쯔쯔가무시병에 의한 길랑-바레증후군

이학승,이영주,박현영 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2

대뇌 백색질병변을 보인 크로이츠펠트-야콥병

이학승,박현영,장혁 대한노인병학회 2013 Annals of geriatric medicine and research Vol.17 No.4

This is a report of a patient with Creutzfeldt-Jakob disease. The 67-year-old male first developed partial and secondary generalized tonic-clonic seizures. He was disoriented and could not perform calculations nor recall objects shown to him 5 minutes earlier. Magnetic resonance images revealed hyperintensities of white matter lesions in fluid-attenuated inversion recovery weighted image. We detected protein 14-3-3 in the cerebrospinal fluid.

경부 대상포진 감염과 연관된 횡격막 신경 마비

이학승,박현영,조광호 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2

원발성 유방암에서 p53 단백발현과 예후와의 상관성에 관한 연구

이학승,이광만,채권묵,문형배 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1

p53 is a nuclear phosphoprotein which is normally expressed at very low level in all mammalian cells and plays a role in the regulation of cell proliferation. It has also been suggested that normal p53(wild type) serves as a tumor suppressor gene, and inhibits the oncogene-mediated cellular transformation and the rate of cellular proliferation. But, wild type p53 is hardly stained by immunohistochemistry because of its low intracellular concentration and very short half-life. Mutant form of p53 protein is detectable in various human malignancies e.g. colon, stomach, lung and breast cancer by immunohistochemical stain because of its prolonged half-life. In breast cancer, p53 protein expression has been regarded as an unfavorable prognostic factor, but the results of studies about the relationship between the p53 protein expression and prognosis are equivocal. So, author performed this study to evaluate the prognostic significance of p53 expression in 54 patients with primary breast cancer who underwent surgical treatment at Wonkwang University Hospital from October 1985 to September 1991. Follow-up period was 24-91 months (mean: 54.7months). p53 protein was stained by immunohistochemical methods in formalin-fixed, paraffin-embedded tissues using monoclonal antibody(DAKO-p53, DO-7). The prognostic significance of p53 protein was evaluated by positivity and 5-year survival rate, and comparing with well-known prognostic factors of breast cancer. p53 protein was expressed 48.1%(26/54) of primary breast cancers. 5-year survival rate of patients with p53 protein expression was 42.0%, and that of patients without p53 protein expression was 76.4%(p = 0.0277) There was no relationship between p53 protein expression and tumor size, lymph node metastasis, histologic grade or vascular invasion. These results suggest that p53 protein expression is another independent prognostic factor in primary breast cancer.

혈전용해술 후 뇌경색 반대측 미세출혈에서 발생한 뇌출혈

이학승,박현영,김요식 대한신경과학회 2007 대한신경과학회지 Vol.25 No.2

복시로 발현한 신경베체트증후군

이학승 대한신경과학회 2015 대한신경과학회지 Vol.33 No.4

측두와에 발생한 피부모양기형낭종

이학승,최승석,안희창,이장현 대한두개안면성형외과학회 2010 Archives of Craniofacial Surgery Vol.11 No.1

Purpose: Dermoid cysts are benign neoplasms that are derived from both ectoderm and mesoderm. Approximately 7 percent of all dermoid cysts occur in the head and neck,as most common sites are the lateral ends of the eyebrows,the midline in the nasal root and neck. Rarely they can be found in the frontal sinus, temporal bone, maxilla and the floor of the mouth. Dermoid cysts in the temporal fossa are extremely rare. We experienced a characteristic dermoid cyst that occupied the temporal fossa. Methods: A 16-year-old man had a progressive enlarging mass on the left eyebrow. Computerized tomographic scan showed a bulging mass in the temporal fossa, and it had the density similar to that of fat. The size of the mass was 3 × 3 × 2 cm, and it was composed of high density of fat with clear margin. There was no bony invasion, but the mass was fixed on bone. Results: We performed the surgery through coronal incision under general anesthesia. Because the mass was closely connected with temporal fat pads, we removed this mass with some portion of temporal fat pads, avoiding damage to the facial nerve. The postoperative course was ordinary without complication. Conclusion: The reports about dermoid cyst on the temporal fossa is uncommon. However, if there is a mass in the temporal fossa which has the density similar to that of fat in CT scan, we should consider the possibility of dermoid cyst. We suggest that excision through coronal incision with bewaring temporal fat pad can induce good result. (J Korean Cleft Palate Craniofac Assoc 11: 65, 2010)

