HPLC를 이용한 Alnus속 식물에서의 diarylheptanoids의 정량분석

정동욱,김준식,조수민,이연아,김광호,김세원,이민원 중앙대학교 약학연구소 1999 약학 논총 Vol.13 No.-

Quantitative determination of diarylheptanoids (oregonin and hirsutanonol), which were characteristic components of Alnus spp. has been conducted by High Performance Liquid Chromatography. The HPLC analysis was carried out using an YMC J'sphere ODS-H80 column [150×4.6mm, S-4μm. 80A(particle)] and a combination of acetonitrile and H2O was used as mobile phase in gradient solvent system. The results showed differnce in the species (Alnus japonica, A hirsuta and A. hirsuta var. sibirica)

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

저장 온도 및 상대습도가 비타민 정제 중 지용성 비타민 함량의 변화에 미치는 영향

김동섭,이재황,김세곤,이동언,박석준,이진희,이강표,최성원,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

치과기공사의 스트레스 증상과 직무요인과의 관련성 연구

김지환,오세윤,김웅철,유진호,김태석,이준석,이원철 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.2

This study was carried out to investigate psychiatric stress symptoms and stress- inducing factors, such as role overload, work demand, work procedure and so forth in korean dental laboratory technicians. Questionnaires were mailed to randomly selected 1000 dental technicians who were systematically selected. Among them, 786 dental technicians completed the questionnaires and returned them. Validity test and reliability test on the questionnaires were done prior to the main survey, using the SCL-90-R as a standard. Stress-inducing factors were identified with a multiple regression analysis on the continuous variables. To investigate stress-inducing factors on stress symptoms, analysis on distribution of characteristics was performed, and then correlation analysis and multiple regression analysis was carried out. The results of the study were as follows: According to multiple regression analysis, there was a statistical correlation between stress symptoms and role overload, work procedure, occupation conflict, interpersonal relationship, social support, personality traits in stress symptom(GSID). The stress symptoms in korean dental laboratory technicians seemed to be mostly job related ones, and considering the results obtained from the study, it is suggested that reducing work load and proper health promotion programs for dental technicians be necessary.

Seasonal Fluctuation and Vertical Microdistribution of Drosophilid Flies Dwelling in the Broad-leaved Forests on Cheju-do(Quelpart Island)

김원택,김승범,정세호,강효식 濟州大學校 師範大學 科學敎育硏究所 1995 科學敎育 Vol.12 No.1

Community organization of the drosophilid flies was investigated with respect to the seasonal variation in species abundance and vertical microdistribution on the basis of the trapped collections in the two natural forests on Cheju-do from May to October 1994. The dominant species were Drosophila bizonata. D. curviceps. D. lutescens. D. angularis. D. pengi. and D. immigrans in the annual collections. The pattern in seasonal changes of the dominant species was similar at the two survey sites. Seasonal fluctuation in the species diversity was more affected by evenness than by species richness (number of species). The seasonal variation of abundance showed an unimodal pattern in all of the dominant species. The seasonal patterns of vertical microdistribution revealed difference in some of the dominant species between the two survey sites. These results suggest that the predominant species in the forest avoid niche overlap by means of seasonal separation of breedings and that the vertical microdistribution is strongly affected by factors associated with season and vertical site in the deep wooded forests.

