개질재를 혼입한 재생아스콘의 역학적 특성에 관한 실험적 연구

박승범,조광연,조청휘,김정환,채용주 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

This paper presents the results of an experimental study on the mechanical properties of modified recycling asphalt concrete. Research has been performed to obtain the characteristics of the modified recycling asphalt concrete such as marshall test, indirect tensile test, resilient modulus and wheel tracking test by varying contents of modifier (SBS, SBR) and recycled aggregate(30, 50, 70%). Modified recycling asphalt concrete showed better performance than new asphalt concrete in dynamic stability. Each quality property of the modified recycling asphalt concrete satisfied requirement of pavement construction specification.

기질재를 혼입한 재생아스팔트의 물리적특성에 관한 실험적 연구

박승범,조청휘,김정환,채용주 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

This paper present the results of an experimental study on the mechanical properties of reclaimed asphalt using modified additives. This study has been performed to obtain the properties of recovered asphalt such as penetration, softening point and ductility, weight change ratio, penetration change ratio after thin film oven test according to contents of modified additives(3∼5%). Recovered-modified asphalt has improved in the temperature sensitivity, which is ductile at higher temperature and brittle at lower temperature compared to virgin one. Penetration, softening point, ductility test and mass and weight changing rate and thin film oven test of recovered-modified asphalt satisfied the standard fir the modified asphalt II. Therefore, it could be possible to produce a recovered-modified asphalt mixture similar to those of virgin-modified asphalt mixture.

지역균형개발을 위한 문화관광권의 투자 자원 배분 연구

임범종,최승국,임재영 문화관광연구학회 2001 문화관광연구 Vol.3 No.2

By the result of critical analysis based on the Multi-Regional IO Model for the whole country that divided into 8 boundaries of land, the whole national demand in tourism showed the 34.2% of increase by the impacts of tourism investment on regional economic growth. However it also analysed that the economical gap between the regions through these investment showed more broaden and wider than before. Accordingly in order to mollify the economical gap between the regions but with the encouragement of product increase, the policy scenario on the distribution of investment resource had designed effectively for the analysis per each scenario. In consequence of this policy analysis, all of the scenario showed that it had mollified the economical gap between the regions comparing to the tourism investment of 7 culture tourism belts.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Efficacy of the Subclavian Portal Approach in Arthroscopic Repair of Isolated Subscapularis Tendon Tear

Seung Bum Chae,Chang Hyuk Choi,Suk-han Jung 대한견주관절의학회 2014 대한견주관절학회지 Vol.17 No.1

Background: To evaluate the efficacy of the subclavian portal approach for the arthroscopic repair of isolated subscapularis tendon tear. Methods: We used the subclavian portal to carry out arthroscopic repair of the isolated subscapularis tendon tear. The surgery was carried out in 18 cases (average age of 53) from May 2006 to December 2009 with a mean follow-up period of 35 months. Of these cases, 13 patients had the tear in their dominant arms, 16 were male, and 12 were from traumatic ruptures with on average 7.6 months of symptom period to operation. Additional surgery, acromioplasty and subacromial debridement, were carried out on 4 cases each during the subscapularis repair. The integrity of cuff status was assessed by ultrasonographic examination at 6 months and at 1 year after operation. Results: The initial average range of motion in forward flexion, external rotation, and internal rotation were 160°, 50° and L4, respectively. At the 1 year follow-up period, these improved to 160°, 52° and T12, respectively. The initial average functional scores were assessed by KSS, ASES, UCLA, and Constant scoring systems, which were 67, 60, 26, and 65, respectively. These scores improved progressively with time. At 3 months after operation, the scores were 74, 67, 27, and 74; at 6 months, 83, 77, 31, and 75; at 1 year, 88, 86, 32, and 79; and at the final follow-up of 35 months, 84, 92, 34, and 84. Conclusions: In the repair of isolated subscapularis tendon tear, the subclavian portal approach provided a good angle for anchor insertion and sufficient space to manage the upper portion of the tendon tear. In turn, these provisions resulted in satisfactory clinical results.

