DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase

Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3

<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>

상용차 기반에 대한 주차보조시스템 사용자 감성 평가

전재석(Jaeseok Jeon),박현배(Hyunbae Park),문희석(Heeseok Moon),곽수진(Sujin Kwag) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5

In this paper, we described about evaluation of human sensibility using park assist system of the commercial vehicle. The perpendicular parking and parallel parking have been carried out as a user test and subjects are classified as beginning drivers, drivers with less than 1 year experience and over 3 years experience. As a result, parking duration of beginning drivers and drivers with less than 1 year experience who use automatic parking assistance system is similar to drivers with over 3 years experience. However error occurred according to sensor position and distance between vehicle and parking space. And also it occurred that the vehicle leaves from parking line or does not recognize the parking space. Therefore, if we improve its completeness by compensating problems that came up from this evaluation and distribute the automatic parking assistance system, it is expected that the park assistance system is to help driver providing convenience of parking.

저전력 주차 안내 시스템 설계

박주용(Ju-Yong Park),임형규(Hyeong-giu Lim) 한국엔터테인먼트산업학회 2011 한국엔터테인먼트산업학회논문지 Vol.5 No.1

주차안내 시스템은 주차장에서 주차정보를 제공하여 운전자에게 주차 편리성을 제공한다. 동시에 다수의 센서, 디스플레이와 제어모듈을 이용하여 아주 소량의 전기 에너지 만을 소모한다. 녹색 빌딩 설계의 요구가 점차 증가함에 따라 주차관리 시스템의 운용 전력 감축 문제가 이수화 되고 있다. 본 논문에서는 주차 관리 시스템의 감지기와 디스플레이 장치의 설계와 소비전력 감축의 결과를 제시한다. 이 시스템은 무선 Park Tile 과 Park Disk를 사용하여 전력소비를 감축 시키고, 여러 개의 주차공간 감지기와 자동차 카운터, 정보 디스플레이 장치, 안내 터미널과 제어장치로 구성되어 있다. 그리고 시스템 구조설계와 통신망 설계, 주차정보 서비스 시나리오 설계, .배터리 수명 제어, 운영 전력 평가 등이 수행되었다. 주차장당 운영전력은 0.4W로 평가 되었으며, 이는 기존 시스템의 17%정도 이고 매년 유지비는 기존 시스템에 비해 43%에 해당된다. The parking guidance system can increase driver’s convenience with detailed parking information service in the parking lot. At the same time, parking guidance system consumes non-negligible electrical energy with large amount of sensors, displays and control modules. With the increase in the demand for green and sustainable building design all over the world, it becomes a meaningful issue for parking guidance system to reduce operating power. This paper presents the preliminary design and estimated results of a parking guidance system which is optimized to reduce the power consumption mainly on detectors and displays. The system design is based on pre-developed wireless parking detectors, Park Tile and Park Disk. The system has a number of parking space detectors, vehicle count detectors, information displays, guidance terminals and other control units. We have performed system architecture design, communication network design, parking information service scenario planning, battery life regulation and at last operating power estimation. The estimated operating power was 0.4 watt per parking-slot, which is 17% of traditional systems. The estimated annual maintain cost was 43% of traditional systems.

