서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

Stented Graft의 임상경험

권태원,김호성,김도균,성규보,조용필,김건언 대한혈관외과학회 2000 Vascular Specialist International Vol.16 No.2

Purpose: Endovascular repair is a alternative treatment with favorable short-term result, but long term results are not available compared to standard operation. The authors have reviewed experiences of Asan Medical Center on stented graft, performed from Aug. 1998 to Feb. 2000, and the results as to age, operative indication, clinical condition, anatomic location, complication, follow-up are reported. Method: Seven patients who has received stented graft between Aug. 1998 and Feb. 2000 are reviewed retrospectively. Result: Of the seven patients, 6 were male and 1 was female. The mean age was 46.4 years (17~71). Indication for stented graft were two pseudoaneurysms, two iatrogenic arterio-venous fistulas, one thoracic aorta aneurysm, one abdominal aortic aneurysm, and one iliac artery occlusion with blue toe syndrome. Three different types of stented graft devices were utilized: Dacron-covered nitinol stented graft (made by the Asan Medical Center medical device team), Vanguard II (by Boston Scientific Corp.), and PTFE with nitinol stented graft (by Tae-woong). There was no perioperative mortality, and the technical success was achieved in five cases (71%). The patency at 14-month were 1009o (5/5). Two immediate complications are hemorrhage due to iliac & femoral artery avulsion requiring emergency bypass grafting, and deployment failure of stented graft requiring removal of retained graft device. Conclusion: Stented graft may be utilized even in complicated vascular situation but will need further development of device and more experience to prevent possible catastrophic complication. Indication should be decided by team approach and vascular surgeon should be prevent or participate during the procedure.

[논문]ZCS를 이용한 간단한 long pulse CO2 레이저 전원

김태균,이임근,김희제 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-

30Torr 이하 저압 공진기에서 ms order의 long pulse duration을 가진 간단한 펄스 CO2 레이저를 구현하였다. 레이저 시스템의 새로운 전원은 직접 상용전원을 스위칭한다. 이 새로운 전원의 방전 회로에는 정류기, 축전용 커패시터, 또는 전류 제한용 저항이 필요하지 않다. 레이저 출력을 제어하기 위해 펄스 반복률을 최대 60Hz까지 조절했고,SCR의 스위칭각은 30°에서 150°까지 변화시켰다. ZCS circuit과 PIC one-chip microprocessor는 SCR 게이트 신호를 제어하기 위해서 사용되었다. 18 Torr 압력,60Hz 의 펄스 반복률,SCR 스위칭각 90°에서 최대 레이저 출력 35 W를 얻었다. 또한 다른 CO2 레이저와 비교해서 long 펄스를 얻을 수 있었고 이는 대략 3ms(FWHM) 였다.

사람 말초 혈액 임파구의 interleukin-2 수용체(Tac 항원)발현 및 증식능의 조절에 대한 연구

김태근,조양자,정태준,김정목 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1

Proliferation of T lymphocytes has been determined by a threshold of signals generated by the interaction between interleukin-2 (IL-2) and its spedific membrane receptor (IL-2R). Regulation of IL-2R expression on the surface of lymphocytes is important in the generation of cytototocix T cells and lymphokine-activated killer (LAK) cells carrying anti-tumor effector functions in the body. To obtain the ideas in designing in vivo immunotherapy using biological response modifiers, this study examined the effects of the interferon(IFN)s, steroid, or colchicine on the IL-2R expression and proliferation of human peripheral blood lymphocytes(PBL). As incubation time was lengthened up to 72 hours, the number of Tac-positive cells and prolongation potential of human PBL upon stimulation wit IL-2 or mitogens were increased. IFN-α resulted in a significant inhibition of IL-2R expression induced by IL-2 but IFN-Υ had no effect. Colchicine or dexaamethasone also inhibited IL-2R expression and cell proliferation induced by IL-2 or mitogens. These findings suggest that IL-2R expression and proliferation of human PBL are inhibited by IFN-α, colchicine, or dexamethasone.

