Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

제2형 당뇨병 환자에서 알부민뇨와 심혈관계 질환의 유병율에 대한 연구

강태수,최소래,김영아,박흥수,서정건,황학진,윤세정,신석균,강신욱,최규헌,이호영,한대석,허애정,하성규 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

미세입자(PM_(2.5))의 배출원 구성물질 성분비 개발에 관한 연구

이학성,강충민,강병욱,이상권 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.3

The purpose of this study was to develop the PM_(2.5) source profiles, which are mass abundances (fraction of total mass) of a chemical species in PM_(2.5) source emissions. The source categories studied were soil, road dust, gasoline and diesel vehicles, industrial source, municipal incinerator, coal-fired power plant, biomass burning, and marine. The chemicals analyzed were ions, elements, and carbons. From this study. soil source had the crustal components such as Si, AI, and Fe. In the case of road dust, Si, OC, Ca, Fe had large abundances. The abundant species were SO₄^(2-), Cl^(-), NH₄^(+), and EC in the gasoline vehicle and EC, OC, Cl^(-), and SO₄^(2-) in the diesel vehicle. The main components were SO₄^(2-), S, NH₄^(+), and EC in the industrial source using bunker C oil as fuel. ^(-), NH₄^(+), Fe, and OC in the municipal incinerator source, and Si, Al, SO₄^(2-), and OC in the coal-fired power plant source. In the case of biomass burning, OC, EC, and CI- were mainly emitted. The main components in marine were Cl^(-), Na^(+), and SO₄^(2-).

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

肺臟에 發生한 過誤腫의 一部 例

尹康爀,鄭相愚,李學相 全南大醫大 1974 전남의대학술지 Vol.11 No.4

태권도공원 선정기준유형이 방문의도에 미치는 영향을 통한 세계화방안

정길상,김학신,강진형 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

This study was conducted for national participants in leisure sports convention events, the strong opinion leaders in the leisure sports tourism market. They have specialized and high-level of insights into the leisure sports tourism market. and it could give very meaningful suggestions to identify the effect of Taekwondo park selection criterion on their potential revisit. The results of this study were found as follows: It was found that the male group thought more importantly of the economic efficiency and ease of access than the female counterparts in terms of the criterion for selection of the Taekwondo park. Second, it was found that the ground of high school graduates thought importantly of beautiful natural environment and scenery, while the well-educated group of college graduate school and more than graduate school thought importantly of the culture and history of Taekwondo and economic efficiency of development. Third, it was found that the age group of 21-30 years old attached more importance to the cultural and historical background of Taekwondon, its growability into world-class tourist attraction, economic efficiency of development than the age group of less than 20 years old. Fifth, it was found that such Taekwondo park selection criteria as the cultural and historical background of Taekwondo(differentiated history, native culture), its growability into world-class tourist attraction(specified image and high name recognition, economic efficiency of development(developable image, tourism industry infrastructure), ease of access(convenience of access to the traffic network from home and abroad, full local transportation(road, parking lots and the like) had a significant effect on the potential intention to revisit). The Korean Taekwondo park should highlight the phase of the country of its origin and grow into the world-class attraction for traditional martial arts. Only the region that can maximize the direct and indirect history and culture related to Taekwond can maximize the consumption value needs of quality tourists at home and abroad and globalize the prestigious and hihg-profile traditional Korean culture.

자발성 후골간신경 손상

정진성,강현구,김진석,이학승,장혁 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

요골신경의 분지인 후골간 신경손상은 주로 요골골두 손상이나 골절에 의해 나타나며, 지방종, 결절종, 점액낭염, 섬유종 또는 류마티스양 활막염 등의 비 외상성 압박에 의해서도 발생할 수 있으나 특별한 원인 없이 자발적으로 발생하는 후골간 신경손상은 비교적 드물다. 저자들은 수면 후 발생한 좌 상지 근력저하를 주소로 내원하여 시행한 신경학적 검사와 전기 생리학적 검사에서 특별한 원인 없이 자발적으로 발생한 후골간 신경손상을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Posterior interosseous nerve, deep muscular branch of radial nerve, can be compressed by tumor, ganglion, fibroma, bursitis, or rheumatoid synovitis. But, spontaneous posterior interosseous nerve neuropathy is relatively rare. We report a case of spontaneous, non-traumatic paralysis of the posterior interosseous nerve.

건설계측을 위한 IBM-PC 응용 I

김학수,서강석,정상용 湖南大學校 1997 호남대학교 학술논문집 Vol.18 No.2

Nowadays construction market shows an increasing tendency to apply the computerized measuring and control system in order to meet the growing requirements for accuracy and optimization in construction quality. Accordingly this study is focused on putting IBM-PC interfacing unit into practical use in measuring and control, and suggested are the application of automated measuring and control system in the construction fields.

패턴구성에 따른 RPNN의 음성인식 성능비교

김주성,한학용,허강인 東亞大學校 附設 情報通信硏究所 1997 情報通信硏究所論文誌 Vol.5 No.1

In this paper, we use th RPNN as a non-linear predictor according to the time variation of a speech without an alignment procedure. We perform the recognition experiment of Korean 100 syllables based on RPNN In the experiment, we compare the recognition rates, by increasing the prediction order and the number of hidden(recursive) units, and by composing the pattern. When the prediction order is 3-rd order and the hidden units are 10 units, the recognition rates show better result than others. And when we compose the pattern as the method 2, they are far improved than the method 1. In the method 1, the highest recognition rate is 82.40% at the 4-th prediction order and the 10 hidden units. And in the method 2, it is 84.90% at the 3-rd prediction order and the 10hidden units, and it is improved at 2.50% than the method 1

고강도 콘크리트(80MPa이상)를 이용한 콘크리트충전강관구조 적용을 위한 기초물성 연구

이장환,강용학,정근호,김진호,정상진,최문식 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

One of the most important reasons that CFT is used in many conditions is by using that we can achieve the effect, which reduce the section of the member. This research purpose to find the most ideal composition, which is achieved by the investigation in the concrete's property of matter like ability of Slump, Slump Flow, Air content, Bleeding, and Settlement when the high strength of concrete which is over 80MPa is used m the CFT column.