치과기공사 국가시험 과목 타당성 연구

김웅철,이원철,손영석,오세윤,김부섭,유진호,김지환 한국보건의료인국가시험원 2005 보건의료교육평가 Vol.2 No.1

This study prepared a basic framework for the development and improvement of Korean Dental Technicians' Licensing Examination, based on actual test questions. A peer review was conducted to ensure relevance to current practices in dental technology. For the statistical analysis, 1000 dental laboratory technicians were selected; specialists in dental laboratory technology (laboratory owners, educators, etc.) were involved in creating valid and reliable questions. Results indicated that examination subjects should be divided into three categories: basic dental laboratory theory, dental laboratory specialties, and a practical examination. To ensure relevance to current practice, there should be less emphasis on basic dental laboratory theory, including health-related laws, and more emphasis on dental laboratory specialties. Introduction to dental anatomy should be separated from oral anatomy and tooth morphology; and fixed prosthodontics should be separated from crown and bridge technology and dental ceramics technology. Removable orthodontic appliance technology should be renamed 'orthodontic laboratory technology'. There should be less questions related to health related law, oral anatomy, dental hygiene, dental materials science and inlay, while the distribution ratio of questions related to tooth morphology should be maintained. There should be a decrease in the distribution ratio of questions related to crown and bridge technology, dental ceramics technology, complete dentures and removable partial dentures technology, and orthodontic laboratory technology. In the practical examination, the current multiple choice test should be replaced with tooth carving using wax or plaster. In dental laboratory specialties, subjects related to contemporary dental laboratory technology should be included in the test items.

한라산의 곤충상(나비목 제외) : I .관음사 등산코스 일대

정세호,김원택 제주대학교 환경연구소 2000 환경연구논문집 : 제주대 Vol.8 No.-

Insect fauna of Mt. Hallasan was investigated along the climbing course of Kwanum Temple. Total of 400 species belong to the 103 families, 14 orders was identified and enumerated. Among them, five species, Menida violacea of Pentatomidae (Hemiptera), Episcuphu gorhamj of Erotylidae, Circopes suturulis of Nitidulidae, Chrysunthia integricollis of Oedemeridae, and Noturis oryzae of Curculionidae (Coleoptera) were new to the Jeju fauna. The composition of species number of each order was comparative to that of Jeju Island. These results may reflect that the natural environment of Kwaneum Temple area is relatively specific on this island and well conserved.

烏貝散이 HCI-aspirin 으로 유발된 십이지장궤양에 미치는 조직학적 영향

구세광,이형식,김종대,한상원,김상찬,이재현 慶山大學校 基礎科學硏究所 1999 基礎科學 Vol.3 No.-

오패산이 HCI-aspirin tm으로 유발된 rat 십이지장궤양에 미치는 조직학적 영향을 관찰하기 위하여, 오패산을 1,3 및 5일 동안 경구투여하고 십이지장의 조직학적 변화를 관찰하였던 바 다음과 같은 결과를 얻었다. 실험 전 기간동안 대조군에서는 십이지장 융모의 위축과 붕괴가 관찰되었으며, 조직학적으로는 점막상피의 변성 및 탈락이 관찰되었고 점막고유층에서는 염증세포의 침윤(infilteration)의 소견이 관찰된 반면 오패산 투여군의 투여 1일에서는 대조군과 유사하게 관찰되었으나, 투여 3일후부터 점막상피의 첨부에서 경미한 카타르성 물질이 관찰된 이외에 정상군과 유사한 소견을 나타내었다. 이상에서 오패산이 십이지장궤양의 치유를 촉진시키는 것으로 관찰되었다. In order to study, the histological effects of Opeaesan on the duodenal ulcer induced by HCI-aspirin tm in rate, experiments were done by oral administration and observed histological profiles of the ulcerative lesions. Ulcerative lesions were unmerously detected in control groups especially in pylorus-duodenal junctions. Histologically, very severe injury to duodenal epithelium wer observed in control groups and these injuries were increased with time intervals. But in the Opaesan-administration groups, no gross lesion of ulcer were demonstrated and histologically minor injury to the mucosal epithelium were observed. Among the Opaesan treatment groups, most slight injuries to duodenal mucosa were detected in 5 days after administration when the histological profiles were similar to that of normal groups. According to these result, it is suggested that Opaesan should be used in treatment of the duodenal ulcer but the funcitonal mechanisms were unknown.

마이코플라스마 폐염

이찬세,김원동,김계방 대한감염학회 1977 감염 Vol.9 No.1