심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

토착형 말라리아 (Plasmodium vivax) 2례

이영진,박도심,정병학 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

In korea indigenous malaria was known as "Hak-chil" in many centuries and they were disappeared from 1984 to 1992. But indegenous malaria (Plasmodium vivax) was detected in 1993 among soldiers and residents in western parts of the demilitarized zone (DMZ). Nowadays infected cases of indeginous malaria are progressively increased and social problem because infected mosquitos and bloods can transmit to other people. We detected 2 cases of indigenous malaria (P.vivax) that they were worked in western parts of the demilitarized zone (DMZ) during army period few months ago but never went out of korea, received blood products and intravenous drugs. We considered that they were were infected malaria at DMZ.

톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향

이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.

생체분해성 고분자의 특성 및 의학적 응용

이진호,최선웅,강길선,노승무,민병무,김용백,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

"Biomaterials" are nonviable materials used in medical devices, intended to interact with biological systems. They should have "biocompativility", which is defined as the ability of materials to perform with an appropriate host response in a specific application. It includes many materials that are often classified as biomaterials. Metals, ceramics, polymers, glasses, carbons, and composite materials are some examples. Among them, biodegradable polymers are discussed in this revies article. Since a biodegradable polymeric implant does not have to be removed surgically once it is no longer needed, biodegradable polymers are of value in short-term applications that require only the temporary presence of a polymeric implant. Main short-term medical applications of biodegradable polymers include the temporary tissue scaffold, the temporary adhesion barrier, the drug delivery device, and the multifunctional implant. In this article, the properties, processing methods, and medical applications of the biodegradable polymers are reviewed.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

폴리프로필렌 纖維用 Carbene染料의 開發에 關한 硏究

李學沂,林龍進,민경은 慶北大學校 1982 論文集 Vol.33 No.-

Reactive dyes, which reaction center is carbene, were prepared and the dyeability of polypropylene fiber by those dyestuffs was investigated. Furthermore, a new say of dyeing and an applied technique for pretreating polypropylene with carbenic precursor were studied to improve dyeability. In this experiment, ketones were used as starting materials because these are mostly common functional group in dyes and dyestuff intermediates. Ketones could be changed to tosylhydrazone derivatives by tosylhydrazine in methanol at 0℃ in the presence of aqueous hydrochloric acid. Reactive carbenic dyes were prepared by the reaction of n-butyllithium and these hydrazone derivatives in ethly ether solvent. Dyed polypropylene showed excellent endurance to the light and preserverance to laundry, which were confirmed by means of blue and gray scales. The fact that polypropylene was bonded covalently to dyestuff molecules was confirmed by extraction and reprecipitation. Using the aldehyde as the starting material, carbenic precursor was also prepared analogous route to the dyestuff. After pretreating polypropylene fiber with this precursor, dyeing pattern of fiber in acidic media with butyl orange showed similar adsorption curve which is the typical results of acidic dyeing process. It means that polypropylene could be dyed easily in acidic media if it had pretreated by carbenic precursor.

韓國 알미늄 箔産業의 마케팅 戰略

李容鶴,文學鎭 수원대학교 기업경영연구소 1992 企業經營硏究 Vol.1 No.-

Korean Aluminium Foil Industry has grown, during the last five years, as the average annul growth rate was 19.1%, But in the late 80's, with the new foil manufacturers participation, the already established manufacturers have worried over the increased production capacity. The industry is in a transitional stage changing from excess demand to excess supply. The study suggests the marketing strategy for the Korean Aluminium Foil industry as follows. First, the industry needs to reform its management from the reproduction emphasis to marketing emphasis. With the product surplus, the manufacturers have to sell to survive by the circulation of production -sales-reproduction. Second, through a marketing mix, the industry has to promote a new demand and enhance the marketability without pricing competitiveness. There has to be an effort to develop a new product, as well as enhancing the product quality. Third, aggressive export strategy has to be developed. And lastly, Green Marketing should be introduced into the Aluminium Foil industry.

Imidazole-Azo유도체의 Spectra

李學沂,林龍進 慶北大學校 1976 論文集 Vol.21 No.-

In order to investigate the possibility as a dyestuff, the spectra of imidazole azo derivatives were studied in comparison with phenyl azo ones. The λmax of imidazole azo derivatives was 17-23 nm longer wave region than that of phenyl derivatives and it means that imidazole azo dyes have more bathochromic effect than phenly azo dyes. The spectra of substituted 2'-oxyphenyl azo imidazole showed isosbestic points in accordance with the variation of pH range in the methanol-water solution. It will be due to the protonation and deprotonation of dyes in acid-alkali solution. The authors discussed these imidazole azo dervatives on the possibility as a disperse azo dye.

난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

食用獨活의 生態에 關한 硏究 : 越冬前 地下莖의 芽數와 翌年發生 莖數와의 相關 Correlation between the number of crownbuds in autumn and the number of stalk produced in the following season in chonnam area

李相來,鄭丁采,金鶴鎭 順天大學校 1983 論文集 Vol.2 No.1

全南地方에 있어서 食用獨活의 地下莖에는 翌春에 嫩莖이될 芽(crown bud)가 形成되여 있으나 翌年度에 發芽되는 莖數와의 相互關係를 알고 收穫期間의 決定의 資料를 얻고자 全南地方의 推定 收穫 限界期라고 生覺되는 5月 下旬까지만 莖을 除去하고 그 以後부터서 가을 霜降時까지 그대로 放任한 區와 嫩莖이 發達한 直前의 月末까지(7月末日) 收穫하였다가 그 後 부터서 霜降까지 그대로 放任한 區等의 3個의 試驗區를 亂塊法 三反覆으로 試驗하였으니 그 結果를 要約하면 다음과 같다. 1. 前年度 가을에 芽數와 翌年 發生 莖數와의 높은 相關을 認定할 수 있었다. 2. 收穫 期間이 가장 길었던 7月末 까지의 收穫區는 越冬前 根群을 調査한 結果 根群 發生이 不良하여 減收의 原因이 되였다. 3. 發生 莖數는 越冬前의 芽數와 多小 關係가 있는 것 같으나 收穫期의 長短이 더욱 큰 影響을 주었다. 4. 全南地方의 收穫 限界期는 5月 末日까지로 보는 것이 좋을 것 같다. This experiment was conducted to investigate the ecological characteristics of Japanease udo in Chonnam area. During the summer and autumn poriod after the previous year cutting crownbuds of Japanease udo which is edible spears in the following spring are formed. This study was made to dertimine the relationship between the number of corwnbuds in the previned and the number of ber of stalks produced in the following season. The results obtained were as follows: previous num- 1. There was a highly positive correlation between the sum of spears and stalks produced. 2. The plots harvested until the end of July were caused low yield due to the poor development of root system. 3. The number of stalks produced were slightly correlated with the crownbuds of previous year but the length of the harvesting period were influenced severely. 4. The marginal harvesting period of Japanease udo in Chonnam area were determined to the end of May. previous autumn and the num-