토양에서 분리한 Toluene 분해 세균의 동정 및 일부 특성

김종구,박근태,이건,이상준,손홍주 부산대학교 환경문제연구소 1998 環境硏究報 Vol.16 No.-

경상남도 양산천 일대의 토양시료로 부터 toluene을 유일한 탄소원 및 에너지원으로 생육하는 미생물들을 분리하였고, 그 중 toluene의 분해능이 가장 우수한 균주를 선별하여 공시균으로 선택하였다. 공시균의 형태학적, 배양적, 생화학적 및 화학분류학적 제반 특성들을 토대로 분류학적 위치를 검토한 결과 Rhodococcus 속으로 동정되어 편의상 Rhodococcus sp. EL-43P로 명명하였다. Rhodococcus sp. EL-43P는 phenol 및 다양한 phenol 유도체, benzene 등의 방향족화합물 기질에서 생육할 수 있었다. 특히 phenol 분해에 관련된 각종 환경조건을 최적화시키면 실제의 phenol 함유 폐수처리공정에서 충분히 적용가능성이 있음을 알 수 있었다. Rhodococcus sp. EL-43P는 catechol 1,2-dioxygenase의 활성을 가지고 있어 ortho pathway에 의하여 phenol을 분해함을 알 수 있었다. 또한 본 공시균은 toluene dioxygenase의 활성도 가지고 있었다. The microorganisms which degrade toluene as the sole and energy source were isolated from soil around Yangsan river. Among them, the strain EL-43P had the highest toluene degradability and identified as a Rhodococcus sp. according to morphological, cultural, biochemical and chemotaxonomical properties. Rhodococcus sp. EL-43P was able to grow at the various chlorinated phenols such as o-, p-chlorophenol, 2,3-,2,5-, 2,6- and 3,4-dichlorophenol, and benzene, respectively. If detailed phenol degradation conditions are established, the treatment of phenol wastewater using Rhodococcus sp. EL-43P would be possible. Rhodococcus sp. EL-43P had the catechol 1,2-dioxygenase which degrades Phenol derivatives by ortho pathway. This strain also had toluene dioxygenase.

초등학생의 영어불안이 영어성적에 미치는 영향

김명철,정태근 부산교육대학교 학생생활연구소 2003 學生指導硏究 Vol.23 No.-

The purpose of this study was to find out the effects of English anxiety on English achievement according to gender and anxiety levels as 210 elementary students. The major findings are as follows: 1. There is no significant difference in English anxiety according to gender, but there is a significant difference in English achievement according to gender. 2. There is a significant difference in English achievement according to anxiety levels. 3. There is a significant difference and negative correlation between English anxiety and English achievement.

뇌자기공명영상촬영술상 병변을 관찰할 수 없는 허혈성 뇌경색

김진석,김태완,임정근 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.4

1. 임상적으로 뇌졸중이 의심되어 증상 발생후 24시간에서 2개월까지 Brain MRI을 실시한 722명의 환자들 중 결과가 가음성인 환자는 모두 22명 (3.1%)이었다. 2. Brain MRI상 병변은 관찰되지 않으나 임상 양상 및 신경학적 이상 소견으로 추정되는 병변의 위치를 구분해 보면 뇌간부가 13명 (59%)으로 가장 많았고, 피질하부 8명 (36%), 피질 1명 (4.5%)의 순 이었다. 3. 대뇌혈관 (large cerebral artery)폐쇄 보다는 분지 동맥 (branch artery)이나 소 관통동맥 (small perforating artery)의 폐쇄에 의한 것으로 추정되는 허혈성 뇌경색의 병변의 빈도가 높았다. 4. 병력, 뇌졸증 위험 인자, 임상 양상, 심전도 검사, 심초음파 검사 및 뇌혈관조영술등에서 혈전성 뇌경색은 12명 (55%), 색전성 뇌경색은 3명 (13%), 원인이 확실하지 않은 경우는 7명(32%)으로 혈전성 뇌경색의 빈도가 뚜렷하게 높았다. 5. T1강조 영상, T2,강조 영상 및 FLAIR sequence를 같이 실시함으로써 허혈성 뇌경색의 조기 발견은 과거의 연구 보고에 비하여 상당히 높아졌으나 계속적으로 Brain MRI상 가음성인 허혈성 뇌경색이 있음으로, 허혈성 뇌경색의 조기 진단에는 새로운 기법인 확산강조 자기공명영상, 관류강조 자기공명영상, 자기공명 분광경 등의 다른 특수한 Brain MRI이 필요할 것으로 생각되며, 항상 신경학적인 검사를 통한 임상적인 진단이 선행되어야 한다. Background : Brain magnetic resonance imaging (MRI) is more sensitive than computed tomography in the diagnosis of acute ischemic stroke, but may not visualize all acute ischemic stroke. For deeper understanding of MRI negative strokes, we reviewed case histories, abnormal neurological finding, and localized ischemic lesions presumedly which were not present in brain MRI scans. Methods : Patients with a clinically definite first ischemic stroke and absence of corresponding lesion in brain MRI scans were studied retrospectively with hospital records dating from January 1994 to November 1996 and prospectively from December 1996 to August 1997. Patient with transient ischemic stroke, postictal paralysis, central nervous system infection, demyelinating disease, hemiplegic migraine, functional or hysterical cause, multiple cerebral infarction, scans within 24 hours and equivocal findings were excluded. Brain MRI was scanned with T2WI, T1WI and FLAIR sequence. Results: We studied 722 patients with clinically diagnosed definite acute ischemic stroke during the study period and identified 22 patients (3.1%) with the absence of corresponding lesion in brain MRI scan. The ischemic strokes without brain lesions on MRI scan were clinically localized to the brain stem (n=13, 59%), subcortex (n=8, 36%) and in the cortex (n=1, 4.5%). Perforating arterial and thrombotic ischemic lesions seemed to be more common than large arterial & embolic lesions. Risk factors was not different between MRI positive and MRI negative ischemic stroke. Summary: Acute ischemic stroke with absence of brain lesion in MRI scans is more common in brain stem and subcortex than in the cortex. There is some potential limitation of standard MRI scan for diagnosis of acute ischemic stroke, therefore further scans with new imaging studies such as perfusion/diffusion weighted magnetic resonance imaging are required in selected cases.

