The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

결핵 진단을 위한 검사 방법간의 효율성에 관한 비교 분석

이원재,최석철,정천환,성희경,김태운 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

최근 다약제 내성균주의 출현과 후천성 면역결핍증으로 인한 결핵발병률의 증가는 전세계적으로 중요한 보건문제가 되었다. 따라서 보다 빠르고 신뢰할 만한 진단법은 결핵박멸을 위한 가장 중요한 필요조건 중의 하나일 것이다. 본 연구는 171명의 환자를 대상으로 폐결핵 진단의 전통적 방법들 (X-선,항산성 염색,배양)과 PCR법간의 진단적 가치와 효율성을 비교 검토하기 위해 시행하였다. 흉부 X-선 소견 및 검사 결과 그리고 다른 임상 소견들을 통해 결핵으로 확진된 예는 전체 171건의 검체 중 39예 (22.8%)였다. 이러한 확진을 근거로 할 때 각 검사별 민감도, 특이도, 효율성, 위양성률, 위음성률을 살펴 보면 흉부 X-선의 경우 각각 69.2%, 87.1%, 83.0%, 12.9%, 30.8%; 항산성 염색의 경우 79.9%, 95.5%, 91.8%, 4.6%, 20.5%; 배양의 경우 56.4%, 99.2%, 89.5%, 0.8%, 43.6%; PCR의 경우 82.1%, 96.2%, 93.0%, 3.8%, 17.9%였다. PCR의 경우 가장 높은 민감도 및 효율성과 가장 낮은 위음성률을 보였다. 배양법은 가장 높은 특이도와 가장 낮은 위양성률을 보였다. 결론적으로 PCR은 결핵 진단을 위한 신속하고 효율적인 우수한 검사 방법이므로 일상적 임상 검사로의 활용가치가 매우 높다고 하겠다. 그러나 전통적인 여러 방법들 역시 임상상황에 따라 그 나름대로의 특별한 가치를 지니고 있으므로 철저한 정도관리를 통해 PCR과 병행한다면 결핵균 검출율을 보다 높일 수 있으리라 판단된다. In recent years continuously increasing number of tuberculosis (TB) cases due to the emergence of strains with multidrug resistance and AIDS is a significant global health problem. Therefore, more rapid and reliable diagnosis of TB may be one of the most urgent needs in efforts to eradicate the disease. The present study was designed to compare and assess the diagnostic values and efficiencies between the conventional methods (X-ray, AFB stain and culture) and PCR for pulmonary TB on 171 cases. Chest X-ray finding and clinical features revealed that 39 (22.8%) of 171 sputum specimens were pulmonary TB cases. The statistical data were taken on the basis of the definitive diagnosis: In X-ray, overall sensitivity, specificity, efficiency and false positive and false negative incidence was respectively 69.2%, 87.1%, 83.0%, 12.9%, and 30.8%; 79.5%, 95.5%, 91.8%, 4.6% and 20.5% in AFB-stain; 56.4%, 99.2%, 89.5%, 0.8% and 43.6% in culture; 82.1%, 96.2%, 93.0%, 3.8% and 17.9% in PCR. PCR got a highest sensitivity and efficiency as well as a lowest false negative incidence. Culture had a highest specificity with a lowest false positive incidence. These results imply that PCR assay is fast, sensitive and efficient method for diagnosis of pulmonary TB. However, combined use of the conventional methods wish thorough quality control may offer more opportunities for detecting Mycobacterium tuberculosis and diagnosting TB although they have some limits.

필드버스시스템의 효율적인 테이터 서비스를 위한 온라인 토큰제어

이석원,남부희,김일환 강원대학교 정보통신연구소 1998 정보통신논문지 Vol.2 No.-

A fieldbus system should be designed by considering the number of sensors/actors(actuators+controllers)and their sampling times. But the munber of sensors/actors which are connected to the network bus can be varied by addition and/or due to the fault of the field devices. That variation decreases the efficiency of the system which is off-line designed optimally. This paper proposes an algorithm that ensures the transmission of cyclic data of the control system where there can be the number change in the field devices. We assign the different weight values to cyclic data and acyclic data. By simulation and experiment, the cyclic and acyclic data are served for the proposed network and the Profibus system. It is shown that the proposed algorithm is more robust with the uncertainties of the field devices of the control system.

대구·경북지역 전기통신의 수요예측 및 중장기계획 연구

이동만,문석환 경북대학교 경제경영연구소 1991 經商論集 Vol.19 No.3

장소성의 정량적·정성적 평가를 위한 접근방법 및 구성요소

이석환 경성대학교 공학기술연구소 2003 공학기술연구지 Vol.S2 No.2

The purpose of this research is to define the integrated methods between the quantitative approach and the qualitative approach in order to understand the sense of place and at the same time explain it at the same time. For this, it dealt with the observation methods which is proper in researching the sense of place, and then discuss the four domains, fifteen scales and their items contributing to sense of place.

