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박경애,조현주 한국청소년상담복지개발원 2007 청소년상담연구 Vol.15 No.1
This study investigated the thought of counseling or psychotherapy for college students who took thought about counseling or psychotherapy inventory(TACI). The participants were a total of 683 college students (male; 309, female; 374) who live in 6 different providences (Seoul, Kyunggi, Kangwon, Kyungsang, Chulra, Chungchung) in Korea. TACI consists of four factor structures which are counselor responsiveness, social stigma, coercion concerns, image concerns. The four factor structures of TACI were confirmed with Korean college students same as Western people. The students in Seoul had more positive thought of counseling or psychotherapy compared to the students in non-capital regions. Also, the students in high economical level had more positive thought of counseling or psychotherapy compared to the students in other economical levels. However, there were no significant differences of the thought of counseling or psychotherapy between male and female and among three groups which were counseling, no counseling, and need counseling group. 본 연구는 남․녀 4년제 대학생 683명을 대상으로 상담 및 심리치료에 대한 생각이 어떠한지를 조사하였다. 상 담 및 심리치료에 대한 생각을 조사하기 위해서 ‘상담 및 심리치료에 대한 생각 질문지(Thought about Counseling or Psychotherapy Inventory: TACI)’를 사용하였다. TACI는 상담자의 반응성, 사회적 낙인, 변화에 대한 강요, 상담에 대한 이미지 중 자기 지각에 대한 두려움의 4요인으로 구성되어 있다. TACI의 확인적 요인 분석 결과, 서구인과 마찬가지로 한국 대학생들에게도 4요인 구조가 적합한 것으로 나타났다. 한국 대학생의 상 담 및 심리치료에 대한 생각이 성별과 지역별, 경제적 수준에 따라서 차이가 있는지를 알아보았는데, 성별로는 유의한 차이가 없었고, 지역별로는 지방의 학생들이 서울의 학생들 보다 상담에 대해서 부정적인 생각을 가지고 있었다. 경제적 수준에 따라서 차이가 있는 것으로 나타났다. 또한 상담 및 심리치료의 필요성을 느껴서 상담을 받은 집단과 상담을 받지 않은 집단, 상담 불필요 집단 사이에 상담에 대한 생각에서 차이가 있는지를 알아보았 는데, 상담을 받은 집단에 비해서 상담을 받지 않은 집단은 상담에 대해서 가장 두려움을 많이 가지고 있었다.
랫드 간세포 암화과정에서 쇠기름과 옥수수기름이 지질과산화물 생성과 생체막 안정도에 미치는 영향
박경애 가야대학교 2000 가야대학교 논문집 Vol.9 No.-
The purpose of this study is to determine the effect of dietary fats on the hepatic lipid peroxidation, menbrane stability and drug-metabolizing enzymes during chemical hepatocarcinogenesis in rats. Weaning Sprague-Dawley rats were fed the diet of 15% beef tallow or corn oil. For carcinogen-treated groups, the rats were initiated with diethylnitrosamine (DEN), and then fed diets containing 0.02% 2-acetylaminofluorene (AAF) followed by 0.05% phenobarbital (PB) for 10 weeks. Relative liver weight was significantly increased by carcinogen treatment and lower in rats fed beef tallow diet than corn oil diet group. Glucose 6-phosphatase (G6Pase) activity, index of membrane stability was reduced by carcinogene treatment and significantly higher in rats find corn oil than beef tallow group. Lipid peroxide values were increased in rats find corn oil compared to beef tallow group. Aniline hydroxylase activity was increased by carcinogen treatment, but the highest in carcinogen-treated rats fed beef tallow. Glutathione-dependent enzyme activities were increased by carcinogen treatment. Linoleic acid content was increased in corn oil diet group and palmitoleic acid, stearic acid, and oleic acid content were increased in beef tallow diet group. Arachidonic acid content was significantly decreased in beef tallow treatment group compared to corn oil treatment group. These results suggest that lipid petoxide values, membrane stability and detoxifying enzyme system were influenced by dietary fat types and membrane fatty acid composition in rat microsomal fraction was reflected by dietary fats in rat hepatocarcinogenesis induced by DEN, AAF and PB. Therefore, Beef tallow, saturated fatty acid source may be more protective than corn oil during murine hepatocellular chemical carcinogenesis.
화학적으로 유도한 랫드 간세포 암화과정에서 단백질 식이가 생체막 안정도와 glutathione 의존성 효소계에 미치는 영향
박경애 가야대학교 2001 가야대학교 논문집 Vol.10 No.-
The purpose of this study is to determine the effect of dietary proteins on the membrane stability and drug-metabolizing enzyme activities during chemically induced rat hepatocarcinogenesis. Weanling Sprague-Dawley rats were fed the diet containing 20% casein or soy protein isolate and 15% beef tallow for 10 weeks. Hepatocarcinogensis was initiated with diethylnitrosamine(DEN), and the rats were fed diets containing 0.02% 2-acetylaminofluorene (AAF) followed by 0.05% phenobarbital (PB). Relative liver weights were significantly increased by AAF and PB treatment in rats. Glucose 6-phosphatase (G6Pase) activities, an index of membrane stability, were not influenced by AAF and PB treatment, but were higher in soy protein diet compared to casein diet groups treated with carcinogen. Lipid peroxide values also were increased by AAF and PB treatment and were higher in soy protein diet compared to casein diet groups. NADPH-cytochrome P450 reductase activity were significantly increased by AAF and PB treatment in casein diet group and aniline hydroxylase activities were increased by AAF and PB treatment. Glutathione S-transferase enzyme activities were increased by AAF and PB and higher in soy protein diet compared to casein diet groups treated with carcinogen. Glutathione peroxidase and g1utathione reductase were influenced by AAF and PB. Our results suggest that soy protein maintain the membrane stability and influence the glutathione S-transferase during chemically induced rat hepatocarcinogenesis. Soy protein may be protective against the stage of promotion of hepatocarcinogenesis induced by chemical carcinogen. KEY WORD ; glutathione S-transferase, hepatocarcinogenesis, membrane stability, soy protein.