 적었다. Free cholesterol 역시 뇌에 가장 많이 있고 심장에 가장 적었다. Glyceride는 Brain에 가장 많았고 大體로 Triglyceride가 많았다. Lipid is accumlated at adipose tissue, Adipose tissue consists of more than 90% triglyceride. Lipid is main energy source in the animal body as you know. In this experiment, we used brain, heart and lug from rat as samples. We tried to investigate the constituents of neutral lipid, and phospholipids. As a resalt, we separated six different material from nuetral lipid and four from the phospholipid. They were monoglyceride, diglyceride, triglyceride, free cholesterol esterified cholesterol fatty acids and phosphatidyl ethanol amine, phosphatidyl choline, phosphatidyl inositol, and one unknown lipid, respectively. Brain had the highest glyceride content and also highest cholesterol content which was about 4 times as high as that in the heart and lug. Phosphatidyl ethanol amine had the highest phospholipid and total cholesterol amount was the highest at the Brain.

일 대학 보건진료소의 결핵 관리에 관한 조사 연구

박경애 東新大學校 1997 論文集 Vol.9 No.-

The proportion of people who contacted T.B. in Korea has drastically decreased as a result of the incessant effort of the Korean government which adopted a policy of "Drive out T.B." as its foremost health policy. However, the proportion still remains relatively high compared with that of developed countries. This study was conducted to find some means for guiding and counseling university students who have T.B. The subjects of this study was consisted of 315 students at C university who were diagnosed as T.B. patients and registered at the C university health clinic front 1991 to 1996. The findings were as follows; 1) Prevalence rates of T.B. according to years were 0.5% in average 2) Incident rates of bacteriologically confirmed T.B. by years were 3.1% in average 3) According to the route of case finding, 91.4% of T.B. patients were identified by period phygical examination. 4) Rates of T.B. patients according to registered agents were 84.5% in average by university health clinic. 5) Seventy-two point six percent of patients were minimal and 20.7% were moderately advanced and 6.7% were far advanced. 6) Eighty-five point seven percent of patients were discharged after complete treatment, 2.0% of them were transfered, 2.3% were changed their diagnosis and 9.1% were under teatment. 7-1) Advantages in utilization of university health clinic were accessibility(61.5%), availability(46.2%), comprehensiveness and affordability(42.3%), care continuity(26.9% ) in order. 7-2) Disadvantages in utilization of university health clinic were difficult in contact doctor(60.0%), too burdensome of staff in clinic(56.0%), fear to be known as T.B. patient to the colleague(44.0%) in order.

日本 紀行歌辭의 계보와 日本觀의 변모양상

박애경 열상고전연구회 2006 열상고전연구 Vol.23 No.-

이 글의 목적은 조선 후기부터 일제 강점기에 사이에 씌여진 세 편의 일본 기행가사를 통해 일본관의 변화를 살피려는 것이다. 이를 위해 18세기 저작인 <일동장유가>, 한말 저작인 <유일록>, 일제 강점기에 나온 「東遊感興錄」을 대상으로 삼았다. 일본 기행가사에 나타난 일본관의 의미를 당대 문화적 환경과 관련하여 살피기 위해 먼저 공식적 여행의 체험을 그린 사행가사가 나오게 된 배경을 가사 장르 자체의 변화와 관련하여 살펴보았다. 또한 사행가사가 유학자이자 관료인 작가의 공적 여행의 기록인 동시에 조선 지식층의 내면의식을 보여주는 통로라는 것을 확인하였다. 3편의 일본 기행가사는 주권 왕조에서 식민지로 급전직하한 국가 운명만큼이나 달라진 대일관을 보여주고 있다. <일동장유가>가 화이관의 지속을 보여준다면, <유일록>은 화이관의 지속과 균열을 보여주는 동시에 일본에 대한 양가적 시선을 드러내고 있다. 일제 강점기 통치정책의 하나로 시행된 내지 시찰의 경험을 담은 「동유감흥록」은 말할 것도 없이, 식민지 담당자의 의도에 포섭된 자의 시선이 두드러지게 나타난다. 이렇듯 일본 기행가사에는 조선 후기 이후 달라진 대일 관계와 양국의 지위, 한학과 유학을 하던 조선의 전통적 지식층들이 시대의 변화를 바라보는 관점이 유장한 호흡 속에 나타나 있다. 따라서 일본 기행가사는 일본관 형성의 기저, 조선 지식층들의 대외 인식의 일단을 살피는 시대적 기록으로서의 가치가 크다고 할 수 있다. The purpose of this study is to inguire the change of an awareness of Japan through 3 works of Ilbon Kihaeng Kasa (Kasa which discribes the experience of a travel in Japan) written in the late of Chosun Dynasty and in the colonial period. For this purpose, this study deals 'Ildongjangyuga(日東壯遊歌)' written in the 18C, 'Yuilrok(游日錄)' written in the late of 19C and 'Dongyugamheungrok(東遊感興錄)‘ written in the colonial period. For analizing the meaning of an awareness of Japan in relation to the cultrural circumstance at that time, this styudy observes the condition for forming Sahaeng Kasa, as the records of the experience of official trip to other contries with a focus on the transformation of Kasa. In addition, this study tries to verificate the fact that Sahaeng Kasa was not only the records of official trip to other contries by the Confucian bureaucrats but also the path to come out their inner consciousness. Each work represents different view of Japan as a consequence of the change of the nation status from a sovereign dynasty to a colony. The meaning of Ilbon Kihaeng Kasa can be summarized as the records of an age which present the origin of a view of Japan as much as the understanding other contries of the intellectuals in Chosun Dynasty.

한국 노인의 특성에 따른 맛 감지 능력의 차이에 관한 연구

박경애,이희주,박명숙,이정희,전상은,김종성,최스미 대한노인병학회 2002 대한노인병학회지 Vol.6 No.4

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

대전 충남지역 국민학교의 학교급식 실태에 관한 조사

박영숙,이경애,김연순 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.1

The foodservice management of school-lunch program was studied to certify the fulfillment of it's objectives. One hundred thirtheen primary schools in Taejon and Chungnam province were participated in our survey. The results of this study were as follows: 1. Average cost per meal for each student was 772 won, that was less in central kitchen system. Productivity in terms of meals per worker was also higher in centralized kitchen system. 2. The menu was mostly planned weekly and not cyclic. 3. The dietitian's work covered all 5 parts of material handling duties in conventional system which were described in the school-lunch program laws. However it was mainly concentrated on 2 parts of the food purchase order and of the inspection of delivered foods in co-management and central kitchen systems. 4. Our results indicated that nutrition education in school-lunch program especially in co-management and central kitchen systems was almost neglected. It was stressed that school-lunch program should be extended without omitting its objectives especially nutrition education, which is important for the young.