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Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
윤성호,박지희,박정규,김만섭,김달원,송문용,강규일,황원구,구세광,장광호,권영삼,Yun, Sung-Ho,Park, Jihee,Park, Jeongkyu,Kim, Manseop,Kim, Dalwon,Song, Moon-Yong,Kang, Gyoo-Il,Hwang, Won-Koo,Ku, Sae-Kwang,Jang, Kwang-Ho,Kwon, Young-Sam The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
The objective of this study was to compare the biocompatibility for local irritation and bioavailability of $Gentacol^{TM}$ and $Collatamp^{TM}$, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded regions. No detectable gentamicin was observed in the plasma of $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of $Collatamp^{TM}$ and $Gentacol^{TM}$. These results suggest $Gentacol^{TM}$ may show favorable local bioavailability and induce only slight local irritations as comparable as $Collatamp^{TM}$ without systemic exposures in the condition of this experiment. 본 연구의 목적은 겐타마이신 함유 스폰지인 겐타콜과 콜라템프를 랫드 근육내 이식 후 생체적합성을 비교하는 것이다. SD 랫드 66 마리를 네 그룹으로 나누었다; (1) 대퇴사두근에 무처치한 군 (대조군, 6 마리), (2) 대퇴사두근에 겐타마이신 액을 주사한 군 (겐타마이신 군, 6 마리), (3) 대퇴사두근에 콜라템프를 이식한 군 (콜라템프 군, 27마리), (4) 대퇴사두근에 겐타콜을 이식한 군 (겐타콜 군, 27 마리). 겐타콜과 콜라템프 이식 한근육 내 겐타마이신 농도는 시간이 지남에 따라 점차 감소하였다. 혈액 내에 겐타마이신 농도는 측정되지 않았다. 조직학적으로 겐타마이신액을 주사 후 근육 내에 다형핵백혈구, 림프구, 대식세포를 포함하는 염증세포가 중등도에서 심하게 침윤되었고, 경도에서 중등도의 근육내 부종이 관찰되었다. 그러나, 이러한 국소 자극의 조직학적 변화는 콜라템프와 겐타콜 군에서는 현저히 감소하였다. 이상의 결과, 겐타콜은 콜라템프와 비교하였을 때에 전신적인 영향을 미치지 않으며 국소자극의 정도가 유사하였고, 생체이용성이 유사하여 좋은 생체적합성을 가지는 것으로 생각된다.
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윤성호,양형채,Nutsalai Galiulina,강태구,김희영,임혜린,임상철 대한이비인후과학회 2020 대한이비인후과학회지 두경부외과학 Vol.63 No.1
Background and Objectives Nasal surgery is known to improve the quality of life in patientswith obstructive sleep apnea; however, its effect on the airway structure is little known. This study attempted to identify the impact of nasal surgery on the pharyngeal airway structure. Subjects and Method We enrolled in the study patients who underwent nasal surgery fromJuly 2015 to March 2018 due to nasal obstruction with severe snoring or sleep apnea. Patientswith palate surgery or previous history of airway surgery were excluded. Demographic factors,symptoms regarding nasal obstruction, sleep study, preoperative cephalometry, and postoperative3-month cephalometry were taken into account and analyzed. We also performed asubgroup analysis according to the severity of sleep apnea. Results Sixty-three patients were enrolled in this study. Soft palate thickness showed no significantchange. Pre and postoperative soft palate thickness were 10.82±3.00 and 11.11±3.35(p=0.261), respectively. However, the pharyngeal airway space was enlarged via nasal surgeryfrom 12.05±3.35 to 13.04±3.35 (p=0.006), respectively. The subgroup analysis showed that thepharyngeal airway was mainly enlarged in the patients with lower Apnea-Hypopnea Index (AHI). Conclusion Although nasal surgery does not reduce soft palate thickness, it can enlarge thepharyngeal airway space. The effect of surgery would be more prominent in patients withAHI of lower than 15 event/hour (p=0.005) as nasal surgery alone does not affect the pharyngealairway of patients with AHI greater than 15.
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미숙아에서 경비지속기도양압과 가습고유량비강캐뉼라의 사용에 대한 비교 연구
윤성호,권영희,박현경,김창렬,설인준,이현주 대한신생아학회 2011 Neonatal medicine Vol.18 No.2
Purpose: The aim of the study was to investigate the change in usage and clinical outcomes of using a humidified high flow nasal cannula (HHFNC) in preterm infants. Methods: A retrospective review of patients with gestational age <32 weeks born at our neonatal intensive care unit from January 2008 to March 2011 was performed. First, data were compared between Era 1 (January 2008 to February 2009) and Era 2 (March 2009 to March 2011) to describe the increased usage of HHFNC. Second, the patients (gestational age 25-30 weeks) were divided into two groups to compare clinical outcomes. nasal continuous positive airway pressure (NCPAP) and HHFNC groups who received either NCPAP or HHFNC as a respiratory support within 14 days of birth. Results: Compared to Era 1, HHFNC usage increased from 10 to 55% in Era 2, whereas NCPAP usage decreased from 40 to 5%. No difference in pulmonary or adverse outcomes including the incidence of reintubation and bronchopulmonary dysplasia (BPD), days on oxygen and a ventilator, and other outcomes was observed between the HHFNC and NCPAP groups. Days to reach full feed (32.2±16.7 vs. 24.7±10.2, P=0.05) and regain birth weight (20.9±16.9 vs. 17.2±4.3, P=0.04) decreased in the HHFNC group. Conclusion: HHFNC was feasible and did not differ in respiratory and other outcomes, but days to reach full feed and regain birth weight decreased in the HHFNC, when compared with the NCPAP. An additional prospective multicenter designed study is needed to better define safety and efficacy of HHFNC.
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용융 Si 침윤법에 의해 제조된 반응소결 탄화규소 복합체에서 SiC 입자 크기의 영향
윤성호,조경선,정훈,김영도,박상환,Yun, Sung-Ho,Cho, Kyung-Sun,Tan, Phang Nhun,Cheong, Hun,Kim, Young-Do,Park, Sang-Whang 한국세라믹학회 2008 한국세라믹학회지 Vol.45 No.8
Reaction bonded silicon carbide(RBSC) composite for heat-exchanger was fabricated by molten Si infiltration method. The raw materials with variable particle sizes were used in this experience. The finer the particle size in sintered silicon carbide was the more increasing 3-point bending strength and fracture toughness. As the adaptable particle sizes had been occupied interstice arising from packing sample, the mechanical properties were increased. In the PCS1-1 sample, the 3-point bending strength and fracture toughness were 323MPa and $4.9\;MPa{\cdot}m^{1/2}$, respectively.
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