서구 공원 녹지 배치 계획 이론의 초기 발전 과정과 특성

박구원 ( Koo Won Park ) 한국녹지환경디자인학회 2006 녹지환경학회지 Vol.2 No.2

In America and Europe from the latter part of the 19th century to the beginning of the 20th century, the planning ideologies of park system and greenbelts were made and these planning ideologies are called Green Network System. They are different in terms of the purpose, type and method, but they have common characteristics of encouraging order and amenity in cities based on the consecutive connection of green space, and of coping with the problems happening in cities. Just as the park system was made, centering around new America and greenbelts were developed to meet with the problems happening in large cities, the structural arrangement and the roles of greens should be different. However, this connection system of greens was oriented in the circumstances of America and Europe at that time so it has not been confirmed what sizes of cities it would be useful for. On the other hand, separately from the Green Network System, the theory of park arrangement is being developed. It intends to cope with deterioration of the living environment caused by overcrowded cities and with increase in the demands of public parks. It is based on the neighborhood unit and the science of human settlement. In addition, the theory of park arrangement is based on the effects of greens in use, rather than, in decoration so it encourages dispersion and hierarchical system of parks, having the human settlement as base. Consequently, the theory of park arrangement is influenced by the characteristics and the type of households, and it has a required area and planning unit. However, this theory has the right for walking and human scale as the basic unit so for the large parks that are beyond the human scale, the planning criteria are not clear. The theory of park arrangement, which is based on the neighborhood unit, may be useful for the cities with tens of thousands of residents, but it is partially applied for the cities with 500,000~1,000,000 residents. And further, in organizing the green system for the whole city, the theory of park arrangement can be ignored. As seen in the above, the existing arrangement theory has some problems: it is just for partial application; and it is not suitable for the size and the growing speed of cities. The greens in cities should be operated as the comprehensive system, but greenbelts and park arrangement have been studied separately so far. That`s why it is necessary to review again the existing arrangement theory.

도시공원의 이용후 평가에 기초한 공원의 개발지표 설정 : 부산광역시 암남공원을 사례로 Case Study of Amnam Park in Busan City

박승범,김승환,남정칠,강영조,이기철,김석규 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

The purpose of this study is to investigate the prime factors that affect to user postoccupancy evaluation of activities and facilities in urban parks, to classify those factors, to find out factors about them, and then to suggest important indicators in the urban park planning, design, and development. The survey research was done using the self-administered questionnaire method by 435 peoples in the Busan City who participated in recreational activities in the Amnam Park. The Analysis of the data primarily consists of two phase: The first analysis was dealt an exploratory factor analysis which identified major factors involved in user postoccupancy evaluation with reacreational activities and facilities in Amnam Park by the SPSS(Ver.6.0) program and the second analysis was used to investigate the factors affected to user postoccupancy evaluation in the urban park by the Regression Analysis. According to the factor analysis, user postoccupancy evaluation of facilities in urban parks concerning the 20 variables, 5 prime factors by the staistical values were considered. The factor analysis showed that user postoccupancy evaluation of activities in urban parks concerning the 11 variables, 3 prime factors by the staistical values were analysed. Postoccupancy evaluation in the urban park by the Regression Analysis suggested that the two varlables as 'the directions of park development' and 'companies with the personal specific characteristics' are significant in addition to the some variables presented in user postoccupancy evaluation with reacreational activities and facilities in Amnam Park by the factor analysis. Furthomore the analysis models were identified as having significant effects on the factor and regression analysis. Overall fits of both models were very good. These significant relationships indicate important factors and variables that should be considered in planning, design, and development of the urban parks. Therefore, development direction of the h a m park has to be analyzed as significant factors concerning user postoccupancy evaluation in a systematic way, recognized as important variables for planning process. The urban park has to be fully designed and established in the planning process not by the decision-maker's subjective evaluation but by user postoccupancy evaluation.

노인의 공원이용 활성화를 위한 공원환경 평가지표 선정 및 환경 인식 분석-대구광역시를 중심으로-

박영은 ( Park Youngeun ),이우성 ( Lee Woosung ) 한국공간디자인학회 2021 한국공간디자인학회논문집 Vol.16 No.4

