한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

SAN을 이용한 큐잉모델 해결방법

장경수,신호진,이상호,김병기,신동렬 成均館大學校 科學技術硏究所 2000 論文集 Vol.51 No.2

Queueing analysis, in general., has the intrinsic problem of large state space dimension and complex computation. In fact, the petri net is a graphical and mathematical model. It has been used for the modeling of various applications, in particular, manufacturing systems. It can deal with parallelism, concurrence, deadlock avoidance, and asynchronism. Currently it has been applied to the performance of computer networks and protocol verifications. This paper presents a technique for modeling and analyzing queueing model using stochastic activity networks (SANs). And then some examples are showed for the verification of the technique presented in this paper.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

알코올이 Dynamic Posturography에 미치는 영향

이진춘,고의경,장민호,이병주,백무진,노환중,왕수건,전경명 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

서방형 Diltiazem제제의 개발을 위한 약동학/약력학적 특성 검토

유경상,배균섭,조주연,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업의 효과와 학생들의 인식

장진아,이경희,박소영,김동진,최병순,박국태 韓國敎員大學校 敎育硏究院 2009 敎員敎育 Vol.25 No.3

이 연구는 7학년 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업이 중학교 1학년 학생들의 개념 이해와 학업 성취도에 미치는 효과와 학생들의 인식을 알아보기 위한 것이다. 연구를 위하여 S시 소재 Y중학교 1학년 3개 학급 107명을 실험집단l파 실험집단2 및 통제집단으로 나누어, 실험집단l에는 학생간의 사회적 상호작용을 강조한 탐구실험 수엽을 실시하고, 실험집단2에는 교사와 학생간의 사회적 상호작용을 강조한 탐구실험 수업을 실시하였으며, 통제집단에는 전통적인 실험 수엽을 실시하였다. 수업 전과 후에 개념 이해도 검사를 하였으며, 성취도 검사와 인식 조사는 수업 후에 실시하였다. 연구 결과에 의하면, 실험집단1과 섣험집단2의 사회적 상호작용을 강조한 탐구싣험 수업이 통제집단의 전통적인 설험 수엽에 비하여 분자의 운동에 대한 개념 이해에 효과적이었다. 학업 성취도에 있어서는 사회적 상호작용을 강조한 실험집단1과 실험집단2의 학업 성취도 평균이 통제집단의 학업 성취도 평균에 비해 통계적으로 유의마하게 높았다. 실험집단1과 실험집단2의 학생들은 전반적으로 분자의 운동 단원에서 사회적 상호작용을 강조한 탐구실험 수업을 긍정적으로 인식하였다. 실험집단1에서 인지수준이 높은 학생들은 명확하게 답을 제시해 주는 것보다 동료와의 상호작용을 통해 시행착오를 거치면서 스스로의 힘으로 문제를 해결함으로써 자신감과 만족감을 느꼈다. 실험집단2에서 인지수준이 중하위인 학생들은 애매하고 시행착오적인 동료와의 상호작용보다는 교사와의 상호작용을 통해 직접적으로 답에 이르고 명확하게 개념 정리를 해주는 것을 선호하였다. The purpose of this study was to investigate effects of the inquiry experiment instruction emphasizing social interaction in the 7th grade motion of molecules unit on middle school students' scientific concept, achievement, and the perception of the instructions. For this study, 107 7th grade students were divided into three groups: the experimental group I, the experimental group 2, and the control group. The experimental group 1 were given inquiry experiment instruction emphasizing student-student interaction and the experimental group 2 were given inquiry experiment instruction emphasizing teacher-student interaction, while the control group were given traditional experiment instruction. They were all tested on their level of scientific concept understanding before and after the instruction and after the instruction they were given achievement test and surveyed on their perception. According to the result of this study, the inquiry experiment instruction emphasizing social interaction of experimental group 1 and 2 was more effective than the traditional experiment instruction of the control group in understanding the scientific concept of molecular motion, and the achievement level of experimental group 1 and 2 was significantly higher than the control group. Generally both students of group 1 and 2 were found to affirmatively perceive the inquiry experiment instruction emphasizing social interaction in the motion of molecules unit. Students of group 1 with high cognitive level were satisfied when they were able to independently solve problems by trial and error through student-student interaction than being given the exact answers. Meanwhile students of group 2 with middle to low cognitive level preferred the inquiry experiment instruction emphasizing teacher-student interaction that easily and cleary gives them the correct answer than student-student interaction which can be obscure and requires trial and error.

정신과 문제로 병사용 진단서를 발급받은 환자들의 임상적 특징

장혁진,김학렬,박상학,김상훈,조용래,표경식 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Most Korean young men should take a military physical examination. This study attempted to search the social, economical and psychological features of Korean youths who have psychiatric problems in taking the military physical examination. So this study was intended to help decide whether the youths enter the military service or not. Materials and Methods : This study analyzed diagnostic features that were grouped by 7 categories (antisocial and borderline personality disorder group, the other personality disorders group, psychosis group, organic mental disorder group, neurosis group, pervasive developmental disorders group, the other groups). The study was conducted from 1994 to May 1999 at Chosun University hospital with about 143 patients who were issued the psychiatric certificate for military affairs. Results : According to the results of the psychiatric examination, the antisocial and borderline personality disorder group had increased more year by year than the other groups. Classified by the residential distribution, the residents of agricultural areas belonged to the psychosis group more than others. Classified by the job distribution, the antisocial and borderline personality disorder group had more gangsters than the other groups. Also the pervasive developmental disorders group included those Who were without an occupation. Classified by visiting companion, those who were included in the antisocial and borderline personality disorder group and pervasive developmental disorders group used to come alone as compared with the other groups. In the case of those who have experienced psychiatric treatment in the past and who have been treated psychiatrically after being given the psychiatric certificate, the psychosis group comprised more than 50% statistically. In the case of the existence of a tattoo and self-injured scars, the antisocial and borderline personality disorder group has more than the others statistically. According to psychological examination, by measure of validity scale of MMPI, the antisocial and borderline personality disorder group appeared as the inverted V shape that L, K value was low and F value was high. And the antisocial and borderline personality disorder group measured by the Pd, Pa measure. Pd, Pa measure value got higher points than the organic mental disorder group statistically. Conclusion : The number of the antisocial and borderline personality disorder patients’ visits increased at the psychiatric hospital year by year and there were many gangsters or persons without regular occupation in that kind of patients’group. And there were many visitors who came by themselves to the hospital. Also they tended to have a tattoo or self-injured scars. And most of patients didn’t do commuting psychiatric care after receiving the psychiatric certificate. In the aspect of the psychological examination, they were likely to exaggerate their symptoms or disguise having psychiatric trouble intentionally.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

음식물 폐기물류로 제조된 퇴비의 고형연료 가치 평가 연구

이경섭,장한별,정은지,도아름,하진욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In 2019, the daily generation of food waste in Korea was 14,314 tons, which is a steady increase compared to the past. To efficiently use food waste as an effective resource, composting and feeding are carried out. In Korea, attention is gradually focused on a sustainable resource circulation society. Compost made of food waste has problems with foreign substances, heavy metals, and salt content, and solid fuelization research is being actively conducted to compensate for this. In this study, infrared spectroscopy(FT-IR), organic content measurement(TGA), and chemical composition were measured to compare the fuel characteristics with wood pellets, which are major solid fuels, in order to examine the physical and chemical properties of food waste compost.

오렌지로부터 아플라톡신B₁의 정량분석에 관한 연구

장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2

Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.