인산 칼슘을 사용한 수산화아파타이트 시멘트의 응결·경화 특성에 관한 연구

김한엽,박찬근,송태웅 경남대학교 신소재연구소 1996 論文集 Vol.6 No.-

습식법이나 수열법으로 합성한 hydroxyapatite(HAp)의 분말을 성형, 열처리한 소결체는 지금까지 알려진 바이오 세라믹스 중 생체친화성이 가장 우수한 것으로 입증되고 있으나 소결에 따르는 제조상의 몇가지 문제점을 안고 있다. 본 연구에서는 소결에 의하지 않고 tetracalcium phosphate(TTCP)분말과 dicalcium phosphate dihydrate(DCPD) 분말의 혼합물로 만든 paste를 용해·침전반응으로 응결·경화시켜 직접 HAp 경화체를 얻고, 이때 몇가지 변수가 HAp의 생성과 응결 및 경화특성에 미치는 영향을 검토하였다. TTCP와 DCPD로 조합한 시멘트의 수화반응생성물은 HAp 경화체였으며 이의 미소결정의 interlocking에 의해 응결·경화 하였다. 반응온도 및 HAp 종자의 첨가는 주로 초기단계의 반응속도에 영향을 주었다. 50℃에서의 HAp 생성 반응은 24시간 이내에 거의 완료되었다. Hydroxyapatite ceramics, one of the excellent biocompatible materials, are usually prepared by sintering of hydroxyapatite powders from wet chemical methods. But some problems caused by sintering process are still remained. In this study, instead of powder sintering methods. hardened bodies of hydroxyapatite were prepared by self-hardening reaction of cement paste composed of powdered tetracalcium phosphate(TTCP) and dicalcium phosphate dihydrate(DCPD). Some effects of seeding, reaction temperature on setting and hardening properties were investigated . The hydration products of the hardened paste were composed of finely-crystallized hydroxyapatite which causes setting and hardening by interlocking themselves. Self setting and hardening reaction are accelerated by elevating reaction temperature and addition of hydroxyapatite powders as a seeding materials. The hydration reaction of the paste. at 50C. was nearly finished within 24 hours after mixing with water.

척수손상·비손상인의 신체부위별 신체구성 및 골밀도 비교

김성수,황부근,김태수,이충일,양정수,이동희 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

This study was designed to compare segmental body composition and bone mineral density in spinal cord-injured(SCIS; n=9, SCIA; n=9) and non-injured control(AB; n=9) subjects. Dual-energy X-ray absorptiometry(DEXA) was used to measure %body fat, body fat mass, lean body mass, bone mineral contents, and bone mineral density in total and various body regions(arms, legs, trunk). The present results showed that body fat mass and %body fat were significantly higher and lean body mass was significantly lower in the SCIS group compared to AB group, while there was no difference between the SCIA and AB group in those of parameters. In BMC, there was no difference among groups and in BMD, SCI group was significantly lower that AB group, but there was no difference between SCIA group and AB group. Based on these results, in can be suggested that long-term regular exercise can reduce the negative changes in body composition, bone mineral density by spinal cord injury.

만성 통증 질환들의 새로운 분류 및 진단 기준 : 류마티스 관절염, 섬유근육통 및 척추관절염

김근태 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.1

Rheumatoid arthritis, fibromyalgia, and spondylarthritis are important diseases causing chronic pain and disability in rheumatologic areas. The classification and diagnostic criterias of them were made on the basis of clinical features, radiologic and laboratory findings and have been used decades ago. According to the development of new knowledge about etiology and pathogenesis of rheumatic diseases, the need for new criteria has been increased. In recent years, new criteria for these diseases have been developed, and they allow the early assignment of diseases and early start of therapy. In this review, the author summarizes recent advances and changes in diagnosis of rheumatoid arthritis, fibromyalgia, and spondylarthritis.