(Background and Purpose) Neighborhood parks are places where the elderly can easily access and perform various physical activities without without financial burden and are urban facilities where they can improve physical strength and maintain health. However, many parks in Korea are built according to the subjective and uniform design standards of the landscape designers, so there are many inconveniences for the elderly to use them. Therefore, the purpose of this study is to select the assessment indicators in order promote park use the elderly as a place for maintaining health, to analyze the perception of park environment by applying the indicators targeting the neighborhood parks of Daegu Metropolitan City, and to explore the differences in perception of park environment according to the individual characteristics. (Method) The study areas were Jung-gu, Dong-gu, Nam-gu, and Seo-gu of Daegu, where the ratio of the elderly population was 14% or more and one neighborhood park was selected for each administrative district. The assessment indicators of park environment were selected based on 10 previous studies and brainstorming and the questionnaire survey was conducted in two rounds for the elderly. Descriptive statistics, frequency analysis, T-test, and F-test (Scheffe’s method) were used to analyze the questionnaire data. (Results) Through the review and brainstorming related to the park environment from the perspective of the elderly, a total of 20 indicators were selected such as 'various exercise facilities', 'safety of exercise facilities', 'enough resting facilities', and 'convenience of resting facilities'. As a result of analyzing the perception of the elderly's park environment based on the 290 survey data, the indicators such as 'distance to the park', 'area of green space', 'shade by trees', and 'convenience of walk' had a high environmental level of 4.0 or more. On the other hand, the indicators such as 'horticultural support space', 'various attractions', and 'linkage with welfare facilities' were evaluated at a low environmental level of 3.2 points or less. In addition, as a result of analyzing the difference in perception of park environment according to the individual characteristics of the elderly, the differences according to gender, age group, education level, and income level were analyzed statistically significant. Women rather than men perceived the overall park environment more positively. Those in their 60s had positive perceptions of dynamic facilities and those in their 80s had positive perceptions of static facilities. (Conclusions) The findings from this study will be meaningful basic data to carry out a remodeling for a neighborhood park or a project for improving the neighborhood environment in the elderly concentration area.

Usufruct Rights Conflicts during the Exploitation and Management of Forest Parks in China

Hao Zhang,Bong-woo Park 강원대학교 산림과학연구소 2009 Journal of Forest Science Vol.25 No.3

Forest parks are regarded as one of the scientific ways to keep the forest sustainably developed, meanwhile deliver the benefits to the general public. The development of forest parks in China has experienced simply more than 20 years and both the exploitation and management institutions haven’t been set up systematically, which, in reality, reflects as inadequate legislative and policy framework. Without the regulatory guidance and collaborating assistance of environment relating governmental sectors at both national and local levels, it’s inevitable that the development of forest parks in the country would face constant problems and conflicts. Therefore, it might be helpful to sort out this conflicts and problems and further more to work out how to solve the barriers. The research in this report started with introducing the IUCN Protected Areas Categories, the overall current situations in China and compared the definition of forest parks in the country and that in international experience. It is to aim to find out the real usufruct rights conflicts during the exploitation and management of forest parks and the method used in this report is field visit, previous investigation, collecting secondary materials, interview, analysis and comparison. The research result in this report couldn’t cover all the conflict situations during the forest parks’ exploitation and management in China but will provide the analysis of this problem from the legal perspective. Practical application and concerning suggestion will be fully discussed in Part 5 in terms of legislative, social and environmental effects.

의열단원 박재혁(朴載赫)의 생애와 부산경찰서 투탄(投彈)

박철규 ( Park Chul-kyu ) 부산광역시사편찬위원회 2019 항도부산 Vol.37 No.-

Jae-hyuk Park was born as the only son in 183 Beomil-dong on May 17, 1895. At the age of 15, his father passed away and he lived with his mother and sister. On March 22, 1911, he graduated from Busanjin Primary School, and on March 22, 1915, he was the fourth graduate of Busan Public Commercial School. While attending Busan Public Commercial School, Jae-hyuk Park secretly reproduced and distributed 『Dongguk History』 with Cheon-taek Choi, Byeong-tae Kim and Hong-gyu Park. In his third grade, he formed Gusedan(救世團) with Cheon-taek Choi, Byeong-tae Kim, Hong-gyu Park, and Jae-young Oh, and issued a noticed to promote national identity in Busan and the whole region of Gyeongsangnam-do Province. Jae-hyuk Park left Busan in June 1917 to Shanghai and Singapore for more than three years to work in the trade industry. At the same time, he was seeking ways to contribute to the independence movement while interacting with his companions. He then decided to devote himself to the independence movement after the March 1 Independence Movement. Busan Police Station was targeted as the attack after the March 1 Independence Movement when Euiyeoldan had been organized by declaring the change of direction to the existing independence movement, and it was when everyone involved was arrested upon failure of the first national full-scale attack plan in June 1920. As a result, Euiyeoldan needed to achieve results and reverse the situation in a short time. Busan was also a gateway from Japan to Joseon and was developed as the typical colonial city, and had its symbolism as it was called as the second Osaka. In preparation for the rebellion, Jae-hyuk Park obtained information that Hashimoto, the Busan police chief, liked ancient books and disguised himself as the Chinese ancient book dealer by taking advantage of his experience in trade business. At about 2:30p.m. on September 14, 1920, he entered the Busan Police Station pretending to be on duty, approached chief Hashimoto from the right side and threw a bomb after declaring himself as a member of Euiyeoldan when the chief turned his body towards him. At that time, chief Hashimoto was slightly injured. Jae-hyuk Park was arrested at the scene after failing to escape due to his injury. Jae-hyuk Park was consistently charged with 'attempted murder' from the first trial of the Busan District Court to the third trial of the Gyeongseong High Court on March 31, 1921. Jae-hyuk Park was sentenced to life imprisonment at the Busan District Court. However, the appeal by the prosecution annulled the original decision at the trial at the Daegu High Court, and Jae-hyuk Park was sentenced to death. Eventually, Jae-hyuk Park was sentenced to death as his final judgment on March 31, 1921 after the third trial of the Gyeongseong High Court. Jae-hyuk Park suffered from lung diseases due to tortures after arrest and injuries from the bomb, but his spirit was never thwarted. He died in Daegu prison at 11:20a.m. on May 11, 1921 before the execution.