인삼 투여가 정신지체아의 GPX와 MDA에 미치는 영향

이소영,장석암,김창환,권광선 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study is to investigate the change of antioxidant enzyme(GPX) and lipid peroxide (MDA) by ginseng supplementation for nine weeks. Choosing as objects of test women mental retardation, this study analyzed the blood obtained from the objects who were in a rest, immediately and 30 minutes after maximal exercise. The comclusions obtained from this study were as follow. 1. In the tendency of whole activation of GPX, ginseng supplemintation group showed more GPX activation than placebo group. 2. In the change of GPX activation according to the passage of exercise time, there was no difference between each group before and after supplementation for nine weeks. 3. In the change of GPX activation according to (before and after) supplementation, there was no significant difference between each group at a rest, immediately and 30 minutes after maximal exercise. 4. In the change of MDA concentration according to the passage of exercise time, there was no difference between each group before and after supplemintation for nine weeks. 5. In the change of MDA concentration according to (before and after) supplementation there was o significant difference between each group at a rest, immediately and 30 minutes after maximal exercise.

비행청소년의 식생활태도와 식이자기효능감에 관한 연구

이정숙,이현자,송병춘,김은경,이춘복,김석환 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.5

The purpose of this study was to identify the factors associated with dietary attitudes and dietary self-efficacy of juvenile delinquents. Out of 110 questionnaires distributed to the juvenile detention home students in Daegu, and 150 questionnaires distributed to the juvenile detention home students in Anyang, 210 were analyzed (80.7% analysis rate). These data were analyzed by SPSS program. The results are summarized as follows. Almost all parents’ educational levels showed ‘graduation of middle school’, and only 43.8% of the juvenile detention students were living with parents. In case of incoming status, average income per month was 2,000,000 won, which was lower than normal one. Diet attitude score was higher in boy students than girl students (p < 0.05). There was a higher score of diet attitude in higher educational levels of father. The average score of dietary self-efficacy was 2.51 ± 0.86. This value was lower than the normal juvenile. There was a higher diet attitude score in the higher dietary self-efficacy score (p < 0.001). Therefore, proper nutrition education is required to improve their dietary self-efficacy. The results of this study could be useful data to plan and develop nutritional education programs of juvenile delinquents.

Equisetum arvense L.이 고혈당 쥐의 혈중 포도당 농도에 미치는 영향

이현자,김석환,손기호,강우규,최종원 慶星大學校 環境問題硏究所 1992 環境硏報 Vol.2 No.1

The effect of methanol extract of Equisetum arvense L.(EM) on blood glucose level in streptozotocin-induced diabetic rat and acute toxicity of EM were investigated. Male Sprague-Dawley rats(200∼250g), with free access to commercial rat chow and water, were divided into four groups: Group 1 served as control; Group 2 received STZ only: Group 3 received EM only; Group 4 received pretreatment with EM followed by STZ administration. EM did not affect the normal blood glucose level and LD50 was about 6,250㎎/㎏. EM pretreatment in STZ-induced diabetic rats slightly inhibited Weight loss and water consumption. EM pretreatment in STZ-induced diabetic rats slightly inhibited the rise of serum glucose concentration. Serum transaminase(AST, ALT) and sorbitol dehydrogenase(SDH) were slightly increased by STZ induced changes in the serum glucose level.

도시의 현대성 극복을 위한 장소론

이석환,김영환 永同工科大學校 1996 硏究論叢 Vol.2 No.1

본 연구의 목적은 현대성이 도시를 장소보다는 공간으로 간주하기 때문에 사람들을 도시로부터 소외시키고 있다는 인식하에, 도시를 장소라는 시각에서 바라봄으로써 인간과 도시의 통합 가능성을 재발견하려는 것이다. 이러한 가능성을 찾기 위하여 먼저 현대성이 장소에 끼친 부정적 결과를 논의한 다음, 장소의 본래적 의미 및 그와 관련된 인간의 체험방식을 파악하고 장소로서의 도시의 의미를 포착한다. 궁 극적으로 본 연구는 도시가 단순히 물적 대상물이 아니라 인간과 대상물의 통합체라는 시각에서 도시계획 및 도시설계가 진행되어야 하는 당위성을 강조하고자 한다. The purpose of this study is to rediscover the possibilities of integration between man and city from the viewpoint of city as place, recognizing that modernity alienates people from city because it let us see the city as space rather than as place. To search for these possibilities, we first discuss the negative impacts of modernity upon place, get hold of the intrinsic meaning of place and the lived-experience way of man related to it, and grasp the meaning of city as place. Ultimately this study emphasizes that urban planning and urban design should be pursued in the position that city is not a physical object but a consolidation between man and object.