Biomechanical Analysis of Three Different Reconstruction Techniques for Scapholunate Instability: A Cadaveric Study

Seung-Bum Chae,Jun Ho Nam,Il-Jung Park,Steve S. Shin,Michelle H. McGarry,Thay Q. Lee 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.4

Background: This study aimed to compare the biomechanical strength of 360° scapholunate interosseous ligament (SLIL) reconstruction only using an artificial material (AM), double dorsal limb (DDL) SLIL reconstruction only using AM, and the modified Brunelli technique (MBT) with ligament. Methods: Eight cadaver wrists were used for this study. The SL interval, SL angle, and radiolunate (RL) angle were recorded with MicroScribe. The SL distance was measured after dividing the volar and dorsal aspects. We utilized four different wrist postures (neutral, flexion, extension, and clenched fist) to compare five conditions: intact wrist, SLIL resection, 360° SLIL reconstruction using AM, DDL SLIL reconstruction using AM, and MBT SLIL reconstruction with ligament. Results: The dorsal SL distance in the SLIL resection was widened in all wrist positions. The dorsal SL distance was restored with all three techniques and in all wrist positions. The volar SL distance in the wrist extension position was widened in the SLIL resection condition. The volar SL distance was restored in the extension position after 360° SLIL reconstruction using AM condition. There were no statistically significant differences in SL and RL angles among the conditions. Conclusions: All three reconstruction techniques could restore the dorsal SL distance. However, only the 360° SLIL reconstruction using AM restored the volar SL distance in the wrist extension position. DDL SLIL reconstruction using AM tended to overcorrect, whereas 360° SLIL reconstruction using AM effectively stopped volar SL interval widening.

쇄골 원위부 골절에 대한 변형긴장대선 수술의 안정력 강화를 위한 K-강선 및 추가 봉합의 효과

채승범 ( Seung Bum Chae ),최창혁 ( Chang Hyuk Choi ),김동영 ( Dong Young Kim ) 대한골절학회 2016 대한골절학회지 Vol.29 No.2

목 적: 쇄골 원위부 골절에 대하여 변형긴장대선 고정술과 K-강선 및 추가 봉합을 이용한 수술의 치료결과를 분석하였다. 대상 및 방법: 2009년 5월부터 2013년 12월까지 쇄골 원위부 골절로 진료를 받은 59명을 대상으로 하였다. Craig 분류에 따른 골절양상은 group II의 제2형 골절은 12명, 제3형 골절 33명, 제4형 골절 8명, 제5형 골절 6명이었고, 평균 47.2세, 평균 추시기간은 27.9개월이었으며, 수상 후 평균 3.1일에 수술을 시행하였다. 임상적 결과는 수술 후 1년에 University of California at Los Angeles scores (UCLA), American Shoulder and Elbow Surgeons scores (ASES) 및 KoreanShoulder Society scores (KSS) 점수를 이용하여 평가하였다. 결 과: 골유합 기간은 평균 3.7개월이었으며, 최종 추시 시 운동범위는 굴곡 159.0도, 외회전 59.8도, 내회전 4.3점이었고, 불유합 2예였다. 기능평가상 UCLA 31.3점, KSS 91.6점, ASES 93.0점이었다. 결 론: 쇄골 원위부 골절의 치료로 변형긴장대선 고정술에 K-강선 및 비흡수성 봉합사로 추가고정 시 조기 관절운동이 가능하고, 연부조직과 관절의 손상을 줄이며, 견봉 쇄골 관절염을 피할 수 있는 유용한 술식으로 생각된다. Purpose: We attempted to evaluate the clinical results of modified tension band wiring (MTBW) with additional K-wire fixation and suture for distal clavicle fracture. Materials and Methods: Fifty-nine patients with a distal clavicle fracture from May 2009 to December 2013 treated with MTBW were enrolled in this study. Their fracture types were type 2, 12; and type 3, 33; type 4, 8; and type 5, 6 according to Craig classification group II; average age was 47.2 years with a mean follow-up period of 27.9 months. The operations were performed within a mean of 3 . 1 days a fter t rauma. The c linical results were evaluated u sing University of California at Los Angeles scores (UCLA), American Shoulder and Elbow Surgeons scores (ASES) and Korean Shoulder Society scores (KSS) at 1 year after surgery. Results: Radiographic bone union was achieved at a mean of 3.7 months after the operation. In the last observation, their range of motion was forward flexion 159.0o, external rotation 59.8o, and internal rotation 4.3 points, and there were 2 cases of nonunion. Each average functional score was UCLA 31.3 points, KSS 91.6 points, and ASES 93.0 points. Conclusion: For the surgical treatment of distal clavicle fractures, MTBW with additional K-wire fixation and suture is a useful technique allowing early range of motion exercises, minimizing soft tissue damage, and preserving the acromio-clavicular joint.