공공개발지구 내 주차장용지에 주차전용건축물이 집합건물일 경우 부대시설 수분양자의 주차장 지분배분에 관한 연구

박창률(Park, Chang-Yul),윤정득(Yoon, Jeong-Duck) 대한국토·도시계획학회 2020 國土計劃 Vol.55 No.7

In the past, the implementers (public enterprises or local public corporations) of projects in public development districts sold parking lot land to local governments for free or at cost. However, after the parking-lot law was amended in 1999, the land was sold to the private sector under a general competitive bidding method. As a result, the provision of parking lot land in public development project districts did not do more to ameliorate the parking shortage than when it was supplied to local governments. While there are a variety of reasons for this, the most significant cause is that the development of parking lots involved parking-only buildings, but in most cases collective building were built. In general commercial land, semi-residential, or residential areas, the requirements for establishing an aggregated building are clearly defined in the Collective Building Act, but the requirements for parking areas are applied differently. That is, the law was often misinterpreted. In the case of parking-only buildings for parking lots, it is necessary to establish a system of laws to better ensure the securing of parking lots from the perspective of pre-sale consumers. This study argues that the conditions of collective buildings must be met for parking-only buildings. Local governments stipulate the allowable range of additional facilities for parking lots by ordinance, but if the construction of parking-only buildings involves a collective building, it cannot be sold under the same concept as the general commercial building. This study concludes that revision of the Enforcement Rules of the Parking Lot Law is requires to protect these rights by securing the parking lot shares of those receiving pre-sale facilities.

국립공원 구역 조정에 따른 환경,경제,사회적 파급효과 분석

홍현정 ( Hyun Jung Hong ),최현아 ( Hyun Ah Choi ),변병설 ( Byung Seol Byun ),박용하 ( Yong Ha Park ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2013 한국환경복원기술학회지 Vol.16 No.6

As ten years have passed since national parks were adjusted and released inceptively, it is the time for evaluating the effectiveness of the national park policy and improving it on the basis of the evaluation result. In this study, the method of appraising the environmental and socio-economical ripple effect on the implementation of national park regulation were provided, based on the institutional consideration, the environment analysis, the survey of residents consciousness, the statistical analysis and so on. It is applied to target sites where were released from national parks, and the policy direction was suggested for sustainable use and management of national parks. National parks, that exhibit various characteristics depending on geographical and local conditions, were categorized through the statistical approach. Released sites from Seoraksan National park, where was categorized as the core national park for sustainable use and management, were evaluated environmentally based on the time-series analysis of environmental thematic maps and socio-economically based on the survey on residents perceptions. As a result of this study, the environmental effect of released sites has been declined or threatened, and the residents` economic, social and living condition in these areas are still not improved(p<0.05) since the adjustment of national parks. Based on the policy approach reflecting regional characteristics, natural resources are kept and enhanced for the sustainable use and management of national parks. And a consensus on the national park policy of national park should be developed between local residents and voluntary participation and public awareness should be attracted from them, based on the construction and the supplement of the infrastructure.