진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

Speaker Verification System Using Hybrid Model

강현규,양성일,권영헌 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-

본 논문은 하이브리드 모델을 이용한 화자 식별시스템에 대한 연구이다. 화자 식별을 위하여 설계한 하이브리드 화자 인식기는 일반적으로 사용되고 있는 HMM과 DTW를 사용하여 구성하였다. 인식기의 성능을 판단하기 위한 실험은 다음의 세 가지에 대하여 수행하였다. 시스템에 등록되어 있는 화자의 식별과 비 등록 화자의 등록된 화자 키워드 도용에 대한 시스템 거부, 그리고 등록된 화자의 다른 등록 화자에 대한 키워드 도용에 따른 시스템 거부에 관하여 검토하였다. 키워드는 화자의 이름을 사용하였고, 시스템에 사용된 특징 파라메터는 15차 켑스트럼(CEP), 10차 line spectrum pairs (LSP), 10개 대역으로 나뉘어진 주파수 대역별 에너지값(FB)을 사용하였다. 이 세 가지의 특징 파라메터들과 두 개의 인식기를 조합, 무두 여섯 개의 인식 결과 값을 누적하여 인식 여부를 결정하도록 하였다. 개별적 시스템에서 발생되는 오인식을 Hybrid model을 이용하여 처리한 본 시스템에서는 좋은 결과를 얻을 수 있었다. This paper is a study on the speaker verification system(SVS) using hybrid model. For speaker verification, we design a hybried-recognizer composed of conventional methods (such as HMM, DTW), We verified the performance; system access for registered speaker using correct keyword, system deny-Ⅰfor non-registered speaker using arbitrary keyword, and system deny-Ⅱ forregistered speaker using keyword of another registered speaker. A name of speaker is used as keyword. We use three classes of feature vectors respectively; line spectrum pairs (LSP), cepstrum (CEP), and filter bank energy (FB). Hybridrecognizer using these three features will give rise to six results with respect to feature and recognizer. Though a single system makes some recognition error, this speaker verification system using hybridmodel shows a good results in this experiment.

都市便益施設에 의한 定住環境 分析에 관한 硏究

權俊五,金宇赫,姜聲泰 조선대학교 국토개발연구소 1996 국토개발연구 Vol.16 No.1

This Study is to obtain the technical index using the urban facilities on the objects of urban in Korea, compares and analyzes the urban scale of according to the population, analyzes the living environment of urban and them is to suggest the policies for the balanced development of nation and the effective growth of urban systems, and the research of nation and the effective growth of urban systems, and the research results are as follows; ① in the case of the urban of the population more than 500,000, educational, hygienic and cultural facilities have the most influence on it, ② in the case of one with 200,000 to 500,000, information, communication, social welfare, administration and leisure facilities and ③ in the cse of one with population less than 200,000, social welfare, leisure and hygienic facilities, so, it is considered that the expansion of each urban facility is required in the living environment of each city.

급냉 제강슬래그를 잔골재로 사용한 차폐콘크리트의 공학적 특성에 관한 실험적 연구

강기웅,조성현,정원섭,권기주,김진만,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The steel slag, a by~product which is produced during the manufacture of steel by refining pig iron, is mainly used as road materials after aging it. It is necessary to age steel slag for long time in air because the reaction with water and free-CaO in steel slag could make the expansion of volume. This problem prevents steel slag from being used as aggregate for concrete. However, steel slag used in this study was controled by a air-jet method which rapidly cools substance melted at a high temperature. The rapid-chilling method prevents from generation of free-CaO in steel slag. The rapid-chilled steel slag is similar to be spherical shape and has the heavier specific gravity than natural aggregate. Therefore, it could be used to manufacture radiation shielding concrete as fine aggregate. This paper investigated the engineering properties of radiation shielding concrete when using rapid-chilled steel slag as fine aggregate. As results of this study, the increase of use of rapid-chilled steel slag decreased the desirable water content of concrete but developed the rate of radiation shielding of concrete. The strength of concrete using it is similar to that of concrete using river sand.

1회선 분기점을 갖는 병행 2회선 송전선로 고장점 표정 알고리즘

權寧珍,美想熙,李承宰,崔勉松 明知大學校 産業技術硏究所 2002 産業技術硏究所論文集 Vol.21 No.-

This paper presents a fault location algorithm of a single phase-to-ground fault on a parallel transmission line which contains a teed circuit. The method uses only the local end voltage and current signals. Zero sequence currents of other lines are calculated by distribution factors. Instead of zero sequence current, negative sequence current is used to remove the effect of load current and to calculate the voltage of a fault resistance. There are three distance equations in this algorithm. One of them is to calculate inner part fault location without teed circuit and another equation is for outer part fault location without teed circuit and the other is to calculate inner part fault location with teed circuit. Correct fault distance is selected by the condition of each solution. Extensive simulation studies using EMTP have verified that the proposed algorithm can calculate an accurate fault distance in spite of effects of various error sources.