Solid-state nanopore analysis on conformation change of p53TAD-MDM2 fusion protein induced by protein-protein interaction

Chae, Hongsik,Kwak, Dong-Kyu,Lee, Mi-Kyung,Chi, Seung-Wook,Kim, Ki-Bum The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.36

<P>Although protein-protein interactions (PPIs) are emerging therapeutic targets for human diseases, development of high-throughput screening (HTS) technologies against PPI targets remains challenging. In this study, we propose a protein complex structure to effectively detect conformational changes of protein resulting from PPI using solid-state nanopore for a novel, widely-applicable drug screening method against various PPI targets. To effectively detect conformational changes resulting from PPI, we designed a fusion protein MLP (MDM2-linker-p53TAD), where p53TAD and MDM2 are connected by a 16 amino acid linker. The globular conformation of MLP exhibited a single-peak translocation event, whereas the dumbbell-like conformation of nutlin-3-bound MLP revealed as a double-peak signal. The proportion of double-peak to single-peak signals increased from 9.3% to 23.0% as nutlin-3 concentration increased. The translocation kinetics of the two different MLP conformations with varied applied voltage were analyzed. Further, the fractional current of the intra-peak of the double-peak signal was analyzed, probing the structure of our designed protein complex. This approach of nanopore sensing may be extendedly employed in screening of PPI inhibitors and protein conformation studies.</P>

Sustainability and Global Logistics

Seung Bum Ahn,Junjae Chae 인하대학교 정석물류통상연구원 2019 JOURNAL OF INTERNATIONAL LOGISTICS AND TRADE Vol.17 No.2

Medical Image Segmentation for Mobile Electronic Patient Charts Using Numerical Modeling of IoT

Chae, Seung-Hoon,Moon, Daesung,Lee, Deok Gyu,Pan, Sung Bum Hindawi Limited 2014 Journal of applied mathematics (JAM) Vol.2014 No.-

<P>Internet of Things (IoT) brings telemedicine a new chance. This enables the specialist to consult the patient’s condition despite the fact that they are in different places. Medical image segmentation is needed for analysis, storage, and protection of medical image in telemedicine. Therefore, a variety of methods have been researched for fast and accurate medical image segmentation. Performing segmentation in various organs, the accurate judgment of the region is needed in medical image. However, the removal of region occurs by the lack of information to determine the region in a small region. In this paper, we researched how to reconstruct segmentation region in a small region in order to improve the segmentation results. We generated predicted segmentation of slices using volume data with linear equation and proposed improvement method for small regions using the predicted segmentation. In order to verify the performance of the proposed method, lung region by chest CT images was segmented. As a result of experiments, volume data segmentation accuracy rose from 0.978 to 0.981 and from 0.281 to 0.187 with a standard deviation improvement confirmed.</P>