21세기 새로운 시대를 준비하는 원광대학교 의과대학의 교육목표 개정과정

이학승,김요식,송윤강,오재민,양연식,정선관 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

교육목적은 대학의 교육이 지향하는 대전제이다. 그러므로 대학교육 목적과 목표가 어떤가에 따라 교육과정과 교육방법이 달라진다. 원광대학교 의과대학의 교육목표는, '지덕겸수'로 요약되는 '과학과 도학을 겸비한 전인교육'의 건학정신과 '학술탐구'와 '덕성함양'의 원광대학교 교육목표와 일치하게 현재까지 유지되었다. 그러나 현행 교육목표의 여러 문제점이 발견되었고, 시대상의 변화에 따라 원광대학교 의과대학에서도 사회적 변화 빛 의료인에 대한 시대적 요구에 걸맞은 의학교육의 목적 및 목표의 재설정 과정을 시작하게 되었다. 그 결과 개정 작업을 통해 새로운 교육목표를 설정하게 되었으며 그 내용은 다음과 같다. 1. 기본진료능력을 지닌 의사를 양성한다. 2. 원불교 교리 이념을 반영한 윤리적, 도덕적인 의사를 양성한다. 3. 평생 학습하는 연구하는 의사 혹은 의과학자를 양성한다. 4. 사회적 책무를 수행하는 리더십을 갖춘 의사를 양성한다. 5. 지역 사회에 공헌하는 봉사정신을 갖춘 의사를 양성한다. Purpose : With the changes to the medical environments and to the medical educational systems, we aimed to evaluate the current mission statement of the School of Medicine, Wonkwang University, and to revise it. Methods : To establish the new goal and mission statement, a Special Committee for the Revision of Medical School Mission and advisory group were organized in 2008. This special committee conducted through five steps of action, which are composed of investigation, education, development, surveillance of various opinions, and announcement. Results : For the development of new goal and mission, the revised, final goal and mission statements decided through the five steps of action. The new mission of Wonkwang University School of Medicine was as follows; 1. Doctor who can diagnose and treat easily 2. Ethical and moral doctor who practice Won Buddhism 3. Doctor or Medical Scholar who studies lifelong study 4. Doctor who has leadership to social responsibility 5. Doctor who goes into service to a local community. Conclusion : The authors expect that the new goal and mission of Wonkwang University School of Medicine would be helpful in giving the guideline on the educational process of medical school and will give the information to reform the medical school system according to the rapidly changing educational environment.

Infective Endocarditis Associated with Transcatheter Aortic Valve Replacement: Potential Importance of Local Trauma for a Deadly Nidus

이학승,이승표,정지현,김혜미,김지혜,박준빈,김형관,김용진,김효수,손대원 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.3

Recently, transcatheter aortic valve replacement (TAVR) has emerged as an alternative for the treatment of severe symptomaticaortic stenosis patients. Although experience with TAVR is increasing exponentially, few cases of post-TAVR endocarditis arereported. We present a case of 76-year-old man with infective endocarditis after TAVR who was definitely diagnosed byechocardiography.

삼능(Scirpus Maritimus)의 항암성 연구

이학승,황우익 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.3

This study was devised to observe the cytotoxic activities of the petroleum ether extract of Scirpus Maritimus (crude extract) and its partially purified fraction from silicic acid column chromatography (acetone fraction) against mouse leukemic cell (L_(1210)), hepatoma cell (Hep G2), human rectum (HRT-18) and colon (HT-29) cancer cells, in vitro. Each cell line was cultured in medium containing serial concentration of the crude extract or acetone fraction for 72 hours. And then the growth rate, dose-response and morphological change of each cell were determined. The results obtained are summarized as follows, 1. The doubling times of L_(1210), HRT-18, HT-29 and Hep G2 cells were about 12, 20, 22 and 40 hours, respectively, 2. The growth inhibition rates of L_(1210), HRT-18, HT-29 and Hep G2 cells were gradually increased in proportion to the concentration of the crude extract or acetone fraction in culture medium. 3. The cytotoxic activity of acetone fraction on the each cell line was more potent than that of the crude extract. 4. The growth inhibition rates of the cells treated with crude or acetone fraction were shown the difference among the each cell and greatest in the L_(1210) cell. 5. The numbers and size of HRT-18 cultured in medium containing acetone fraction were significantly reduced and deformed compared with the control group and the effect of actone fraction was more potent than that of the crude extract. In view of the results, there are contained the growth inhibitory substance on the several cancer cells in the acetone fraction of Scirpus Maritimus, it could be suggested that active compound is glycolipid.