工團地域 小河川의 底泥中 重金屬 含量

權五億,梁成鎬,姜善泰 대구산업정보대학 1992 논문집 Vol.6 No.-

This study was carried out to investigate the contents of six heavy metals (Cd, Cr, Cu, Mn, Pb and Zn) in sediment collected at seven sites of 3-Gongdan stream receiving industrial wastewater. The mean Zn, Cu, Mn, Pb, Cr and Cd contents in sediment of all sites investigated was 1496.6mg/kg, 764.4mg/kg, 562.0 mg/kg, 231.6 mg/kg, 37.3 mg/kg and 9.5 mg/kg, respectively. It can be esteimated that the high amount of heavy metals is possibly due to the industrial wastewater, and alkaline pH water when most of the heavy metals are precipitated.

흉막삼출의 유무에 따른 쯔쯔가무시증 환자간의 비교

권세훈,김형호,강지인,하재하,한경택,이재록,김동민,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Scrub typhus is a potentially fatal infectious disease caused by the organism Orientia tsutsugamushi. Clinical manifestations are fever, skin rash, eschar and varying degree of respiratory distress. The pleural effusion in scrub typhus is rare and secondary to the destruction of vascular endothelium. Because the respiratory symptoms are generally mild and the pleural effusion in scmb typhus is rare than in interstitial pneumonia, there are few comments about the characteristics of scmb typhus with pleural effusion. So we made the comparative study of scmb typhus patients between with pleural effusion and without pleural effusion. 연구배경 치명적일 수 있는 감염질환 중 하나인 쯔쯔가무시중(Scrub typhus)에서 드문 흉막삼출을 동반한 환자에 대한 고찰은 다른 문헌에서도 자주 언급되지 않았다. 따라서 본 저자들은 흉막삼출이 있는 경우와 없는 경우에 따른 쯔쯔가무시중 환자들을 비교하고자 하였다. 방법 2003년에서 2006년까지 조선대학교 병원 내과에 입원중인 환자 중 쯔쯔가무시중 진단을 받은 총 109명의 환자를 대상으로 하여 흉부 X선 검사 및 혈청학적 검사(CPK, LDH, ESR, CRP, AST, ALT, ADA), 혈액학적 검사(WBC, PLT) 및 백분율 검사등을 실시하였다. 결과 흉막삼출이 있는 환자들의 경우 흉막 삼출이 없는 환자들에 비해 ESR 수치가 통계학적으로 의의있게 높았다(p-vaule < 0.05). 결론 흉막삼출 유무에 따른 쯔쯔가무시중 환자간의 비교에 있어 ESR 수치가 통계학적인 의의를 가졌다.

Bacillus sp. KCM-101에 의한 내열성 α-amylase의 생산 및 효소학적 성질

강상모,최유정,황윤영,이동희,권태종 건국대학교 산업기술연구원 2000 건국기술연구논문지 Vol.25 No.-

A strain isolated from soil was able to produce thermostable α-amylase. The strain (KC-101) was identification as Bacillus sp. Bacillus sp. KC-101 was treated NTG(N-methyl-nitro-nitrosoguanidine). The mutant KCM-101 increased α-amylase activity and decreased pretease activity. The condition for production, purification, and properties of α-amylase were investigated. α-Amylase production was maximized when was grown on soluble starch 2.0%, yeast extract 0.5%, K2HPO4 0.1% and MnCl2 0.02% for 24hrs at 37℃, and initial pH 7.0. The enzyme production was also increased by the addition of 0.01% Triton X-100. The enzyme was purified by ultrafiltration(MW 10,000), 80% ammonium sulfate precipitation, and Sephadex G-75 gel chromatography and it's yield 15.0%, The characteristics of purified α-amylase were as follow : MW 55,000, optimal pH and temperature were 7.0 and 95℃, respectively. The enzyme was activated by Ca++ and Mn++ ion but inhibited Co++, Cu++, Hg++, and Pb++ ion. The enzyme was stable at 95℃ and it's thermostability was greatly increased by the addition of Ca++. In kinetic studies, the Km value of α-amylase for soluble starch was 0.93mg/mL.

Garcin 증후군으로 발현된 연골육종 1예

강성수,김명권,박현미,류근신,신동진 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

점증적 최대운동이 항산화 효소의 혈중 농도에 미치는 영향

강신범,이상우,김상권,서해근,김준모 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study is to examine how exercise stimulus effects on the boold concentration of antioxidant enzymes. And then, the results of analysing the boold concentration of antioxidant enzymes before and after graded maximal exercise based on high school's 7 males, are as follows: 1. The blood concentration of SOD is found to have a significant increase before and after graded maximal exercise. 2. The blood concentration of CAT is found to have a significant increase before and after graded maximal exercise. 3. The blood concentration of CAT is found to have a significant change. As the above results, the severe exercise of short time is found to increase the blood concentration of SOD as well as CAT. And then, the blood concentration of GPX is found not to have a significant exchange. To examine the mechanism of the above results manifestly, it is considered that the deep study based on exercise style, duration time and exercise intensity, should be continued.